Gene: TFF3

7033
ITF|P1B|TFI
trefoil factor 3
protein-coding
21q22.3
Ensembl:ENSG00000160180 MIM:600633 Vega:OTTHUMG00000086798 UniprotKB:Q07654
NC_000021.9
PubMed
0   ANCO-SNPs
OD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.709e-1 (AD)  2.717e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TG0.865
IYD0.85
TPO0.838
FOXE10.829
SLC26A70.804
TSHR0.77
DIO10.768
KRT70.749
CCL210.732
WDR720.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG8-0.336
ANO8-0.327
ZNF575-0.327
HDDC3-0.318
SORCS2-0.318
TMEM53-0.303
CNGA4-0.3
C3orf18-0.298
D2HGDH-0.297
CCDC24-0.295

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of TFF3 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of TFF3 mRNA"26377693
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of TFF3 mRNA"22129739
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TFF3 mRNA"27413110
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TFF3 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TFF3 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TFF3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TFF3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TFF3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TFF3 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of TFF3 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of TFF3 mRNA15606129|1756273
C499366Active Hexose Correlated CompoundActive Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]17449585
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TFF3 mRNA23630614
D000638AmiodaroneAmiodarone results in decreased expression of TFF3 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TFF3 mRNA16483693
C015001arsenitearsenite results in increased expression of TFF3 mRNA18991936
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TFF3 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of TFF3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TFF3 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TFF3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TFF3 mRNA21964900
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TFF3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TFF3 mRNA16202921|1647417
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of TFF3 mRNA17404688
D004958EstradiolEstradiol results in decreased expression of TFF3 mRNA28476547
C006780bisphenol Abisphenol A results in increased expression of TFF3 mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of TFF3 mRNA28476547
C006780bisphenol Abisphenol A results in decreased expression of TFF3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TFF3 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TFF3 mRNA12734012
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of TFF3 mRNA"22129739
D002922CiguatoxinsCiguatoxins affects the expression of TFF3 mRNA18353800
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TFF3 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of TFF3 mRNA24386269
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TFF3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TFF3 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TFF3 mRNA19167446
D003561CytarabineCytarabine results in increased expression of TFF3 mRNA21198554
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of TFF3 mRNA28962523
D004008DiclofenacDiclofenac results in increased expression of TFF3 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of TFF3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of TFF3 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TFF3 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TFF3 mRNA17602206
D004054Diethylstilbestrol[sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of TFF3 mRNA19665456
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of TFF3 mRNA"27840820
D004317DoxorubicinDoxorubicin affects the expression of TFF3 protein17415656
D004317DoxorubicinDoxorubicin results in decreased expression of TFF3 protein18440303
D004317DoxorubicinDoxorubicin results in increased expression of TFF3 mRNA24742701
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of TFF3 mRNA12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TFF3 mRNA12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TFF3 mRNA15212814
C024565ethylene dichlorideethylene dichloride results in decreased expression of TFF3 mRNA28189721
D005047EtoposideTFF3 protein affects the susceptibility to Etoposide16217747
D015025ZearalenoneZearalenone results in increased expression of TFF3 mRNA28965971
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of TFF3 mRNA22213190
C070081fulvestrantfulvestrant results in decreased expression of TFF3 mRNA16202921
C039281furanfuran results in increased expression of TFF3 mRNA24183702
C039281furanfuran results in increased expression of TFF3 mRNA27387713
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in decreased expression of TFF3 mRNA20664735
D019833GenisteinGenistein results in increased expression of TFF3 mRNA16474171
D017313FenretinideFenretinide results in decreased expression of TFF3 mRNA15958647|1667109
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TFF3 mRNA20044591
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of TFF3 mRNA"26377693
D007213IndomethacinIndomethacin results in decreased expression of TFF3 mRNA10567023
C051890irinotecanirinotecan affects the expression of TFF3 mRNA20097248
C020251kappa-casein glycomacropeptidekappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]15867298
C533894LG 100815LG 100815 results in decreased expression of TFF3 mRNA16951191
C011907melaminemelamine results in decreased expression of TFF323052191
D016685MitomycinTFF3 protein affects the susceptibility to Mitomycin16217747
D008942MitoxantroneTFF3 protein affects the susceptibility to Mitoxantrone16217747
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of TFF3 mRNA20551477
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of TFF3 mRNA"16951191
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TFF3 mRNA"25510870
D010634PhenobarbitalPhenobarbital results in decreased expression of TFF3 mRNA19270015
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of TFF3 mRNA16474171
C045362prochlorazprochloraz results in increased expression of TFF3 mRNA29038839
D011374ProgesteroneProgesterone results in decreased expression of TFF3 mRNA23018184
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of TFF3 mRNA17404688
C005556propionaldehydepropionaldehyde results in decreased expression of TFF3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of TFF3 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TFF3 mRNA16202921
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TFF3 mRNA16202921
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TFF3 mRNA19167446
C059514resveratrolresveratrol results in increased expression of TFF3 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TFF3 mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of TFF3 mRNA16507464
C017947sodium arsenite[sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of TFF3 mRNA19665456
C017947sodium arsenitesodium arsenite results in increased expression of TFF3 mRNA17077188
D012460SulfasalazineSulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]17449585
C025462sulindac sulfidesulindac sulfide results in decreased expression of TFF3 mRNA16184548
D013629TamoxifenTamoxifen results in decreased expression of TFF3 mRNA16202921
D013629TamoxifenTamoxifen results in increased expression of TFF3 mRNA25123088
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of TFF3 mRNA20189893
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TFF3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TFF3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TFF3 mRNA20067830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TFF3 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TFF3 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of TFF3 mRNA23557971
C024746tobacco tartobacco tar results in decreased expression of TFF3 mRNA19559774
D014241TrichloroethyleneTrichloroethylene results in decreased expression of TFF3 mRNA17905399
D014302Trinitrobenzenesulfonic AcidActive Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]17449585
D014302Trinitrobenzenesulfonic Acidkappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]15867298
D014302Trinitrobenzenesulfonic AcidSulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]17449585
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA15867298|1744958
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TFF3 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TFF3 mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of TFF3 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of TFF3 mRNA24535564
D024483Vitamin K 3Vitamin K 3 affects the expression of TFF3 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA8454642  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24825609Neuropeptide trefoil factor 3 attenuates naloxone-precipitated withdrawal in morphine-dependent mice. (2014 Dec)Wu PPsychopharmacology (Berl)
17727719Effect of active smoking on the human bronchial epithelium transcriptome. (2007 Aug 29)Chari RBMC Genomics
21717156Synergistic anti-inflammatory effect of Radix Platycodon in combination with herbs for cleaning-heat and detoxification and its mechanism. (2013 Jan)Li YHChin J Integr Med
25691144Differential regional and cellular distribution of TFF3 peptide in the human brain. (2015 May)Bernstein HGAmino Acids