Gene info: ID 7010

Gene: TEK

GENE ID: 7010

Description: TEK receptor tyrosine kinase

Gene type: protein-coding

Location: 9p21.2

dbXrefs: Ensembl:ENSG00000120156 MIM:600221 Vega:OTTHUMG00000019712 UniprotKB:Q02763

RefSeq: NG_011828.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.068e-1 (AD) 5.387e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FGD5	0.792
PODXL	0.788
HEG1	0.783
SVIL	0.767
PTPRB	0.763
PALMD	0.753
SYNE2	0.751
ETS1	0.749
ITPR3	0.739
TGFBR2	0.734

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.328
OR4F5	-0.317
FAM43B	-0.281
RBM34	-0.277
C19orf73	-0.273
FEZF2	-0.27
CHST8	-0.266
MYADML2	-0.255
SOST	-0.252
CRYBB2	-0.251

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00415	Ampicillin	Small Molecule	69-53-4	Approved	Target
DB05294	Vandetanib	Small Molecule	443913-73-3	Approved	Target
DB08221	N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE	Small Molecule		Experimental	Target
DB08896	Regorafenib	Small Molecule	755037-03-7	Approved	Target
DB08901	Ponatinib	Small Molecule	943319-70-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TEK mRNA"	21354444
C501339	2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione	"2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione results in decreased activity of TEK protein"	21788198
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TEK mRNA	16788091
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of TEK mRNA	21983209
C048324	abamectin	abamectin results in decreased activity of TEK protein	21788198
D000082	Acetaminophen	Acetaminophen results in decreased expression of TEK mRNA	26690555
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TEK gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TEK mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TEK mRNA	15073043
D001374	Azacitidine	Azacitidine results in increased expression of TEK mRNA	18037191
D001372	Aza Compounds	Aza Compounds results in decreased expression of TEK mRNA	20521778
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TEK mRNA	21569818
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of TEK mRNA	20660070
D004958	Estradiol	Estradiol affects the expression of TEK mRNA	15598610
C006780	bisphenol A	bisphenol A results in decreased expression of TEK mRNA	26063408
D002211	Capsaicin	Capsaicin results in increased expression of TEK mRNA	21310942
D002211	Capsaicin	Capsaicin results in increased expression of TEK protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TEK mRNA	15135347
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TEK protein	15135347
C473711	Chir 99021	[Chir 99021 results in increased susceptibility to Tobacco Smoke Pollution] which results in increased expression of TEK mRNA	29221954
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TEK mRNA	19320972
C551994	crizotinib	crizotinib results in decreased activity of TEK protein	21812414
D003561	Cytarabine	Cytarabine results in decreased expression of TEK mRNA	21198554
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TEK mRNA	28628672
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TEK mRNA	17034775
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of TEK mRNA]	17034775
D004237	Diuron	Diuron results in decreased expression of TEK mRNA	25152437
D004237	Diuron	Diuron results in increased expression of TEK mRNA	21551480
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased activity of TEK protein"	25856345
D004656	Enalapril	Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]	19958114
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TEK mRNA	17555576
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of TEK protein	28549617
D005472	Fluorouracil	Fluorouracil results in increased expression of TEK mRNA	15817675
C061365	flusilazole	flusilazole results in decreased expression of TEK mRNA	22382673
C039281	furan	furan results in increased methylation of TEK gene	22079235
D005665	Furosemide	Furosemide results in increased expression of TEK mRNA	16526316
C419708	gefitinib	gefitinib inhibits the reaction [TGFA protein results in decreased expression of TEK mRNA]	18424623
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of TEK mRNA]	22687549
D007211	Indoles	Indoles results in decreased expression of TEK mRNA	20521778
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TEK mRNA	28628672
D007213	Indomethacin	Indomethacin results in increased expression of TEK mRNA	28201806
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TEK mRNA	28628672
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TEK mRNA	24796395\|2596192
D048628	Ketolides	Ketolides analog results in decreased expression of TEK mRNA	24967691
C467567	lenalidomide	lenalidomide results in decreased expression of TEK mRNA	15618473
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of TEK mRNA]	22687549
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TEK mRNA	22687549
C013099	mancozeb	mancozeb results in increased activity of TEK protein	21251949
C013099	mancozeb	mancozeb results in decreased activity of TEK protein	21788198
D008344	Maneb	Maneb results in decreased activity of TEK protein	21788198
C025340	manganese chloride	manganese chloride results in increased expression of TEK mRNA	17467022
D008727	Methotrexate	Methotrexate affects the expression of TEK mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TEK mRNA	26272509\|2800136
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TEK mRNA	26011545
D015735	Mifepristone	Mifepristone results in increased expression of TEK mRNA	17584828
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D009525	Niacin	Niacin results in increased expression of TEK mRNA	17557352
D009525	Niacin	Niacin results in increased phosphorylation of TEK protein	17557352
C507134	ON 01910	ON 01910 results in decreased phosphorylation of TEK protein	25472472
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TEK mRNA	25729387
D010118	Oxytetracycline	Oxytetracycline results in decreased activity of TEK protein	21788198
D010126	Ozone	Ozone results in decreased expression of TEK mRNA	12763052
C073402	PD 123319	PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]	14638905
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TEK mRNA	26705709
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in decreased expression of TEK mRNA	28973697
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of TEK protein	21251949
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of TEK protein	21788198
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the activity of TEK protein	21251949
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased activity of TEK protein	21788198
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TEK mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TEK mRNA	19482888
D010705	Phosgene	Phosgene affects the expression of TEK mRNA	16300373
D010936	Plant Extracts	Plant Extracts results in decreased expression of TEK mRNA	23557933
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of TEK mRNA]	17034775
C008971	polymarcine	polymarcine results in decreased activity of TEK protein	21788198
C545373	ponatinib	ponatinib analog results in decreased activity of TEK protein	21561767
C545373	ponatinib	ponatinib results in decreased activity of TEK protein	19878872
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of TEK mRNA	20660070
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TEK mRNA	24780913
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of TEK mRNA	17667850
D012402	Rotenone	Rotenone results in increased expression of TEK mRNA	19013527
C079198	S 1 (combination)	S 1 (combination) results in decreased expression of TEK mRNA	18607998
D019821	Simvastatin	Simvastatin inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]	20821229
D019821	Simvastatin	Simvastatin results in increased expression of and results in increased activity of TEK protein	18544044
D019821	Simvastatin	Simvastatin results in increased expression of TEK	18544044
D019821	Simvastatin	Simvastatin results in increased expression of TEK mRNA	18544044
D053260	Soot	Soot results in decreased expression of TEK mRNA	26551751
D013311	Streptozocin	Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]	19958114
D013311	Streptozocin	Simvastatin inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]	20821229
D013311	Streptozocin	Streptozocin results in increased expression of TEK mRNA	15643138\|1995811
D013311	Streptozocin	Streptozocin results in increased expression of TEK protein	15643138
D013467	Sulindac	Sulindac analog results in decreased phosphorylation of and results in decreased activity of TEK protein	16215210
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TEK protein]	22150557
D013629	Tamoxifen	Tamoxifen affects the expression of TEK mRNA	17555576
D013654	Taurine	Taurine results in increased expression of TEK mRNA	16579726
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TEK mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of TEK mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TEK mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TEK mRNA	16495355
D013792	Thalidomide	Thalidomide results in decreased expression of TEK mRNA	15618473
D013792	Thalidomide	Thalidomide results in decreased activity of TEK protein	21788198
C009495	titanium dioxide	titanium dioxide results in decreased expression of TEK mRNA	23557971
D014028	Tobacco Smoke Pollution	[Chir 99021 results in increased susceptibility to Tobacco Smoke Pollution] which results in increased expression of TEK mRNA	29221954
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TEK mRNA	20133372
D014050	Toluene	Toluene results in increased expression of TEK mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TEK mRNA	25729387
C057693	troglitazone	troglitazone results in increased expression of TEK mRNA	17569031
C057693	troglitazone	[Urethane co-treated with troglitazone] results in increased expression of TEK mRNA	18465119
D014520	Urethane	[Urethane co-treated with troglitazone] results in increased expression of TEK mRNA	18465119
D014520	Urethane	Urethane results in increased expression of TEK mRNA	18465119
D014635	Valproic Acid	Valproic Acid results in decreased expression of TEK mRNA	23179753\|2800136
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]	14638905
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of TEK gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of TEK mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of TEK mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of TEK mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	TAS	8382358
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IDA	11513602
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IEA	-
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005515	protein binding	-	IPI	8980223 15893672 16732286 19167335 19451274 19922791 20708158
GO:0005524	ATP binding	-	IEA	-
GO:0019838	growth factor binding	-	IEA	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0038023	signaling receptor activity	-	TAS	10766762

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0001525	angiogenesis	-	ISS	-
GO:0001666	response to hypoxia	-	IEA	-
GO:0001934	positive regulation of protein phosphorylation	-	IDA	15284220
GO:0001934	positive regulation of protein phosphorylation	-	IMP	18425120
GO:0001935	endothelial cell proliferation	-	ISS	-
GO:0001938	positive regulation of endothelial cell proliferation	-	TAS	18425120
GO:0001958	endochondral ossification	-	IEA	-
GO:0002040	sprouting angiogenesis	-	IMP	14665640
GO:0007165	signal transduction	-	TAS	8382358
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IDA	15284220
GO:0007267	cell-cell signaling	-	TAS	8980225
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007507	heart development	-	ISS	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010595	positive regulation of endothelial cell migration	-	IDA	15284220
GO:0010595	positive regulation of endothelial cell migration	-	IMP	12816861 18425120
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	IMP	12816861 18425120 19223473
GO:0016525	negative regulation of angiogenesis	-	IMP	18425120
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	11513602
GO:0030154	cell differentiation	-	IBA	21873635
GO:0032878	regulation of establishment or maintenance of cell polarity	-	IMP	18425119
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0034446	substrate adhesion-dependent cell spreading	-	IMP	18425119
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	TAS	18366015
GO:0043114	regulation of vascular permeability	-	TAS	18366015 18425120
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0043434	response to peptide hormone	-	IEA	-
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	IMP	12816861 18425120
GO:0043627	response to estrogen	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	IDA	15284220
GO:0045766	positive regulation of angiogenesis	-	IMP	18425120
GO:0046777	protein autophosphorylation	-	IDA	11513602
GO:0048014	Tie signaling pathway	-	IDA	15284220 19223473
GO:0050728	negative regulation of inflammatory response	-	TAS	18366015
GO:0050900	leukocyte migration	-	TAS	-
GO:0051259	protein complex oligomerization	-	IDA	19424712
GO:0051591	response to cAMP	-	IEA	-
GO:0051894	positive regulation of focal adhesion assembly	-	IMP	18425120
GO:0051897	positive regulation of protein kinase B signaling	-	IDA	19615361
GO:0051897	positive regulation of protein kinase B signaling	-	IMP	18425120
GO:0060216	definitive hemopoiesis	-	TAS	18366015
GO:0060347	heart trabecula formation	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IDA	19615361
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	18425120
GO:0072012	glomerulus vasculature development	-	ISS	-
GO:1902533	positive regulation of intracellular signal transduction	-	IMP	19223473
GO:2000251	positive regulation of actin cytoskeleton reorganization	-	IMP	12816861
GO:2000351	regulation of endothelial cell apoptotic process	-	TAS	18425120
GO:2000352	negative regulation of endothelial cell apoptotic process	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001725	stress fiber	colocalizes_with	IDA	18425119
GO:0005576	extracellular region	-	IEA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IEA	-
GO:0005815	microtubule organizing center	-	IDA	-
GO:0005884	actin filament	colocalizes_with	IDA	18425119
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	19689429
GO:0005902	microvillus	-	IDA	19424712
GO:0005911	cell-cell junction	-	IDA	18425120
GO:0005925	focal adhesion	-	IEA	-
GO:0009925	basal plasma membrane	-	IDA	18425120
GO:0009986	cell surface	-	IDA	19689429
GO:0016323	basolateral plasma membrane	-	IDA	19424712
GO:0016324	apical plasma membrane	-	IDA	19424712
GO:0043235	receptor complex	-	IBA	21873635
GO:0045121	membrane raft	-	IDA	19615361

KEGG ID	KEGG Term
hsa05323	Rheumatoid arthritis

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-109582	Hemostasis	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	IEA
R-HSA-210993	Tie2 Signaling	TAS
R-HSA-210993	Tie2 Signaling	IEA
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26230583	Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress. (2015)	Slattery ML	PLoS One
20970515	Similar gene expression profiles in smokers and patients with moderate COPD. (2011 Feb)	Llinas L	Pulm Pharmacol Ther