Gene: TFPI

7035
EPI|LACI|TFI|TFPI1
tissue factor pathway inhibitor
protein-coding
2q32.1
Ensembl:ENSG00000003436 MIM:152310 Vega:OTTHUMG00000132634 UniprotKB:P10646
NG_029714.2
PubMed
ND
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.543e-1 (AD)  6.998e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHG20.883
TNFAIP80.875
VEGFC0.863
NAALADL10.841
ARHGAP290.84
FBLIM10.839
EDNRA0.839
LILRB20.834
RNF144B0.831
MAP3K80.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.574
SVOP-0.562
LRTM2-0.561
MYADML2-0.559
ASPDH-0.551
KLHL35-0.549
KCNB2-0.548
BCL11A-0.546
CYP46A1-0.544
ST6GALNAC5-0.544

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00036Coagulation factor VIIa Recombinant HumanBiotechDrug102786-61-8ApprovedTarget
DB06779DalteparinSmall Molecule9005-49-6ApprovedTarget
ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane results in decreased expression of TFPI mRNA"28591870
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TFPI mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TFPI mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TFPI mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TFPI mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TFPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TFPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TFPI mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in decreased expression of TFPI mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TFPI gene27153756
D000447AldehydesAldehydes results in decreased expression of TFPI mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TFPI mRNA16483693
D000661AmphetamineAmphetamine results in decreased expression of TFPI protein20118172
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TFPI mRNA"18687144
C487081belinostatbelinostat results in increased expression of TFPI mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
D001554BenzeneBenzene results in decreased expression of TFPI mRNA15929907
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TFPI mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TFPI mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TFPI mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TFPI mRNA"20018196
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of TFPI mRNA]24758408
D004958EstradiolEstradiol affects the expression of TFPI mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TFPI mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TFPI mRNA19619570
D004958EstradiolEstradiol results in decreased expression of and results in decreased secretion of TFPI protein17029634
D004958EstradiolEstradiol results in decreased expression of TFPI mRNA21185374|2475840
D004958EstradiolEstradiol results in increased expression of TFPI mRNA19619570
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TFPI mRNA28591870
C006780bisphenol Abisphenol A results in decreased expression of TFPI mRNA28711546
C006780bisphenol Abisphenol A results in increased expression of TFPI mRNA22687993
C006780bisphenol Abisphenol A results in increased expression of TFPI mRNA25181051
D002066BusulfanBusulfan results in decreased expression of TFPI mRNA22286157
C018475butyraldehydebutyraldehyde results in decreased expression of TFPI mRNA26079696
C584509C646 compoundC646 compound results in increased expression of TFPI mRNA26191083
C043211carvedilol[irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA21229253
C043211carvedilol[irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein21229253
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of TFPI mRNA26272509
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of TFPI protein28596144
D002994ClofibrateClofibrate results in decreased expression of TFPI mRNA16081524
D002995Clofibric AcidClofibric Acid affects the expression of TFPI mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TFPI mRNA17602206
D002996ClomipheneClomiphene results in increased expression of TFPI mRNA26865669
C018021cobaltous chloridecobaltous chloride results in decreased expression of TFPI mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TFPI mRNA20971185
D019327Copper SulfateCopper Sulfate affects the expression of TFPI mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TFPI mRNA"19167446
D003471CuprizoneCuprizone results in decreased expression of TFPI mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of TFPI mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of TFPI mRNA21198554
D003703DemecolcineDemecolcine results in increased expression of TFPI mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of TFPI mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TFPI mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TFPI mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TFPI mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of TFPI mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of TFPI mRNA21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TFPI mRNA17602206
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TFPI mRNA26865669
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TFPI mRNA21658437
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of TFPI mRNA24834073
D004237DiuronDiuron results in increased expression of TFPI mRNA21551480|2515243
D004317DoxorubicinTFPI protein affects the susceptibility to Doxorubicin16217747
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) affects the expression of TFPI mRNA"15964915
D004970EstroneEstrone results in decreased expression of TFPI mRNA26865669
D000431EthanolEthanol results in decreased expression of TFPI mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of and results in decreased secretion of TFPI protein17029634
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased activity of TFPI protein15857755
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TFPI mRNA17557909
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TFPI protein15857755
D004997Ethinyl Estradiolfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]15857755
D004997Ethinyl Estradiolnorethindrone acetate promotes the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]15857755
D008656MestranolMestranol results in decreased expression of TFPI mRNA26865669
C024565ethylene dichlorideethylene dichloride results in decreased expression of TFPI mRNA28189721
D005047EtoposideTFPI protein affects the susceptibility to Etoposide16217747
D005472FluorouracilTFPI protein affects the susceptibility to Fluorouracil16217747
C065180fluvastatinfluvastatin results in increased expression of TFPI protein16142594
D005557FormaldehydeFormaldehyde results in increased expression of TFPI mRNA23649840
C070081fulvestrant[fulvestrant co-treated with Raloxifene Hydrochloride] results in increased secretion of TFPI protein17029634
C070081fulvestrantfulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein]17029634
C070081fulvestrantfulvestrant results in decreased secretion of TFPI protein17029634
C070081fulvestrantfulvestrant results in increased expression of TFPI mRNA26865669
C070081fulvestrantfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]15857755
C070081fulvestrantfulvestrant inhibits the reaction [norethindrone acetate results in decreased activity of TFPI protein]15857755
C001277geldanamycingeldanamycin results in increased expression of TFPI mRNA26705709
D019833GenisteinGenistein results in decreased expression of TFPI mRNA18847459|2686566
D019833GenisteinGenistein results in increased expression of TFPI mRNA17341692
D006589HexestrolHexestrol results in decreased expression of TFPI mRNA26865669
D017313FenretinideFenretinide results in decreased expression of TFPI mRNA28973697
C492448ICG 001ICG 001 results in increased expression of TFPI mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of TFPI mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TFPI mRNA25613284
C081309irbesartan[irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA21229253
C081309irbesartan[irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein21229253
C051890irinotecanirinotecan analog results in decreased expression of TFPI mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TFPI mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TFPI mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of TFPI protein17337753
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TFPI mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TFPI mRNA24796395|2511904
D007854LeadLead affects the expression of TFPI mRNA28903495
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of TFPI mRNA20843944
C042720mercuric bromidemercuric bromide results in increased expression of TFPI mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TFPI mRNA23179753|2800136
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TFPI mRNA23179753|2627250
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TFPI mRNA"26251327
D016685MitomycinTFPI protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TFPI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TFPI mRNA"25554681
C024262norethindrone acetatefulvestrant inhibits the reaction [norethindrone acetate results in decreased activity of TFPI protein]15857755
C024262norethindrone acetatenorethindrone acetate promotes the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]15857755
C024262norethindrone acetatenorethindrone acetate results in decreased activity of TFPI protein15857755
C024262norethindrone acetatenorethindrone acetate results in decreased expression of TFPI protein15857755
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TFPI mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TFPI mRNA26272509
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TFPI mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of TFPI mRNA25119042
C046012pentanalpentanal results in decreased expression of TFPI mRNA26079696
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of TFPI mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of TFPI mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TFPI mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of TFPI mRNA19162173
D010938Plant OilsPlant Oils results in increased expression of TFPI mRNA23370395
C054694polyoxyethyleneaminepolyoxyethyleneamine results in decreased expression of TFPI mRNA28711546
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TFPI mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TFPI mRNA20660070
C005556propionaldehydepropionaldehyde results in decreased expression of TFPI mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of TFPI mRNA24780913
D011794QuercetinQuercetin results in decreased expression of TFPI mRNA21632981
D020849Raloxifene Hydrochloride[fulvestrant co-treated with Raloxifene Hydrochloride] results in increased secretion of TFPI protein17029634
D020849Raloxifene Hydrochloridefulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein]17029634
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein17029634
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of TFPI mRNA26865669
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of TFPI mRNA21852083
D012822Silicon DioxideSilicon Dioxide analog affects the expression of TFPI mRNA25895662
D012834SilverSilver results in decreased expression of TFPI mRNA27131904
D012906SmokeSmoke results in increased expression of TFPI mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of TFPI mRNA19072884
D013629TamoxifenTamoxifen results in decreased expression of and results in decreased secretion of TFPI protein17029634
D013739TestosteroneTestosterone results in increased expression of TFPI20442653
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TFPI mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TFPI mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TFPI mRNA19619570
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TFPI mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TFPI mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TFPI mRNA18087596
D019772TopotecanTFPI protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of TFPI mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TFPI mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TFPI mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TFPI mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TFPI mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TFPI mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of TFPI mRNA24383497|2493525
D014638VanadatesVanadates results in increased expression of TFPI mRNA22714537
D014750VincristineVincristine results in increased expression of TFPI mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TFPI mRNA26272509
C088658zoledronic acidzoledronic acid results in increased expression of TFPI mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS9252393  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS9252393  
GO:0007598blood coagulation, extrinsic pathway-TAS-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030195negative regulation of blood coagulation-IDA21868574  
GO:0032355response to estradiol-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0071383cellular response to steroid hormone stimulus-IEP21868574  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA19065458  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005901caveola-IDA21868574  
GO:0009986cell surface-HDA19581412  
GO:0009986cell surface-IDA21868574  
GO:0031090organelle membrane-IEA-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140834Extrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19845509Tissue factor: beyond coagulation in the cardiovascular system. (2009 Oct 26)Breitenstein AClin Sci (Lond)
28074087The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese. (2017)Chang XThromb J
12186791Smoking is associated with altered endothelial-derived fibrinolytic and antithrombotic factors: an in vitro demonstration. (2002 Aug 20)Barua RSCirculation
11320586[Tissue factor and it's inhibitor in patients up to 50 years of age with ischemic stroke]. (2001 Feb)Sobol ABPol Merkur Lekarski
21624643Thrombin generation in chronic obstructive pulmonary disease: dependence on plasma factor composition. (2011 Oct)Undas AThromb Res
15380459Potential of free-form TFPI and PAI-1 to be useful markers of early atherosclerosis in a Japanese general population (the Suita Study): association with the intimal-medial thickness of carotid arteries. (2004 Oct)Sakata TAtherosclerosis
18781916Dysfunction of pulmonary vascular endothelium in chronic obstructive pulmonary disease: basic considerations for future drug development. (2008 Sep)Yang QCurr Drug Metab
21071578A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. (2011 Jan)Balasenthil SCancer Prev Res (Phila)
15279664Systemic haemostasis after intermittent pneumatic compression. Clues for the investigation of DVT prophylaxis and travellers thrombosis. (2004 Aug)Giddings JCClin Lab Haematol
23631910The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis. (2013 May)Winckers KBlood Rev
18560491Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families. (2008 Jun)Nowak-Gottl UEnviron Health Perspect
27110300The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)Ma KClin Epigenetics
28716011Association study to evaluate TFPI gene in CAD in Han Chinese. (2017 Jul 17)Zhao YBMC Cardiovasc Disord
28749986The role of the tissue factor and its inhibitor in the development of subclinical atherosclerosis in people living with HIV. (2017)Barska KPLoS One
19467658Tissue factor pathway inhibitor, vascular risk factors and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. (2009 Nov)Mitchell CTAtherosclerosis