Gene: TFAP2C

7022
AP2-GAMMA|ERF1|TFAP2G|hAP-2g
transcription factor AP-2 gamma
protein-coding
20q13.31
Ensembl:ENSG00000087510 MIM:601602 Vega:OTTHUMG00000032805 UniprotKB:Q92754
NC_000020.11
PubMed
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.396e-1 (AD)  5.280e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MSX10.747
MCC0.739
FUT100.718
CDC14A0.713
ITGB50.708
ARHGAP310.702
GRTP10.696
PAX60.691
RFX20.685
NHSL10.682

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRG1-0.505
ADTRP-0.468
DRD5-0.459
PCSK1-0.455
RXFP1-0.455
GRIK3-0.455
FOXP2-0.452
TRABD2A-0.45
SEMA3E-0.446
SLC7A14-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TFAP2C mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TFAP2C mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TFAP2C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TFAP2C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TFAP2C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TFAP2C mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
D000638AmiodaroneAmiodarone results in increased expression of TFAP2C mRNA19774075
C006632arsenic trioxidearsenic trioxide results in decreased expression of TFAP2C mRNA15761015
C015001arsenitearsenite results in increased methylation of TFAP2C promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TFAP2C mRNA"18687144
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of TFAP2C mRNA"19446018
C487081belinostatbelinostat results in increased expression of TFAP2C mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TFAP2C mRNA23735875
D004958EstradiolEstradiol affects the expression of TFAP2C mRNA23557687
D004958EstradiolEstradiol affects the expression of TFAP2C mRNA21826169
D004958EstradiolEstradiol results in increased activity of TFAP2C protein27592001
D004958EstradiolEstradiol results in increased expression of TFAP2C mRNA26865669|2871154
D004958EstradiolEstradiol results in increased expression of TFAP2C mRNA19484750
C006780bisphenol Abisphenol A affects the expression of TFAP2C mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TFAP2C mRNA23557687
C006780bisphenol Abisphenol A affects the expression of TFAP2C mRNA21826169
C006780bisphenol Abisphenol A results in decreased expression of TFAP2C mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TFAP2C mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of TFAP2C mRNA25979313
D002330CarmustineTFAP2C mRNA affects the susceptibility to Carmustine16365179
D002857ChromiumChromium results in increased expression of TFAP2C mRNA21437242
D002994ClofibrateClofibrate results in increased expression of TFAP2C mRNA17585979
D002996ClomipheneClomiphene results in decreased expression of TFAP2C mRNA26865669
D003300CopperCopper deficiency results in increased expression of TFAP2C mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TFAP2C mRNA"19167446
C089595cylindrospermopsincylindrospermopsin results in increased expression of TFAP2C mRNA24921660
C014347decitabinedecitabine affects the expression of TFAP2C mRNA23300844
C014347decitabine[decitabine co-treated with TFAP2C protein] results in increased expression of ESR1 mRNA19458056
C014347decitabine[decitabine co-treated with TFAP2C protein] results in increased expression of RERG mRNA19458056
C014347decitabine[decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter]19458056
C014347decitabine[decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA]19458056
C014347decitabinedecitabine results in increased expression of TFAP2C mRNA16367923
C014347decitabineTFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA]19458056
C014347decitabineTFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of RERG mRNA]19458056
D002945CisplatinCisplatin affects the expression of TFAP2C mRNA23300844
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TFAP2C mRNA26865669
C118739entinostatentinostat results in increased expression of TFAP2C mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
D004970EstroneEstrone results in increased expression of TFAP2C mRNA26865669
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TFAP2C mRNA17942748
D008656MestranolMestranol results in increased expression of TFAP2C mRNA26865669
C061365flusilazoleflusilazole affects the expression of TFAP2C mRNA21195148
D004397FonofosFonofos results in increased methylation of TFAP2C promoter22847954
C070081fulvestrantfulvestrant results in decreased expression of TFAP2C mRNA26865669
D019833GenisteinGenistein results in increased expression of TFAP2C mRNA26865669
D019833GenisteinGenistein results in increased expression of TFAP2C mRNA23160963
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of TFAP2C mRNA22467014
D006427HeminHemin results in decreased expression of TFAP2C mRNA20016031
C409722hexaconazolehexaconazole affects the expression of TFAP2C mRNA21195148
D006589HexestrolHexestrol results in increased expression of TFAP2C mRNA26865669
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TFAP2C mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of TFAP2C mRNA26191083
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of TFAP2C mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TFAP2C mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TFAP2C mRNA23179753|2800136
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TFAP2C mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C029938nickel sulfatenickel sulfate results in increased expression of TFAP2C mRNA22714537
D017239PaclitaxelPaclitaxel results in decreased expression of TFAP2C mRNA19682730
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TFAP2C mRNA26272509
D010278ParathionParathion results in increased methylation of TFAP2C promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TFAP2C mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TFAP2C mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TFAP2C mRNA26705709
D010936Plant ExtractsPlant Extracts results in decreased expression of TFAP2C mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TFAP2C mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of TFAP2C mRNA22238285
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TFAP2C mRNA26865669
C059514resveratrolresveratrol results in increased localization of and results in increased activity of TFAP2C protein16488535
D012822Silicon DioxideSilicon Dioxide results in increased expression of TFAP2C mRNA25351596
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of TFAP2C mRNA22467014
C047246temozolomideTFAP2C mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of TFAP2C promoter22847954
D013749TetrachlorodibenzodioxinSRC protein promotes the reaction [Tetrachlorodibenzodioxin affects the expression of TFAP2C mRNA]14708085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TFAP2C mRNA14708085|1696218
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TFAP2C mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TFAP2C mRNA17035482|2405805
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TFAP2C mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of TFAP2C gene26756918
D014118Toxins, Biological"Toxins, Biological affects the expression of TFAP2C mRNA"19682533
C032910triadimefontriadimefon affects the expression of TFAP2C mRNA21195148
C012589trichostatin A[decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter]19458056
C012589trichostatin A[decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA]19458056
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C012589trichostatin ATFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA]19458056
C012589trichostatin ATFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of RERG mRNA]19458056
C012589trichostatin A[trichostatin A co-treated with TFAP2C protein] results in increased expression of ESR1 mRNA19458056
C012589trichostatin A[trichostatin A co-treated with TFAP2C protein] results in increased expression of RERG mRNA19458056
C012589trichostatin Atrichostatin A results in increased expression of TFAP2C mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TFAP2C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TFAP2C mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of TFAP2C mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of TFAP2C mRNA23034163
D024483Vitamin K 3Vitamin K 3 results in increased expression of TFAP2C mRNA25270620
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2C mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TFAP2C mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TFAP2C mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA24413532  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11278550  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11278550  
GO:0003677DNA binding-IDA12072434  
GO:0003700DNA-binding transcription factor activity-TAS9113991  
GO:0005515protein binding-IPI11694877  12072434  12586840  19115315  24413532  24835590  
GO:0046983protein dimerization activity-IDA12072434  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007267cell-cell signaling-TAS9113991  
GO:0008584male gonad development-IEP17848411  
GO:0040029regulation of gene expression, epigenetic-IMP24413532  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA22735262  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048856anatomical structure development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA24413532  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsIEA
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsTAS
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsIEA
R-HSA-8866906TFAP2 (AP-2) family regulates transcription of other transcription factorsTAS
R-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factorsTAS
R-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsTAS
R-HSA-8866911TFAP2 (AP-2) family regulates transcription of cell cycle factorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23103204Abnormal regulation for progesterone production in placenta with prenatal cocaine exposure in rats. (2012 Dec)Wu LPlacenta