Gene: TFR2

7036
HFE3|TFRC2
transferrin receptor 2
protein-coding
7q22.1
Ensembl:ENSG00000106327 MIM:604720 Vega:OTTHUMG00000159598 UniprotKB:Q9UP52
NG_007989.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.277e-2 (AD)  6.529e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10681065chr7:100239172TFR24.080e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCG40.876
NPM20.872
KATNB10.871
PKNOX20.868
DGKQ0.866
SPIRE20.866
PNMA30.865
NYAP10.86
RIMS30.859
EIF4E1B0.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGMS2-0.54
RAI14-0.537
REST-0.533
YES1-0.507
HEY2-0.503
SH2D1A-0.499
ACTL6A-0.488
CNN2-0.48
WWTR1-0.477
SEPT10-0.471

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05260Gallium nitrateSmall Molecule13494-90-1Approved|InvestigationalTransporter
DB06784Gallium citrate Ga 67Small Molecule41183-64-6ApprovedTransporter
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TFR2 mRNA"23829299
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TFR2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of TFR2 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TFR2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of TFR2 protein"25633564
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFR2 mRNA"27188386
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of TFR2 mRNA"25633564
C0524109-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of TFR2 protein"25633564
D000082AcetaminophenAcetaminophen affects the expression of TFR2 mRNA25064622
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TFR2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TFR2 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of TFR2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TFR2 mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TFR2 mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of TFR2 mRNA25064622
D001151ArsenicArsenic results in increased methylation of TFR2 gene28242323
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TFR2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TFR2 mRNA19770486
D004958EstradiolEstradiol affects the expression of TFR2 mRNA23557687
D004958EstradiolEstradiol results in decreased expression of TFR2 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TFR2 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of TFR2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TFR2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TFR2 mRNA25993096
D002746ChlorpromazineChlorpromazine affects the expression of TFR2 mRNA25064622
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of TFR2 mRNA17382205
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TFR2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of TFR2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TFR2 mRNA]17585979
D003300CopperCopper deficiency results in decreased expression of TFR2 protein20164366|2245724
D003471CuprizoneCuprizone results in increased expression of TFR2 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of TFR2 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of TFR2 mRNA25562108
D003676DeferoxamineDeferoxamine results in decreased expression of TFR2 protein25633564
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TFR2 mRNA19061943
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TFR2 protein19061943
D004052DiethylnitrosamineIron inhibits the reaction [Diethylnitrosamine results in decreased expression of TFR2 protein]19061943
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TFR2 mRNA25064622
D028441F2-Isoprostanes[HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of F2-Isoprostanes22383097
D028441F2-IsoprostanesTFR2 gene mutant form results in increased abundance of F2-Isoprostanes22383097
C013531ferric ammonium citrateferric ammonium citrate results in decreased expression of TFR2 protein25633564
D005485FlutamideFlutamide results in decreased expression of TFR2 mRNA24136188
C056933fumonisin B1fumonisin B1 results in decreased expression of TFR2 mRNA16221962
C039281furanfuran results in decreased expression of TFR2 mRNA25539665
D005897GlafenineGlafenine results in increased expression of TFR2 mRNA24136188
C004312glycidolglycidol results in increased expression of TFR2 mRNA24915197
D007501Iron[HFE protein binds to TFR2 protein] which affects the susceptibility to Iron16893896
D007501IronTFR2 protein affects the susceptibility to Iron16893896
D007501Iron[HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA17018382
D007501Iron[HBB-B2 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA17018382
D007501Iron[HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron22383097
D007501IronIron inhibits the reaction [Diethylnitrosamine results in decreased expression of TFR2 protein]19061943
D007501IronTFR2 protein affects the metabolism of Iron17194590|1724188
D007501IronTFR2 protein mutant form results in increased uptake of Iron16935854
D007501IronIron deficiency results in decreased expression of TFR2 protein20164366|2245724
D007505Iron-Dextran ComplexIron-Dextran Complex results in increased expression of TFR2 protein27095094
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TFR2 mRNA24796395|2675264
C119620kenpaullonekenpaullone results in decreased expression of TFR2 mRNA25633564
C045463leflunomideleflunomide results in increased expression of TFR2 mRNA24136188
D008054Lipid Peroxides[HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Lipid Peroxides22383097
D008701MethapyrileneMethapyrilene results in decreased expression of TFR2 mRNA28935588
D008701MethapyrileneMethapyrilene results in decreased expression of TFR2 mRNA28935588
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TFR2 mRNA22776087
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TFR2 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TFR2 mRNA19812364
D009532NickelNickel results in decreased expression of TFR2 mRNA24084258
C022838nickel chloridenickel chloride results in increased expression of TFR2 mRNA24577088
C029938nickel sulfatenickel sulfate results in increased expression of TFR2 mRNA17382205
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TFR2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TFR2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TFR2 mRNA20880076
D010269ParaquatParaquat affects the expression of TFR2 mRNA25064622
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of TFR2 mRNA17097637
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of TFR2 mRNA26678675
C006253pirinixic acidpirinixic acid results in decreased expression of TFR2 mRNA16221962
D010936Plant ExtractsPlant Extracts results in decreased expression of TFR2 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TFR2 mRNA17382205
D011192Potassium DichromatePotassium Dichromate results in increased expression of TFR2 mRNA23608068
D011794QuercetinQuercetin affects the expression of TFR2 mRNA21632981
C433985SU 9516SU 9516 results in decreased expression of TFR2 protein25633564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TFR2 mRNA18163543|2821309
D013752TetracyclineTetracycline affects the expression of TFR2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of TFR2 mRNA25064622
D013853ThioacetamideThioacetamide results in decreased expression of TFR2 mRNA23411599
C066340tolcaponetolcapone results in increased expression of TFR2 mRNA24136188
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TFR2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TFR2 mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of TFR2 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFR2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TFR2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TFR2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of TFR2 mRNA20546886
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TFR2 gene25487561
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TFR2 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of TFR2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004998transferrin receptor activity-IDA18353247  
GO:0004998transferrin receptor activity-NAS10409623  
GO:0005515protein binding-IPI18353247  22728873  25635054  
GO:0033570transferrin transmembrane transporter activity-IEA-  
GO:0039706co-receptor binding-IPI22728873  
GO ID GO Term Qualifier Evidence PubMed
GO:0006826iron ion transport-NAS10409623  
GO:0006879cellular iron ion homeostasis-TAS15319276  
GO:0006898receptor-mediated endocytosis-IGI18353247  
GO:0006953acute-phase response-IEA-  
GO:0010039response to iron ion-IMP21173098  
GO:0033216ferric iron import-IGI18353247  
GO:0033572transferrin transport-IGI18353247  
GO:0033572transferrin transport-TAS-  
GO:0045807positive regulation of endocytosis-IGI18353247  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI25635054  
GO:0055072iron ion homeostasis-IC18353247  
GO:0055072iron ion homeostasis-IMP21173098  
GO:0071281cellular response to iron ion-IGI18353247  
GO:0090277positive regulation of peptide hormone secretion-IMP21173098  
GO:0097286iron ion import-IGI18353247  
GO:1903319positive regulation of protein maturation-IGI18353247  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IGI18353247  
GO:0005887integral component of plasma membrane-NAS10409623  
GO:0009897external side of plasma membrane-IGI18353247  
GO:0031410cytoplasmic vesicle-IDA12704209  
GO:1990712HFE-transferrin receptor complex-IDA12704209  22728873  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-917937Iron uptake and transportTAS
R-HSA-917977Transferrin endocytosis and recyclingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23751596Association between genetic variations in TFR2 gene and coronary heart disease in Chinese: a case-control study. (2014 May)Shi YJ Cardiovasc Med (Hagerstown)
26474245The role of genetic factors in patients with hepatocellular carcinoma and iron overload - a prospective series of 234 patients. (2016 May)Funakoshi NLiver Int
21422745The A Allele of the -576G>A polymorphism of the transferrin gene is associated with the increased risk of age-related macular degeneration in smokers. (2011 Apr)Wysokinski DTohoku J Exp Med