Gene info: ID 7015

Gene: TERT

GENE ID: 7015

Description: telomerase reverse transcriptase

Gene type: protein-coding

Location: 5p15.33

dbXrefs: Ensembl:ENSG00000164362 MIM:187270 Vega:OTTHUMG00000090357 UniprotKB:O14746

RefSeq: NG_009265.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 56

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.910e-1 (AD) 8.334e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg25939350	chr5:1269270	TERT	Gene body	2.736e-4	Alcohol use disorders	26763658
cg02601800	chr5:1274702	TERT	Gene body	5.783e-4	Alcohol use disorders	26763658
cg24908166	chr5:1268800	TERT		1.900e-9	Smoking	27651444
cg24908166	chr5:1268800	TERT		6.350e-10	Tobacco smoking	28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TRAIP	0.625
ATG9B	0.621
SLC22A25	0.611
TNK1	0.599
STRIP2	0.598
PTPRQ	0.594
MYB	0.589
TMEM120B	0.588
ISM2	0.588
RAB40A	0.587

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNJ8	-0.326
CSAG1	-0.297
CCDC102A	-0.29
LY96	-0.284
RAI14	-0.272
PGF	-0.268
TMEM92	-0.267
IL7R	-0.267
KCNE4	-0.267
GIMAP2	-0.265

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00495	Zidovudine	Small Molecule	30516-87-1	Approved	Target
DB05036	Grn163l	Small Molecule	-	Investigational	Target
DB12747	Tertomotide	BiotechDrug	915019-08-8	Investigational	Target

ID	Drug Name	Action	PubMed
C489138	1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile	"[4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]"	23382840
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TERT mRNA"	28903501
C031709	2',3'-dideoxyguanosine 5'-triphosphate	"2',3'-dideoxyguanosine 5'-triphosphate metabolite results in decreased activity of TERT protein"	27146145
C081766	2,4,4'-trichlorobiphenyl	"2,4,4'-trichlorobiphenyl metabolite inhibits the reaction [Tetanus Toxoid results in increased expression of TERT mRNA]"	27146145
C081766	2,4,4'-trichlorobiphenyl	"2,4,4'-trichlorobiphenyl metabolite results in decreased expression of TERT mRNA"	27146145
C081766	2,4,4'-trichlorobiphenyl	"2,4,4'-trichlorobiphenyl metabolite results in decreased expression of TERT protein"	27146145
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of TERT protein]"	26330309
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]"	26330309
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TERT mRNA"	26330309
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of TERT protein"	26330309
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of TERT protein]	16798746
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of TERT protein]	15590986
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	15590986
C026600	2'-deoxyadenosine triphosphate	2'-deoxyadenosine triphosphate analog results in decreased activity of TERT protein	11563329
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA]"	26330309
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of TERT protein]"	26330309
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]"	26330309
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of TERT protein"	26330309
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TERT mRNA"	26330309
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]]	16798746
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
C048336	3-adenin-9-yl-2-hydroxypropanoic acid isobutyl ester	3-adenin-9-yl-2-hydroxypropanoic acid isobutyl ester affects the expression of TERT mRNA	18045574
C025160	3-aminobenzamide	3-aminobenzamide inhibits the reaction [TERT protein mutant form results in decreased susceptibility to temozolomide]	12488552
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of TERT mRNA"	18648102
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	"[4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]"	23382840
C059356	5-fluoropyrimidin-2-one beta-ribofuranoside	5-fluoropyrimidin-2-one beta-ribofuranoside results in increased expression of TERT mRNA	18045574
C016391	9-(2,3-dihydroxypropyl)adenine	"9-(2,3-dihydroxypropyl)adenine results in increased expression of TERT mRNA"	18045574
C106538	abacavir	abacavir results in decreased activity of TERT protein	19358275
D019342	Acetic Acid	Acetic Acid affects the expression of TERT protein	21296659
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TERT protein]	19409983
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased activity of TERT protein]	18336854
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein]	18336854
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TERT mRNA	19770486
C103303	alitretinoin	alitretinoin results in decreased expression of TERT mRNA	16180984
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein]	20112180
C068073	Am 580	[Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA	16482212
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TERT mRNA	16483693
D000814	Aniline Compounds	Aniline Compounds results in decreased activity of TERT protein	25123791
D000814	Aniline Compounds	Aniline Compounds results in decreased expression of TERT mRNA	25123791
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TERT mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of TERT gene	25304211
D001151	Arsenic	Arsenic results in increased expression of TERT mRNA	19337508\|2291711
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [SP1 protein binds to TERT promoter]	15761015
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [SP1 protein results in increased expression of TERT mRNA]	11714746
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Tretinoin results in decreased activity of TERT protein]	16107885
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Tretinoin results in decreased expression of TERT mRNA]	16107885
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of TERT mRNA	17275888
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of TERT protein	12962562\|1522866
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TERT gene	21544632
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TERT mRNA	11714746\|1522866
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TERT protein	11714746\|1696627
C006632	arsenic trioxide	[arsenic trioxide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of TERT mRNA	18336854
C006632	arsenic trioxide	GH1 protein promotes the reaction [arsenic trioxide results in decreased expression of TERT mRNA]	23851143
C006632	arsenic trioxide	TERT protein results in decreased susceptibility to [arsenic trioxide co-treated with Tretinoin]	16107885
C006632	arsenic trioxide	Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased activity of TERT protein]	18336854
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of TERT protein	18336854
C006632	arsenic trioxide	CAT protein inhibits the reaction [arsenic trioxide results in decreased activity of TERT protein]	18336854
C006632	arsenic trioxide	diphenyleneiodonium inhibits the reaction [arsenic trioxide results in decreased activity of TERT protein]	18336854
C045816	arsenic trisulfide	arsenic trisulfide results in decreased activity of TERT protein	19811737
C045816	arsenic trisulfide	arsenic trisulfide results in decreased expression of TERT mRNA	17643074\|1981173
C045816	arsenic trisulfide	TERT protein affects the susceptibility to arsenic trisulfide	17643074
D001241	Aspirin	Aspirin results in increased expression of TERT mRNA	20457246
D001374	Azacitidine	Azacitidine analog results in decreased expression of TERT mRNA	18045574
D001374	Azacitidine	Azacitidine results in decreased activity of TERT protein	19451745
D001374	Azacitidine	Azacitidine results in decreased expression of TERT mRNA	19451745
D001374	Azacitidine	Azacitidine results in decreased methylation of TERT promoter	19451745
D001374	Azacitidine	E2F1 protein affects the reaction [Azacitidine results in decreased activity of TERT protein]	19451745
D001374	Azacitidine	E2F1 protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA]	19451745
D001374	Azacitidine	MYC protein affects the reaction [Azacitidine results in decreased activity of TERT protein]	19451745
D001374	Azacitidine	MYC protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA]	19451745
C037689	benzamide	benzamide results in decreased activity of TERT protein	11563329\|1609820
C037689	benzamide	benzamide results in decreased activity of TERT protein	16098204
C037689	benzamide	benzamide results in decreased ADP-ribosylation of TERT protein	16098204
D001554	Benzene	[Benzene co-treated with Selenium] results in increased activity of TERT protein	19080380
D001554	Benzene	Benzene results in increased activity of TERT protein	19080380
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TERT mRNA	26001963
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [APP protein modified form results in decreased expression of and results in decreased activity of TERT protein]	21520056
D001599	Berberine	Berberine results in decreased activity of TERT protein	25265580
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of TERT protein]	16798746
D004958	Estradiol	dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	16051634
D004958	Estradiol	Ellagic Acid inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	19501078
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TERT mRNA	20823114
D004958	Estradiol	Estradiol results in increased activity of TERT protein	16327978\|1679874
D004958	Estradiol	Estradiol results in increased expression of TERT	15585566
D004958	Estradiol	Estradiol results in increased expression of TERT mRNA	16051634\|1632797
D004958	Estradiol	Estradiol results in increased expression of TERT mRNA alternative form	19501078
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	19501078
D004958	Estradiol	Metribolone inhibits the reaction [Estradiol results in increased activity of TERT protein]	19561322
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased activity of TERT protein]	19561322
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	16051634
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	19501078
D004958	Estradiol	[Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased activity of TERT protein	16327978
D004958	Estradiol	[Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased expression of TERT mRNA	16327978
D004958	Estradiol	U 0126 inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	23409030
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of TERT protein]	15590986
D004958	Estradiol	Estradiol promotes the reaction [TERT protein binds to RELA protein]	15590986
D004958	Estradiol	Estradiol results in increased phosphorylation of and results in increased activity of TERT protein	15590986
C053541	bicalutamide	bicalutamide results in decreased activity of TERT protein	15638997
C053541	bicalutamide	bicalutamide results in decreased expression of TERT mRNA	15638997
C088060	bisindolylmaleimide	bisindolylmaleimide results in decreased activity of TERT protein	9434777
C006780	bisphenol A	bisphenol A results in increased expression of TERT mRNA	15368248
C006780	bisphenol A	bisphenol A affects the methylation of TERT promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of TERT mRNA	24534842
C006780	bisphenol A	bisphenol A results in decreased expression of TERT mRNA	25181051
D001761	Bleomycin	TERT gene mutant form results in decreased susceptibility to Bleomycin	18008008
C011686	boldine	boldine affects the splicing of TERT mRNA	25746354
C011686	boldine	boldine results in decreased activity of TERT protein	25746354
C099813	bromochloroacetic acid	bromochloroacetic acid results in increased expression of TERT protein	21296659
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased activity of TERT protein	14729356
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of TERT protein	21181359
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TERT mRNA	16600092\|2118135
D019256	Cadmium Chloride	Selenium inhibits the reaction [Cadmium Chloride results in increased expression of TERT mRNA]	16600092
D002330	Carmustine	TERT protein mutant form results in decreased susceptibility to Carmustine	12488552
C062047	chelidonine	chelidonine results in decreased activity of TERT protein	25265580
C062047	chelidonine	chelidonine results in decreased expression of TERT mRNA	25265580
D002794	Choline	Choline affects the expression of TERT mRNA	17616785
C074702	chromium hexavalent ion	TERT protein results in decreased susceptibility to chromium hexavalent ion	20585393
D019343	Citric Acid	[Citric Acid co-treated with zinc chloride] results in decreased activity of TERT protein	16624386
C007095	cobaltiprotoporphyrin	[IL1B protein co-treated with cobaltiprotoporphyrin] results in increased expression of TERT mRNA	21954917
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TERT mRNA	19549813
C029892	cupric chloride	cupric chloride results in decreased expression of TERT mRNA	24650576
D003471	Cuprizone	Cuprizone results in decreased expression of TERT mRNA	27523638
D003474	Curcumin	Curcumin results in decreased activity of TERT protein	17096185
C014347	decitabine	decitabine affects the expression of TERT mRNA	18045574
C014347	decitabine	decitabine affects the methylation of TERT promoter	17267411
C014347	decitabine	decitabine affects the reaction [CTCF protein binds to TERT promoter]	17267411
C014347	decitabine	decitabine affects the reaction [[CTCF protein binds to TERT promoter] which affects the expression of TERT mRNA]	17267411\|1726741
C014347	decitabine	decitabine results in decreased activity of TERT protein	18021753
C014347	decitabine	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Cisplatin	18021753
C014347	decitabine	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Paclitaxel	18021753
C014347	decitabine	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Tamoxifen	18021753
C014347	decitabine	decitabine results in decreased expression of TERT protein	18021753
D003703	Demecolcine	Demecolcine results in decreased expression of TERT mRNA	23649840
C061481	dibenzoylmethane	dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]	16051634
C061481	dibenzoylmethane	dibenzoylmethane inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	16051634
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TERT mRNA	20823114
D002945	Cisplatin	[Cisplatin co-treated with Quercetin] results in decreased activity of TERT protein	16082193
D002945	Cisplatin	Cisplatin results in decreased expression of TERT mRNA	17923759\|2759478
D002945	Cisplatin	Cisplatin results in increased expression of and results in decreased activity of TERT protein	17923759
D002945	Cisplatin	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Cisplatin	18021753
D002945	Cisplatin	TERT protein mutant form results in increased susceptibility to Cisplatin	12488552
D002945	Cisplatin	Cisplatin results in decreased expression of TERT mRNA	24571982
C000944	dicrotophos	dicrotophos results in increased expression of TERT mRNA	28302478
D004052	Diethylnitrosamine	ATM protein promotes the reaction [Diethylnitrosamine results in increased expression of TERT protein]	19919837
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TERT protein	19919837
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased activity of TERT protein	15682466
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TERT mRNA	15682466
D004052	Diethylnitrosamine	fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]	15682466
D004052	Diethylnitrosamine	fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA]	15682466
D002117	Calcitriol	Calcitriol results in decreased expression of TERT mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of TERT mRNA	21592394
D004121	Dimethyl Sulfoxide	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]"	26330309
D004121	Dimethyl Sulfoxide	"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA]"	26330309
D004121	Dimethyl Sulfoxide	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]"	26330309
D004121	Dimethyl Sulfoxide	[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein	26330309
D004121	Dimethyl Sulfoxide	[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA	26330309
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of TERT mRNA	16180984
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [arsenic trioxide results in decreased activity of TERT protein]	18336854
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein]	18336854
D004317	Doxorubicin	Doxorubicin results in decreased expression of TERT mRNA	16077987
D004317	Doxorubicin	Doxorubicin results in decreased expression of TERT mRNA alternative form	15003732
D004317	Doxorubicin	Doxorubicin results in increased expression of TERT mRNA	18560228
D004317	Doxorubicin	TERT mRNA results in decreased susceptibility to Doxorubicin	18396642
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased activity of TERT protein"	19295228
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of TERT mRNA"	19295228
C479799	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of TERT mRNA	15528975
D004610	Ellagic Acid	Ellagic Acid inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	19501078
D004610	Ellagic Acid	Ellagic Acid results in increased expression of TERT mRNA alternative form	19501078
D004610	Ellagic Acid	Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]	27965107
D004726	Endosulfan	Endosulfan results in increased expression of TERT mRNA	15832825
D004726	Endosulfan	Endosulfan results in increased expression of TERT mRNA	15832825
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of TERT mRNA	18581255\|2070667
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of TERT protein	18581255
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of TERT mRNA	23649840
D005472	Fluorouracil	[Fluorouracil co-treated with gemcitabine] results in decreased activity of TERT protein	16929163
D005472	Fluorouracil	Fluorouracil results in decreased activity of TERT protein	16929163
D005472	Fluorouracil	Fluorouracil results in decreased expression of TERT mRNA	16455633\|1792375
D005472	Fluorouracil	Fluorouracil results in decreased expression of TERT mRNA alternative form	15003732
D005472	Fluorouracil	Fluorouracil results in decreased expression of TERT protein modified form	16455633
D005472	Fluorouracil	TERT mRNA results in decreased susceptibility to Fluorouracil	18396642
D005472	Fluorouracil	TERT protein affects the susceptibility to Fluorouracil	15608686
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of TERT mRNA]	15016801
D005472	Fluorouracil	Fluorouracil results in decreased expression of TERT protein	21296659
C061365	flusilazole	flusilazole results in decreased expression of TERT mRNA	22382673
D004397	Fonofos	Fonofos results in increased methylation of TERT promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of TERT mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of TERT mRNA	18045764
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	19501078
C070081	fulvestrant	fulvestrant results in decreased expression of TERT mRNA alternative form	19501078
C026211	fumagillin	fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]	15682466
C026211	fumagillin	fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA]	15682466
C039281	furan	furan results in increased methylation of TERT gene	22079235
C419708	gefitinib	gefitinib results in decreased expression of TERT mRNA	17094457
C001277	geldanamycin	geldanamycin results in decreased activity of TERT protein	21520056
C056507	gemcitabine	[Fluorouracil co-treated with gemcitabine] results in decreased activity of TERT protein	16929163
C056507	gemcitabine	gemcitabine results in decreased activity of TERT protein	16929163
D019833	Genistein	Genistein results in decreased expression of TERT mRNA	20706672
D019307	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of TERT protein	9434777
D006861	Hydrogen Peroxide	alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein]	20112180
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased activity of TERT protein	20112180
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TERT mRNA	15761015
D007501	Iron	Iron results in increased activity of TERT protein	17189828
D017879	Isothiocyanates	"[4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]"	23382840
D017879	Isothiocyanates	Isothiocyanates results in decreased activity of TERT protein	23382840
D017879	Isothiocyanates	Isothiocyanates results in decreased expression of TERT mRNA	23382840
D017879	Isothiocyanates	Isothiocyanates results in increased activity of TERT protein	23382840
D017879	Isothiocyanates	Isothiocyanates results in increased expression of TERT mRNA	23382840
D017879	Isothiocyanates	[pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]	23382840
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TERT mRNA	21889194\|2340363
C561695	(+)-JQ1 compound	MYC protein inhibits the reaction [(+)-JQ1 compound results in decreased expression of TERT mRNA]	23403638
C067431	letrozole	letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein]	19561322
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TERT mRNA	26378955
C013592	mangiferin	mangiferin results in decreased activity of TERT protein	17634039
C054474	manumycin	Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TERT protein]	19409983
C054474	manumycin	manumycin results in decreased expression of TERT protein	19409983
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TERT mRNA	20823114
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TERT mRNA	26011545
D015741	Metribolone	letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein]	19561322
D015741	Metribolone	Metribolone inhibits the reaction [Estradiol results in increased activity of TERT protein]	19561322
D015741	Metribolone	Metribolone results in increased activity of TERT protein	19561322
D015741	Metribolone	Metribolone results in increased expression of TERT mRNA	19561322
D015741	Metribolone	Tamoxifen inhibits the reaction [Metribolone results in increased activity of TERT protein]	19561322
D016685	Mitomycin	Mitomycin results in decreased expression of TERT protein	24838295
C406082	monomethylarsonous acid	[monomethylarsonous acid results in increased abundance of Reactive Oxygen Species] which results in decreased expression of TERT mRNA	18336854
C406082	monomethylarsonous acid	Acetylcysteine inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein]	18336854
C406082	monomethylarsonous acid	CAT protein inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein]	18336854
C406082	monomethylarsonous acid	diphenyleneiodonium inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein]	18336854
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased activity of TERT protein	18336854
C521094	N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine	"N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine results in decreased expression of TERT mRNA"	21774525
C521094	N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine	"N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine results in decreased expression of TERT protein"	21774525
C003297	nandrolone decanoate	nandrolone decanoate results in increased activity of TERT protein	19561322
C003297	nandrolone decanoate	nandrolone decanoate results in increased activity of TERT protein	26541207
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TERT mRNA"	25620056
D053644	Naphthalimides	Naphthalimides results in decreased activity of TERT protein	16098204
C116108	N,N'-bis(2-1(piperidino)-ethyl)-3,4,9,10-perylene-tetracarboxylic diimide	"N,N'-bis(2-1(piperidino)-ethyl)-3,4,9,10-perylene-tetracarboxylic diimide results in decreased activity of TERT protein"	16101148
C090577	N,N'-bis(salicylideneamino)ethane-manganese(II)	"N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [SOD2 gene mutant form results in decreased expression of TERT protein]"	21195081
C485800	osajin	osajin results in decreased expression of TERT mRNA	20706672
D017239	Paclitaxel	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Paclitaxel	18021753
D017239	Paclitaxel	Paclitaxel results in decreased expression of TERT protein	17701358\|1809827
D017239	Paclitaxel	[Tretinoin co-treated with Paclitaxel] results in decreased expression of TERT protein	17701358\|1809827
C016030	pantogab	pantogab results in decreased expression of TERT mRNA	17379144
D010278	Parathion	Parathion results in increased methylation of TERT promoter	22847954
C011272	perfosfamide	perfosfamide results in decreased expression of TERT mRNA	24571982
C003117	phosalone	Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]	27965107
C003117	phosalone	phosalone results in decreased activity of TERT protein	27965107
D054735	Phosphorothioate Oligonucleotides	Phosphorothioate Oligonucleotides analog results in decreased activity of TERT protein	11563329
C474837	pomiferin	pomiferin results in decreased expression of TERT mRNA	20706672
C107773	pterostilbene	pterostilbene results in decreased expression of TERT mRNA	26459286
C107773	pterostilbene	pterostilbene results in decreased expression of TERT protein	26459286
C107773	pterostilbene	resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT mRNA]	26459286
C107773	pterostilbene	resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT protein]	26459286
C033607	puerarin	puerarin results in decreased expression of TERT mRNA	20706672
C432165	pyrazolanthrone	[pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]	23382840
D011794	Quercetin	[Cisplatin co-treated with Quercetin] results in decreased activity of TERT protein	16082193
D011794	Quercetin	Quercetin results in increased activity of TERT protein	21902895
D011794	Quercetin	Quercetin results in increased expression of TERT mRNA	21632981
D020849	Raloxifene Hydrochloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
D020849	Raloxifene Hydrochloride	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]]	16798746
D020849	Raloxifene Hydrochloride	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
D020849	Raloxifene Hydrochloride	ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
D020849	Raloxifene Hydrochloride	ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]	16798746
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of and results in increased activity of TERT protein	16798746
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of TERT mRNA	16798746
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased phosphorylation of TERT protein	16798746
D020849	Raloxifene Hydrochloride	SN50 peptide inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
D020849	Raloxifene Hydrochloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	15590986
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride promotes the reaction [TERT protein binds to RELA protein]	15590986
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased phosphorylation of and results in increased activity of TERT protein	15590986
D017382	Reactive Oxygen Species	[arsenic trioxide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of TERT mRNA	18336854
D017382	Reactive Oxygen Species	[monomethylarsonous acid results in increased abundance of Reactive Oxygen Species] which results in decreased expression of TERT mRNA	18336854
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of TERT mRNA	15761015
C059514	resveratrol	resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT mRNA]	26459286
C059514	resveratrol	resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT protein]	26459286
C059514	resveratrol	resveratrol results in decreased expression of TERT mRNA	20706672
D015474	Isotretinoin	Isotretinoin results in decreased expression of TERT mRNA	16180984
D012176	Retinoids	[Am 580 co-treated with Retinoids] results in decreased expression of TERT mRNA	16482212
C529148	rosavin	rosavin results in decreased expression of TERT mRNA	20706672
C093642	SB 203580	[pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]	23382840
D012643	Selenium	Selenium results in decreased activity of TERT protein	17948765
D012643	Selenium	Selenium results in decreased expression of TERT mRNA	17948765
D012643	Selenium	[Benzene co-treated with Selenium] results in increased activity of TERT protein	19080380
D012643	Selenium	Selenium inhibits the reaction [Cadmium Chloride results in increased expression of TERT mRNA]	16600092
D017632	Asbestos, Serpentine	"TERT protein results in increased susceptibility to Asbestos, Serpentine"	15182483
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TERT mRNA	25895662
D020123	Sirolimus	Sirolimus results in decreased expression of TERT mRNA	12939469\|1645508
D020123	Sirolimus	Sirolimus results in decreased expression of TERT protein	17996122
C118258	SN50 peptide	SN50 peptide inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]	16798746
C017947	sodium arsenite	sodium arsenite results in decreased activity of TERT protein	22199297
C017947	sodium arsenite	sodium arsenite results in decreased expression of TERT mRNA	16966277\|1946457
C017947	sodium arsenite	sodium arsenite results in decreased expression of TERT protein	16966277\|1946457
C017947	sodium arsenite	sodium arsenite results in increased expression of TERT mRNA	19337508\|1946457
C017947	sodium arsenite	sodium arsenite results in increased methylation of TERT gene	25199682
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased expression of TERT mRNA	17936526
D018038	Sodium Selenite	Sodium Selenite results in increased activity of TERT protein	14673504
D018038	Sodium Selenite	Sodium Selenite results in increased expression of TERT mRNA	14673504
D013110	Sphingosine	Sphingosine affects the activity of TERT protein	9434777
D019311	Staurosporine	Staurosporine results in decreased activity of TERT protein	9434777
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TERT mRNA	26378955
C016766	sulforafan	sulforafan results in decreased expression of TERT mRNA	26833863
D013629	Tamoxifen	[decitabine results in decreased activity of TERT protein] which results in increased susceptibility to Tamoxifen	18021753
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased activity of TERT protein]	19561322
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	16051634
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]	19501078
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Metribolone results in increased activity of TERT protein]	19561322
D013629	Tamoxifen	Tamoxifen results in decreased expression of TERT mRNA alternative form	19501078
C047246	temozolomide	3-aminobenzamide inhibits the reaction [TERT protein mutant form results in decreased susceptibility to temozolomide]	12488552
C047246	temozolomide	TERT protein mutant form results in decreased susceptibility to temozolomide	12488552
C012568	terbufos	terbufos results in increased methylation of TERT promoter	22847954
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of TERT mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of TERT mRNA	21592394
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of TERT mRNA	20189893
D013745	Tetanus Toxoid	"2,4,4'-trichlorobiphenyl metabolite inhibits the reaction [Tetanus Toxoid results in increased expression of TERT mRNA]"	27146145
D013745	Tetanus Toxoid	Tetanus Toxoid results in increased expression of TERT mRNA	27146145
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TERT protein	22015590
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TERT protein	23850740
D013749	Tetrachlorodibenzodioxin	CYP1A1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TERT mRNA]	17141429
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased activity of TERT protein	16327978
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased expression of TERT mRNA	16327978
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of TERT protein	16327978
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TERT mRNA	16327978\|1714142
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TERT mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TERT mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TERT mRNA	26290441
D013749	Tetrachlorodibenzodioxin	MYC protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of TERT protein]	16327978
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of TERT protein	16327978
D013755	Tetradecanoylphorbol Acetate	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of TERT protein]"	26330309
D013755	Tetradecanoylphorbol Acetate	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of TERT protein]"	26330309
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased activity of TERT protein	26330309
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of TERT mRNA	26330309
D014212	Tretinoin	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]"	26330309
D014212	Tretinoin	"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA]"	26330309
D014212	Tretinoin	"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]"	26330309
D014212	Tretinoin	arsenic trioxide promotes the reaction [Tretinoin results in decreased activity of TERT protein]	16107885
D014212	Tretinoin	arsenic trioxide promotes the reaction [Tretinoin results in decreased expression of TERT mRNA]	16107885
D014212	Tretinoin	TERT protein results in decreased susceptibility to [arsenic trioxide co-treated with Tretinoin]	16107885
D014212	Tretinoin	[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein	26330309
D014212	Tretinoin	[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA	26330309
D014212	Tretinoin	[Tretinoin co-treated with Paclitaxel] results in decreased expression of TERT protein	17701358\|1809827
D014212	Tretinoin	Tretinoin results in decreased activity of TERT protein	15770638\|1605412
D014212	Tretinoin	Tretinoin results in decreased expression of TERT mRNA	15770638\|1610788
D014212	Tretinoin	Tretinoin results in decreased expression of TERT protein	15770638\|1770135
D014212	Tretinoin	[UAB 30 co-treated with Tretinoin] results in decreased expression of TERT mRNA	17273765
D014212	Tretinoin	Tretinoin results in decreased expression of TERT mRNA	16180984
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer results in decreased expression of TERT protein	24211270
C012589	trichostatin A	trichostatin A affects the expression of TERT mRNA	16051188
C012589	trichostatin A	trichostatin A affects the expression of TERT protein	16051188
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TERT mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of TERT mRNA	20650001
C113580	U 0126	"[4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]"	23382840
C113580	U 0126	[pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]	23382840
C113580	U 0126	U 0126 inhibits the reaction [Estradiol results in increased expression of TERT mRNA]	23409030
C112106	UAB 30	[UAB 30 co-treated with Tretinoin] results in decreased expression of TERT mRNA	17273765
C112106	UAB 30	UAB 30 results in decreased expression of TERT mRNA	17273765
D014520	Urethane	Urethane results in decreased expression of TERT mRNA	28818685
D014520	Urethane	Urethane results in increased activity of [TERC protein binds to TEP1 protein binds to TERT protein]	11323394
D014520	Urethane	Urethane results in increased expression of TERT mRNA	11323394
D014635	Valproic Acid	Valproic Acid results in increased methylation of TERT gene	29154799
D009536	Niacinamide	Niacinamide results in decreased activity of TERT protein	11563329
D015215	Zidovudine	Zidovudine results in decreased activity of TERT protein	16601281\|1809760
C016837	zinc chloride	[Citric Acid co-treated with zinc chloride] results in decreased activity of TERT protein	16624386
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of TERT mRNA	27504894

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000049	tRNA binding	-	IDA	21937513
GO:0001223	transcription coactivator binding	-	IPI	19571879
GO:0003677	DNA binding	-	IDA	21937513
GO:0003720	telomerase activity	-	IDA	9398860 9443919 12135483 16043710 16507993 17940095 18082603 21531765
GO:0003720	telomerase activity	-	TAS	11927518 23474713 23784080
GO:0003721	telomerase RNA reverse transcriptase activity	-	IBA	21873635
GO:0003721	telomerase RNA reverse transcriptase activity	-	IDA	9398860 15632080 17940095 19701182
GO:0003721	telomerase RNA reverse transcriptase activity	-	IMP	11313459
GO:0003721	telomerase RNA reverse transcriptase activity	-	TAS	14991929
GO:0003723	RNA binding	-	IPI	16507993 17940095 18082603 19701182 20351177
GO:0003964	RNA-directed DNA polymerase activity	-	IDA	21937513
GO:0003964	RNA-directed DNA polymerase activity	-	TAS	25569094
GO:0003968	RNA-directed 5'-3' RNA polymerase activity	-	IDA	19701182
GO:0005515	protein binding	-	IPI	12377759 12699629 15044100 15381700 17237767 17940095 18082603 18358808 19179534 19487455 19567472 19571879 19843693 21119197 21829167 22011238 22226966 24550003 25172512 25589350
GO:0008022	protein C-terminus binding	-	IPI	11701125
GO:0016779	nucleotidyltransferase activity	-	IDA	19701182
GO:0042162	telomeric DNA binding	-	IBA	21873635
GO:0042162	telomeric DNA binding	-	TAS	9288757
GO:0042802	identical protein binding	-	IPI	23474713
GO:0042803	protein homodimerization activity	-	IDA	11432839
GO:0042803	protein homodimerization activity	-	IPI	23474713
GO:0046872	metal ion binding	-	IEA	-
GO:0047485	protein N-terminus binding	-	IPI	11701125
GO:0051087	chaperone binding	-	IPI	10197982 19751963
GO:0070034	telomerase RNA binding	-	IBA	21873635
GO:0070034	telomerase RNA binding	-	IDA	11432839
GO:0070034	telomerase RNA binding	-	IPI	16507993 17940095 18082603 19701182 20351177
GO:0098680	template-free RNA nucleotidyltransferase	-	IDA	19701182

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000723	telomere maintenance	-	TAS	12135483
GO:0001172	transcription, RNA-templated	-	IDA	19701182
GO:0006278	RNA-dependent DNA biosynthetic process	-	IDA	9398860
GO:0007004	telomere maintenance via telomerase	-	IBA	21873635
GO:0007004	telomere maintenance via telomerase	-	IDA	9443919 16043710 17940095 19701182 21531765
GO:0007004	telomere maintenance via telomerase	-	IMP	9454332
GO:0007004	telomere maintenance via telomerase	-	NAS	2805070
GO:0007004	telomere maintenance via telomerase	-	TAS	-
GO:0007005	mitochondrion organization	-	IDA	21937513
GO:0010629	negative regulation of gene expression	-	IDA	11927518
GO:0022616	DNA strand elongation	-	IDA	16043710
GO:0030177	positive regulation of Wnt signaling pathway	-	IGI	19571879
GO:0030422	production of siRNA involved in RNA interference	-	IDA	19701182
GO:0031647	regulation of protein stability	-	IDA	24415760 26194824
GO:0031647	regulation of protein stability	-	IMP	26194824
GO:0032092	positive regulation of protein binding	-	IDA	24415760
GO:0032774	RNA biosynthetic process	-	IDA	19701182
GO:0042635	positive regulation of hair cycle	-	ISS	-
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0046326	positive regulation of glucose import	-	IEA	-
GO:0046686	response to cadmium ion	-	IEA	-
GO:0051000	positive regulation of nitric-oxide synthase activity	-	IDA	11927518
GO:0060253	negative regulation of glial cell proliferation	-	IEA	-
GO:0070200	establishment of protein localization to telomere	-	IDA	25589350
GO:0071456	cellular response to hypoxia	-	IMP	11313459
GO:0071897	DNA biosynthetic process	-	IDA	9398860 19701182
GO:0090399	replicative senescence	-	IMP	9454332
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	-	IEA	-
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	-	IMP	25569094
GO:1903620	positive regulation of transdifferentiation	-	IEA	-
GO:1903704	negative regulation of production of siRNA involved in RNA interference	-	IDA	19701182
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IEA	-
GO:1904751	positive regulation of protein localization to nucleolus	-	IDA	24415760
GO:1904754	positive regulation of vascular associated smooth muscle cell migration	-	IEA	-
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	-
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IEA	-
GO:2000648	positive regulation of stem cell proliferation	-	ISS	-
GO:2000773	negative regulation of cellular senescence	-	IDA	11927518
GO:2000773	negative regulation of cellular senescence	-	IMP	11313459
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IMP	10449030

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000333	telomerase catalytic core complex	-	IBA	21873635
GO:0000333	telomerase catalytic core complex	-	IDA	9398860 9443919 16507993 17940095 18082603
GO:0000333	telomerase catalytic core complex	-	IMP	11313459
GO:0000333	telomerase catalytic core complex	-	IPI	19701182
GO:0000781	chromosome, telomeric region	-	IC	12135483
GO:0000783	nuclear telomere cap complex	-	IC	15632080
GO:0000784	nuclear chromosome, telomeric region	-	IDA	25589350
GO:0005634	nucleus	-	IDA	21829167 24415760
GO:0005654	nucleoplasm	-	IDA	19567472
GO:0005654	nucleoplasm	-	TAS	-
GO:0005697	telomerase holoenzyme complex	-	IDA	12135483 18082603
GO:0005697	telomerase holoenzyme complex	-	IPI	19701182
GO:0005697	telomerase holoenzyme complex	-	TAS	10757788 22527283
GO:0005730	nucleolus	-	IDA	22226966
GO:0005730	nucleolus	-	NAS	26194824
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IEA	-
GO:0016605	PML body	colocalizes_with	IDA	19567472
GO:0016607	nuclear speck	-	IDA	-
GO:0031379	RNA-directed RNA polymerase complex	-	IPI	19701182
GO:0042645	mitochondrial nucleoid	-	IDA	21937513
GO:1990572	TERT-RMRP complex	-	IDA	19701182

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-171319	Telomere Extension By Telomerase	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	TAS
R-HSA-73886	Chromosome Maintenance	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20445798	Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. (2009)	Van Dyke AL	J Cancer Epidemiol
26020272	Association of TERT Polymorphisms with Clinical Outcome of Non-Small Cell Lung Cancer Patients. (2015)	Zhao X	PLoS One
22430809	Association between a genome-wide association study-identified locus and the risk of lung cancer in Japanese population. (2012 May)	Ito H	J Thorac Oncol
28423629	Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population. (2017 Mar 21)	Zhang J	Oncotarget
28814981	CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)	Morandi L	Clin Epigenetics
9200520	Gas chromatographic method using electron-capture detection for the determination of musk xylene in human blood samples. Biological monitoring of the general population. (1997 May 23)	Angerer J	J Chromatogr B Biomed Sci Appl
7864194	Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity. (1995 Feb)	Blache D	Am J Physiol
25516442	Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia. (2015 Jul 15)	Machiela MJ	Int J Cancer
27393504	Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. (2016 Aug)	Zanetti KA	Lung Cancer
25145040	Personal exposure to mixtures of volatile organic compounds: modeling and further analysis of the RIOPA data. (2014 Jun)	Batterman S	Res Rep Health Eff Inst
23908149	Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. (2013 Nov)	Zhong R	Mol Carcinog
23085811	Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand. (2012 Dec)	Fachiroh J	Cancer Causes Control
28789383	Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. (2017 Aug)	Xiao X	Oncol Lett
20502709	Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. (2010 May 19)	Diaz de Leon A	PLoS One
25218484	Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians. (2014 Nov)	Singh V	Urol Oncol
23555636	Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. (2013)	Lan Q	PLoS One
26381690	Telomere length, telomerase expression, and oxidative stress in lead smelters. (2016 Dec)	Pawlas N	Toxicol Ind Health
24681604	Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia. (2014 Apr)	Park SL	J Natl Cancer Inst
22962272	DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. (2012 Nov 15)	Nikolaidis G	Cancer Res
25769456	Quantification of concentration and assessment of EGFR mutation in circulating DNA. (2015)	Mazurek A	Cancer Biomark
21622582	The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema. (2011 Oct)	Wauters E	Eur Respir J
24231251	Telomere length and risk of glioma. (2013 Dec)	Walcott F	Cancer Epidemiol
20056641	Multiple genetic variants in telomere pathway genes and breast cancer risk. (2010 Jan)	Shen J	Cancer Epidemiol Biomarkers Prev
24679952	A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC). (2014 Jun)	Azad AK	Lung Cancer
26149460	TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer. (2015 Nov 15)	Wei R	Clin Cancer Res
25924736	Lower lung cancer rates in Jewish smokers in Israel and the USA. (2015 Nov 1)	Rennert G	Int J Cancer
23050049	Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. (2012)	Pellatt AJ	Int J Mol Epidemiol Genet
21742680	Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. (2011 Sep 1)	Lachance DH	Am J Epidemiol
26554909	Genetic Polymorphism, Telomere Biology and Non-Small Lung Cancer Risk. (2015 Oct 20)	Wei R	J Genet Genomics
22394379	Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72. (2012 Mar 27)	Pandhare A	Biochemistry
24390616	Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies. (2014 May)	Yuan Y	Tumour Biol
29133146	Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018 Feb 5)	Seiki T	Gene
10394630	Electron ionization mass fragmentometric detection of urinary ecgonidine, a hydrolytic product of methylecgonidine, as an indicator of smoking cocaine. (1999 Jun)	Paul BD	J Mass Spectrom
26252750	The Influence of Glycated Hemoglobin on the Cross Susceptibility Between Type 1 Diabetes Mellitus and Periodontal Disease. (2015 Nov)	Lappin DF	J Periodontol
21349926	Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations. (2011 Sep)	Diaz de Leon A	Chest
28927526	Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. (2017 Jul)	Cardoso MFS	Mutat Res
20061363	Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. (2010 May)	Kohno T	Carcinogenesis
20700438	The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. (2010 Aug 5)	Hsiung CA	PLoS Genet
3593487	Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal. (1987)	Szabo G	Alcohol Alcohol
20301408	Pulmonary Fibrosis, Familial (1993)	Talbert JL	-
26043790	Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)	Guo ML	Autophagy
28483762	Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. (2017 Aug 10)	Zink F	Blood
25037574	Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case-control study in a Chinese non-smoking female population. (2014 Aug)	Yin Z	Med Oncol
27352265	Bladder Cancer and Genetic Mutations. (2015 Sep)	Zhang X	Cell Biochem Biophys
27186328	Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality. (2016)	Slattery ML	Int J Mol Epidemiol Genet
18676844	RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. (2008 Aug 1)	Wolff EM	Cancer Res
27797938	Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer. (2017 Jun)	Bao Y	Gut
12962514	Therapy for chronic obstructive pulmonary disease in the 21st century. (2003)	Donnelly LE	Drugs
20301779	Dyskeratosis Congenita (1993)	Savage SA	-
24828667	Small-cell lung cancers in patients who never smoked cigarettes. (2014 Jun)	Varghese AM	J Thorac Oncol
24163739	Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)	Yang IA	J Thorac Dis
25456736	Recurrent TERT promoter mutations in non-small cell lung cancers. (2014 Dec)	Ma X	Lung Cancer
22041560	[The relationship between gene polymorphism of telomerase reverse transcriptase and susceptibility to hepatocellular carcinoma]. (2011 Jul)	Ding CY	Zhonghua Yu Fang Yi Xue Za Zhi
27323854	Tobacco smoking and methylation of genes related to lung cancer development. (2016 Sep 13)	Gao X	Oncotarget
19955392	Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. (2010 Feb)	Wang Y	Carcinogenesis
25233467	Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. (2014)	Tseng TS	PLoS One