Gene: TCF21

6943
POD1|bHLHa23
transcription factor 21
protein-coding
6q23.2
Ensembl:ENSG00000118526 MIM:603306 Vega:OTTHUMG00000015608 UniprotKB:O43680
NG_032121.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.948e-1 (AD)  9.543e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD1E0.506
PLA2G2A0.478
CLDN80.465
FOXD30.455
SIX10.452
KRTAP4-90.447
IFNA170.447
COL15A10.446
CXorf660.44
SPZ10.438

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf134-0.293
RHOXF1-0.27
HDDC3-0.26
SOSTDC1-0.256
TMEM187-0.255
ZNF488-0.25
PIGP-0.241
BOLA1-0.241
FUZ-0.241
CYS1-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TCF21 mRNA19933214
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of TCF21 mRNA17011747
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of TCF21 mRNA17011747
D020106AcrylamideAcrylamide results in decreased expression of TCF21 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TCF21 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TCF21 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TCF21 mRNA24449571
C015001arsenitearsenite results in increased methylation of TCF21 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TCF21 mRNA22228805
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of TCF21 mRNA20404318
D004958EstradiolEstradiol results in decreased expression of TCF21 mRNA15289156
C006780bisphenol Abisphenol A results in decreased expression of TCF21 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TCF21 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TCF21 mRNA20147733
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of TCF21 mRNA26472102
C027561butylbenzyl phthalatebutylbenzyl phthalate results in increased expression of TCF21 mRNA26472102
D002330CarmustineCarmustine results in decreased expression of TCF21 mRNA15980968
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TCF2120938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TCF21 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TCF21 mRNA20938992
D003345CorticosteroneCorticosterone results in increased expression of TCF21 mRNA15755911
D003561CytarabineCytarabine results in decreased expression of TCF21 mRNA21198554
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of TCF21 mRNA29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of TCF21 mRNA29288687
C053316di-(2-ethylhexyl) terephthalatedi-(2-ethylhexyl) terephthalate results in decreased expression of TCF21 mRNA26472102
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TCF21 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TCF21 mRNA26472102
D019422Dietary SucroseDietary Sucrose results in decreased expression of TCF21 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TCF21 mRNA26472102
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TCF21 mRNA26472102
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TCF21 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TCF21 mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TCF21 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TCF21 mRNA17011747
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TCF21 mRNA17011747
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of TCF21 mRNA26472102
C118739entinostatentinostat results in increased expression of TCF21 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TCF2120938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TCF21 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TCF21 mRNA20938992
D019833GenisteinGenistein inhibits the reaction [Tobacco Smoke Pollution results in increased methylation of TCF21 promoter]25214829
D019833GenisteinGenistein results in decreased expression of TCF21 mRNA15289156
D017313FenretinideFenretinide results in increased expression of TCF21 mRNA28973697
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of TCF21 mRNA29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of TCF21 mRNA29288687
C011890kojic acidkojic acid results in decreased expression of TCF21 mRNA16595896
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of TCF21 mRNA29288687
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TCF2120938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TCF21 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TCF21 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of TCF21 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TCF21 mRNA23179753
D008777MethyltestosteroneMethyltestosterone results in increased expression of TCF21 mRNA29191790
D015735MifepristoneMifepristone results in decreased expression of TCF21 mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TCF21 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TCF21 mRNA"25554681|2562005
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TCF21 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TCF21 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TCF21 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of TCF21 mRNA19482888
D010795Phthalic AcidsPhthalic Acids results in increased expression of TCF21 mRNA15728792
D010936Plant ExtractsPlant Extracts results in decreased expression of TCF21 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TCF21 mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of TCF21 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of TCF21 mRNA26079696
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of TCF21 mRNA29288687
D053260SootSoot results in decreased expression of TCF21 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of TCF21 mRNA20937368
D013629TamoxifenTamoxifen results in increased expression of TCF21 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TCF21 protein23135548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TCF21 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCF21 mRNA18691609|1993321
C009495titanium dioxidetitanium dioxide results in decreased expression of TCF21 mRNA23557971
D014028Tobacco Smoke PollutionGenistein inhibits the reaction [Tobacco Smoke Pollution results in increased methylation of TCF21 promoter]25214829
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of TCF21 promoter25214829
D014118Toxins, Biological"Toxins, Biological affects the expression of TCF21 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of TCF21 mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of TCF21 mRNA25979313
C025643vinclozolinvinclozolin affects the expression of TCF21 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of TCF21 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of TCF21 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12493738  
GO:0042826histone deacetylase binding-IEA-  
GO:0043425bHLH transcription factor binding-IPI12493738  
GO:0046983protein dimerization activity-ISS-  
GO:0050681androgen receptor binding-ISS-  
GO:0070888E-box binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12493738  
GO:0001657ureteric bud development-ISS-  
GO:0001658branching involved in ureteric bud morphogenesis-ISS-  
GO:0001763morphogenesis of a branching structure-ISS-  
GO:0001822kidney development-ISS-  
GO:0001944vasculature development-ISS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007530sex determination-ISS-  
GO:0014707branchiomeric skeletal muscle development-ISS-  
GO:0030855epithelial cell differentiation-ISS-  
GO:0032835glomerulus development-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048286lung alveolus development-ISS-  
GO:0048536spleen development-ISS-  
GO:0048557embryonic digestive tract morphogenesis-ISS-  
GO:0048608reproductive structure development-ISS-  
GO:0048732gland development-ISS-  
GO:0060008Sertoli cell differentiation-ISS-  
GO:0060021roof of mouth development-ISS-  
GO:0060425lung morphogenesis-ISS-  
GO:0060426lung vasculature development-ISS-  
GO:0060435bronchiole development-ISS-  
GO:0060539diaphragm development-ISS-  
GO:0060541respiratory system development-ISS-  
GO:0060766negative regulation of androgen receptor signaling pathway-ISS-  
GO:0072162metanephric mesenchymal cell differentiation-ISS-  
GO:0072277metanephric glomerular capillary formation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12493738  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20945327Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers. (2011 Feb 1)Richards KLCancer
18339850Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. (2008 Mar 15)Tessema MCancer Res
25214829Effect of cigarette smoke condensate on gene promoter methylation in human lung cells. (2014)Lyn-Cook LTob Induc Dis
27446425Clinical potential of TCF21 methylation in the diagnosis of renal cell carcinoma. (2016 Aug)Xin JOncol Lett
25469260Association of a transcription factor 21 gene polymorphism with hypertension. (2015 Jan)Fujimaki TBiomed Rep