Gene info: ID 7019

Gene: TFAM

GENE ID: 7019

Description: transcription factor A, mitochondrial

Gene type: protein-coding

Location: 10q21.1

dbXrefs: Ensembl:ENSG00000108064 MIM:600438 Vega:OTTHUMG00000018270 UniprotKB:Q00059

RefSeq: NG_053006.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : 4.950e-1 (AD) 4.253e-3 (ND) (Frontal_Cortex)

Pascal p-value : 7.111e-1 (AD) 7.508e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KPNA3	0.912
SIKE1	0.909
SLC30A5	0.906
SGPP1	0.904
RAB18	0.902
CLINT1	0.902
SUZ12	0.901
TMF1	0.9
SNX13	0.897
YTHDF3	0.897

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.614
OR4F29	-0.559
CSAG1	-0.253
MTRNR2L6	-0.245
MTRNR2L9	-0.232
MTRNR2L10	-0.231
MMP23B	-0.223
RSPO1	-0.222
KLRK1	-0.22
TRPV5	-0.217

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]"	24041027
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]"	24041027
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]"	17179207
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TFAM mRNA"	21856379
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TFAM protein"	21856379
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"AKT1 protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TFAM protein]"	21856379
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"NRF1 protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TFAM protein]"	21856379
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"TFAM protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TH protein]"	21856379
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"TFAM protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased phosphorylation of AKT1 protein]"	21856379
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TFAM mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TFAM mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TFAM mRNA]	24041027
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of TFAM mRNA]	24041027
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]	17179207
C050147	3-(2,2,2-trimethylhydrazine)propionate	"3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of TFAM mRNA"	27559315
C005975	3,4-dihydroxyphenylethanol	"3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of TFAM mRNA]"	20938484
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]"	17438283
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]]"	21163946
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of TFAM protein]"	27363784
C016276	8-bromocyclic GMP	8-bromocyclic GMP results in increased expression of TFAM mRNA	24041027
C016276	8-bromocyclic GMP	tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of TFAM mRNA]	24041027
D000082	Acetaminophen	Acetaminophen results in decreased expression of TFAM mRNA	25704631
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Atorvastatin Calcium results in increased expression of TFAM mRNA]	21775390
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of TFAM mRNA]	26980303
C027696	acipimox	acipimox results in increased expression of TFAM mRNA	25352640
D000171	Acrolein	"3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of TFAM mRNA]"	20938484
D000171	Acrolein	Acrolein results in decreased expression of TFAM mRNA	20938484
C016601	afimoxifene	afimoxifene results in increased expression of TFAM mRNA	22105178
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TFAM gene	27153756
C104223	aluminum lactate	aluminum lactate results in decreased expression of TFAM mRNA	24084166\|2649315
C104223	aluminum lactate	aluminum lactate results in decreased expression of TFAM protein	24084166\|2649315
C104223	aluminum lactate	Quercetin inhibits the reaction [aluminum lactate results in decreased expression of TFAM mRNA]	26493151
C104223	aluminum lactate	Quercetin inhibits the reaction [aluminum lactate results in decreased expression of TFAM protein]	26493151
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TFAM mRNA	16483693
D001151	Arsenic	Arsenic results in increased expression of TFAM	21235219
D001151	Arsenic	Arsenic results in increased expression of TFAM mRNA	21514422
D001151	Arsenic	Arsenic results in increased expression of TFAM protein	21514422
D000069059	Atorvastatin Calcium	Acetylcysteine inhibits the reaction [Atorvastatin Calcium results in increased expression of TFAM mRNA]	21775390
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of TFAM mRNA	21775390
D001280	Atrazine	Atrazine results in decreased expression of TFAM mRNA	22378314\|2711463
D001280	Atrazine	Atrazine results in decreased expression of TFAM mRNA	27114639
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TFAM mRNA	22865514
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TFAM protein	21401886\|2286551
D001564	Benzo(a)pyrene	NRF1 mutant form inhibits the reaction [Benzo(a)pyrene results in decreased expression of TFAM protein]	21401886
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TFAM mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TFAM mRNA"	19150397
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of TFAM mRNA]	20860658
D004958	Estradiol	Estradiol affects the expression of TFAM mRNA	23557687
D004958	Estradiol	Estradiol results in increased expression of TFAM mRNA	22105178
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of TFAM mRNA]	22105178
D004958	Estradiol	[Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNA	16954335
C006780	bisphenol A	bisphenol A results in decreased expression of TFAM mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of TFAM mRNA	25594700
C006780	bisphenol A	bisphenol A results in decreased expression of TFAM mRNA	23328667
C006780	bisphenol A	bisphenol A results in increased expression of TFAM mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of TFAM mRNA	28819136
D001786	Blood Glucose	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of TFAM protein	28477916
D001786	Blood Glucose	genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of TFAM protein]	28477916
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA]	20676402
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM protein]	20676402
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of TFAM mRNA	27923775
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TFAM protein	26220685
C459604	candoxin	candoxin results in decreased expression of TFAM mRNA	16309724
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of TFAM mRNA	17179207
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of TFAM protein	17179207
D002248	Carbon Monoxide	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]"	17179207
D002248	Carbon Monoxide	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]	17179207
D002248	Carbon Monoxide	Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]	17179207
D002248	Carbon Monoxide	Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]	17179207
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of TFAM protein	17179207
D002248	Carbon Monoxide	CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]	17179207
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of TFAM protein	25858767
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of TFAM protein	26882442
D002251	Carbon Tetrachloride	Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]	26882442
D002701	Chloramphenicol	Chloramphenicol results in increased expression of TFAM mRNA	22712077
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of TFAM mRNA	23650126
D002976	Clenbuterol	Clenbuterol results in increased expression of TFAM mRNA	17446185
C007095	cobaltiprotoporphyrin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TFAM mRNA]	24041027
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin results in increased expression of TFAM mRNA	24041027
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TFAM mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TFAM mRNA	22982409
D003300	Copper	Copper deficiency results in increased expression of TFAM protein	11694003
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TFAM mRNA	19549813
D016047	Zalcitabine	Zalcitabine affects the expression of TFAM protein	7849699
D003907	Dexamethasone	[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of TFAM mRNA	29288687
D003907	Dexamethasone	[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of TFAM mRNA	29288687
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased activity of TFAM protein	27589886
C000944	dicrotophos	dicrotophos results in decreased expression of TFAM mRNA	28302478
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA	28611668
D004041	Dietary Fats	INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA]	28611668
D004041	Dietary Fats	rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA]	28611668
D004041	Dietary Fats	Dietary Fats results in decreased expression of TFAM mRNA	21632075
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in decreased expression of TFAM mRNA]	21632075
D000073417	Dietary Sugars	[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA	28611668
D000073417	Dietary Sugars	INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA]	28611668
D000073417	Dietary Sugars	rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA]	28611668
D015102	3,4-Dihydroxyphenylacetic Acid	"TFAM gene mutant form results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid"	28595911
D000069462	Dimethyl Fumarate	Dimethyl Fumarate results in increased expression of TFAM mRNA	27277809
D000069462	Dimethyl Fumarate	NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]	27277809
D004298	Dopamine	TFAM gene mutant form results in decreased abundance of Dopamine	28595911
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFAM mRNA	26781513
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFAM protein	28456571
D004317	Doxorubicin	Doxorubicin results in increased expression of TFAM mRNA	26781513
D004317	Doxorubicin	Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]	28456571
D004317	Doxorubicin	PPARGC1A affects the reaction [Doxorubicin results in decreased expression of TFAM mRNA]	26781513
D004317	Doxorubicin	PPARGC1A affects the reaction [Doxorubicin results in increased expression of TFAM mRNA]	26781513
D004317	Doxorubicin	SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of TFAM protein]	28456571
D004317	Doxorubicin	SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]]	28456571
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFAM mRNA	28865727
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFAM protein	18845810\|2667815
D004317	Doxorubicin	HMOX1 protein inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]	18845810
D004610	Ellagic Acid	Ellagic Acid results in decreased expression of TFAM mRNA	12002526
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TFAM protein	23301498
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TFAM mRNA	22079256
D004837	Epinephrine	Epinephrine results in decreased expression of TFAM mRNA	19300450
D004921	Erythropoietin	Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]	28456571
D004921	Erythropoietin	SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]]	28456571
D000431	Ethanol	Ethanol results in decreased expression of TFAM protein	19063909
D000431	Ethanol	SOD2 protein affects the reaction [Ethanol results in decreased expression of TFAM protein]	19063909
D004996	Ethidium	Ethidium results in increased expression of TFAM mRNA	22712077
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TFAM mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TFAM mRNA	17942748
D005047	Etoposide	Etoposide results in increased expression of TFAM mRNA	26259609
D018120	Finasteride	Finasteride results in increased expression of TFAM mRNA	24136188
D005419	Flavonoids	Flavonoids results in increased expression of TFAM mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of TFAM mRNA	24136188
D005492	Folic Acid	Folic Acid results in decreased expression of TFAM	24275386
D005557	Formaldehyde	Formaldehyde results in decreased expression of TFAM mRNA	23649840
D005632	Fructose	Fructose results in increased expression of TFAM protein	11934685
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of TFAM mRNA]	22105178
C070081	fulvestrant	fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of TFAM mRNA]	22105178
D005690	Galactose	[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of TFAM protein	25997894
C007834	genipin	genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of TFAM protein]	28477916
D005839	Gentamicins	Gentamicins results in increased expression of TFAM mRNA	22061828
D005947	Glucose	Glucose deficiency results in increased expression of TFAM mRNA	26811028
D005947	Glucose	[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of TFAM protein	25997894
D006719	Homovanillic Acid	TFAM gene mutant form results in decreased abundance of Homovanillic Acid	28595911
D017313	Fenretinide	Fenretinide affects the expression of TFAM mRNA	16570282
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TFAM mRNA	23859249
D006861	Hydrogen Peroxide	resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of TFAM mRNA]	23859249
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TFAM mRNA	24349266
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TFAM protein	24349266
D007213	Indomethacin	Indomethacin results in increased expression of TFAM mRNA	28201806
C541917	INT 131	INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA]	28611668
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TFAM mRNA	25613284
C051140	iron(II)-ascorbic acid complex	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA]	20676402
C051140	iron(II)-ascorbic acid complex	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM protein]	20676402
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA	20676402
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in increased expression of TFAM protein	20676402
D015056	1-Methyl-3-isobutylxanthine	[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of TFAM mRNA	29288687
D015056	1-Methyl-3-isobutylxanthine	[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of TFAM mRNA	29288687
C544151	jinfukang	jinfukang results in decreased expression of TFAM mRNA	27392435
C006552	kaempferol	kaempferol results in increased expression of TFAM mRNA	17327447
C432503	licarin A	[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of TFAM mRNA	29288687
D001556	Lindane	Lindane results in increased expression of TFAM mRNA	23777605
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]]"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of TFAM mRNA"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA"	24041027
C482199	lipopolysaccharide, E coli O55-B5	"tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of TFAM mRNA]"	24041027
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TFAM mRNA"	21767162
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TFAM protein"	21767162
D008550	Melatonin	Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein]	21797922
D008550	Melatonin	Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]	26882442
D008687	Metformin	Metformin results in increased expression of TFAM mRNA	16380484
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TFAM mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TFAM mRNA	29104120
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TFAM protein"	21856379
D000068577	Nebivolol	Nebivolol results in increased expression of TFAM	23886954
C051752	nefazodone	nefazodone results in increased expression of TFAM mRNA	24136188
C022838	nickel chloride	Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein]	21797922
C022838	nickel chloride	nickel chloride results in decreased expression of TFAM protein	21797922
C012655	nimesulide	nimesulide results in increased expression of TFAM mRNA	24136188
D009573	Nitrites	[Nitrites co-treated with Oxygen deficiency] results in increased expression of TFAM mRNA	22892143
D009638	Norepinephrine	[Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNA	16954335
D009638	Norepinephrine	[Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNA	16954335
D062907	Oxaloacetic Acid	Oxaloacetic Acid results in increased expression of TFAM mRNA	26811028
D010100	Oxygen	[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of TFAM protein	28477916
D010100	Oxygen	genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of TFAM protein]	28477916
D010100	Oxygen	Oxygen deficiency results in increased expression of TFAM mRNA	23539316
D010100	Oxygen	[Nitrites co-treated with Oxygen deficiency] results in increased expression of TFAM mRNA	22892143
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TFAM mRNA	19616056
D010862	Pilocarpine	Pilocarpine results in increased expression of TFAM mRNA	20446108
D010862	Pilocarpine	Pilocarpine results in increased expression of TFAM protein	20446108
C060836	pioglitazone	pioglitazone results in decreased expression of TFAM mRNA	20860658
C006253	pirinixic acid	pirinixic acid inhibits the reaction [PNPLA2 gene mutant form results in decreased expression of TFAM mRNA]	25285770
C006253	pirinixic acid	pirinixic acid results in increased expression of TFAM mRNA	18301758\|2381119
D010894	Piroxicam	Piroxicam results in decreased expression of TFAM mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of TFAM mRNA	23557933
D011189	Potassium Chloride	Potassium Chloride results in increased expression of TFAM mRNA	20438809
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TFAM mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of TFAM mRNA	22079256
D045542	PQQ Cofactor	PQQ Cofactor results in decreased expression of TFAM mRNA	28578007
D045542	PQQ Cofactor	PQQ Cofactor results in increased expression of TFAM mRNA	25843018
D011374	Progesterone	[Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNA	16954335
D011374	Progesterone	Progesterone results in increased expression of TFAM mRNA	16954335
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of TFAM mRNA	16609681
D019289	Pyruvic Acid	[Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] results in increased expression of TFAM protein	25997894
D011794	Quercetin	Quercetin results in increased expression of TFAM protein	21051700
D011794	Quercetin	Quercetin inhibits the reaction [aluminum lactate results in decreased expression of TFAM mRNA]	26493151
D011794	Quercetin	Quercetin inhibits the reaction [aluminum lactate results in decreased expression of TFAM protein]	26493151
D020849	Raloxifene Hydrochloride	fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of TFAM mRNA]	22105178
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of TFAM mRNA	22105178
C059514	resveratrol	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]"	24041027
C059514	resveratrol	"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]]"	21163946
C059514	resveratrol	resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of TFAM mRNA]	23859249
C059514	resveratrol	"resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]"	24041027
C059514	resveratrol	resveratrol results in decreased expression of TFAM mRNA	12002526
C059514	resveratrol	resveratrol results in increased expression of TFAM mRNA	21163946\|2122425
C059514	resveratrol	SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]	21163946
C059514	resveratrol	"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]]"	24041027
C059514	resveratrol	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]	24041027
C059514	resveratrol	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]"	17438283
C059514	resveratrol	"[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of TFAM mRNA"	24041027
C059514	resveratrol	resveratrol results in increased expression of TFAM mRNA	17438283\|2122425
C059514	resveratrol	"tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of TFAM mRNA]"	24041027
C059514	resveratrol	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]	24041027
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in decreased expression of TFAM mRNA]	21632075
C059514	resveratrol	resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]	26770656
C059514	resveratrol	resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM protein]	26770656
C059514	resveratrol	resveratrol results in increased expression of TFAM	23790948
C059514	resveratrol	resveratrol results in increased expression of TFAM mRNA	20429690
D012263	Ribonucleosides	Ribonucleosides results in increased expression of TFAM mRNA	16380484
C089730	rosiglitazone	[rosiglitazone co-treated with Rotenone] results in increased expression of TFAM protein	24374061
C089730	rosiglitazone	rosiglitazone results in increased expression of TFAM protein	24374061
C089730	rosiglitazone	rosiglitazone affects the expression of TFAM mRNA	22013433
C089730	rosiglitazone	[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of TFAM mRNA	29288687
C089730	rosiglitazone	rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of TFAM mRNA]	28611668
D012402	Rotenone	[rosiglitazone co-treated with Rotenone] results in increased expression of TFAM protein	24374061
D012402	Rotenone	resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]	26770656
D012402	Rotenone	resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM protein]	26770656
D012402	Rotenone	Rotenone results in decreased expression of TFAM mRNA	26770656
D012402	Rotenone	Rotenone results in decreased expression of TFAM protein	26770656
D012643	Selenium	NRF1 protein promotes the reaction [Selenium results in increased expression of TFAM mRNA]	17936198
D012643	Selenium	Selenium results in increased expression of TFAM mRNA	17936198
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TFAM mRNA	25895662
C110881	S-nitro-N-acetylpenicillamine	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]"	24041027
C110881	S-nitro-N-acetylpenicillamine	HMOX1 mutant form inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]	24041027
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA	24041027
C110881	S-nitro-N-acetylpenicillamine	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]	24041027
C110881	S-nitro-N-acetylpenicillamine	S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA	24041027
C110881	S-nitro-N-acetylpenicillamine	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]	24041027
C017947	sodium arsenite	sodium arsenite results in increased expression of TFAM mRNA	12016162
C017947	sodium arsenite	sodium arsenite results in decreased expression of TFAM mRNA	26767369\|2742564
C017947	sodium arsenite	sodium arsenite results in decreased expression of TFAM protein	26767369\|2742564
C016104	sodium bichromate	sodium bichromate results in decreased expression of TFAM mRNA	22561333
C016104	sodium bichromate	sodium bichromate results in increased expression of TFAM mRNA	22561333
C009279	sodium bisulfite	Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of TFAM mRNA]	26980303
C009279	sodium bisulfite	sodium bisulfite results in decreased expression of TFAM mRNA	26980303
C009279	sodium bisulfite	sodium bisulfite results in decreased expression of TFAM protein	26980303
C009279	sodium bisulfite	TFAM protein inhibits the reaction [sodium bisulfite results in decreased expression of COX3 mRNA]	26980303
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of TFAM protein	28918527
C016766	sulforafan	sulforafan results in increased expression of TFAM protein	27993529
C016766	sulforafan	sulforafan results in increased expression of TFAM protein	27993529
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of TFAM mRNA	26980303
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of TFAM protein	26980303
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased expression of TFAM mRNA	22677886
D013605	T-2 Toxin	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of TFAM protein]"	27363784
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of TFAM protein	27363784
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TFAM mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TFAM mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TFAM mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TFAM mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TFAM mRNA	16960034
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TFAM mRNA	16960034
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TFAM mRNA	25613284
D019284	Thapsigargin	TFAM protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]	22378314
D019284	Thapsigargin	Thapsigargin results in decreased expression of TFAM mRNA	22378314
D013963	Thyroid Hormones	[Thyroid Hormones results in increased expression of NRF1] which results in increased expression of TFAM	14584751
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of TFAM mRNA]	24041027
C032628	tin protoporphyrin IX	"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]]"	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]	24041027
C032628	tin protoporphyrin IX	"tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of TFAM mRNA]"	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]	24041027
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]	24041027
C476530	tricarbonylchloro(glycinato)ruthenium(II)	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of TFAM mRNA]	24041027
C476530	tricarbonylchloro(glycinato)ruthenium(II)	tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of TFAM mRNA	24041027
C057693	troglitazone	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of TFAM mRNA]	20860658
C057693	troglitazone	PPARGC1A protein inhibits the reaction [troglitazone results in decreased expression of TFAM mRNA]	20860658
C057693	troglitazone	troglitazone results in decreased expression of TFAM mRNA	20860658
D014415	Tunicamycin	Tunicamycin results in decreased expression of TFAM mRNA	22378314
C022884	undecane	undecane results in decreased expression of TFAM protein	17337753
D014501	Uranium	Uranium affects the expression of TFAM mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of TFAM mRNA	15672453
C406224	valdecoxib	valdecoxib results in increased expression of TFAM mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of TFAM mRNA	25979313
D014635	Valproic Acid	Valproic Acid affects the expression of TFAM mRNA	17292431
D015215	Zidovudine	Zidovudine results in increased expression of TFAM mRNA	10535663
D015034	Zinc Oxide	Zinc Oxide affects the expression of TFAM mRNA	28648595

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001018	mitochondrial promoter sequence-specific DNA binding	-	IDA	19304746
GO:0001223	transcription coactivator binding	-	IEA	-
GO:0003682	chromatin binding	-	IDA	18063578
GO:0003700	DNA-binding transcription factor activity	-	IMP	22037171
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0005515	protein binding	-	IPI	12897151 25416956 29445193 29568061
GO:0008301	DNA binding, bending	-	IDA	22037171
GO:0031072	heat shock protein binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IDA	29445193

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006390	mitochondrial transcription	-	IMP	22037171
GO:0006391	transcription initiation from mitochondrial promoter	-	IDA	20410300
GO:0006391	transcription initiation from mitochondrial promoter	-	TAS	-
GO:0007005	mitochondrion organization	-	TAS	-
GO:0033108	mitochondrial respiratory chain complex assembly	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	20410300

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005739	mitochondrion	-	IDA	-
GO:0005759	mitochondrial matrix	-	IDA	29445193
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0032991	protein-containing complex	-	IDA	29445193
GO:0042645	mitochondrial nucleoid	-	IDA	18063578

KEGG ID	KEGG Term
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-163282	Mitochondrial transcription initiation	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75944	Transcription from mitochondrial promoters	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20863902	Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H. (2011 Jan)	Palacin M	Mitochondrion
26893822	Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle. (2016)	Konokhova Y	Skelet Muscle
20807714	TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia? (2010 Dec)	Remels AH	FASEB J