Gene: TGFA

7039
TFGA
transforming growth factor alpha
protein-coding
2p13.3
Ensembl:ENSG00000163235 MIM:190170 Vega:OTTHUMG00000129669 UniprotKB:P01135
NG_029975.1
PubMed
ND
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.100e-1 (AD)  4.878e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FRMD4B0.884
FAM107B0.868
TMEM1440.862
EVI2A0.862
CLDND10.86
ERMN0.857
C21orf910.857
TMCC30.854
SLC44A10.854
TBC1D120.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.46
CHRNA2-0.444
PCDH8-0.414
PRTN3-0.411
LTK-0.406
SCRT2-0.406
ASB2-0.398
NEUROD1-0.396
SHROOM3-0.392
HCN4-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [ELANE protein results in increased expression of TGFA protein]"17456367
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[IL6 protein co-treated with HGF protein co-treated with TGFA protein] affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B1 mRNA]"27530964
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TGFA mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFA mRNA"21277884
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TGFA protein results in increased expression of FOS protein]19749156
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TGFA protein results in increased expression of GPER1 protein]19749156
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFA mRNA"21277884
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TGFA mRNA"8603490
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of TGFA mRNA21983209|2284181
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFA mRNA]12668121
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Silicon Dioxide analog results in increased secretion of TGFA protein]24844442
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in increased expression of TGFA mRNA20540524
C0652504-hydroxy-equileninfulvestrant inhibits the reaction [4-hydroxy-equilenin results in increased expression of TGFA mRNA]20540524
C0415944-nonylphenol4-nonylphenol results in increased secretion of TGFA protein28703301
C0415944-nonylphenolADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]28703301
C0415944-nonylphenolADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]28703301
C0415944-nonylphenolGW280264X inhibits the reaction [4-nonylphenol results in increased secretion of TGFA protein]28703301
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one promotes the reaction [gefitinib inhibits the reaction [TGFA protein results in increased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one]]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"[5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] which results in increased expression of TGFA mRNA"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in increased expression of TGFA mRNA"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in increased expression of TGFA protein"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"gefitinib inhibits the reaction [TGFA protein results in increased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"TGFA protein inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of EGFR protein]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"TGFA protein inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MAPK1 protein]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"TGFA protein inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of MAPK3 protein]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"TGFA protein inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of RPS6 protein]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"TGFA protein results in increased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"21266357
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein]15342401
D000082AcetaminophenAcetaminophen results in increased expression of TGFA mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]15945272
C058956acteoside[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA21756928
C058956acteosideacteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]21967610
C058956acteosideacteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]21967610
C058956acteosideacteoside inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
C058956acteosideacteoside inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
C058956acteosideacteoside inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]21967610
C058956acteosideacteoside inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]21967610
C058956acteosideacteoside inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]21967610
C058956acteosideacteoside inhibits the reaction [TGFA protein results in increased phosphorylation of EGFR protein]21967610
C058956acteosideacteoside results in decreased susceptibility to TGFA protein21967610
C058956acteosideacteoside results in increased susceptibility to TGFA protein21967610
C058956acteoside[leptomycin B co-treated with TGFA protein co-treated with acteoside] affects the localization of EGFR protein modified form21967610
C058956acteosidePD168393 inhibits the reaction [[TGFA protein co-treated with acteoside] results in increased expression of CXCL8 mRNA]21967610
C058956acteoside[TGFA protein co-treated with acteoside] results in increased expression of CXCL8 mRNA21967610
D000393Air PollutantsAir Pollutants analog results in increased expression of TGFA mRNA21757418
D024502alpha-Tocopherolalpha-Tocopherol results in decreased susceptibility to TGFA protein7593635
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TGFA mRNA16483693
D000728AndrogensTGFA protein results in increased abundance of Androgens15353178
D039741Antigens, Dermatophagoides"Antigens, Dermatophagoides results in increased secretion of TGFA protein"12077271
D039741Antigens, Dermatophagoides"Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of TGFA protein]"12077271
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TGFA mRNA24449571
C526219apple polyphenol extractapple polyphenol extract results in increased expression of TGFA mRNA18351577
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of TGFA mRNA19962721
D001151ArsenicArsenic results in decreased expression of TGFA mRNA19962721
D001151ArsenicArsenic results in increased expression of TGFA mRNA19945496
D001151ArsenicArsenic results in increased expression of TGFA protein17056473
C006632arsenic trioxideTGFA protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite results in increased expression of TGFA mRNA25257954
C015001arsenitearsenite results in increased expression of TGFA protein25257954
C015001arsenitearsenite results in increased methylation of TGFA promoter23974009
D001241Aspirin[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA9726391
D001241AspirinAspirin results in decreased expression of TGFA mRNA12231391
C080985batimastatbatimastat inhibits the reaction [TAC1 protein results in increased secretion of TGFA protein]15319441
C080985batimastatbatimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TGFA protein]27117977
C080985batimastatbatimastat results in decreased secretion of TGFA protein27117977
D004958EstradiolEstradiol affects the expression of TGFA mRNA14699072
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of TGFA mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TGFA mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFA mRNA19619570
D004958EstradiolEstradiol results in increased expression of TGFA mRNA11813992|1512041
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]20540524
D004958EstradiolTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of TGFA mRNA]24758408
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]24758408
D004958EstradiolBromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]1534540
D004958EstradiolEstradiol results in increased expression of TGFA mRNA11498938|1534540
D004958EstradiolEstradiol results in increased expression of TGFA mRNA12594813
C006780bisphenol Abisphenol A affects the expression of TGFA mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of TGFA mRNA19371625|2301914
C006780bisphenol A[ADAM17 protein co-treated with ADAM10 protein] affects the reaction [bisphenol A results in increased secretion of TGFA protein]28703301
C006780bisphenol Abisphenol A results in decreased expression of TGFA mRNA26063408
C006780bisphenol Abisphenol A results in increased secretion of TGFA protein28703301
C006780bisphenol AGW280264X inhibits the reaction [bisphenol A results in increased secretion of TGFA protein]28703301
C006780bisphenol Abisphenol A affects the expression of TGFA mRNA25181051
D001971BromocriptineBromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]1534540
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased susceptibility to TGFA protein7593635
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TGFA mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of TGFA mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of TGFA mRNA17720352
D002118CalciumTGFA protein results in increased abundance of Calcium11527950
D002118CalciumTGFA protein inhibits the reaction [Neomycin results in decreased abundance of Calcium]9263032
D002118CalciumTGFA protein results in increased abundance of Calcium9263032
D002211CapsaicinCapsaicin results in increased expression of TGFA mRNA11989832
D002211CapsaicinCapsaicin results in increased expression of TGFA protein11989832
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TGFA mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TGFA mRNA17468546
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of TGFA protein25858767
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGFA mRNA17631135|8847708
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TGFA mRNA24763279
D000068579CelecoxibCelecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]15309881
D004390ChlorpyrifosChlorpyrifos results in increased expression of TGFA mRNA20350560
C551994crizotinibEGFR protein promotes the reaction [TGFA protein results in decreased susceptibility to crizotinib]22553343
C551994crizotinibErlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib]22553343
C551994crizotinibTGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of AKT1 protein]22553343
C551994crizotinibTGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK1 protein]22553343
C551994crizotinibTGFA protein inhibits the reaction [crizotinib results in decreased phosphorylation of MAPK3 protein]22553343
C551994crizotinibTGFA protein results in decreased susceptibility to crizotinib22553343
D003471CuprizoneCuprizone results in decreased expression of TGFA mRNA26577399|2752363
D003513CycloheximideCycloheximide results in increased expression of TGFA mRNA15228094
C093628cyproconazolecyproconazole results in increased expression of TGFA mRNA22334560
C515055darinaparsindarinaparsin results in decreased expression of TGFA mRNA22535156
C014347decitabinedecitabine results in increased expression of TGFA mRNA27915011
D003907Dexamethasone"Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of TGFA protein]"12077271
D003980DiazooxonorleucineDiazooxonorleucine inhibits the reaction [Glucose results in increased expression of TGFA mRNA]8638660
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TGFA mRNA21266533
D002945CisplatinCisplatin results in increased expression of TGFA mRNA27392435|2759478
D002945CisplatinTGFA protein results in decreased susceptibility to Cisplatin16734730
D004008DiclofenacDiclofenac results in increased expression of TGFA mRNA19022234
D004041Dietary FatsDietary Fats results in increased expression of TGFA mRNA25016146
D004052DiethylnitrosamineBCL2 protein inhibits the reaction [TGFA protein results in increased susceptibility to Diethylnitrosamine]12000706
D004052Diethylnitrosamine[Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein28634113
D004052Diethylnitrosamine[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein28634113
D004052DiethylnitrosamineTGFA protein results in increased susceptibility to Diethylnitrosamine12000706
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TGFA mRNA15660382|1866515
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TGFA protein18367157
D004052DiethylnitrosaminePlant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of TGFA protein]18367157
D004052DiethylnitrosamineTGFA affects the susceptibility to Diethylnitrosamine7923571
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TGFA mRNA19371625
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TGFA mRNA15336711
D002117CalcitriolCalcitriol results in increased expression of TGFA mRNA16002434
D004177DipyroneDipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]15309881
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]15987631
C109476epoxiconazoleepoxiconazole results in increased expression of TGFA mRNA22334560
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib]22553343
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TGFA mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TGFA mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TGFA mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TGFA mRNA23550701
D005047EtoposideEtoposide results in increased expression of TGFA mRNA15228094
C574336excavatolide Bexcavatolide B results in decreased expression of TGFA protein26790859
D015025ZearalenoneZearalenone results in increased expression of TGFA mRNA19371625
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of TGFA mRNA8340253
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of TGFA protein8340253
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of TGFA mRNA19962721
D005459FluoridesFluorides results in decreased expression of TGFA mRNA19962721
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of TGFA mRNA]15016801
D005557FormaldehydeFormaldehyde results in decreased expression of TGFA mRNA28937961
C070081fulvestrantfulvestrant inhibits the reaction [4-hydroxy-equilenin results in increased expression of TGFA mRNA]20540524
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]20540524
C070081fulvestrantfulvestrant inhibits the reaction [resveratrol results in increased expression of TGFA mRNA]12594813
D005665FurosemideFurosemide results in increased expression of TGFA mRNA16526316
C419708gefitinib"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one promotes the reaction [gefitinib inhibits the reaction [TGFA protein results in increased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one]]"21266357
C419708gefitinibgefitinib inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]15723263
C419708gefitinibgefitinib inhibits the reaction [irinotecan results in increased secretion of TGFA protein]15723263
C419708gefitinib"gefitinib inhibits the reaction [TGFA protein results in increased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one]"21266357
C419708gefitinibTGFA protein results in decreased susceptibility to gefitinib16230376
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of EDNRB mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of FOXF1 mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of KDR mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of PECAM1 mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of TEK mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in decreased expression of VEGFA mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in increased expression of MDK mRNA]18424623
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in increased expression of SERPINF1 mRNA]18424623
D019833GenisteinGenistein inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]10783318
D019833GenisteinGenistein results in increased expression of TGFA mRNA19371625|2301914
D019833Genistein[Genistein co-treated with vinclozolin] affects the expression of TGFA mRNA23410115
D019833Genistein[Genistein co-treated with vinclozolin] results in decreased expression of TGFA mRNA22317923
D019833GenisteinGenistein results in decreased expression of TGFA mRNA23410115
D005944GlucosamineGlucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]1518840
D005944Glucosamine[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein1518840
D005947GlucoseDiazooxonorleucine inhibits the reaction [Glucose results in increased expression of TGFA mRNA]8638660
D005947GlucoseEGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]8638660
D005947GlucoseGlucose promotes the reaction [EGF protein results in increased expression of TGFA mRNA]8638660
D005947GlucoseGlucose results in increased expression of TGFA mRNA8638660
D005947GlucoseGlucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]1518840
D005947Glucose[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein1518840
D005947GlucoseGlucose results in increased expression of TGFA mRNA1518840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TGFA mRNA24763279
C492546GW280264XGW280264X inhibits the reaction [4-nonylphenol results in increased secretion of TGFA protein]28703301
C492546GW280264XGW280264X inhibits the reaction [bisphenol A results in increased secretion of TGFA protein]28703301
C492546GW280264XGW280264X inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TGFA protein]28703301
D006581Hexachlorobenzene[Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein28634113
D006581Hexachlorobenzene[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein28634113
D017313FenretinideFenretinide results in increased expression of TGFA mRNA28973697
D006851Hydrochloric Acid[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA9726391
D006851Hydrochloric AcidCelecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]15309881
D006851Hydrochloric AcidDipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]15309881
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of TGFA protein15309881
D006851Hydrochloric AcidPiroxicam promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]15309881
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGFA mRNA25613284
C051890irinotecangefitinib inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]15723263
C051890irinotecangefitinib inhibits the reaction [irinotecan results in increased secretion of TGFA protein]15723263
C051890irinotecanirinotecan metabolite results in increased secretion of TGFA protein15723263
C051890irinotecanirinotecan results in increased secretion of TGFA protein15723263
C051890irinotecanrottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]15723263
C051890irinotecanrottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein]15723263
C051890irinotecanTGFA protein results in decreased susceptibility to irinotecan16734730
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of TGFA mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TGFA mRNA25961927
C006552kaempferolkaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]10783318
C107086KB R7785KB R7785 inhibits the reaction [CXCL8 protein results in increased cleavage of and results in increased secretion of TGFA protein]15300588
D064747LansoprazoleLansoprazole results in increased expression of TGFA protein9881512
C045463leflunomideleflunomide results in increased expression of TGFA mRNA28988120
C038753leptomycin Bacteoside inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
C038753leptomycin Bacteoside inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
C038753leptomycin B[leptomycin B co-treated with TGFA protein co-treated with acteoside] affects the localization of EGFR protein modified form21967610
C038753leptomycin B[leptomycin B co-treated with TGFA protein co-treated with polydatin] affects the localization of EGFR protein modified form21967610
C038753leptomycin B[leptomycin B co-treated with TGFA protein co-treated with Quercetin] affects the localization of EGFR protein21967610
C038753leptomycin B[leptomycin B co-treated with TGFA protein co-treated with Quercetin] affects the localization of EGFR protein modified form21967610
C038753leptomycin B[leptomycin B co-treated with TGFA protein co-treated with resveratrol] affects the localization of EGFR protein modified form21967610
C038753leptomycin B[leptomycin B co-treated with TGFA protein co-treated with Rutin] affects the localization of EGFR protein modified form21967610
C038753leptomycin Bleptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]21967610
C038753leptomycin Bleptomycin B promotes the reaction [TGFA protein affects the localization of EGFR protein]21967610
C038753leptomycin Bleptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]21967610
C038753leptomycin BQuercetin inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
C038753leptomycin BQuercetin inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
C038753leptomycin Bresveratrol inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
C038753leptomycin Bresveratrol inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
C038753leptomycin BRutin inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
C038753leptomycin BRutin inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
C533894LG 100815LG 100815 results in increased expression of TGFA mRNA16951191
D008012LidocaineLidocaine results in decreased expression of TGFA protein18382663
C008281limonenelimonene results in increased expression of TGFA mRNA12815608
D008070LipopolysaccharidesDextromethorphan inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]15987631
D008070LipopolysaccharidesDizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]15987631
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of TGFA15987631
C015329lycopenelycopene results in increased expression of TGFA mRNA16886892
D008345ManganeseManganese results in increased expression of TGFA mRNA18284614
C100342marimastatmarimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein]15342401
D008555MelittenMelitten results in increased secretion of TGFA protein22613720
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TGFA mRNA10901180
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TGFA protein10901180
D003915DextromethorphanDextromethorphan inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]15987631
D008727MethotrexateMethotrexate results in decreased expression of TGFA mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of TGFA mRNA21678067
D008727MethotrexateTGFA protein inhibits the reaction [Methotrexate results in decreased expression of BCL2 mRNA]18803016
D008727MethotrexateTGFA protein inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]18803016
D008727MethotrexateTGFA protein inhibits the reaction [Methotrexate results in increased expression of BAX mRNA]18803016
D008727MethotrexateTGFA protein inhibits the reaction [Methotrexate results in increased expression of BAX protein]18803016
D015735MifepristoneMifepristone results in decreased expression of TGFA mRNA18591650
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TGFA mRNA20886546
D009151Mustard GasMustard Gas results in increased expression of TGFA mRNA18955075
C092152N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased expression of TGFA protein]"17456367
C092152N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Silicon Dioxide analog results in increased secretion of TGFA protein]"24844442
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D009355NeomycinTGFA protein inhibits the reaction [Neomycin results in decreased abundance of Calcium]9263032
C029938nickel sulfateTGFA protein affects the susceptibility to nickel sulfate19131640
C029938nickel sulfate[TGFA protein binds to and affects the activity of EGFR protein] which results in decreased susceptibility to nickel sulfate19131640
C029938nickel sulfateTGFA protein inhibits the reaction [nickel sulfate results in decreased expression of SFTPB protein]11954676
D009538NicotineNicotine results in increased secretion of TGFA protein17630920
D009583NitrofurazoneAcetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]15945272
D009583NitrofurazoneNitrofurazone results in increased expression of TGFA mRNA15945272
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TGFA mRNA17616710
C516714NVP-TAE684TGFA protein results in decreased susceptibility to NVP-TAE68422553343
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of TGFA mRNA"16951191
C016340o,p'-DDT"o,p'-DDT results in increased expression of TGFA mRNA"19371625
D010100OxygenOxygen deficiency results in increased expression of TGFA mRNA11171960
D010100OxygenOxygen deficiency results in increased expression of TGFA protein11171960
D010126OzoneOzone results in increased expression of TGFA protein26464147
D010269ParaquatParaquat affects the expression of TGFA mRNA15206577|1685451
D052638Particulate MatterAR protein affects the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate Matter[AR protein co-treated with TGFA protein co-treated with HBEGF protein] affects the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate MatterEGFR protein affects the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate MatterHBEGF protein affects the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate MatterN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate MatterParticulate Matter results in increased expression of TGFA mRNA24555532
D052638Particulate MatterParticulate Matter results in increased secretion of TGFA protein22820758|2455553
D052638Particulate MatterTGFA protein affects the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate Mattertyrphostin AG 1478 inhibits the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
D052638Particulate MatterParticulate Matter results in increased expression of TGFA mRNA22820758
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFA mRNA"21277884
C509204PD168393PD168393 inhibits the reaction [TGFA protein affects the localization of EGFR protein]21967610
C509204PD168393PD168393 inhibits the reaction [TGFA protein affects the localization of EGFR protein modified form]21967610
C509204PD168393PD168393 inhibits the reaction [[TGFA protein co-treated with acteoside] results in increased expression of CXCL8 mRNA]21967610
C509204PD168393PD168393 inhibits the reaction [[TGFA protein co-treated with polydatin] results in increased expression of CXCL8 mRNA]21967610
C509204PD168393PD168393 inhibits the reaction [[TGFA protein co-treated with polydatin] results in increased secretion of CXCL8 protein]21967610
C509204PD168393PD168393 inhibits the reaction [[TGFA protein co-treated with Quercetin] results in increased expression of CXCL8 mRNA]21967610
C509204PD168393PD168393 inhibits the reaction [[TGFA protein co-treated with resveratrol] results in increased expression of CXCL8 mRNA]21967610
C509204PD168393PD168393 inhibits the reaction [[TGFA protein co-treated with resveratrol] results in increased secretion of CXCL8 protein]21967610
C509204PD168393PD168393 inhibits the reaction [TGFA protein results in increased expression of CXCL8 mRNA]21967610
C509204PD168393PD168393 inhibits the reaction [TGFA protein results in increased secretion of CXCL8 protein]21967610
C509204PD168393PD168393 promotes the reaction [TGFA protein results in increased expression of CCL2 mRNA]21967610
C509204PD168393PD168393 promotes the reaction [TGFA protein results in increased expression of CXCL10 mRNA]21967610
C509204PD168393[PD168393 results in decreased activity of EGFR protein] which results in decreased susceptibility to TGFA protein21967610
D010634PhenobarbitalTGFA affects the susceptibility to Phenobarbital7923571
D010672PhenytoinPhenytoin results in increased expression of TGFA mRNA9988880
C018637phoronephorone affects the expression of TGFA mRNA18198479
C121565pifithrinpifithrin results in decreased expression of TGFA protein12143041
C121565pifithrinTP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]12143041
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TGFA mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of TGFA mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of TGFA mRNA19162173
D010894PiroxicamPiroxicam promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]15309881
D010936Plant ExtractsPlant Extracts results in increased expression of TGFA mRNA18351577
D010936Plant ExtractsPlant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of TGFA protein]18367157
C058229polydatin[polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA21756928
C058229polydatin[polydatin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA21756928
C058229polydatinpolydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein]21967610
C058229polydatin[leptomycin B co-treated with TGFA protein co-treated with polydatin] affects the localization of EGFR protein modified form21967610
C058229polydatinPD168393 inhibits the reaction [[TGFA protein co-treated with polydatin] results in increased expression of CXCL8 mRNA]21967610
C058229polydatinPD168393 inhibits the reaction [[TGFA protein co-treated with polydatin] results in increased secretion of CXCL8 protein]21967610
C058229polydatinpolydatin inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]21967610
C058229polydatinpolydatin promotes the reaction [[TGFA protein co-treated with IFNG protein] results in increased expression of and results in increased secretion of CXCL8 protein]21967610
C058229polydatinpolydatin promotes the reaction [[TGFA protein co-treated with IFNG protein] results in increased expression of CXCL8 mRNA]21967610
C058229polydatinpolydatin promotes the reaction [TGFA protein results in increased expression of CXCL8 mRNA]21967610
C058229polydatinpolydatin promotes the reaction [TGFA protein results in increased expression of CXCL8 protein]21967610
C058229polydatin[TGFA protein co-treated with polydatin] results in increased expression of CXCL8 mRNA21967610
C058229polydatin[TGFA protein co-treated with polydatin] results in increased secretion of CXCL8 protein21967610
C443641poly(propyleneimine)poly(propyleneimine) analog results in increased expression of TGFA mRNA16308212
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TGFA mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of TGFA mRNA18591650
C045950propiconazolepropiconazole results in increased expression of TGFA mRNA22334560
D011794Quercetin[Quercetin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA21756928
D011794Quercetin[Quercetin co-treated with TGFA protein] results in increased expression of TNF mRNA21756928
D011794QuercetinQuercetin inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]10783318
D011794QuercetinQuercetin inhibits the reaction [TGFA protein results in increased phosphorylation of AKT1 protein]12888923
D011794QuercetinQuercetin inhibits the reaction [TGFA protein results in increased phosphorylation of ELK1 protein]12888923
D011794QuercetinQuercetin inhibits the reaction [TGFA protein results in increased phosphorylation of ERBB2 protein]12888923
D011794QuercetinQuercetin inhibits the reaction [TGFA protein results in increased phosphorylation of ERBB3 protein]12888923
D011794QuercetinQuercetin inhibits the reaction [TGFA protein results in increased phosphorylation of RAF1 protein]12888923
D011794Quercetin[leptomycin B co-treated with TGFA protein co-treated with Quercetin] affects the localization of EGFR protein21967610
D011794Quercetin[leptomycin B co-treated with TGFA protein co-treated with Quercetin] affects the localization of EGFR protein modified form21967610
D011794QuercetinPD168393 inhibits the reaction [[TGFA protein co-treated with Quercetin] results in increased expression of CXCL8 mRNA]21967610
D011794QuercetinQuercetin inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
D011794QuercetinQuercetin inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
D011794QuercetinQuercetin inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]21967610
D011794QuercetinQuercetin inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]21967610
D011794QuercetinQuercetin inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]21967610
D011794QuercetinQuercetin promotes the reaction [TGFA protein affects the localization of EGFR protein]21967610
D011794QuercetinQuercetin promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]21967610
D011794QuercetinQuercetin results in increased susceptibility to TGFA protein21967610
D011794Quercetin[TGFA protein co-treated with Quercetin] results in increased expression of CXCL8 mRNA21967610
C005266quinomethionatequinomethionate affects the expression of TGFA mRNA15387888
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TGFA mRNA19059307
C031389resorcinolresorcinol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]10783318
C059514resveratrol[resveratrol co-treated with TGFA protein] results in increased expression of CXCL8 mRNA21756928
C059514resveratrolresveratrol inhibits the reaction [TGFA protein affects the localization of EGFR protein]21967610
C059514resveratrolresveratrol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]10783318
C059514resveratrolresveratrol results in increased expression of TGFA mRNA15120416
C059514resveratrolfulvestrant inhibits the reaction [resveratrol results in increased expression of TGFA mRNA]12594813
C059514resveratrol[leptomycin B co-treated with TGFA protein co-treated with resveratrol] affects the localization of EGFR protein modified form21967610
C059514resveratrolPD168393 inhibits the reaction [[TGFA protein co-treated with resveratrol] results in increased expression of CXCL8 mRNA]21967610
C059514resveratrolPD168393 inhibits the reaction [[TGFA protein co-treated with resveratrol] results in increased secretion of CXCL8 protein]21967610
C059514resveratrolresveratrol inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
C059514resveratrolresveratrol inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
C059514resveratrolresveratrol inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]21967610
C059514resveratrolresveratrol promotes the reaction [[TGFA protein co-treated with IFNG protein] results in increased expression of and results in increased secretion of CXCL8 protein]21967610
C059514resveratrolresveratrol promotes the reaction [[TGFA protein co-treated with IFNG protein] results in increased expression of CXCL8 mRNA]21967610
C059514resveratrolresveratrol promotes the reaction [TGFA protein results in increased expression of CXCL8 mRNA]21967610
C059514resveratrolresveratrol promotes the reaction [TGFA protein results in increased expression of CXCL8 protein]21967610
C059514resveratrolresveratrol results in increased expression of TGFA mRNA12594813
C059514resveratrol[TGFA protein co-treated with resveratrol] results in increased expression of CXCL8 mRNA21967610
C059514resveratrol[TGFA protein co-treated with resveratrol] results in increased secretion of CXCL8 protein21967610
C013672riddelliineriddelliine results in decreased expression of TGFA mRNA18047727
C085746rottlerinrottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]15723263
C085746rottlerinrottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein]15723263
D012431RutinRutin inhibits the reaction [TGFA protein affects the localization of EGFR protein]21967610
D012431Rutin[leptomycin B co-treated with TGFA protein co-treated with Rutin] affects the localization of EGFR protein modified form21967610
D012431RutinRutin inhibits the reaction [leptomycin B inhibits the reaction [TGFA protein results in decreased secretion of CCL2 protein]]21967610
D012431RutinRutin inhibits the reaction [leptomycin B promotes the reaction [TGFA protein results in increased secretion of CXCL8 protein]]21967610
D012431RutinRutin inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]21967610
D012431RutinRutin inhibits the reaction [[TGFA protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]21967610
D012431RutinRutin promotes the reaction [TGFA protein results in increased phosphorylation of EGFR protein]21967610
C410733scriptaidscriptaid affects the expression of TGFA mRNA18813790
D012822Silicon Dioxide4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Silicon Dioxide analog results in increased secretion of TGFA protein]24844442
D012822Silicon Dioxide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Silicon Dioxide analog results in increased secretion of TGFA protein]"24844442
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TGFA mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased secretion of TGFA protein24844442
D012906SmokeSmoke results in decreased nitrosation of TGFA protein21652289
C017947sodium arsenitesodium arsenite affects the methylation of TGFA gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased stability of TGFA mRNA8917704
C017947sodium arsenitesodium arsenite results in increased expression of TGFA mRNA20886546|9219559
C017947sodium arsenitesodium arsenite results in increased secretion of TGFA protein8917704|9219559
C017947sodium arsenitesodium arsenite results in increased expression of TGFA mRNA9846968
C017947sodium arsenitesodium arsenite results in increased expression of TGFA protein9846968
D013629TamoxifenTamoxifen affects the expression of TGFA mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of TGFA mRNA19059307
D013629TamoxifenTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of TGFA mRNA]24758408
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]24758408
D013749Tetrachlorodibenzodioxin3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFA mRNA]12668121
D013749Tetrachlorodibenzodioxin[AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]27117977
D013749Tetrachlorodibenzodioxin[AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]27117977
D013749Tetrachlorodibenzodioxinbatimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TGFA protein]27117977
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFA mRNA11309286|1148935
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFA protein11309286|1266812
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of TGFA protein2033054|27117977
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased stability of TGFA mRNA1447203
D013749TetrachlorodibenzodioxinSRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFA mRNA]14708085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFA mRNA12167310
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGFA mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGFA protein2260090
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFA mRNA14708085|1566782
D013749TetrachlorodibenzodioxinTGFA gene mutant form affects the susceptibility to Tetrachlorodibenzodioxin11399798
D013749TetrachlorodibenzodioxinTGFA gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PEPCK mRNA]16906519
D013749TetrachlorodibenzodioxinTGFA gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPB mRNA]16906519
D013749TetrachlorodibenzodioxinTGFA gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK1 mRNA]16906519
D013749TetrachlorodibenzodioxinTGFA gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SRC mRNA]16906519
D013749TetrachlorodibenzodioxinTGFA protein affects the susceptibility to Tetrachlorodibenzodioxin16906519
D013749Tetrachlorodibenzodioxin[TGFA protein co-treated with EGF protein] affects the susceptibility to Tetrachlorodibenzodioxin12520078
D013749TetrachlorodibenzodioxinTGFA protein results in decreased susceptibility to Tetrachlorodibenzodioxin14514962
D013749TetrachlorodibenzodioxinTretinoin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of TGFA protein]2260090
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased stability of TGFA mRNA10833433
D013755Tetradecanoylphorbol AcetateADAM17 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TGFA protein]28703301
D013755Tetradecanoylphorbol AcetateGW280264X inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TGFA protein]28703301
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of TGFA protein15066986
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of TGFA protein28703301
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGFA mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased secretion of TGFA protein27404394
D014212TretinoinTretinoin results in increased expression of TGFA mRNA21934132
D014212TretinoinTretinoin results in increased secretion of TGFA protein16473924
D014212TretinoinTretinoin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of TGFA protein]2260090
D014212TretinoinTretinoin results in increased expression of TGFA mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of TGFA mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TGFA mRNA19042947
C057693troglitazonetroglitazone results in increased expression of TGFA mRNA19022234
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Particulate Matter results in increased secretion of TGFA protein]24555532
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [TGFA protein results in increased expression of FOS protein]19749156
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [TGFA protein results in increased expression of GPER1 protein]19749156
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of AKT1 protein]11309286
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]11309286
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]11309286
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D014635Valproic AcidValproic Acid results in increased expression of TGFA mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of TGFA mRNA10689198
D014638VanadatesVanadates results in increased expression of TGFA mRNA22714537
D001335Vehicle EmissionsAR protein affects the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle Emissions[AR protein co-treated with TGFA protein co-treated with HBEGF protein] affects the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle EmissionsEGFR protein affects the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle EmissionsHBEGF protein affects the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle EmissionsN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle EmissionsTGFA protein affects the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle Emissionstyrphostin AG 1478 inhibits the reaction [Vehicle Emissions results in increased secretion of TGFA protein]24555532
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TGFA mRNA24555532
D001335Vehicle EmissionsVehicle Emissions results in increased secretion of TGFA protein24555532
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of TGFA mRNA27169980
C025643vinclozolin[Genistein co-treated with vinclozolin] affects the expression of TGFA mRNA23410115
C025643vinclozolin[Genistein co-treated with vinclozolin] results in decreased expression of TGFA mRNA22317923
C025643vinclozolinvinclozolin results in decreased expression of TGFA mRNA23410115
D014801Vitamin AVitamin A deficiency results in increased expression of TGFA mRNA7519440
D002762Cholecalciferol[Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein28634113
D019287Zinc SulfateZinc Sulfate results in increased expression of TGFA mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005154epidermal growth factor receptor binding-IBA21873635  
GO:0005154epidermal growth factor receptor binding-IDA11278323  
GO:0005515protein binding-IPI12297049  15064403  15652357  18757723  24658140  25416956  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-IDA11278323  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IBA21873635  
GO:0000187activation of MAPK activity-IDA11278323  
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007173epidermal growth factor receptor signaling pathway-IBA21873635  
GO:0008283cell proliferation-TAS10861448  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0045741positive regulation of epidermal growth factor-activated receptor activity-IDA11278323  
GO:0045840positive regulation of mitotic nuclear division-IDA11278323  
GO:0048208COPII vesicle coating-TAS-  
GO:0050679positive regulation of epithelial cell proliferation-IDA11278323  
GO:0051781positive regulation of cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA12743035  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-NAS10918572  
GO:0009986cell surface-IDA12743035  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016323basolateral plasma membrane-IDA17553928  
GO:0031410cytoplasmic vesicle-IDA15064403  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IDA15064403  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9684776Infant TGF-alpha genotype, orofacial clefts, and maternal periconceptional multivitamin use. (1998 Jul)Shaw GMCleft Palate Craniofac J
9988882Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts. (1999 Jan)Romitti PATeratology
15643916Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction. (2005 Jan)Zeiger JSCleft Palate Craniofac J
9927220Oral clefts, transforming growth factor alpha gene variants, and maternal smoking: a population-based case-control study in Denmark, 1991-1994. (1999 Feb 1)Christensen KAm J Epidemiol
14639706Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads. (2003 Dec)Jugessur AGenet Epidemiol
27356075Associations Between TGFA/TGFB3/MSX1 Gene Polymorphisms and Congenital Non-Syndromic Hearing Impairment in a Chinese Population. (2016 Jun 29)Du JMed Sci Monit
8644715Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants. (1996 Mar)Shaw GMAm J Hum Genet
28303469Association between maternal exposure to tobacco, presence of TGFA gene, and the occurrence of oral clefts. A case control study. (2018 Jan)Junaid MClin Oral Investig
9415696Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. (1997 Dec 19)Maestri NEAm J Med Genet
18698632Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft. (2008 Sep 15)Chevrier CAm J Med Genet A
9345615Testing for interaction between maternal smoking and TGFA genotype among oral cleft cases born in Maryland 1992-1996. (1997 Sep)Beaty THCleft Palate Craniofac J
27996298Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study. (2017 Nov)Mossey PACleft Palate Craniofac J
27279979Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants. (2016 Apr)Ebadifar AIran J Basic Med Sci