Gene: TCN2

6948
D22S676|D22S750|II|TC|TC II|TC-2|TC2|TCII
transcobalamin 2
protein-coding
22q12.2
Ensembl:ENSG00000185339 MIM:613441 Vega:OTTHUMG00000151095 UniprotKB:P20062
NG_007263.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.732e-1 (AD)  3.711e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLA-E0.832
KANK30.803
TRIOBP0.795
HLA-A0.774
ACVRL10.761
ITGA60.76
SLC2A10.76
NOSTRIN0.759
DOCK60.757
EPAS10.756

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNF1A-0.384
KCNB2-0.373
MYADML2-0.37
KCNG1-0.37
GABRG3-0.367
DRD5-0.362
SHH-0.36
NTSR1-0.356
ANKRD34C-0.356
SMIM18-0.356

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTransporter
DB00200HydroxocobalaminSmall Molecule13422-51-0ApprovedCarrier
ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of TCN2 mRNA"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TCN2 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TCN2 mRNA"23196670
D000082AcetaminophenAcetaminophen affects the expression of TCN2 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TCN2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TCN2 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of TCN2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TCN2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TCN2 mRNA27195522
C006780bisphenol Abisphenol A results in increased expression of TCN2 mRNA29275510
C018475butyraldehydebutyraldehyde results in decreased expression of TCN2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TCN2 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TCN2 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TCN2 mRNA18804290
D002737ChloropreneChloroprene results in increased expression of TCN2 mRNA23125180
D002994ClofibrateClofibrate results in decreased expression of TCN2 mRNA17585979
C029892cupric chloridecupric chloride results in decreased expression of TCN2 mRNA24650576
D003471CuprizoneCuprizone results in increased expression of TCN2 mRNA26577399
D003907DexamethasoneDexamethasone results in decreased expression of TCN2 mRNA12732289
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TCN2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of TCN2 mRNA18042831
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TCN2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TCN2 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCN2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TCN2 mRNA16174780
D005485FlutamideFlutamide results in decreased expression of TCN2 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of TCN2 mRNA19167457
D007545IsoproterenolIsoproterenol results in increased expression of TCN2 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TCN2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TCN2 mRNA27392435
D001556LindaneLindane results in decreased expression of TCN2 mRNA18804290
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TCN2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TCN2 mRNA26378955
D008727MethotrexateTCN2 gene polymorphism affects the metabolism of Methotrexate15753437
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of TCN2 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TCN2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TCN2 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased expression of TCN2 mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TCN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TCN2 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TCN2 mRNA25729387
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of TCN2 mRNA"23246600
D000073878Palm OilPalm Oil results in decreased expression of TCN2 mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TCN2 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TCN2 mRNA18804290
D010578PetroleumPetroleum affects the expression of TCN2 mRNA25208076
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TCN2 mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TCN2 mRNA25895662
D012834SilverSilver results in decreased expression of TCN2 mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of TCN2 mRNA19590694
C016104sodium bichromatesodium bichromate results in decreased expression of TCN2 mRNA24612858
D012999SomanSoman results in increased expression of TCN2 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TCN2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TCN2 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of TCN2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCN2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCN2 mRNA17942748
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of TCN2 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TCN2 mRNA21215274
D013806TheophyllineTheophylline results in increased expression of TCN2 mRNA16083514
C009495titanium dioxidetitanium dioxide results in decreased expression of TCN2 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of TCN2 mRNA23131501|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TCN2 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TCN2 mRNA25729387
D014635Valproic AcidValproic Acid results in decreased expression of TCN2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TCN2 mRNA19136453
D014640VancomycinVancomycin results in increased expression of TCN2 mRNA18930951
D014805Vitamin B 12TCN2 protein binds to and results in increased uptake of Vitamin B 1214632784
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of TCN2 mRNA"25208076
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of TCN2 mRNA"23246600
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27411955  
GO:0031419cobalamin binding-IDA8443384  16537422  27411955  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006824cobalt ion transport-IEA-  
GO:0009235cobalamin metabolic process-TAS-  
GO:0015889cobalamin transport-IDA8443384  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA8443384  
GO:0005768endosome-TAS-  
GO:0043202lysosomal lumen-TAS-  
KEGG ID KEGG Term
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-3296469Defects in cobalamin (B12) metabolismTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3359454Defective TCN2 causes hereditary megaloblastic anemiaTAS
R-HSA-3359485Defective CD320 causes methylmalonic aciduriaTAS
R-HSA-5668914Diseases of metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
23552396Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA. (2013 Jun)Tajuddin SMEnviron Health Perspect