Gene info: ID 7037

Gene: TFRC

GENE ID: 7037

Synonyms: CD71|IMD46|T9|TFR|TFR1|TR|TRFR|p90

Description: transferrin receptor

Gene type: protein-coding

Location: 3q29

dbXrefs: Ensembl:ENSG00000072274 MIM:190010 Vega:OTTHUMG00000155714 UniprotKB:P02786

RefSeq: NG_046395.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.881e-1 (AD) 6.707e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg09470983	chr3:195805948	TFRC	Promoter	8.187e-5	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
WIPI1	0.699
SCML1	0.689
SLC31A1	0.67
HIF1A	0.67
DENND4C	0.647
SBF2	0.628
SLC19A2	0.627
NMD3	0.617
DDX3X	0.617
UBXN4	0.616

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.435
OR4F5	-0.425
KLRG1	-0.247
AADAC	-0.232
SERPINC1	-0.232
MOGAT2	-0.225
RAX2	-0.222
ADRA2C	-0.219
MIA	-0.216
KCNG1	-0.215

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05260	Gallium nitrate	Small Molecule	13494-90-1	Approved\|Investigational	Transporter
DB06784	Gallium citrate Ga 67	Small Molecule	41183-64-6	Approved	Transporter
DB01592	Iron	Small Molecule	7439-89-6	Approved	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in increased expression of TFRC mRNA"	19502547
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TFRC mRNA"	21354444
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of TFRC mRNA"	19095052
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TFRC mRNA"	19114083
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TFRC mRNA"	21346803
C120275	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in increased expression of TFRC protein	12807743
C477898	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
C477898	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in decreased expression of TFRC protein"	20667997
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TFRC protein"	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TFRC mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of TFRC mRNA"	19561079
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of TFRC mRNA"	21346803
C029370	4-toluidine	4-toluidine results in increased expression of TFRC mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of TFRC protein"	25633564
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TFRC mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of TFRC mRNA	25704631
D000082	Acetaminophen	Acetaminophen results in increased expression of TFRC protein	20025956
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D020106	Acrylamide	Acrylamide results in increased expression of TFRC protein	20025956
D020106	Acrylamide	Acrylamide results in increased expression of TFRC mRNA	28959563
C096064	actein	actein results in increased expression of TFRC mRNA	19527300
D012436	S-Adenosylmethionine	S-Adenosylmethionine results in decreased expression of TFRC mRNA	18571630
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of TFRC mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TFRC mRNA	19770486
D016604	Aflatoxin B1	[sulforafan co-treated with Aflatoxin B1] affects the expression of TFRC mRNA	25450479
D000376	Agmatine	Agmatine inhibits the reaction [MBP protein results in increased expression of TFRC protein]	24070732
C000188	alachlor	alachlor results in increased expression of TFRC mRNA	12419858
D000438	Alcohols	Alcohols results in increased expression of TFRC mRNA	24025710
D000497	Alloys	Alloys results in increased expression of TFRC mRNA	23499988
D000534	Alum Compounds	Alum Compounds promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]	18390722
D000535	Aluminum	Aluminum results in decreased expression of TFRC mRNA	11068183
D000535	Aluminum	TFRC protein affects the uptake of Aluminum	9630424
D017607	Aluminum Compounds	Aluminum Compounds results in decreased expression of TFRC mRNA	9504407
D000536	Aluminum Hydroxide	Aluminum Hydroxide promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]	18390722
D000640	Amitrole	Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]	24964743
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TFRC mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TFRC mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TFRC protein	16174796\|2541905
D001194	Asbestos	Asbestos results in decreased expression of TFRC mRNA	22398240
D001194	Asbestos	Asbestos results in increased expression of TFRC mRNA	22398240
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of TFRC mRNA"	25351596
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of TFRC protein"	25351596
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D000069059	Atorvastatin Calcium	Atorvastatin Calcium affects the expression of TFRC protein	16387846
D001280	Atrazine	Atrazine results in decreased expression of TFRC mRNA	22378314
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid results in increased expression of TFRC mRNA	17350462
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of TFRC mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TFRC mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TFRC mRNA	18061397
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TFRC mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TFRC mRNA"	20018196
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TFRC mRNA	25566086
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TFRC mRNA]	25566086
D004958	Estradiol	Estradiol results in increased expression of TFRC mRNA	18556351\|2301914
D004958	Estradiol	Estradiol affects the expression of TFRC mRNA	16684588
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of TFRC mRNA	18556351
C044887	beta-methylcholine	beta-methylcholine affects the expression of TFRC mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of TFRC mRNA	25181051
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of TFRC mRNA	19000923
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of TFRC mRNA	15336504\|1596398
C018475	butyraldehyde	butyraldehyde results in decreased expression of TFRC mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in decreased expression of TFRC mRNA	12800193
C584509	C646 compound	C646 compound results in decreased expression of TFRC mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of TFRC mRNA	23358150\|2406772
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TFRC mRNA	26525392
D002110	Caffeine	"Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]"	20230807
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA"	20230807
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the activity of TFRC protein	16819174
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of TFRC protein	18340409
D002251	Carbon Tetrachloride	Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein]	18340409
C034221	catechol	catechol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TFRC protein]	12749906
D002509	Cephaloridine	Cephaloridine results in increased expression of TFRC mRNA	18500788
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of TFRC mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of TFRC mRNA	23650126
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of TFRC protein	22094459
C100187	chloropicrin	chloropicrin results in increased expression of TFRC mRNA	26352163
D019826	Cholic Acid	Cholic Acid results in increased expression of TFRC protein	20025956
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFRC gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of TFRC mRNA	28472532
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of TFRC mRNA	24418189
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of TFRC mRNA	24418189
D002922	Ciguatoxins	Ciguatoxins affects the expression of TFRC mRNA	18353800
D002994	Clofibrate	Clofibrate inhibits the reaction [Iron deficiency results in increased expression of TFRC mRNA]	11969379
D002994	Clofibrate	Clofibrate results in decreased expression of TFRC mRNA	11969379
C018021	cobaltous chloride	[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of TFRC protein	17442736
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TFRC mRNA	17553155\|1932097
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TFRC mRNA	21139344
C060728	cobalt oxide	cobalt oxide analog results in increased expression of TFRC mRNA	24821434
C026305	cobalt sulfate	cobalt sulfate results in increased expression of TFRC mRNA	19502547
D003042	Cocaine	Cocaine results in increased expression of TFRC mRNA	15009677\|1671032
D003300	Copper	[Copper co-treated with Diethylnitrosamine] results in increased expression of TFRC mRNA	20302851
D003300	Copper	[Copper co-treated with Diethylnitrosamine] results in increased expression of TFRC protein	20302851
D003300	Copper	Copper deficiency results in increased expression of TFRC mRNA	17298691\|2402438
D003300	Copper	[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA	20302851
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TFRC mRNA	21595052
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TFRC protein	21595052
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TFRC mRNA	19549813
C030123	coumarin	coumarin results in increased expression of TFRC mRNA	18480146
D003375	Coumestrol	Coumestrol results in increased expression of TFRC mRNA	19167446
C467608	CP-470711	[CP-470711 results in decreased activity of SORD protein] which results in decreased expression of TFRC protein	18549825
D003474	Curcumin	Curcumin results in increased expression of TFRC mRNA	17198877
D003474	Curcumin	Curcumin results in increased expression of TFRC mRNA	24634837
D003474	Curcumin	Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein]	18340409
C038459	curdlan	curdlan results in decreased expression of TFRC mRNA	23543010
D016572	Cyclosporine	Cyclosporine results in decreased expression of TFRC mRNA	20106945\|2163298
D017373	Cyproterone Acetate	[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of TFRC protein	16002536
D003676	Deferoxamine	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of TFRC mRNA	12393473
D003676	Deferoxamine	[Deferoxamine results in decreased abundance of Oxygen] which results in increased expression of TFRC protein	17442736
D003676	Deferoxamine	Deferoxamine results in increased expression of TFRC mRNA	16039939\|1676046
D003676	Deferoxamine	Deferoxamine results in increased expression of TFRC protein	12807743\|1599333
D003676	Deferoxamine	Deferoxamine affects the reaction [Magnetite Nanoparticles results in decreased expression of TFRC mRNA]	23086747
D003676	Deferoxamine	Deferoxamine results in increased expression of TFRC mRNA	11054110\|1807320
D003676	Deferoxamine	Deferoxamine inhibits the reaction [Doxorubicin results in decreased expression of TFRC mRNA]	24089420
D003676	Deferoxamine	Deferoxamine results in increased expression of TFRC mRNA	24089420
D003676	Deferoxamine	Deferoxamine results in increased expression of TFRC protein	16568477\|1746913
D013759	Dronabinol	Dronabinol results in increased expression of TFRC mRNA	18454173
D003907	Dexamethasone	Dexamethasone promotes the reaction [Tretinoin results in decreased expression of TFRC protein]	7909661
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of TFRC mRNA	24848799
D003907	Dexamethasone	Dexamethasone results in decreased expression of TFRC mRNA	14618091
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of TFRC protein	20025956
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TFRC mRNA	21266533
D003994	Bucladesine	Bucladesine results in decreased expression of TFRC protein	2989362
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of TFRC mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of TFRC mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TFRC mRNA	27594783
D004008	Diclofenac	Diclofenac results in increased expression of TFRC mRNA	26934552
D004041	Dietary Fats	Dietary Fats affects the expression of TFRC mRNA	19680557
D004041	Dietary Fats	[Dietary Fats co-treated with Quercetin] affects the expression of TFRC mRNA	25047408
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of TFRC mRNA	27614199
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TFRC mRNA	19061943
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TFRC protein	19061943
D004052	Diethylnitrosamine	Iron inhibits the reaction [Diethylnitrosamine results in increased expression of TFRC protein]	19061943
D004052	Diethylnitrosamine	[Copper co-treated with Diethylnitrosamine] results in increased expression of TFRC mRNA	20302851
D004052	Diethylnitrosamine	[Copper co-treated with Diethylnitrosamine] results in increased expression of TFRC protein	20302851
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TFRC mRNA	19638242
D004052	Diethylnitrosamine	[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA	20302851
D004052	Diethylnitrosamine	[Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC mRNA	20302851
D004052	Diethylnitrosamine	[Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC protein	20302851
D000875	Anthralin	Anthralin results in increased expression of TFRC protein	20025956
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of TFRC mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TFRC mRNA"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TFRC protein"	20025956
D004178	Diquat	Diquat results in increased expression of TFRC mRNA	21698372
D004237	Diuron	Diuron results in increased expression of TFRC mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFRC mRNA	16770644
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFRC protein	16770644
D004317	Doxorubicin	Deferoxamine inhibits the reaction [Doxorubicin results in decreased expression of TFRC mRNA]	24089420
D004317	Doxorubicin	Doxorubicin results in decreased expression of TFRC mRNA	19915844\|2408942
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of TFRC mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of TFRC mRNA	21233418
D000431	Ethanol	Ethanol results in increased expression of TFRC mRNA	15963989
D000431	Ethanol	Ethanol results in decreased expression of TFRC mRNA	29018328
D000431	Ethanol	Ethanol results in increased expression of TFRC mRNA	19167417\|2456906
D000431	Ethanol	[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA	24569067
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in increased expression of TFRC mRNA]	24569067
D000431	Ethanol	Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA]	24569067
D000431	Ethanol	Ethanol affects the expression of TFRC mRNA	11772933
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of TFRC protein	16002536
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TFRC mRNA	17942748
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of TFRC protein	27725143
C007687	etiron	etiron promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
C013531	ferric ammonium citrate	[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA	12393473
C013531	ferric ammonium citrate	ferric ammonium citrate results in decreased expression of TFRC mRNA	16760464
C013531	ferric ammonium citrate	ferric ammonium citrate results in decreased expression of TFRC protein	25633564
C013531	ferric ammonium citrate	ferric ammonium citrate results in decreased expression of TFRC mRNA	11054110\|1807320
C025314	ferric citrate	ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein]	17364964
C000499	ferric oxide	ferric oxide analog results in decreased expression of TFRC mRNA	25086211
C049051	ferric pyrophosphate	[ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein	16772442
C421458	ferric-sorbitol-citrate	ferric-sorbitol-citrate results in decreased expression of TFRC	17257079
C020748	ferrous sulfate	ferrous sulfate results in decreased expression of TFRC mRNA	10966897\|1603993
C020748	ferrous sulfate	ferrous sulfate results in decreased expression of TFRC protein	28993186
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of TFRC mRNA	21785164
C007744	fluorocitrate	fluorocitrate results in increased expression of TFRC protein	17469137
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of TFRC mRNA]	15016801
D005485	Flutamide	Flutamide results in increased expression of TFRC mRNA	24136188
C065180	fluvastatin	Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]	24964743
C065180	fluvastatin	fluvastatin results in decreased expression of TFRC mRNA	24964743
C065180	fluvastatin	fluvastatin results in decreased expression of TFRC protein	24964743
C065180	fluvastatin	[fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron	24964743
C065180	fluvastatin	[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC	24964743
C065180	fluvastatin	Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC mRNA]	24964743
C065180	fluvastatin	Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]	24964743
C065180	fluvastatin	N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]	24964743
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFRC gene	20938992
C070081	fulvestrant	fulvestrant results in increased expression of TFRC mRNA	12154049
C039281	furan	furan results in increased expression of TFRC mRNA	24183702
C039281	furan	furan results in increased expression of TFRC mRNA	25539665
D005708	Gallium	[TF protein binds to Gallium] which binds to TFRC protein	16988841
D005708	Gallium	TFRC protein affects the uptake of Gallium	9630424
D005708	Gallium	TFRC protein affects the uptake of [Gallium binds to TF protein]	9630424
C027235	gallium nitrate	gallium nitrate results in decreased expression of TFRC mRNA	18586083
C069724	gallium-transferrin complex	gallium-transferrin complex binds to TFRC protein	18225897
C546771	gardiquimod	gardiquimod results in increased expression of TFRC mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TFRC mRNA]	28003376
D019833	Genistein	ESR2 promotes the reaction [Genistein results in increased expression of TFRC protein]	20884965
D019833	Genistein	Genistein results in increased expression of TFRC protein	20884965
D019833	Genistein	Genistein results in decreased expression of TFRC mRNA	22553218
D019833	Genistein	Genistein results in increased expression of TFRC mRNA	17341692
C102521	GGTI 298	GGTI 298 results in decreased expression of TFRC protein	24964743
C102521	GGTI 298	[GGTI 298 results in decreased expression of TFRC protein] which results in decreased uptake of Iron	24964743
C102521	GGTI 298	N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [GGTI 298 results in decreased expression of TFRC protein]	24964743
C077458	ginkgetin	ginkgetin results in increased expression of TFRC protein	25968939
C077458	ginkgetin	ginkgetin results in increased expression of TFRC protein	25968939
D005897	Glafenine	Glafenine results in increased expression of TFRC mRNA	24136188
D005990	Glycerol	[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA	28065790
C401858	GW 7604	GW 7604 results in increased expression of TFRC mRNA	12154049
D006427	Hemin	[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA	12393473
D006427	Hemin	Hemin results in decreased expression of TFRC mRNA	16760464\|2141439
D006427	Hemin	Hemin results in decreased expression of TFRC protein	21414390\|2557668
D006427	Hemin	hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]	21414390
D006427	Hemin	hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]	21414390
D006427	Hemin	Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]	21414390
D006427	Hemin	Hemin results in decreased expression of TFRC protein	16568477
D006493	Heparin	Heparin results in decreased expression of TFRC protein	25633564
D006493	Heparin	Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]	16401727
D003932	Heroin	Heroin results in increased expression of TFRC mRNA	16710320
D006581	Hexachlorobenzene	Hexachlorobenzene affects the expression of TFRC mRNA	15159207
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TFRC mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TFRC mRNA	12393473
C031927	hydroquinone	hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TFRC protein]	12749906
C031927	hydroquinone	hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]	21414390
C031927	hydroquinone	hydroquinone results in decreased expression of TFRC protein	21414390
C013038	hydroxyhydroquinone	hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]	21414390
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in decreased expression of TFRC protein	21414390
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of TFRC mRNA	19376150
C492448	ICG 001	ICG 001 results in decreased expression of TFRC mRNA	26191083
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole results in increased expression of TFRC mRNA"	18061397
D007213	Indomethacin	Indomethacin results in decreased expression of TFRC mRNA	16984733
D007455	Iodine	[ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein	16772442
D015759	Ionomycin	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TFRC protein	9766631
C051890	irinotecan	irinotecan analog results in increased expression of TFRC mRNA	18927307
D007501	Iron	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of TFRC mRNA	12393473
D007501	Iron	[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA	12393473
D007501	Iron	[fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron	24964743
D007501	Iron	[GGTI 298 results in decreased expression of TFRC protein] which results in decreased uptake of Iron	24964743
D007501	Iron	[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA	12393473
D007501	Iron	HFE protein inhibits the reaction [TFRC protein results in increased uptake of Iron]	10085150
D007501	Iron	[Iron binds to TF protein] which binds to TFRC protein	16564538
D007501	Iron	Iron results in increased expression of TFRC protein	16988136
D007501	Iron	[TF protein binds to Iron] which binds to TFRC protein	19859668
D007501	Iron	TFRC protein results in increased uptake of Iron	17101452
D007501	Iron	[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA	16988052
D007501	Iron	[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA	24569067
D007501	Iron	Iron deficiency results in increased expression of TFRC mRNA	23776592
D007501	Iron	Iron inhibits the reaction [Diethylnitrosamine results in increased expression of TFRC protein]	19061943
D007501	Iron	Iron results in increased expression of TFRC mRNA	24569067
D007501	Iron	Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA]	24569067
D007501	Iron	Quercetin inhibits the reaction [Iron results in increased expression of TFRC mRNA]	24569067
D007501	Iron	TFRC protein affects the metabolism of Iron	17194590
D007501	Iron	[Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA	18073202
D007501	Iron	[Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein	18073202
D007501	Iron	Clofibrate inhibits the reaction [Iron deficiency results in increased expression of TFRC mRNA]	11969379
D007501	Iron	Iron affects the expression of TFRC mRNA	16428268
D007501	Iron	Iron affects the expression of TFRC protein	16428268
D007501	Iron	[Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of TFRC mRNA	20302851
D007501	Iron	[Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC mRNA	20302851
D007501	Iron	[Iron co-treated with Diethylnitrosamine] results in decreased expression of TFRC protein	20302851
D007501	Iron	Iron deficiency results in increased expression of TFRC mRNA	11969379\|1662916
D007501	Iron	Iron deficiency results in increased expression of TFRC protein	17060373\|2245724
D007501	Iron	Iron results in decreased expression of TFRC mRNA	11068183
D007501	Iron	TFRC protein results in increased uptake of Iron	17091493
D007501	Iron	[[TF protein binds to Iron] which binds to TFRC protein] which results in increased uptake of Iron	19859668
D058085	Iron Compounds	Iron Compounds results in decreased expression of TFRC mRNA	28483490
D058085	Iron Compounds	Iron Compounds results in decreased expression of TFRC mRNA	9504407
D019266	Iron, Dietary	"Iron, Dietary affects the expression of TFRC mRNA"	15637178
C515100	iron pentacarbonyl	iron pentacarbonyl inhibits the reaction [Streptozocin results in increased expression of TFRC mRNA]	22170771
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of TFRC mRNA	24848799
D007545	Isoproterenol	Isoproterenol results in decreased expression of TFRC protein	2989362
D007545	Isoproterenol	Isoproterenol results in decreased expression of TFRC mRNA	20003209
C545474	JAI-51	JAI-51 results in decreased expression of TFRC protein	24134853
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of TFRC mRNA	27392435
C119620	kenpaullone	kenpaullone results in increased expression of TFRC mRNA	25633564
C031895	lead chromate	lead chromate results in increased expression of TFRC mRNA	23584427
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]	18390722
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of TFRC mRNA	11054110
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TFRC mRNA	11054110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TFRC mRNA	10975854
D008070	Lipopolysaccharides	Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]	16401727
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA	16401727
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of TFRC mRNA	19000923
C032881	lysophosphatidic acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C032881	lysophosphatidic acid	[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA	21915944
C032881	lysophosphatidic acid	[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein	21915944
C032881	lysophosphatidic acid	lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
C032881	lysophosphatidic acid	lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C032881	lysophosphatidic acid	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
C032881	lysophosphatidic acid	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C032881	lysophosphatidic acid	WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
D058185	Magnetite Nanoparticles	Deferoxamine affects the reaction [Magnetite Nanoparticles results in decreased expression of TFRC mRNA]	23086747
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of TFRC mRNA	25522732
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in decreased expression of TFRC mRNA	23086747
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TFRC mRNA	21641980\|2308674
D008345	Manganese	Manganese results in increased expression of TFRC mRNA	23499988
D008345	Manganese	Manganese results in increased expression of TFRC mRNA	16545456
D008345	Manganese	Manganese results in increased expression of TFRC protein	16568477\|1670504
C025340	manganese chloride	manganese chloride results in increased expression of TFRC mRNA	15893546\|1654545
C025340	manganese chloride	manganese chloride results in increased expression of TFRC protein	15893546\|1592201
D008550	Melatonin	Melatonin results in decreased expression of TFRC mRNA	17091493\|1857163
D008550	Melatonin	Melatonin results in decreased expression of TFRC protein	17091493
D015122	Mercaptopurine	Mercaptopurine results in decreased expression of TFRC mRNA	23358152
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of TFRC protein	9693280
D008701	Methapyrilene	Methapyrilene results in increased expression of TFRC mRNA	28935588
D008701	Methapyrilene	Methapyrilene results in increased expression of TFRC mRNA	28935588
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFRC gene	20938992
C005219	methyl cellosolve	methyl cellosolve results in increased expression of TFRC mRNA	19643169
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of TFRC protein	26558463
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TFRC mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TFRC protein	12523938
D015655	1-Methyl-4-phenylpyridinium	TFRC protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]	12523938
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TFRC protein	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TFRC protein	12523938
D015655	1-Methyl-4-phenylpyridinium	TFRC protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]	12523938
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]"	20230807
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC mRNA]	24964743
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]	24964743
C011309	mezerein	mezerein results in increased expression of TFRC mRNA	19000923
C089950	MF59 oil emulsion	MF59 oil emulsion promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein]	18390722
C523184	mocetinostat	mocetinostat results in decreased expression of TFRC mRNA	27255383
D016686	Monocrotaline	Monocrotaline results in increased expression of TFRC mRNA	28818515
C437683	motexafin gadolinium	motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]	16357179
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of TFRC mRNA	16357179
C104820	N-(3-(aminomethyl)benzyl)acetamidine	N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]	24964743
C104820	N-(3-(aminomethyl)benzyl)acetamidine	N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [GGTI 298 results in decreased expression of TFRC protein]	24964743
C496401	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TFRC mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TFRC mRNA"	25620056
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of TFRC mRNA	19812364
C051752	nefazodone	nefazodone results in increased expression of TFRC mRNA	24136188
D009525	Niacin	Niacin results in decreased expression of TFRC protein	18549825
C022838	nickel chloride	[nickel chloride results in increased activity of ACO1 protein] which results in increased expression of and results in increased stability of TFRC mRNA	16039939
C022838	nickel chloride	nickel chloride results in increased expression of TFRC mRNA	16039939
C022838	nickel chloride	nickel chloride results in increased expression of TFRC mRNA	24577088
C028007	nickel monoxide	nickel monoxide affects the expression of TFRC mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of TFRC mRNA	16166746
D009538	Nicotine	[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA	28065790
D009538	Nicotine	Nicotine results in increased expression of TFRC mRNA	16949557
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]"	20230807
C012655	nimesulide	nimesulide results in increased expression of TFRC mRNA	24136188
D009569	Nitric Oxide	[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC	24964743
D009599	Nitroprusside	[Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of TFRC mRNA	12393473
C504137	nitrosonium ion	[Nitroprusside results in increased abundance of nitrosonium ion] which results in decreased expression of TFRC mRNA	12393473
C570897	NSC668394	NSC668394 results in increased expression of TFRC mRNA	27137931
D019319	Okadaic Acid	Okadaic Acid results in increased expression of TFRC mRNA	19000923
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of TFRC mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of TFRC mRNA	25729387
C029341	oxophenylarsine	oxophenylarsine affects the localization of TFRC protein	2643384
D010100	Oxygen	[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of TFRC protein	17442736
D010100	Oxygen	[Deferoxamine results in decreased abundance of Oxygen] which results in increased expression of TFRC protein	17442736
D010100	Oxygen	Oxygen deficiency results in increased expression of TFRC mRNA	19502547
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of TFRC mRNA	18636392
D010126	Ozone	Ozone results in increased expression of TFRC mRNA	16716893
D000073878	Palm Oil	Palm Oil affects the expression of TFRC mRNA	19680557
C010272	palytoxin	palytoxin results in increased expression of TFRC protein	20025956
D010269	Paraquat	Paraquat results in increased expression of TFRC mRNA	16854511
D052638	Particulate Matter	Particulate Matter results in increased expression of TFRC mRNA	23638009
D010396	Penicillamine	Penicillamine results in increased expression of TFRC mRNA	19575532
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TFRC mRNA	27614199
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TFRC protein	20025956
D015232	Dinoprostone	Dinoprostone results in decreased expression of TFRC protein	2989362
D010634	Phenobarbital	Phenobarbital results in increased expression of TFRC mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of TFRC mRNA	19162173
D019800	Phenol	Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]	21414390
D019800	Phenol	Phenol results in decreased expression of TFRC protein	21414390
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TFRC mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of TFRC mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of TFRC mRNA	15728792
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TFRC mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of TFRC mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of TFRC mRNA	18445702\|2081375
D010936	Plant Extracts	Plant Extracts results in increased expression of TFRC mRNA	18061397
D008926	Plicamycin	Plicamycin results in increased expression of TFRC mRNA	23814049
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TFRC mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TFRC mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of TFRC mRNA	18556351
D011374	Progesterone	Progesterone results in increased expression of TFRC mRNA	20726854
D019946	Propylene Glycol	[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA	28065790
C045950	propiconazole	propiconazole results in increased expression of TFRC mRNA	21278054
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TFRC mRNA]	28003376
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in increased expression of TFRC mRNA	25626140
D011791	Quartz	Quartz results in increased expression of TFRC mRNA	19836432
D011794	Quercetin	ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein]	17364964
D011794	Quercetin	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
D011794	Quercetin	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
D011794	Quercetin	Quercetin results in decreased expression of TFRC protein	19207037
D011794	Quercetin	Quercetin results in increased expression of TFRC protein	17364964
D011794	Quercetin	[Dietary Fats co-treated with Quercetin] affects the expression of TFRC mRNA	25047408
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in increased expression of TFRC mRNA]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [[Iron co-treated with Ethanol] results in increased expression of TFRC mRNA]	24569067
D011794	Quercetin	Quercetin inhibits the reaction [Iron results in increased expression of TFRC mRNA]	24569067
D011794	Quercetin	Quercetin affects the expression of TFRC mRNA	18178720
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of TFRC mRNA	12154049
D011899	Ranitidine	Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]	16401727
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA	16401727
C052785	rebamipide	rebamipide results in increased expression of TFRC mRNA	18299717
C059514	resveratrol	resveratrol results in decreased expression of TFRC mRNA	25667456
C059514	resveratrol	resveratrol results in increased expression of TFRC protein	24526417
D015474	Isotretinoin	Isotretinoin results in decreased expression of TFRC mRNA	20436886
C116926	rofecoxib	rofecoxib affects the expression of TFRC mRNA	17070997
C089730	rosiglitazone	rosiglitazone results in increased expression of TFRC mRNA	24848799
D012439	Saccharin	Saccharin results in increased expression of TFRC mRNA	19000923
D012524	Sarin	Sarin results in decreased expression of TFRC mRNA	19522546
C016727	sepiapterin	sepiapterin results in decreased expression of TFRC protein	24964743
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TFRC mRNA	25351596
D019821	Simvastatin	Simvastatin affects the expression of TFRC protein	16387846
D012906	Smoke	Smoke results in increased expression of TFRC mRNA	20015843
C017947	sodium arsenite	sodium arsenite results in increased expression of TFRC mRNA	12377979
C017947	sodium arsenite	sodium arsenite results in increased expression of TFRC mRNA	19000923
C016104	sodium bichromate	sodium bichromate results in increased expression of TFRC mRNA	22561333
D053260	Soot	Soot results in increased expression of TFRC mRNA	22461453\|2655175
C023599	stannous chloride	stannous chloride results in increased expression of TFRC mRNA	19000923
D013311	Streptozocin	iron pentacarbonyl inhibits the reaction [Streptozocin results in increased expression of TFRC mRNA]	22170771
D013311	Streptozocin	Streptozocin results in increased expression of TFRC mRNA	22170771
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of TFRC mRNA	16214533
D004113	Succimer	[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of TFRC mRNA	25522732
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TFRC mRNA	21641980\|2308674
D013412	Sulfadimethoxine	Sulfadimethoxine results in increased expression of TFRC mRNA	19000923
C016766	sulforafan	[sulforafan co-treated with Aflatoxin B1] affects the expression of TFRC mRNA	25450479
D016559	Tacrolimus	Tacrolimus results in decreased expression of TFRC protein	1701765
C013698	tallow	tallow affects the expression of TFRC mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of TFRC mRNA	20937368
C001803	tempol	tempol results in increased expression of TFRC protein	18073202
D013739	Testosterone	Testosterone results in increased expression of TFRC protein	16002536
D013739	Testosterone	Testosterone results in decreased expression of TFRC mRNA	15788153\|2166921
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of TFRC mRNA	20189893
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of TFRC mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TFRC mRNA	18061397
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TFRC mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TFRC mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TFRC mRNA	23238561
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TFRC mRNA	19770486\|2597527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TFRC protein	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TFRC mRNA	16466705\|2095900
D013755	Tetradecanoylphorbol Acetate	catechol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TFRC protein]	12749906
D013755	Tetradecanoylphorbol Acetate	hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TFRC protein]	12749906
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TFRC protein	12749906
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TFRC mRNA	19000923
D013755	Tetradecanoylphorbol Acetate	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TFRC protein	9766631
D013853	Thioacetamide	Thioacetamide results in increased expression of TFRC mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of TFRC mRNA	23557971\|2776080
C117091	titanium(IV) transferrin	TF protein modified form inhibits the reaction [titanium(IV) transferrin binds to TFRC protein]	18225897
C117091	titanium(IV) transferrin	titanium(IV) transferrin binds to TFRC protein	18225897
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TFRC mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TFRC mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of TFRC mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of TFRC mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of TFRC mRNA	23228038
D014212	Tretinoin	Dexamethasone promotes the reaction [Tretinoin results in decreased expression of TFRC protein]	7909661
D014212	Tretinoin	Tretinoin results in decreased expression of TFRC mRNA	16054129
D014212	Tretinoin	Tretinoin results in decreased expression of TFRC protein	7909661
D014212	Tretinoin	Tretinoin results in decreased expression of TFRC mRNA	16604517
C011559	tributyltin	tributyltin results in increased expression of TFRC mRNA	24848799
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of TFRC mRNA	19042947
C000588561	tris(4-methyl-1-pyrazolyl)borohydride	tris(4-methyl-1-pyrazolyl)borohydride results in increased expression of TFRC protein	24412237
C057693	troglitazone	troglitazone results in increased expression of TFRC mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in decreased expression of TFRC mRNA	22378314
D014520	Urethane	Urethane results in increased expression of TFRC mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of TFRC mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased expression of TFRC mRNA	23527032
D014635	Valproic Acid	Valproic Acid results in decreased expression of TFRC mRNA	20546886
D014638	Vanadates	Vanadates results in increased expression of TFRC mRNA	19000923
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of TFRC gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of TFRC mRNA	23034163
D014801	Vitamin A	Vitamin A results in decreased expression of TFRC protein	16960172
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TFRC mRNA	20044591
C519885	WP1066	WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C066632	yessotoxin	yessotoxin results in increased expression of TFRC protein	25576684
D015032	Zinc	Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D015032	Zinc	[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D015032	Zinc	etiron promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D015032	Zinc	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]	18073202
D015032	Zinc	[Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA	18073202
D015032	Zinc	[Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein	18073202
D015032	Zinc	Zinc deficiency results in increased expression of TFRC mRNA	18073202
D015032	Zinc	Zinc deficiency results in increased expression of TFRC protein	18073202
D019345	Zinc Acetate	motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of TFRC mRNA	16357179
C016837	zinc chloride	zinc chloride results in increased expression of TFRC mRNA	19000923
C088658	zoledronic acid	zoledronic acid results in increased expression of TFRC mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0003723	RNA binding	-	HDA	22658674
GO:0003725	double-stranded RNA binding	-	IDA	21266579
GO:0004998	transferrin receptor activity	-	IC	18353247
GO:0004998	transferrin receptor activity	-	IDA	26642240
GO:0004998	transferrin receptor activity	-	NAS	1871153
GO:0005515	protein binding	-	IPI	9465039 9546397 9990067 10638746 14691533 15965644 16271884 16325581 16354665 18353247 20133674 20404192 20618438 21788477 23384347 25416956 26642240
GO:0033570	transferrin transmembrane transporter activity	-	IEA	-
GO:0042802	identical protein binding	-	IPI	20208545 23384347
GO:0042803	protein homodimerization activity	-	IPI	9546397

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	NOT	IMP	7556058
GO:0006879	cellular iron ion homeostasis	-	NAS	1871153
GO:0030316	osteoclast differentiation	-	IEA	-
GO:0030890	positive regulation of B cell proliferation	-	IDA	26642240
GO:0031623	receptor internalization	-	IDA	26642240
GO:0033572	transferrin transport	-	IC	18353247
GO:0033572	transferrin transport	-	IDA	26642240
GO:0033572	transferrin transport	-	TAS	-
GO:0035690	cellular response to drug	-	IDA	16254249
GO:0042102	positive regulation of T cell proliferation	-	IDA	26642240
GO:0042127	regulation of cell proliferation	NOT	IMP	7556058
GO:0045780	positive regulation of bone resorption	-	IEA	-
GO:0045830	positive regulation of isotype switching	-	IDA	26642240
GO:0046718	viral entry into host cell	-	IEA	-
GO:0061024	membrane organization	-	TAS	-
GO:0097286	iron ion import	-	IDA	7556058
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	1871153
GO:0005615	extracellular space	-	HDA	22664934
GO:0005768	endosome	-	IDA	14612438
GO:0005769	early endosome	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IGI	18353247
GO:0005905	clathrin-coated pit	-	IDA	12857860
GO:0009897	external side of plasma membrane	-	IGI	18353247
GO:0009986	cell surface	-	IDA	7556058
GO:0010008	endosome membrane	-	IDA	16380373
GO:0010008	endosome membrane	-	TAS	-
GO:0016020	membrane	-	NAS	1871153
GO:0016323	basolateral plasma membrane	-	IDA	9990067
GO:0030665	clathrin-coated vesicle membrane	-	TAS	-
GO:0031410	cytoplasmic vesicle	-	IDA	15229288
GO:0042470	melanosome	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	16380373 20202662
GO:0055037	recycling endosome	-	IDA	22456507 24561039
GO:0070062	extracellular exosome	-	HDA	20458337
GO:0072562	blood microparticle	-	HDA	22516433
GO:1903561	extracellular vesicle	-	HDA	24769233
GO:1990712	HFE-transferrin receptor complex	-	IDA	9465039 9546397 9990067

KEGG ID	KEGG Term
hsa04144	Endocytosis
hsa04145	Phagosome
hsa04640	Hematopoietic cell lineage

Reactome ID	Reactome Term	Evidence
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199992	trans-Golgi Network Vesicle Budding	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-421837	Clathrin derived vesicle budding	TAS
R-HSA-432722	Golgi Associated Vesicle Biogenesis	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS
R-HSA-917937	Iron uptake and transport	TAS
R-HSA-917977	Transferrin endocytosis and recycling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29291011	Transferrin receptor 1 upregulation in primary tumor and downregulation in benign kidney is associated with progression and mortality in renal cell carcinoma patients. (2017 Dec 5)	Greene CJ	Oncotarget
25915522	Transferrin receptor levels and polymorphism of its gene in age-related macular degeneration. (2015)	Wysokinski D	Acta Biochim Pol