Gene: TFAP2A

7020
AP-2|AP-2alpha|AP2TF|BOFS|TFAP2
transcription factor AP-2 alpha
protein-coding
6p24.3
Ensembl:ENSG00000137203 MIM:107580 Vega:OTTHUMG00000014235 UniprotKB:P05549
NG_016151.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.062e-1 (AD)  8.826e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EBF10.603
OLFML10.595
FZD100.592
MAP3K10.587
FOXC20.581
COL1A20.579
TGFB1I10.578
S100A40.575
PDE5A0.575
AJUBA0.572

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGAT2-0.413
PABPC1L2B-0.399
HTR5A-0.397
GPR150-0.396
AGBL4-0.394
MYADML2-0.391
ADPRHL1-0.388
CKMT1A-0.383
SLC27A2-0.382
LRFN2-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of TFAP2A mRNA"22101062
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of TFAP2A mRNA23792671
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Cytarabine results in increased expression of TFAP2A mRNA]"23264188
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TFAP2A mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TFAP2A mRNA29067470
C016601afimoxifeneafimoxifene results in decreased expression of TFAP2A mRNA19901195
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TFAP2A gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TFAP2A mRNA24449571
C015001arsenitearsenite results in decreased methylation of TFAP2A promoter23974009
C487081belinostatbelinostat results in increased expression of TFAP2A mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TFAP2A mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TFAP2A mRNA"19150397|2001819
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TFAP2A mRNA"17944540
D004958EstradiolEstradiol affects the expression of TFAP2A mRNA23557687
D004958EstradiolEstradiol results in decreased expression of TFAP2A mRNA26865669|2871154
C006780bisphenol Abisphenol A affects the expression of TFAP2A mRNA23557687
C006780bisphenol Abisphenol A affects the methylation of TFAP2A promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TFAP2A mRNA25181051
C027561butylbenzyl phthalatebutylbenzyl phthalate affects the localization of TFAP2A protein22552774
C027561butylbenzyl phthalatebutylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]22552774
C027561butylbenzyl phthalate[butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA22552774
C027561butylbenzyl phthalateN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]22552774
C027561butylbenzyl phthalateTFAP2A mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of HDAC6 protein]22552774
C027561butylbenzyl phthalatetyrphostin AG 1478 inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]22552774
C018475butyraldehydebutyraldehyde results in decreased expression of TFAP2A mRNA26079696
D000068579CelecoxibCelecoxib results in decreased expression of TFAP2A mRNA28201806
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of TFAP2A mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFAP2A gene20938992
C059262cidofovircidofovir results in decreased expression of TFAP2A mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of TFAP2A mRNA25596134
D002996ClomipheneClomiphene results in increased expression of TFAP2A mRNA26865669
D003300CopperCopper results in decreased expression of TFAP2A mRNA26293553
D003471CuprizoneCuprizone results in increased expression of TFAP2A mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of TFAP2A mRNA25596134
D003561Cytarabine"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Cytarabine results in increased expression of TFAP2A mRNA]"23264188
D003561CytarabineCytarabine results in increased expression of TFAP2A mRNA23264188
C014347decitabinedecitabine results in increased expression of TFAP2A mRNA16204029
C014347decitabinedecitabine results in increased expression of TFAP2A protein16204029
C014347decitabine[decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to Cisplatin16204029
C014347decitabine[decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to Doxorubicin16204029
D003703DemecolcineDemecolcine results in decreased expression of TFAP2A mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TFAP2A mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of TFAP2A protein28453788
D016190CarboplatinTFAP2A protein results in increased susceptibility to Carboplatin16204029
D003993Dibutyl PhthalateDibutyl Phthalate affects the localization of TFAP2A protein22552774
D003993Dibutyl PhthalateDibutyl Phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]22552774
D003993Dibutyl Phthalate[Dibutyl Phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA22552774
D003993Dibutyl PhthalateN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein]22552774
D003993Dibutyl PhthalateTFAP2A mutant form inhibits the reaction [Dibutyl Phthalate results in increased expression of HDAC6 protein]22552774
D003993Dibutyl Phthalatetyrphostin AG 1478 inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein]22552774
D002945CisplatinCisplatin results in decreased expression of TFAP2A mRNA25596134
D002945CisplatinCisplatin results in increased expression of TFAP2A protein16204029
D002945Cisplatin[decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to Cisplatin16204029
D002945CisplatinTFAP2A protein affects the susceptibility to Cisplatin16217747
D002945Cisplatin[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Cisplatin21489314
D002945CisplatinTFAP2A protein results in increased susceptibility to Cisplatin16204029|2148931
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of TFAP2A mRNA26924002
D018119StavudineStavudine results in decreased expression of TFAP2A mRNA17926646
D004041Dietary FatsDietary Fats results in increased expression of TFAP2A mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TFAP2A mRNA26865669
D002117CalcitriolCalcitriol results in increased expression of TFAP2A mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of TFAP2A mRNA26924002
D004317Doxorubicin[decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to Doxorubicin16204029
D004317DoxorubicinDoxorubicin results in increased expression of TFAP2A protein16204029
D004317DoxorubicinTFAP2A protein results in increased susceptibility to Doxorubicin16204029
C118739entinostatentinostat results in increased expression of TFAP2A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]21499124|2195155
D000069347Erlotinib HydrochlorideTetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]21499124|2195155
D000431EthanolEthanol results in decreased expression of TFAP2A protein28919490
D000431EthanolEthanol results in increased expression of TFAP2A mRNA28986285
D008656MestranolMestranol results in decreased expression of TFAP2A mRNA26865669
D005047EtoposideTFAP2A protein affects the susceptibility to Etoposide16217747
D005047EtoposideTFAP2A protein results in increased susceptibility to Etoposide16204029
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists results in increased expression of and results in increased activity of TFAP2A protein17550430
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFAP2A gene20938992
C070081fulvestrantfulvestrant results in increased expression of TFAP2A mRNA26865669
C039281furanfuran results in increased expression of TFAP2A mRNA25539665
C419708gefitinibgefitinib inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]21499124|2195155
C419708gefitinibTetradecanoylphorbol Acetate inhibits the reaction [gefitinib inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]21499124|2195155
C056507gemcitabine[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine21489314
C056507gemcitabineTFAP2A protein results in increased susceptibility to gemcitabine21489314
D019833GenisteinGenistein results in decreased expression of TFAP2A mRNA26865669
D006589HexestrolHexestrol results in decreased expression of TFAP2A mRNA26865669
D017313FenretinideFenretinide results in increased expression of TFAP2A mRNA28973697
D007069IfosfamideIfosfamide results in decreased expression of TFAP2A mRNA25596134
D019469IndinavirIndinavir results in decreased expression of TFAP2A mRNA17926646
C544151jinfukangjinfukang results in increased expression of TFAP2A mRNA27392435
D008345ManganeseManganese results in increased expression of TFAP2A protein24845367
C042720mercuric bromidemercuric bromide results in increased expression of TFAP2A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of TFAP2A mRNA28341135
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFAP2A gene20938992
D008727MethotrexateMethotrexate affects the expression of TFAP2A mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TFAP2A mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TFAP2A mRNA23179753|2627250
D016685MitomycinTFAP2A protein affects the susceptibility to Mitomycin16217747
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TFAP2A mRNA26924002
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]22552774
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein]22552774
C017557nickel subsulfidenickel subsulfide results in decreased expression of TFAP2A mRNA12760830
D010126OzoneOzone promotes the reaction [TFAP2A protein binds to BRS3 promoter]17355223
D010126OzoneOzone results in increased activity of TFAP2A protein17355223
D010126OzoneTFAP2A protein affects the reaction [Ozone results in increased expression of BRS3 mRNA]17355223
D017239PaclitaxelPaclitaxel results in increased expression of TFAP2A protein16204029
D017239PaclitaxelTFAP2A protein results in increased susceptibility to Paclitaxel16204029
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TFAP2A mRNA26272509
D017374ParoxetineParoxetine results in increased expression of TFAP2A protein28844482
D052638Particulate MatterParticulate Matter results in increased expression of TFAP2A mRNA21703343
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TFAP2A mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TFAP2A mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of TFAP2A mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of TFAP2A mRNA23684756
D011441PropylthiouracilPropylthiouracil results in increased expression of TFAP2A mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of TFAP2A mRNA26865669
C059514resveratrolresveratrol results in increased localization of and results in increased activity of TFAP2A protein16488535
C085746rottlerinrottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]21499124
C078903seocalcitolseocalcitol results in increased expression of TFAP2A mRNA12040012
D020280SertralineSertraline results in increased expression of TFAP2A protein28844482
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TFAP2A mRNA19901195|2290382
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TFAP2A mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTFAP2A mRNA affects the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]16085934
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]21499124|2195155
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [gefitinib inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]21499124|2195155
D014212TretinoinTretinoin results in increased expression of TFAP2A mRNA14534139
D014212TretinoinTretinoin affects the localization of TFAP2A protein17229153
D014212TretinoinTretinoin inhibits the reaction [TFAP2A protein binds to DPYSL2 promoter]17229153
D014212TretinoinTretinoin promotes the reaction [NPM1 protein binds to TFAP2A protein]17318229
D014212TretinoinTretinoin promotes the reaction [[NPM1 protein binds to TFAP2A protein] which binds to NPM1 promoter]17318229
D014212TretinoinTretinoin results in increased expression of TFAP2A mRNA17138961|1731822
D014241TrichloroethyleneTrichloroethylene results in increased expression of TFAP2A mRNA21135412
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TFAP2A mRNA24935251|2627250
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]22552774
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein]22552774
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TFAP2A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TFAP2A mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of TFAP2A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TFAP2A mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of TFAP2A mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TFAP2A gene25560391
D014750VincristineVincristine results in decreased expression of TFAP2A mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2A mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TFAP2A mRNA26272509
D015215ZidovudineZidovudine results in decreased expression of TFAP2A mRNA17926646

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IDA18718911  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA7555706  9520389  21084835  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA7555706  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21084835  
GO:0000987proximal promoter sequence-specific DNA binding-IDA7559606  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11278550  20808827  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9520389  11278550  20066163  
GO:0003682chromatin binding-ISS-  
GO:0003713transcription coactivator activity-IDA7555706  12586840  
GO:0005515protein binding-IPI10987820  11447109  11694877  12072434  12586840  17318229  
19115315  24835590  25416956  25609649  
GO:0042803protein homodimerization activity-TAS7559606  
GO:0043565sequence-specific DNA binding-IDA12586840  
GO:0044212transcription regulatory region DNA binding-IDA12586840  
GO:0046983protein dimerization activity-IDA12072434  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA8321221  9520389  20066163  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0001822kidney development-IMP21204207  
GO:0003404optic vesicle morphogenesis-ISS-  
GO:0003409optic cup structural organization-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007605sensory perception of sound-IMP21204207  
GO:0008285negative regulation of cell proliferation-IDA20607706  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010842retina layer formation-IEP20607706  
GO:0010944negative regulation of transcription by competitive promoter binding-IMP11278550  
GO:0021559trigeminal nerve development-ISS-  
GO:0021623oculomotor nerve formation-ISS-  
GO:0030501positive regulation of bone mineralization-IDA19578371  
GO:0035115embryonic forelimb morphogenesis-ISS-  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042472inner ear morphogenesis-IMP21204207  
GO:0043066negative regulation of apoptotic process-IDA20066163  
GO:0043525positive regulation of neuron apoptotic process-IDA20607706  
GO:0045595regulation of cell differentiation-IDA20607706  
GO:0045892negative regulation of transcription, DNA-templated-IDA20607706  
GO:0045893positive regulation of transcription, DNA-templated-IDA12586840  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA7555706  7559606  11278550  20808827  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048701embryonic cranial skeleton morphogenesis-ISS-  
GO:0048856anatomical structure development-IBA21873635  
GO:0060021roof of mouth development-IMP21204207  
GO:0060349bone morphogenesis-ISS-  
GO:0061029eyelid development in camera-type eye-ISS-  
GO:0070172positive regulation of tooth mineralization-IDA19578371  
GO:0071281cellular response to iron ion-IDA20808827  
GO:2000378negative regulation of reactive oxygen species metabolic process-IDA20066163  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA19115315  20607706  
GO:0005634nucleus-IMP12586840  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005794Golgi apparatus-IDA-  
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationIEA
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsIEA
R-HSA-3232118SUMOylation of transcription factorsIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-597592Post-translational protein modificationIEA
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsIEA
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsIEA
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsTAS
R-HSA-8866906TFAP2 (AP-2) family regulates transcription of other transcription factorsTAS
R-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factorsTAS
R-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsTAS
R-HSA-8866911TFAP2 (AP-2) family regulates transcription of cell cycle factorsTAS
R-HSA-8869496TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29796116Genome-wide analysis of DNA methylation in bronchial washings. (2018)Um SWClin Epigenetics