Gene: TCF7L2

6934
TCF-4|TCF4
transcription factor 7 like 2
protein-coding
10q25.2-q25.3
Ensembl:ENSG00000148737 MIM:602228 Vega:OTTHUMG00000019070 UniprotKB:Q9NQB0
NG_012631.1
PubMed
0   ANCO-SNPs
ND
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.980e-1 (AD)  2.209e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00831931chr10:114823094TCF7L2Gene body6.293e-4Alcohol use disorders26763658
cg00159523chr10:114713187TCF7L22.770e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACOX10.849
SEMA4B0.824
TPP10.817
MCCC20.796
EPB41L50.793
APPL20.792
BBS20.789
SLC44A20.787
GPR75-ASB30.787
HERPUD20.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.549
OR4F29-0.514
KRT78-0.265
CHP2-0.236
FIBCD1-0.231
CETP-0.215
CBY3-0.209
SPRR1B-0.206
SPRR2D-0.199
TSPAN8-0.194

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF7L2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF7L2 mRNA"27188386
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7L2 protein19407222
D000082AcetaminophenAcetaminophen results in decreased expression of TCF7L2 mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TCF7L2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TCF7L2 mRNA]17585979
C016601afimoxifeneafimoxifene results in increased expression of TCF7L2 mRNA19901195
C046926AH 23848[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7L2 protein19407222
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TCF7L2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of TCF7L2 mRNA20458559
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TCF7L2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TCF7L2 mRNA27858113
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TCF7L2 mRNA]22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TCF7L2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TCF7L2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TCF7L2 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TCF7L2 mRNA"19150397|2001819
D004958EstradiolEstradiol results in decreased expression of TCF7L2 mRNA19167446
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TCF7L2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TCF7L2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of TCF7L2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TCF7L2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TCF7L2 gene28505145
D000069286BortezomibBortezomib results in increased expression of TCF7L2 mRNA17895889
D000069287CapecitabineTCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]18678097
D002220CarbamazepineCarbamazepine affects the expression of TCF7L2 mRNA24752500|2597931
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TCF7L2 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TCF7L2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TCF7L2 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TCF7L2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TCF7L2 mRNA]17585979
D003033Coal TarCoal Tar results in decreased expression of TCF7L2 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of TCF7L2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of TCF7L2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of TCF7L2 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]19294764
D003474CurcuminCurcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]19294764
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TCF7L2 mRNA27392435
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of TCF7L2 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of TCF7L2 mRNA21603599|2739243
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of TCF7L2 mRNA]27392435
D004008DiclofenacDiclofenac affects the expression of TCF7L2 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of TCF7L2 mRNA28302478
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of TCF7L2 mRNA17490981
D004317DoxorubicinDoxorubicin affects the expression of TCF7L2 protein17415656
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of TCF7L2 mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TCF7L2 mRNA17606305
D005472FluorouracilTCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]18678097
D005472FluorouracilFluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC1 protein]25178657
D005472FluorouracilFluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC2 protein]25178657
D005472FluorouracilFluorouracil results in decreased expression of TCF7L2 mRNA25178657
D005472FluorouracilFluorouracil results in decreased expression of TCF7L2 protein25178657
D005472Fluorouracil[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]]25178657
D005472Fluorouracil[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]25178657
D005472FluorouracilTCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]25178657
D005472FluorouracilTCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]25178657
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TCF7L2 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TCF7L2 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of TCF7L2 mRNA20655997
C039281furanfuran results in decreased expression of TCF7L2 mRNA26194646
C546771gardiquimodgardiquimod results in increased expression of TCF7L2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TCF7L2 mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of TCF7L2 mRNA28973697
D007213IndomethacinIndomethacin inhibits the reaction [[CTNNB1 protein binds to TCF7L2 protein] which binds to CCND1 promoter]11756231
D007213IndomethacinIndomethacin results in increased expression of TCF7L2 mRNA28201806
C051890irinotecanirinotecan analog results in decreased expression of TCF7L2 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TCF7L2 mRNA27392435
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of TCF7L2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of TCF7L2 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of TCF7L2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of TCF7L2 mRNA28988120
C045463leflunomideleflunomide results in increased expression of TCF7L2 mRNA24136188
D018021Lithium ChlorideLithium Chloride inhibits the reaction [TCF7L2 protein binds to GCG promoter]19582394
D018021Lithium ChlorideLithium Chloride inhibits the reaction [TCF7L2 protein binds to GIP promoter]19582394
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TCF7L2 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TCF7L2 gene20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TCF7L2 mRNA26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TCF7L2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TCF7L2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of TCF7L2 promoter"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TCF7L2 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TCF7L2 mRNA26558463
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TCF7L2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TCF7L2 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of TCF7L2 mRNA23811387
D009532NickelNickel results in decreased expression of TCF7L2 mRNA24768652|2558310
C119536nickel acetatenickel acetate affects the expression of TCF7L2 mRNA12915101
C015157N,N-dimethylaniline"N,N-dimethylaniline analog results in decreased expression of TCF7L2 mRNA"21291235
C015157N,N-dimethylaniline"N,N-dimethylaniline analog results in decreased expression of TCF7L2 protein"21291235
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of TCF7L2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TCF7L2 mRNA25729387
D010575PesticidesPesticides results in decreased methylation of TCF7L2 gene28396702
D010634PhenobarbitalPhenobarbital affects the expression of TCF7L2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of TCF7L2 mRNA18445702
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TCF7L2 mRNA]28003376
D011794QuercetinQuercetin results in decreased expression of TCF7L2 mRNA19440933
C059514resveratrolresveratrol results in decreased expression of TCF7L2 protein21291235
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of TCF7L2 mRNA19244175
D012643SeleniumSelenium results in decreased expression of TCF7L2 mRNA19244175
D012834SilverSilver results in decreased expression of TCF7L2 mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of TCF7L2 mRNA29319823
D053260SootSoot results in decreased expression of TCF7L2 mRNA26551751
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of TCF7L2 mRNA26496021
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of TCF7L2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCF7L2 mRNA19901195
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TCF7L2 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TCF7L2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TCF7L2 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCF7L2 mRNA19770486
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TCF7L2 mRNA18087596
D014050TolueneToluene results in increased expression of TCF7L2 mRNA22967744
D019772TopotecanTCF7L2 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of TCF7L2 mRNA25729387
D019772TopotecanTopotecan affects the expression of TCF7L2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TCF7L2 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TCF7L2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TCF7L2 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of TCF7L2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TCF7L2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of TCF7L2 gene28853863
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of TCF7L2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of TCF7L2 mRNA19244175
D014873Water PollutantsWater Pollutants results in increased expression of TCF7L2 mRNA23591932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA19443654  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001103RNA polymerase II repressing transcription factor binding-IPI19443654  
GO:0003682chromatin binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA9727977  
GO:0005515protein binding-IPI11713475  11713476  16434966  16442529  16569639  16724116  
17283121  17873903  17875931  18193033  18772112  19202075  
19816403  20126258  22014570  22056988  22304967  24589551  
GO:0008013beta-catenin binding-IBA21873635  
GO:0008013beta-catenin binding-IDA9065401  
GO:0008013beta-catenin binding-IPI12408825  19443654  
GO:0008134transcription factor binding-IPI16007074  
GO:0019901protein kinase binding-IPI16714285  
GO:0035257nuclear hormone receptor binding-IPI12799378  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA14661054  
GO:0043565sequence-specific DNA binding-IMP16532032  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA20128911  
GO:0045295gamma-catenin binding-IPI14661054  
GO:0070016armadillo repeat domain binding-IPI12408825  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12799378  
GO:0001568blood vessel development-IMP15578569  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA9727977  
GO:0007050cell cycle arrest-IMP12408868  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0008283cell proliferation-IMP12408868  
GO:0009749response to glucose-ISS19168596  
GO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic process-IMP15853773  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0031016pancreas development-TAS18216022  
GO:0032024positive regulation of insulin secretion-IMP19386626  
GO:0032092positive regulation of protein binding-IDA12799378  
GO:0032350regulation of hormone metabolic process-IDA15525634  
GO:0042593glucose homeostasis-IDA15525634  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA12799378  
GO:0043570maintenance of DNA repeat elements-IMP18755497  
GO:0044334canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition-IMP17072303  
GO:0045444fat cell differentiation-IDA10937998  
GO:0045892negative regulation of transcription, DNA-templated-IDA12799378  15525634  
GO:0045892negative regulation of transcription, DNA-templated-IMP16532032  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9065401  19168596  
GO:0046827positive regulation of protein export from nucleus-IMP19386626  
GO:0048625myoblast fate commitment-IDA10937998  
GO:0048660regulation of smooth muscle cell proliferation-IMP17122440  
GO:0051897positive regulation of protein kinase B signaling-IMP19386626  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IC9065401  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP16532032  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO:2000675negative regulation of type B pancreatic cell apoptotic process-ISS-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA19443654  
GO:0005634nucleus-IDA9065401  16532032  19386626  
GO:0005654nucleoplasm-IDA19168596  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0016605PML body-IEA-  
GO:0032993protein-DNA complex-IDA14661054  
GO:0070369beta-catenin-TCF7L2 complex-IDA9065401  9065402  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma
hsa05221Acute myeloid leukemia
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promotersTAS
R-HSA-4641265Repression of WNT target genesTAS
R-HSA-4641265Repression of WNT target genesIEA
R-HSA-4791275Signaling by WNT in cancerTAS
R-HSA-5339700TCF7L2 mutants don't bind CTBPTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8951430RUNX3 regulates WNT signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18268068Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study. (2008 May)Folsom ARDiabetes Care
22885420Lack of association between the CC genotype of the rs7903146 polymorphism in the TCF7L2 gene and rheumatoid arthritis. (2012 Aug)Mota LMRev Bras Reumatol
22361517Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. (2012 May)Wassel CLAtherosclerosis
24653947Cumulative Effect of Common Genetic Variants Predicts Incident Type 2 Diabetes: A Study of 21,183 Subjects from Three Large Prospective Cohorts. (2011 Nov 1)Yang JEpidemiology (Sunnyvale)
23235198Consumption of whole grain reduces risk of deteriorating glucose tolerance, including progression to prediabetes. (2013 Jan)Wirstrom TAm J Clin Nutr
24914535Differential methylation of TCF7L2 promoter in peripheral blood DNA in newly diagnosed, drug-naive patients with type 2 diabetes. (2014)Canivell SPLoS One
29312594Investigation of TCF7L2, LEP and LEPR polymorphisms with esophageal squamous cell carcinomas. (2017 Dec 12)Qiu HOncotarget
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med
18498660Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. (2008 May 22)Laramie JMBMC Med Genet
23536853Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms in TCF7L2 with type 2 diabetes in 9,619 Han Chinese population. (2013)Wang JPLoS One
29100364TCF7L2 rs290481 T>C polymorphism is associated with an increased risk of type 2 diabetes mellitus and fasting plasma glucose level. (2017 Sep 29)Zhu LOncotarget
25516658Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. (2014 Dec 14)Kuruma SWorld J Gastroenterol
18689695Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). (2008 Oct)Balkau BDiabetes Care
17503332Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. (2007 Jun)Freathy RMAm J Hum Genet
24098343Genome-wide association study of gene by smoking interactions in coronary artery calcification. (2013)Polfus LMPLoS One