Gene: TEAD3

7005
DTEF-1|ETFR-1|TEAD-3|TEAD5|TEF-5|TEF5
TEA domain transcription factor 3
protein-coding
6p21.31
Ensembl:ENSG00000007866 MIM:603170 Vega:OTTHUMG00000014571 UniprotKB:Q99594
NC_000006.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.298e-1 (AD)  6.530e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20595752chr6:35458416TEAD31.990e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF1A0.883
MSN0.881
LTBR0.875
MOB3C0.868
LIMS10.861
YBX30.857
MYD880.855
OSMR0.854
TUBB60.853
TRIP100.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALHM1-0.625
ABCC12-0.62
PPEF1-0.616
KCNB2-0.614
NEUROD6-0.613
SLC7A4-0.607
SMIM18-0.594
MARCH4-0.592
PTPRR-0.591
XKR4-0.583

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TEAD3 mRNA"23829299
D000082AcetaminophenAcetaminophen affects the expression of TEAD3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of TEAD3 mRNA28959563
D001151ArsenicArsenic affects the methylation of TEAD3 gene25304211
D001280AtrazineAtrazine results in decreased expression of TEAD3 mRNA25929836
C006780bisphenol Abisphenol A affects the methylation of TEAD3 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of TEAD3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TEAD3 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TEAD3 mRNA16934159
D002737ChloropreneChloroprene results in decreased expression of TEAD3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD3 gene20938992
D003471CuprizoneCuprizone results in increased expression of TEAD3 mRNA26577399|2752363
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TEAD3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TEAD3 mRNA27392435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD3 gene20938992
D019833GenisteinGenistein results in decreased expression of TEAD3 mRNA16705744
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TEAD3 mRNA27392435
C410337K 7174K 7174 results in increased expression of TEAD3 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD3 gene20938992
D008777MethyltestosteroneMethyltestosterone results in decreased expression of TEAD3 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TEAD3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TEAD3 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of TEAD3 mRNA19167457
C006253pirinixic acidpirinixic acid results in increased expression of TEAD3 mRNA17951219
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TEAD3 mRNA27029645
D012643SeleniumSelenium results in increased expression of TEAD3 mRNA19244175
D012645SelenomethionineSelenomethionine affects the expression of TEAD3 mRNA17222674
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TEAD3 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TEAD3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TEAD3 mRNA21570461|2405805
C012589trichostatin Atrichostatin A affects the expression of TEAD3 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TEAD3 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of TEAD3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TEAD3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of TEAD3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TEAD3 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IPI23946438  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA18579750  19324877  
GO:0005515protein binding-IPI18579750  19324877  25416956  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-TAS9148898  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007565female pregnancy-TAS9148898  
GO:0035329hippo signaling-IBA21873635  
GO:0035329hippo signaling-IDA18579750  19324877  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0048568embryonic organ development-IBA21873635  
GO:0055059asymmetric neuroblast division-IGI23946438  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8951671RUNX3 regulates YAP1-mediated transcriptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29050244The prognostic impacts of TEA domain (TEAD) transcription factor polymorphisms in Chinese hepatocellular carcinoma patients. (2017 Sep 19)Xia HOncotarget