Gene: TECTA

7007
DFNA12|DFNA8|DFNB21
tectorin alpha
protein-coding
11q23.3
Ensembl:ENSG00000109927 MIM:602574 Vega:OTTHUMG00000149908 UniprotKB:O75443
NG_011633.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.282e-1 (AD)  2.976e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TARBP10.867
DHDDS0.843
ARMCX40.84
EML60.837
ICA1L0.832
RPS6KL10.83
FAM160A20.83
SLX40.829
DOPEY10.824
PCYOX1L0.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.488
RAB13-0.479
MDFI-0.459
CLEC2B-0.448
GIMAP2-0.446
TSPO-0.439
ROM1-0.438
TMEM102-0.438
DLEU1-0.438
MTRNR2L9-0.431

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of TECTA mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of TECTA mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TECTA gene27153756
C547126AZM551248AZM551248 results in decreased expression of TECTA mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TECTA mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TECTA mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TECTA mRNA22300585
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TECTA mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of TECTA mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TECTA gene28505145
D002994ClofibrateClofibrate results in decreased expression of TECTA mRNA22300585
D016572CyclosporineCyclosporine results in increased methylation of TECTA promoter27989131
D004041Dietary FatsDietary Fats results in increased expression of TECTA mRNA18042831
D019833GenisteinGenistein results in decreased expression of TECTA protein24552547
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TECTA mRNA26846883
D007213IndomethacinIndomethacin results in increased expression of TECTA mRNA28201806
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of TECTA mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of TECTA mRNA19564919
D000073878Palm OilPalm Oil results in increased expression of TECTA mRNA18042831
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TECTA mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of TECTA mRNA24780913
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of TECTA mRNA19564919
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TECTA mRNA25172293

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007160cell-matrix adhesion-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
GO:0062023collagen-containing extracellular matrix-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol