Gene: TCF15

6939
EC2|PARAXIS|bHLHa40
transcription factor 15
protein-coding
20p13
Ensembl:ENSG00000125878 MIM:601010 Vega:OTTHUMG00000031640 UniprotKB:Q12870
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.475e-1 (AD)  5.299e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EVA1B0.666
ISG200.662
VASP0.662
CCRL20.661
CLDN50.658
SLC15A30.657
APOL30.656
SEMA3F0.649
ORAI10.64
STX110.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR4-0.465
SPHKAP-0.45
CCDC177-0.434
DNAJC28-0.434
PPEF1-0.433
KIAA1024-0.432
DOK6-0.428
GRIN3A-0.425
EPHA5-0.424
ESRRG-0.423

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TCF15 mRNA"23146750
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TCF15 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF15 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TCF15 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of TCF15 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of TCF15 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of TCF15 mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TCF15 mRNA24763279
D002994ClofibrateClofibrate results in increased expression of TCF15 mRNA17585979
D004041Dietary FatsDietary Fats results in decreased expression of TCF15 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of TCF15 mRNA18042831
D004147DioxinsDioxins affects the expression of TCF15 mRNA20463971
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TCF15 mRNA24763279
D017313FenretinideFenretinide results in increased expression of TCF15 mRNA28973697
D007854LeadLead results in decreased expression of TCF15 mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride affects the expression of TCF15 mRNA21613230
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TCF15 mRNA26011545
D000073878Palm OilPalm Oil results in increased expression of TCF15 mRNA18042831
D010936Plant ExtractsPlant Extracts results in decreased expression of TCF15 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of TCF15 mRNA24780913
C428725pyridabenpyridaben results in decreased expression of TCF15 mRNA22563483
C017947sodium arsenitesodium arsenite results in decreased expression of TCF15 mRNA20371982
D012969Sodium FluorideSodium Fluoride results in decreased expression of TCF15 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCF15 mRNA16714409
C009495titanium dioxidetitanium dioxide results in increased expression of TCF15 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TCF15 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of TCF15 mRNA9281340
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF15 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TCF15 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8041747  8825648  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001756somitogenesis-IEA-  
GO:0003016respiratory system process-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8825648  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007498mesoderm development-TAS8041747  
GO:0036342post-anal tail morphogenesis-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043583ear development-IEA-  
GO:0043588skin development-IEA-  
GO:0045198establishment of epithelial cell apical/basal polarity-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048339paraxial mesoderm development-IEA-  
GO:0048644muscle organ morphogenesis-IEA-  
GO:0048705skeletal system morphogenesis-IEA-  
GO:0050884neuromuscular process controlling posture-IEA-  
GO:0060231mesenchymal to epithelial transition-IEA-  
GO:1903053regulation of extracellular matrix organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0090575RNA polymerase II transcription factor complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26428460Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. (2015 Oct 1)Yang WYBMC Genet