Gene: ZEB1

6935
AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A
zinc finger E-box binding homeobox 1
protein-coding
10p11.22
Ensembl:ENSG00000148516 MIM:189909 Vega:OTTHUMG00000017907 UniprotKB:P37275
NG_017048.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.981e-1 (AD)  1.895e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13303654chr10:31610754ZEB1Gene body3.022e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC500.816
ARHGAP120.804
SYNCRIP0.804
RBBP90.798
SMAD20.789
ZHX10.786
NUCKS10.786
HIPK10.786
AIDA0.782
SP30.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.677
OR4F29-0.667
KCNG2-0.19
NPW-0.187
C8G-0.178
CLPSL1-0.175
LRRC26-0.163
PABPN1L-0.156
CRYBB2-0.154
TGM3-0.15

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of ZEB1 mRNA19041380
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ZEB1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of ZEB1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ZEB1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ZEB1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ZEB1 mRNA"25510870
C5259212-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine"2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of ZEB1 protein"29108245
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ZEB1 mRNA"25510870
C0484603-deazaneplanocin3-deazaneplanocin inhibits the reaction [resveratrol results in decreased expression of ZEB1 mRNA]26934322
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ZEB1 mRNA21420995
C016601afimoxifeneafimoxifene results in increased expression of ZEB1 mRNA12154049
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ZEB1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ZEB1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZEB1 mRNA24449571
D001151ArsenicArsenic affects the methylation of ZEB1 gene25304211
C006632arsenic trioxideZEB1 protein results in increased susceptibility to arsenic trioxide20707922
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZEB1 mRNA27221058
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ZEB1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZEB1 mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZEB1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of ZEB1 mRNA12154049
D004958EstradiolEstradiol results in decreased expression of ZEB1 mRNA15289156
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of ZEB1 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of ZEB1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ZEB1 mRNA17553608
C459604candoxincandoxin results in decreased expression of ZEB1 mRNA16309724
D004390ChlorpyrifosChlorpyrifos results in increased expression of ZEB1 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZEB1 protein20548288
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZEB1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of ZEB1 mRNA23518002
C018021cobaltous chloridecobaltous chloride results in increased expression of ZEB1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of ZEB1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ZEB1 mRNA20106945|2556210
C007262deoxynivalenoldeoxynivalenol results in decreased activity of ZEB1 protein11893416
C007262deoxynivalenol[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [deoxynivalenol results in decreased expression of ZEB1 protein]11893416
D003907DexamethasoneDexamethasone results in increased expression of ZEB1 mRNA25047013
D004008DiclofenacDiclofenac results in decreased expression of ZEB1 protein19628293
C000944dicrotophosdicrotophos results in decreased expression of ZEB1 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ZEB1 mRNA15289156
D004237DiuronDiuron results in decreased expression of ZEB1 mRNA25152437
D004237DiuronDiuron results in increased expression of ZEB1 mRNA21551480
D004317DoxorubicinZEB1 protein affects the susceptibility to Doxorubicin19839049
C010945embelinembelin results in decreased expression of ZEB1 protein24694877
C118739entinostatentinostat results in decreased expression of ZEB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
D004967EstrogensEstrogens results in increased expression of ZEB1 mRNA18622689
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZEB1 mRNA17942748
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of ZEB1 protein19167416
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZEB1 protein20548288
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZEB1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ZEB1 mRNA20655997|2364984
D019833GenisteinGenistein results in decreased expression of ZEB1 mRNA15289156
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of ZEB1 gene28505145
D005839GentamicinsGentamicins results in increased expression of ZEB1 mRNA22061828
C538724HhAntag691HhAntag691 results in decreased expression of ZEB1 mRNA21249152
D007213IndomethacinIndomethacin results in increased expression of ZEB1 mRNA16984733
D007213IndomethacinIndomethacin results in increased expression of ZEB1 mRNA16184411
D007213Indomethacinrebamipide inhibits the reaction [Indomethacin results in increased expression of ZEB1 mRNA]16184411
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [deoxynivalenol results in decreased expression of ZEB1 protein]11893416
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ZEB1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of ZEB1 mRNA27392435
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ZEB1 mRNA25119042
C045463leflunomideleflunomide results in increased expression of ZEB1 mRNA28988120
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ZEB1 mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZEB1 protein20548288
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZEB1 gene20938992
D008727MethotrexateMethotrexate affects the expression of ZEB1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZEB1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ZEB1 mRNA"26251327
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of ZEB1 mRNA27221058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ZEB1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of ZEB1 mRNA22714537
C029938nickel sulfatenickel sulfate results in increased expression of ZEB1 mRNA18651567
D009538NicotineNicotine results in increased expression of ZEB1 mRNA16949557
C047330N-methylisoindigotinN-methylisoindigotin results in decreased expression of ZEB1 mRNA26887594
C047330N-methylisoindigotinN-methylisoindigotin results in decreased expression of ZEB1 protein26887594
C030110oxaliplatinoxaliplatin results in decreased expression of ZEB1 mRNA17762391
D010100OxygenDICER1 protein inhibits the reaction [Oxygen deficiency results in increased expression of ZEB1 mRNA]25351418
D010100OxygenOxygen deficiency results in increased expression of ZEB1 mRNA25351418
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]22094256
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ZEB1 mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of ZEB1 mRNA28846189
D052638Particulate MatterParticulate Matter results in increased expression of ZEB1 protein28846189
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ZEB1 mRNA"25510870
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ZEB1 mRNA25119042
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ZEB1 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of ZEB1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ZEB1 protein24157574
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ZEB1 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of ZEB1 mRNA20864642
D011374ProgesteroneProgesterone results in increased expression of ZEB1 mRNA18622689
C045950propiconazolepropiconazole results in decreased expression of ZEB1 mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of ZEB1 mRNA16497877
C052785rebamipiderebamipide inhibits the reaction [Indomethacin results in increased expression of ZEB1 mRNA]16184411
C059514resveratrol3-deazaneplanocin inhibits the reaction [resveratrol results in decreased expression of ZEB1 mRNA]26934322
C059514resveratrolEZH2 mRNA promotes the reaction [resveratrol results in decreased expression of ZEB1 mRNA]26934322
C059514resveratrolresveratrol results in decreased expression of ZEB1 mRNA21304978|2269295
C059514resveratrolresveratrol results in decreased expression of ZEB1 protein22692956|2693432
C059514resveratrolresveratrol results in increased expression of ZEB1 mRNA12154049
C059514resveratrolresveratrol inhibits the reaction [EGF protein results in increased expression of ZEB1 mRNA]21794976
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ZEB1 mRNA21427059
D012524SarinSarin results in decreased expression of ZEB1 mRNA19522546
D012643SeleniumSelenium results in decreased expression of ZEB1 mRNA19244175
D012834SilverSilver results in increased expression of ZEB1 mRNA26014281|2655175
C009277sodium arsenatesodium arsenate results in increased expression of ZEB1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of ZEB1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of ZEB1 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of ZEB1 mRNA12760830|2129264
C471405sorafenibsorafenib results in decreased expression of ZEB1 mRNA21360571
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of ZEB1 mRNA16214533
C016766sulforafansulforafan results in increased expression of ZEB1 mRNA26833863
C004648testosterone enanthatetestosterone enanthate affects the expression of ZEB1 mRNA17440010
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ZEB1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZEB1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZEB1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZEB1 mRNA27562557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZEB1 mRNA15034205|2135428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZEB1 mRNA15644576
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB1 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [deoxynivalenol results in decreased expression of ZEB1 protein]11893416
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ZEB1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ZEB1 mRNA23557971
D019772TopotecanZEB1 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of ZEB1 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of ZEB1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ZEB1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZEB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZEB1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of ZEB1 protein19628293
D014810Vitamin EVitamin E results in decreased expression of ZEB1 mRNA19244175
D014859WarfarinWarfarin results in decreased expression of ZEB1 protein26206560
D015032ZincZinc affects the expression of ZEB1 mRNA16979875
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB1 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA23765923  23814079  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8138542  
GO:0003713transcription coactivator activity-TAS8138542  
GO:0003714transcription corepressor activity-TAS8138542  
GO:0005515protein binding-IPI20418909  
GO:0008134transcription factor binding-IEA-  
GO:0008270zinc ion binding-TAS8138542  
GO:0070888E-box binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA23765923  23814079  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8138542  
GO:0006955immune response-TAS1840704  
GO:0007389pattern specification process-IEA-  
GO:0007417central nervous system development-IEA-  
GO:0008283cell proliferation-TAS1840704  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010464regulation of mesenchymal cell proliferation-IEA-  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0033081regulation of T cell differentiation in thymus-IEA-  
GO:0045602negative regulation of endothelial cell differentiation-IMP23765923  
GO:0045666positive regulation of neuron differentiation-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA20418909  
GO:0045892negative regulation of transcription, DNA-templated-IMP12937339  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048596embryonic camera-type eye morphogenesis-IEA-  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0048752semicircular canal morphogenesis-IEA-  
GO:0051150regulation of smooth muscle cell differentiation-IEA-  
GO:0051216cartilage development-IEA-  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO:0090103cochlea morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA20418909  23814079  25190660  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25600647beta-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. (2015 Mar 15)Pillai SCancer Res
19474681Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor. (2009 Jun)Wei PLAnn Surg
24354880Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. (2014 Jan 15)Yang LAm J Respir Crit Care Med
28468033[Clinicopathologic features and genetic profile of the redefined large cell lung carcinoma]. (2017 May 8)Hou LKZhonghua Bing Li Xue Za Zhi