Gene: TDO2

6999
HYPTRP|TDO|TO|TPH2|TRPO
tryptophan 2,3-dioxygenase
protein-coding
4q32.1
Ensembl:ENSG00000151790 MIM:191070 Vega:OTTHUMG00000161838 UniprotKB:P48775
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  3.627e-2 (ND)   (Frontal_Cortex)
5.362e-1 (AD)  1.209e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRG10.772
EIF5A20.767
CAPS20.76
RBM110.759
SYT20.75
CADPS20.748
RET0.748
AHNAK20.745
LSM110.744
SMYD20.743

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PINLYP-0.466
FOXJ1-0.448
MDFI-0.443
CCDC102A-0.442
LYPD1-0.441
BCL7C-0.437
MSX1-0.435
MTRNR2L2-0.434
YES1-0.427
RAB13-0.424

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00150L-TryptophanSmall Molecule73-22-3Approved|Nutraceutical|WithdrawnEnzyme
DB00500TolmetinSmall Molecule26171-23-3ApprovedEnzyme
DB00779Nalidixic AcidSmall Molecule389-08-2Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TDO2 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TDO2 mRNA"23146750
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TDO2 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA"27188386
C093792680C91680C91 results in decreased activity of TDO2 protein21726069
D000082AcetaminophenAcetaminophen results in decreased expression of TDO2 mRNA17585979
D000082AcetaminophenAcetaminophen affects the expression of TDO2 mRNA17366322
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TDO2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TDO2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TDO2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TDO2 mRNA19770486
D000493AllopurinolAllopurinol affects the activity of TDO2 protein7306070
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TDO2 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of TDO2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TDO2 mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA19737545
C030419andrographolideandrographolide results in increased expression of TDO2 mRNA19737545
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TDO2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TDO2 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of TDO2 mRNA20106945
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TDO2 mRNA26186136
C006780bisphenol Abisphenol A results in decreased expression of TDO2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TDO2 mRNA26186136
D002065BuspironeBuspirone results in increased expression of TDO2 mRNA24136188
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of TDO2 mRNA19925653
D002084Butylated HydroxytolueneButylated Hydroxytoluene affects the expression of TDO2 mRNA18539377
D002110CaffeineCaffeine results in increased activity of TDO2 protein8164501
D012721CarbarylCarbaryl results in decreased activity of TDO2 protein2547861
D012721CarbarylCarbaryl results in decreased activity of TDO2 protein2119399
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TDO2 mRNA27339419
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of TDO2 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of TDO2 mRNA23125180
D002922CiguatoxinsCiguatoxins affects the expression of TDO2 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of TDO2 mRNA17585979
D009249NADPTDO2 protein affects the abundance of NADP7306070
D003345CorticosteroneCorticosterone results in increased activity of TDO2 protein7306070
D016572CyclosporineCyclosporine results in decreased expression of TDO2 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of TDO2 mRNA23830897
C089595cylindrospermopsincylindrospermopsin results in increased expression of TDO2 mRNA24921660
D003609DactinomycinDactinomycin affects the activity of TDO2 protein7306070
D003703DemecolcineDemecolcine results in increased expression of TDO2 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of TDO2 mRNA25110054
D003907DexamethasoneDexamethasone results in increased expression of TDO2 protein25110054
D003907DexamethasoneMetformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA]25110054
D003907DexamethasoneMetformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein]25110054
D003907DexamethasoneDexamethasone promotes the reaction [TDO2 enhancer binds to HNRNPU protein]19632204
D003907DexamethasoneDexamethasone promotes the reaction [TDO2 promoter binds to HNRNPU protein]19632204
D002945CisplatinCisplatin results in increased expression of TDO2 mRNA15464296|1547189
D004041Dietary FatsDietary Fats results in decreased expression of TDO2 mRNA15238619
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TDO2 mRNA19041683
D004117DimethoateDimethoate results in decreased activity of TDO2 protein2547861
D004178DiquatDiquat results in increased expression of TDO2 mRNA22558963
D004298Dopamine[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine16952380
D004298Dopamine[Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine16952380
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of TDO2 mRNA"23811387
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of TDO2 mRNA24534155
D000431EthanolEthanol results in decreased expression of TDO2 mRNA17920746
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of TDO2 mRNA25572481
D005485FlutamideFlutamide results in decreased expression of TDO2 mRNA24793618
D005492Folic AcidFolic Acid results in increased expression of TDO2 mRNA25006883
C056933fumonisin B1fumonisin B1 results in decreased expression of TDO2 mRNA16221962
D005938GlucocorticoidsGlucocorticoids affects the expression of TDO219632204
D006046GoldGold results in decreased expression of TDO2 mRNA25523186
D006418HemeHeme promotes the reaction [pyridine results in increased activity of TDO2 protein]10413312
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of TDO2 mRNA25270620
D012701Serotonin[Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin16952380
D012701Serotonin[Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin16952380
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TDO2 mRNA24796395
C008261lead acetatelead acetate results in increased expression of TDO2 mRNA22839698
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TDO2 mRNA"24930766
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TDO2 protein"24930766
C482199lipopolysaccharide, E coli O55-B5"TDO2 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]"24930766
C482199lipopolysaccharide, E coli O55-B5"TDO2 gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5"24930766
C482199lipopolysaccharide, E coli O55-B5"TLR4 gene mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TDO2 mRNA]"24930766
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TDO2 mRNA20884048
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA]20884048
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TDO2 mRNA26378955
D008550Melatonin[Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin16952380
D008687MetforminMetformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA]25110054
D008687MetforminMetformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein]25110054
D008687MetforminMetformin results in decreased expression of TDO2 mRNA25110054
D008687MetforminMetformin results in decreased expression of TDO2 protein25110054
D009285NaphthoquinonesNaphthoquinones results in increased expression of TDO2 mRNA23811387
D009532NickelNickel results in increased expression of TDO2 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TDO2 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TDO2 mRNA27935865
D010100OxygenOxygen deficiency results in decreased expression of TDO2 mRNA19695866
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TDO2 mRNA27153767
D026023PermethrinPermethrin results in decreased activity of TDO2 protein2547861
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TDO2 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of TDO2 mRNA18445702|2381119
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of TDO2 mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TDO2 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of TDO2 mRNA27413110
D011374ProgesteroneProgesterone results in increased expression of TDO2 mRNA18070364
C045950propiconazolepropiconazole results in decreased expression of TDO2 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of TDO2 mRNA26079696
C023666pyridineHeme promotes the reaction [pyridine results in increased activity of TDO2 protein]10413312
C059514resveratrolresveratrol results in increased expression of TDO2 mRNA25888808
C009250sevofluranesevoflurane affects the expression of TDO2 mRNA15967596
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TDO2 mRNA26378955
D012460SulfasalazineSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA]20884048
D013467SulindacSulindac results in decreased activity of TDO2 protein16952380
D013467Sulindac[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine16952380
D013467Sulindac[Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin16952380
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of TDO2 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TDO2 mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TDO2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TDO2 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TDO2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TDO2 mRNA21215274
D014046TolmetinTolmetin results in decreased activity of TDO2 protein16952380
D014046Tolmetin[Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine16952380
D014046Tolmetin[Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin16952380
D014046Tolmetin[Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin16952380
D014635Valproic AcidValproic Acid results in increased expression of TDO2 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TDO2 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TDO2 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004833tryptophan 2,3-dioxygenase activity-IBA21873635  
GO:0004833tryptophan 2,3-dioxygenase activity-IDA27762317  28285122  
GO:0004833tryptophan 2,3-dioxygenase activity-TAS-  
GO:0005515protein binding-IPI16189514  25416956  25910212  27107014  
GO:0016597amino acid binding-IEA-  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IDA27762317  28285122  
GO:0042802identical protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006569tryptophan catabolic process-TAS-  
GO:0019441tryptophan catabolic process to kynurenine-IDA27762317  
GO:0019441tryptophan catabolic process to kynurenine-IEA-  
GO:0019442tryptophan catabolic process to acetyl-CoA-IBA21873635  
GO:0051289protein homotetramerization-IDA27762317  28285122  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71240Tryptophan catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14714090Predisposition to alcoholism, tryptophan oxygenase activity, and structure of intron 6 in the corresponding gene of C57BL/6J, CC57BR/Mv, and BALB/cJ mice. (2003 Oct)Kaledin VIBull Exp Biol Med
7748306Serotonin and the biochemical genetics of alcoholism: lessons from studies of attention deficit hyperactivity disorder (ADHD) and Tourette syndrome. (1993)Comings DEAlcohol Alcohol Suppl
15048644Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. (2004 Apr 1)Sullivan PFAm J Med Genet B Neuropsychiatr Genet
16448631Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. (2006 Feb 16)Miller CLBrain Res