Gene: MLX

6945
MAD7|MXD7|TCFL4|TF4|bHLHd13
MLX, MAX dimerization protein
protein-coding
17q21.2
Ensembl:ENSG00000108788 MIM:602976 Vega:OTTHUMG00000180246 UniprotKB:Q9UH92
NG_029442.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.207e-1 (AD)  7.036e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARCN10.932
AKIRIN10.93
BFAR0.926
GORASP20.923
RSL1D10.923
MRPL490.922
TMED20.921
CCT20.919
TFG0.919
RNF40.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.705
OR4F29-0.66
MTRNR2L6-0.309
MTRNR2L9-0.294
MTRNR2L10-0.291
KLRB1-0.264
CTNNA3-0.251
KLRK1-0.248
RSPO1-0.245
MTRNR2L3-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MLX mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MLX mRNA"18648102
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of MLX mRNA26975756
D000082AcetaminophenAcetaminophen results in decreased expression of MLX mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MLX gene27153756
D000638AmiodaroneAmiodarone affects the expression of MLX mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of MLX mRNA18355885
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MLX mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MLX promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MLX mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MLX mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of MLX mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of MLX promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of MLX promoter27312807
C006780bisphenol Abisphenol A results in increased expression of MLX mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MLX gene28505145
D002997ClomipramineClomipramine affects the expression of MLX mRNA18355885
D019327Copper SulfateCopper Sulfate results in decreased expression of MLX mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MLX mRNA25562108
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MLX mRNA29038839
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MLX mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MLX mRNA21266533
D004147DioxinsDioxins affects the expression of MLX mRNA20463971
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MLX mRNA29038839
D000431EthanolEthanol results in increased expression of MLX mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MLX mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MLX mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MLX mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MLX mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MLX mRNA23649840
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated affects the localization of MLX protein"16644726
D005231Fatty Acids, Unsaturated"MLX protein inhibits the reaction [Fatty Acids, Unsaturated results in decreased expression of PKLR mRNA]"16644726
D005485FlutamideFlutamide results in increased expression of MLX mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of MLX mRNA23649840
D005632FructoseFructose results in increased expression of MLX mRNA18346472
D007099ImipramineImipramine affects the expression of MLX mRNA18355885
D007654KetoconazoleKetoconazole affects the expression of MLX mRNA18355885
C045463leflunomideleflunomide results in increased expression of MLX mRNA24136188
D008727MethotrexateMethotrexate results in decreased expression of MLX mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MLX mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of MLX mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MLX mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MLX mRNA"25554681
C051752nefazodonenefazodone results in increased expression of MLX mRNA24136188
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MLX mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MLX mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of MLX mRNA23608068
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MLX mRNA29038839
C017947sodium arsenitesodium arsenite results in increased stability of MLX mRNA25493608
D013629TamoxifenTamoxifen affects the expression of MLX mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MLX mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MLX mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of MLX mRNA25975270
D019284ThapsigarginThapsigargin results in decreased expression of MLX protein24648495
C057693troglitazonetroglitazone results in increased expression of MLX mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MLX mRNA17292431
D014638VanadatesVanadates results in decreased expression of MLX mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA10918583  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA10918583  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP10918583  
GO:0003677DNA binding-IDA11230181  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-NAS10918583  
GO:0005515protein binding-IPI16189514  22458338  25416956  
GO:0008134transcription factor binding-IPI11230181  
GO:0042803protein homodimerization activity-IPI11230181  
GO:0046982protein heterodimerization activity-IPI11230181  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP10918583  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS10593926  10918583  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IDA11230181  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11073985  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10918583  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA10918583  
GO:0005829cytosol-IDA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-163765ChREBP activates metabolic gene expressionTAS
R-HSA-163765ChREBP activates metabolic gene expressionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24284182[Relationship between estimated glomerular filtration rate level and clinical characteristics and outcome in patients with angiographic coronary artery disease and normal serum creatinine]. (2013 Jul)Li QZhonghua Xin Xue Guan Bing Za Zhi
12610058Smoking and progression of diabetic nephropathy in type 1 diabetes. (2003 Mar)Hovind PDiabetes Care