Gene info: ID 7005

Gene: TEAD3

GENE ID: 7005

Description: TEA domain transcription factor 3

Gene type: protein-coding

Location: 6p21.31

dbXrefs: Ensembl:ENSG00000007866 MIM:603170 Vega:OTTHUMG00000014571 UniprotKB:Q99594

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.298e-1 (AD) 6.530e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg20595752	chr6:35458416	TEAD3		1.990e-8	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNFRSF1A	0.883
MSN	0.881
LTBR	0.875
MOB3C	0.868
LIMS1	0.861
YBX3	0.857
MYD88	0.855
OSMR	0.854
TUBB6	0.853
TRIP10	0.851

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CALHM1	-0.625
ABCC12	-0.62
PPEF1	-0.616
KCNB2	-0.614
NEUROD6	-0.613
SLC7A4	-0.607
SMIM18	-0.594
MARCH4	-0.592
PTPRR	-0.591
XKR4	-0.583

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TEAD3 mRNA"	23829299
D000082	Acetaminophen	Acetaminophen affects the expression of TEAD3 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of TEAD3 mRNA	28959563
D001151	Arsenic	Arsenic affects the methylation of TEAD3 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of TEAD3 mRNA	25929836
C006780	bisphenol A	bisphenol A affects the methylation of TEAD3 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of TEAD3 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of TEAD3 promoter	22457795
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of TEAD3 mRNA	16934159
D002737	Chloroprene	Chloroprene results in decreased expression of TEAD3 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD3 gene	20938992
D003471	Cuprizone	Cuprizone results in increased expression of TEAD3 mRNA	26577399\|2752363
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of TEAD3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TEAD3 mRNA	27392435
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD3 gene	20938992
D019833	Genistein	Genistein results in decreased expression of TEAD3 mRNA	16705744
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of TEAD3 mRNA	27392435
C410337	K 7174	K 7174 results in increased expression of TEAD3 mRNA	24086573
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD3 gene	20938992
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of TEAD3 mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TEAD3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TEAD3 mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in increased expression of TEAD3 mRNA	19167457
C006253	pirinixic acid	pirinixic acid results in increased expression of TEAD3 mRNA	17951219
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TEAD3 mRNA	27029645
D012643	Selenium	Selenium results in increased expression of TEAD3 mRNA	19244175
D012645	Selenomethionine	Selenomethionine affects the expression of TEAD3 mRNA	17222674
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of TEAD3 mRNA	25895662
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TEAD3 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TEAD3 mRNA	21570461\|2405805
C012589	trichostatin A	trichostatin A affects the expression of TEAD3 mRNA	28542535
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TEAD3 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of TEAD3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TEAD3 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of TEAD3 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of TEAD3 mRNA	17963808

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001085	RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0001085	RNA polymerase II transcription factor binding	-	IPI	23946438
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	IDA	18579750 19324877
GO:0005515	protein binding	-	IPI	18579750 19324877 25416956
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0044212	transcription regulatory region DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006357	regulation of transcription by RNA polymerase II	-	TAS	9148898
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0007565	female pregnancy	-	TAS	9148898
GO:0035329	hippo signaling	-	IBA	21873635
GO:0035329	hippo signaling	-	IDA	18579750 19324877
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0048568	embryonic organ development	-	IBA	21873635
GO:0055059	asymmetric neuroblast division	-	IGI	23946438

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29050244	The prognostic impacts of TEA domain (TEAD) transcription factor polymorphisms in Chinese hepatocellular carcinoma patients. (2017 Sep 19)	Xia H	Oncotarget