Gene: BTK

695
AGMX1|AT|ATK|BPK|IMD1|PSCTK1|XLA
Bruton tyrosine kinase
protein-coding
Xq22.1
Ensembl:ENSG00000010671 MIM:300300 Vega:OTTHUMG00000022022 UniprotKB:Q06187
NG_009616.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCKAP1L0.945
SYK0.94
SLC7A70.938
DOCK20.938
CD860.933
PTPRC0.932
LAIR10.926
SASH30.924
TLR10.921
TFEC0.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.455
KCNIP3-0.415
WNT7A-0.41
ASPDH-0.409
HES5-0.406
MAGIX-0.4
CPLX3-0.395
HAGHL-0.388
ARSF-0.384
ZSCAN1-0.375

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB01863Inositol 1,3,4,5-TetrakisphosphateSmall MoleculeExperimentalTarget
DB05204XL418Small Molecule-InvestigationalTarget
DB09053IbrutinibSmall Molecule936563-96-1ApprovedTarget
DB11703AcalabrutinibSmall Molecule1420477-60-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of BTK mRNA28959563
D0150812-Naphthylamine2-Naphthylamine results in increased expression of BTK mRNA18247414
C006632arsenic trioxidearsenic trioxide results in increased expression of BTK mRNA23911876
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BTK mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of BTK gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BTK mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BTK mRNA22300585
D004958EstradiolEstradiol results in increased expression of BTK mRNA23373633
C006780bisphenol Abisphenol A results in decreased methylation of BTK promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of BTK mRNA25181051
D002118CalciumBTK protein affects the transport of Calcium12848851
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BTK mRNA20938992
D003042CocaineCocaine results in decreased expression of BTK mRNA17898221
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of BTK mRNA24690739
D003471CuprizoneCuprizone results in increased expression of BTK mRNA27523638
D000069439DasatinibDasatinib binds to and results in decreased activity of BTK protein17684099
D000069439DasatinibDasatinib binds to and results in decreased phosphorylation of BTK protein18180381
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BTK mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of BTK mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of BTK mRNA24690739
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BTK mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BTK mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of BTK mRNA23649840
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of BTK mRNA20846436
C568713GSK1210151AGSK1210151A results in decreased phosphorylation of and results in decreased expression of BTK protein26254443
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [PCI 32765 results in decreased phosphorylation of and results in decreased expression of BTK protein]26254443
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BTK mRNA23086925|2625444
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased phosphorylation of and results in decreased expression of BTK protein26254443
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BTK mRNA24332044
C561695(+)-JQ1 compoundPCI 32765 promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of and results in decreased expression of BTK protein]26254443
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of BTK mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BTK mRNA25982114
C045463leflunomideleflunomide results in decreased expression of BTK mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BTK mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BTK mRNA23649840
C576094methylsulfonyl benzothiazolemethylsulfonyl benzothiazole binds to BTK protein26675335
D015735MifepristoneMifepristone results in increased expression of BTK mRNA17584828
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BTK mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BTK mRNA"25554681
D009532NickelNickel results in increased expression of BTK mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of BTK mRNA19167457
D009538NicotineNicotine results in decreased expression of BTK mRNA18247414
C551803PCI 32765BTK gene mutant form results in decreased susceptibility to PCI 3276525189416
C551803PCI 32765BTK protein mutant form results in decreased susceptibility to PCI 3276526254443
C551803PCI 32765(+)-JQ1 compound promotes the reaction [PCI 32765 results in decreased phosphorylation of and results in decreased expression of BTK protein]26254443
C551803PCI 32765PCI 32765 binds to BTK protein26174628|2667533
C551803PCI 32765PCI 32765 promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of and results in decreased expression of BTK protein]26254443
C551803PCI 32765PCI 32765 results in decreased activity of BTK protein23296407|2342503
C551803PCI 32765PCI 32765 results in decreased phosphorylation of and results in decreased expression of BTK protein26254443
C551803PCI 32765PCI 32765 results in decreased phosphorylation of BTK protein26254443
C551803PCI 32765PCI 32765 results in decreased activity of BTK protein23617325|2518941
D010936Plant ExtractsPlant Extracts results in increased expression of BTK mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of BTK mRNA19690047
C059514resveratrolresveratrol inhibits the reaction [COL1A1 protein promotes the reaction [PTPN11 protein binds to BTK protein]]26482867
C059514resveratrolresveratrol inhibits the reaction [COL1A1 protein results in increased phosphorylation of BTK protein]26482867
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased expression of BTK mRNA]11355896
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BTK mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of BTK mRNA28111298

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-EXP7518558  
GO:0004713protein tyrosine kinase activity-TAS11913944  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-TAS19290921  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI8892607  9012831  9571151  10556826  11788586  15046600  
15539407  16969585  19214191  22366891  22939624  25910212  
GO:0005524ATP binding-TAS11913944  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-IDA17823121  
GO:0042802identical protein binding-IPI11231015  11577348  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001805positive regulation of type III hypersensitivity-IEA-  
GO:0001812positive regulation of type I hypersensitivity-IEA-  
GO:0001818negative regulation of cytokine production-IEA-  
GO:0002250adaptive immune response-IBA21873635  
GO:0002250adaptive immune response-TAS19290921  
GO:0002344B cell affinity maturation-IEA-  
GO:0002553histamine secretion by mast cell-IEA-  
GO:0002721regulation of B cell cytokine production-TAS19290921  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0002902regulation of B cell apoptotic process-TAS19290921  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-TAS11913944  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0007498mesoderm development-TAS8013627  
GO:0018108peptidyl-tyrosine phosphorylation-IDA11606584  
GO:0019722calcium-mediated signaling-TAS15046600  
GO:0030154cell differentiation-IBA21873635  
GO:0030889negative regulation of B cell proliferation-IEA-  
GO:0034614cellular response to reactive oxygen species-IEA-  
GO:0035556intracellular signal transduction-TAS11913944  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0042113B cell activation-TAS19290921  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-TAS19290921  
GO:0045579positive regulation of B cell differentiation-TAS19290921  
GO:0048469cell maturation-IEA-  
GO:0050852T cell receptor signaling pathway-IBA21873635  
GO:0050853B cell receptor signaling pathway-IBA21873635  
GO:0050853B cell receptor signaling pathway-TAS19290921  
GO:0051092positive regulation of NF-kappaB transcription factor activity-TAS19290921  
GO:0071226cellular response to molecule of fungal origin-IEA-  
GO:0097190apoptotic signaling pathway-TAS8688094  
GO:0098761cellular response to interleukin-7-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS19290921  
GO:0005737cytoplasm-TAS15046600  
GO:0005829cytosol-IDA17823121  
GO:0005829cytosol-TAS19290921  
GO:0005886plasma membrane-IDA17823121  
GO:0005886plasma membrane-TAS19290921  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0042629mast cell granule-IEA-  
GO:0045121membrane raft-IDA15046600  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-2424491DAP12 signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationIEA
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602498MyD88 deficiency (TLR2/4)TAS
R-HSA-5603041IRAK4 deficiency (TLR2/4)TAS
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
4047149Age at exposure versus years of exposure. (1985 May)Seidman HNatl Cancer Inst Monogr