Gene: TCF7

6932
TCF-1
transcription factor 7
protein-coding
5q31.1
Ensembl:ENSG00000081059 MIM:189908 Vega:OTTHUMG00000129124 UniprotKB:P36402
NG_030367.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.980e-1 (AD)  1.175e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPKAPK20.793
CDKN2B0.773
SRGAP10.766
SYDE10.764
MSN0.758
PLCB30.744
LATS20.734
SPPL2A0.732
ZBTB420.732
SLC43A30.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.562
SMIM18-0.55
MYOZ3-0.528
FSTL5-0.52
PTPRR-0.519
LRRC38-0.518
LHX6-0.518
KCNB2-0.514
PLCXD3-0.514
MCF2-0.505

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TCF7 mRNA"25614096
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TCF7 mRNA"18648102
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7 protein19407222
D000079AcetaldehydeAcetaldehyde affects the expression of TCF7 mRNA22634333
D000082AcetaminophenAcetaminophen results in increased expression of TCF7 mRNA22230336
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7 protein19407222
D000447AldehydesAldehydes results in increased expression of TCF7 mRNA25014914
C011512alpha-naphthoflavonealpha-naphthoflavone results in increased expression of TCF7 mRNA18762178
D000638AmiodaroneAmiodarone results in increased expression of TCF7 mRNA19774075
C006632arsenic trioxidearsenic trioxide results in increased expression of TCF7 mRNA27829220
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TCF7 mRNA20498004
D000069286BortezomibBortezomib results in decreased expression of TCF7 mRNA20977926
C018475butyraldehydebutyraldehyde results in increased expression of TCF7 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of TCF7 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TCF7 mRNA17484886
C054133casticincasticin results in decreased expression of TCF7 mRNA28444820
D002392CatechinCatechin results in increased expression of TCF7 mRNA15465739
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TCF7 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of TCF7 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of TCF7 mRNA21041162
C014347decitabinedecitabine results in decreased expression of TCF7 mRNA19387464
C014347decitabinedecitabine results in increased expression of TCF7 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TCF7 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of TCF7 mRNA21041162
D003976DiazinonDiazinon results in increased methylation of TCF7 gene22964155
D003976DiazinonDiazinon affects the expression of TCF7 mRNA22546817
D002945CisplatinCisplatin results in decreased expression of TCF7 mRNA22023808
D004026DieldrinDieldrin affects the expression of TCF7 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of TCF7 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TCF7 mRNA21041162
D005419FlavonoidsFlavonoids results in decreased expression of TCF7 mRNA15465739
D005419FlavonoidsFlavonoids results in increased expression of TCF7 mRNA15465739
C061365flusilazoleflusilazole affects the expression of TCF7 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TCF7 gene20938992
D005839GentamicinsGentamicins results in increased expression of TCF7 mRNA22061828
D017313FenretinideFenretinide results in increased expression of TCF7 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TCF7 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TCF7 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TCF7 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TCF7 mRNA23430699
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TCF7 mRNA21540303
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TCF7 gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TCF7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TCF7 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of TCF7 mRNA14595851
D009532NickelNickel results in increased expression of TCF7 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of TCF7 mRNA22546817
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TCF7 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TCF7 mRNA25729387
D010269ParaquatParaquat results in increased expression of TCF7 mRNA28619522
C046012pentanalpentanal results in increased expression of TCF7 mRNA26079696
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TCF7 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TCF7 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TCF7 mRNA19482888
D010936Plant ExtractsPlant Extracts results in decreased expression of TCF7 mRNA15465739|2355793
D010936Plant ExtractsPlant Extracts results in increased expression of TCF7 mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of TCF7 mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of TCF7 mRNA15465739
C005556propionaldehydepropionaldehyde results in increased expression of TCF7 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TCF7 mRNA27029645
D011794QuercetinQuercetin inhibits the reaction [PLAUR protein results in increased expression of TCF7 protein]22511755
C012526quercitrinquercitrin affects the expression of TCF7 mRNA25193878
C059514resveratrolresveratrol results in decreased expression of TCF7 mRNA19167446|2118812
D064586Selenic AcidSelenic Acid results in increased expression of TCF7 mRNA16444006
C017947sodium arsenitesodium arsenite results in decreased expression of TCF7 mRNA16014739
D018038Sodium SeleniteSodium Selenite results in increased expression of TCF7 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TCF7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TCF7 mRNA21041162|2405805
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TCF7 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TCF7 mRNA25729387
D019772TopotecanTopotecan results in increased expression of TCF7 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TCF7 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of TCF7 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of TCF7 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0005515protein binding-IPI9783587  16442529  17510365  19358846  25678599  26079538  
GO:0008013beta-catenin binding-IBA21873635  
GO:0008013beta-catenin binding-IDA9488439  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA18579517  20128911  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS1569101  
GO:0006955immune response-TAS1569101  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0021915neural tube development-IEA-  
GO:0030538embryonic genitalia morphogenesis-IEA-  
GO:0033153T cell receptor V(D)J recombination-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process-IEA-  
GO:0046632alpha-beta T cell differentiation-IEA-  
GO:0048557embryonic digestive tract morphogenesis-IEA-  
GO:0048619embryonic hindgut morphogenesis-IEA-  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0071353cellular response to interleukin-4-IDA18579517  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA18579517  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005719nuclear euchromatin-IEA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma
hsa05221Acute myeloid leukemia
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promotersTAS
R-HSA-4641265Repression of WNT target genesTAS
R-HSA-4641265Repression of WNT target genesIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8951430RUNX3 regulates WNT signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23590301Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. (2013 Aug)Bahr TMAm J Respir Cell Mol Biol