Gene: TEF

7008
-
TEF, PAR bZIP transcription factor
protein-coding
22q13.2
Ensembl:ENSG00000167074 MIM:188595 Vega:OTTHUMG00000150968 UniprotKB:Q10587
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.218e-1 (AD)  4.050e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IP6K10.93
LZTS30.93
SNPH0.922
CTIF0.919
NCDN0.919
PIK3R20.917
DMTN0.917
JPH40.916
FAIM20.915
CHST10.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.61
OR4F29-0.562
TFPI2-0.538
C9orf135-0.472
KLRB1-0.451
TBX21-0.446
IL18RAP-0.443
FZD10-0.44
KLRF1-0.438
SGMS2-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TEF mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TEF mRNA"21354444|2890350
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of TEF mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TEF mRNA19933214
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TEF mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TEF mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TEF mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TEF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TEF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TEF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TEF mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of TEF mRNA"19799885
D000082AcetaminophenAcetaminophen results in decreased expression of TEF mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TEF mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of TEF mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TEF mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TEF mRNA24449571
C015001arsenitearsenite results in increased methylation of TEF promoter23974009
D001280AtrazineAtrazine results in increased expression of TEF mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of TEF mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TEF mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEF mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEF mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TEF mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TEF mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEF mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TEF mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TEF mRNA26496021
C006780bisphenol Abisphenol A affects the methylation of TEF promoter27334623
C006780bisphenol Abisphenol A results in increased expression of TEF mRNA25594700
C006780bisphenol Abisphenol A affects the expression of TEF mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TEF mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of TEF mRNA22079614
D002065BuspironeBuspirone results in increased expression of TEF mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of TEF mRNA26079696
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of TEF mRNA19072826
D002737ChloropreneChloroprene results in increased expression of TEF mRNA23125180
D002737ChloropreneChloroprene results in increased expression of TEF mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEF gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEF mRNA27858113
C031180chrysenechrysene results in increased expression of TEF mRNA26377693
D003033Coal TarCoal Tar results in decreased expression of TEF mRNA27858113
D003907DexamethasoneDexamethasone results in increased expression of TEF mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TEF mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TEF mRNA28962523
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TEF mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of TEF mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TEF mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TEF mRNA19638242
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TEF mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TEF mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TEF mRNA17942748
C082360fipronilfipronil results in increased expression of TEF mRNA27091632
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of TEF mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEF gene20938992
C069837fullerene C60fullerene C60 results in increased expression of TEF mRNA19167457
D007649KetamineKetamine results in increased expression of TEF mRNA20080153
D064704LevofloxacinLevofloxacin results in increased expression of TEF mRNA24136188
D008694MethamphetamineMethamphetamine results in increased expression of TEF mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEF gene20938992
D008727MethotrexateMethotrexate results in increased expression of TEF mRNA24449571
D008752Methylene ChlorideMethylene Chloride results in increased expression of TEF mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TEF mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TEF mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TEF mRNA"26251327
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TEF mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TEF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TEF mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TEF mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of TEF mRNA24136188
C012655nimesulidenimesulide results in increased expression of TEF mRNA24136188
C005290oxybenzoneoxybenzone results in decreased expression of TEF mRNA22721600
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of TEF mRNA25658374
C046012pentanalpentanal results in decreased expression of TEF mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of TEF mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TEF mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TEF mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TEF mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TEF mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of TEF mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of TEF mRNA17426115
D059808PolyphenolsPolyphenols results in decreased expression of TEF mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of TEF mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of TEF mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of TEF mRNA21278054
C009250sevofluranesevoflurane affects the expression of TEF mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TEF mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of TEF mRNA22700541
D053260SootSoot affects the expression of TEF mRNA26551751
D053260SootSoot results in increased expression of TEF mRNA22461453
D020058StyreneStyrene results in increased expression of TEF mRNA28951217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TEF mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TEF mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TEF mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TEF mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TEF mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of TEF mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of TEF mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TEF mRNA20133372
D014212TretinoinTretinoin results in increased expression of TEF mRNA20530235
D014212TretinoinTretinoin results in increased expression of TEF mRNA16604517
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TEF mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TEF mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TEF mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TEF mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of TEF mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of TEF mRNA15799026
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TEF gene25560391
C025643vinclozolinvinclozolin results in increased expression of TEF mRNA23034163
C111237vorinostatvorinostat results in decreased expression of TEF mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-TAS7835883  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048511rhythmic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19020790Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in sprague-dawley male rats after nicotine cessation. (2009 Jan)Hermizi HCalcif Tissue Int