Gene: TERF2

7014
TRBF2|TRF2
telomeric repeat binding factor 2
protein-coding
16q22.1
Ensembl:ENSG00000132604 MIM:602027 Vega:OTTHUMG00000137566 UniprotKB:Q15554
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.180e-1 (AD)  8.861e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06469895chr16:69418206TERF21.520e-13Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2Q10.954
PRPF190.95
HARS0.949
RNPS10.949
GPI0.949
SRP680.948
RANBP90.945
UBE2V10.945
CLIP30.944
CS0.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.717
OR4F29-0.682
TFPI2-0.329
SH2D1A-0.323
KLRB1-0.321
FZD10-0.3
ASB4-0.296
RAI14-0.291
TIGIT-0.284
MBNL3-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of TERF2 mRNA]"26330309
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dimethyl Sulfoxide co-treated with Tretinoin] results in decreased expression of TERF2 mRNA"26330309
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TERF2 mRNA"26330309
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TERF2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TERF2 mRNA"26330309
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TERF2 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TERF2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TERF2 mRNA24449571
D001151ArsenicArsenic results in decreased expression of TERF2 mRNA25460668
C006632arsenic trioxidearsenic trioxide results in increased expression of TERF2 mRNA15904916
C006632arsenic trioxidearsenic trioxide results in increased expression of TERF2 protein15904916
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TERF2 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of TERF2 mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of TERF2 promoter27334623
C043211carvedilolcarvedilol affects the expression of TERF2 protein22000973
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TERF2 mRNA24763279
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TERF2 mRNA20350560
D019327Copper SulfateCopper Sulfate results in decreased expression of TERF2 mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TERF2 mRNA23640034
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of TERF2 mRNA]21858171
D004121Dimethyl Sulfoxide"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dimethyl Sulfoxide co-treated with Tretinoin] results in decreased expression of TERF2 mRNA"26330309
D004121Dimethyl Sulfoxide[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF2 mRNA26330309
C045651epigallocatechin gallateepigallocatechin gallate affects the expression of TERF2 protein22000973
D005472FluorouracilFluorouracil results in increased expression of TERF2 protein15585135|1680352
D005557FormaldehydeFormaldehyde results in decreased expression of TERF2 mRNA20655997
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TERF2 mRNA24763279
D017953IsocyanatesIsocyanates results in decreased expression of TERF2 protein20685613
D007854LeadLead results in decreased expression of TERF2 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TERF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TERF2 mRNA"25554681
C090577N,N'-bis(salicylideneamino)ethane-manganese(II)"N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [SOD2 gene mutant form results in decreased expression of TERF2 protein]"21195081
D010269ParaquatParaquat results in increased expression of TERF2 mRNA21371552
D019800PhenolPhenol results in increased expression of TERF2 mRNA17547211
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TERF2 mRNA19710929
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of TERF2 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of TERF2 mRNA21858171
D011794QuercetinQuercetin affects the expression of TERF2 protein22000973
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TERF2 mRNA21570461
D013755Tetradecanoylphorbol Acetate"2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of TERF2 mRNA]"26330309
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TERF2 mRNA26330309
D014212Tretinoin"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dimethyl Sulfoxide co-treated with Tretinoin] results in decreased expression of TERF2 mRNA"26330309
D014212Tretinoin[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF2 mRNA26330309
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TERF2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of TERF2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of TERF2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of TERF2 mRNA17292431
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of TERF2 mRNA16330358
C025643vinclozolinvinclozolin results in increased expression of TERF2 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003691double-stranded telomeric DNA binding-IDA18812185  21852327  
GO:0003691double-stranded telomeric DNA binding-ISS9326950  
GO:0003720telomerase activitycontributes_toIDA23685356  
GO:0005515protein binding-IPI10984620  12181313  14690602  15181449  15229185  15314656  
15383534  15657433  16730175  16799465  16880378  17055345  
18202258  19287395  19596235  19596236  19651898  20360068  
20479256  20655466  21044950  21217703  21824286  21829167  
22039056  22157895  24012755  24095731  25399868  25620558  
26496610  27214791  
GO:0008022protein C-terminus binding-IPI12181313  
GO:0019899enzyme binding-IPI20479256  
GO:0042162telomeric DNA binding-IDA19854130  20655466  23685356  
GO:0042803protein homodimerization activity-IPI9326950  
GO:0044877protein-containing complex binding-IPI14690602  24095731  
GO:0098505G-rich strand telomeric DNA binding-IDA17694070  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP20655466  
GO:0006278RNA-dependent DNA biosynthetic process-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007049cell cycle-IEA-  
GO:0008089anterograde axonal transport-IBA21873635  
GO:0010628positive regulation of gene expression-IMP11927518  
GO:0010629negative regulation of gene expression-IMP11927518  
GO:0016233telomere capping-IMP12768206  14690602  15657433  
GO:0016233telomere capping-NAS17395247  
GO:0016233telomere capping-TAS24095731  
GO:0031627telomeric loop formation-IDA10338214  
GO:0031848protection from non-homologous end joining at telomere-IMP14690602  17499040  
GO:0031848protection from non-homologous end joining at telomere-IPI24095731  
GO:0032204regulation of telomere maintenance-IMP22536324  
GO:0032205negative regulation of telomere maintenance-IDA17055345  
GO:0032208negative regulation of telomere maintenance via recombination-IMP15507207  
GO:0032208negative regulation of telomere maintenance via recombination-ISS-  
GO:0032210regulation of telomere maintenance via telomerase-IDA23685356  
GO:0032210regulation of telomere maintenance via telomerase-IMP19864690  
GO:0032211negative regulation of telomere maintenance via telomerase-IC15657433  
GO:0032211negative regulation of telomere maintenance via telomerase-IDA17055345  
GO:0032211negative regulation of telomere maintenance via telomerase-IMP11971978  
GO:0032214negative regulation of telomere maintenance via semi-conservative replication-NAS15007108  
GO:0051000positive regulation of nitric-oxide synthase activity-IMP11927518  
GO:0061820telomeric D-loop disassembly-IGI22039056  
GO:0070198protein localization to chromosome, telomeric region-IMP17499040  
GO:0090398cellular senescence-NAS17395247  
GO:1903770negative regulation of beta-galactosidase activity-IDA11927518  
GO:1903824negative regulation of telomere single strand break repair-NAS17395247  
GO:1904354negative regulation of telomere capping-IMP24270157  
GO:1904357negative regulation of telomere maintenance via telomere lengthening-IMP24012755  
GO:1904430negative regulation of t-circle formation-IMP15507207  
GO:1904430negative regulation of t-circle formation-TAS19581589  
GO:1905778negative regulation of exonuclease activity-IDA15200954  
GO:1905839negative regulation of telomeric D-loop disassembly-IDA15200954  
GO:2000773negative regulation of cellular senescence-IMP11927518  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IDA12768206  20479256  20655466  24012755  
GO:0000783nuclear telomere cap complex-IDA15181449  16880378  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric region-IDA15109494  23685356  24270157  
GO:0005634nucleus-IDA17055345  
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
GO:0030870Mre11 complexcolocalizes_withIDA10888888  
GO:0070187shelterin complex-IDA15383534  23685356  
GO:0070187shelterin complex-IMP21852327  
GO:0070187shelterin complex-TAS18202258  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-171306Packaging Of Telomere EndsTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26066545Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD. (2016 Jan)Rutten EPChest