Gene info: ID 7042

Gene: TGFB2

GENE ID: 7042

Synonyms: G-TSF|LDS4|TGF-beta2

Description: transforming growth factor beta 2

Gene type: protein-coding

Location: 1q41

dbXrefs: Ensembl:ENSG00000092969 MIM:190220 Vega:OTTHUMG00000039521 UniprotKB:P61812

RefSeq: NG_027721.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.543e-1 (AD) 6.840e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07810039	chr1:218524558	TGFB2		1.190e-10	Maternal smoking in pregnancy	27040690
cg07810039	chr1:218524558	TGFB2		3.970e-8	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARHGEF26	0.897
SDC2	0.893
SLC1A3	0.892
PITPNC1	0.891
NOTCH2	0.891
BMPR1B	0.886
YAP1	0.884
FERMT2	0.881
TP53BP2	0.878
PTAR1	0.877

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADTRP	-0.455
TMEFF2	-0.435
GALNT14	-0.42
DRD5	-0.416
QRFPR	-0.415
DUSP27	-0.414
NRG1	-0.412
CACNA1F	-0.407
TRABD2A	-0.407
MYOZ3	-0.402

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of TGFB2 mRNA"	26377693
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of TGFB2 mRNA	25827057
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TGFB2 mRNA	25827057
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TGFB2 mRNA	19933214
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of TGFB2 mRNA]"	19414516
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TGFB2 mRNA"	19167446
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of TGFB2 mRNA"	25710175
C029955	2-nitrotoluene	2-nitrotoluene results in decreased expression of TGFB2 mRNA	16460773
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TGFB2 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGFB2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGFB2 mRNA"	27188386
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of TGFB2 protein	18065773
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGFB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGFB2 mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TGFB2 mRNA"	19936915
D000079	Acetaldehyde	Acetaldehyde affects the expression of TGFB2 mRNA	22634333
D000082	Acetaminophen	Acetaminophen results in increased expression of TGFB2 mRNA	29067470
D020106	Acrylamide	Acrylamide results in decreased expression of TGFB2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TGFB2 mRNA	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of TGFB2 mRNA	21757418
D000499	Allylamine	Allylamine results in increased expression of TGFB2 mRNA	23558518
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TGFB2 mRNA	16483693
C015001	arsenite	arsenite results in decreased expression of TGFB2 mRNA	16085347\|2397400
C015001	arsenite	caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of TGFB2 mRNA]	16085347
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of TGFB2 mRNA	15894712
C015001	arsenite	arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]	26354774
C015001	arsenite	arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]	26354774
C015001	arsenite	arsenite inhibits the reaction [TGFB2 protein results in increased localization of MAPK7 protein]	25145660
C015001	arsenite	arsenite inhibits the reaction [TGFB2 protein results in increased localization of SMAD2 protein]	25145660
C015001	arsenite	arsenite inhibits the reaction [TGFB2 protein results in increased localization of SMAD3 protein]	25145660
C015001	arsenite	arsenite results in decreased expression of TGFB2 mRNA	15894712
C015001	arsenite	leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
C015001	arsenite	leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
C015001	arsenite	Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
C015001	arsenite	Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of TGFB2 mRNA	15305145
D016589	Astemizole	Astemizole results in increased expression of TGFB2 mRNA	20221588
D001280	Atrazine	Atrazine results in decreased expression of TGFB2 mRNA	25929836
C547126	AZM551248	AZM551248 results in increased expression of TGFB2 mRNA	22323515
C487081	belinostat	belinostat results in increased expression of TGFB2 mRNA	23671600
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of TGFB2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TGFB2 mRNA	19181443\|2010694
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of TGFB2 mRNA]	15034205
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of TGFB2 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of TGFB2 mRNA	15037607
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TGFB2 mRNA	15034205\|1589471
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TGFB2 mRNA	22228805
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in decreased expression of TGFB2 mRNA]	24758408
D004958	Estradiol	Estradiol affects the expression of TGFB2 mRNA	14699072
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in decreased expression of TGFB2 mRNA	20404318
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of TGFB2 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGFB2 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of TGFB2 mRNA	16474171\|1916744
D004958	Estradiol	Estradiol results in increased expression of TGFB2 mRNA	11813992\|1948475
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of TGFB2 mRNA	17404688
D004958	Estradiol	[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TGFB2 mRNA	21185374
D004958	Estradiol	Dronabinol promotes the reaction [Estradiol results in increased expression of TGFB2 mRNA]	8390853
D004958	Estradiol	Estradiol affects the expression of TGFB2 mRNA	15598610
D004958	Estradiol	Estradiol results in increased expression of TGFB2 mRNA	19484750\|8390853
D004958	Estradiol	Estradiol results in decreased expression of TGFB2 mRNA	20068009
D001622	Betaine	Betaine results in increased expression of TGFB2 mRNA	26391144
C006780	bisphenol A	bisphenol A affects the expression of TGFB2 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of TGFB2 mRNA	16029874\|1647417
C006780	bisphenol A	bisphenol A results in decreased methylation of TGFB2 promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of TGFB2 mRNA	25181051
D001761	Bleomycin	[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D001761	Bleomycin	[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
C546611	brevetoxin 2	brevetoxin 2 results in increased expression of TGFB2 mRNA	20498034
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB2 mRNA	16997883
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of TGFB2 mRNA	16460773
D002083	Butylated Hydroxyanisole	[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of TGFB2 mRNA	25086368
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TGFB2 mRNA	12634122
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of TGFB2 mRNA]	16085347
D002211	Capsaicin	Capsaicin results in increased expression of TGFB2 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
D002220	Carbamazepine	Carbamazepine affects the expression of TGFB2 mRNA	22634333
D012721	Carbaryl	Carbaryl results in increased expression of TGFB2 mRNA	27829164
D002235	Carbofuran	Carbofuran results in increased expression of TGFB2 mRNA	20211217
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TGFB2 mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TGFB2 mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TGFB2 mRNA	15056808\|2582705
D002251	Carbon Tetrachloride	VWF gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB2 mRNA]	28527913
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TGFB2 mRNA	16644059\|2355851
D002725	Chloroform	Chloroform results in increased expression of TGFB2 mRNA	23558518
D002737	Chloroprene	Chloroprene results in decreased expression of TGFB2 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of TGFB2 mRNA	20350560
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB2 mRNA	22915297
D002794	Choline	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB2 mRNA]	22915297
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TGFB2 mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TGFB2 mRNA	12634122
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in decreased secretion of TGFB2 protein]	21954917
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TGFB2 mRNA	26314263
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TGFB2 mRNA	24386269
D003042	Cocaine	Cocaine results in increased expression of TGFB2 mRNA	17898221
D003300	Copper	Copper deficiency results in increased expression of TGFB2 mRNA	26033743
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TGFB2 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TGFB2 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of TGFB2 mRNA	19167446
C030973	cupric oxide	cupric oxide results in decreased expression of TGFB2 mRNA	22077320
D003471	Cuprizone	Cuprizone results in increased expression of TGFB2 mRNA	26577399
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of TGFB2 mRNA	17654400
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of TGFB2 mRNA	23558518
D016572	Cyclosporine	Cyclosporine results in decreased expression of TGFB2 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of TGFB2 mRNA	23558518
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of TGFB2 mRNA	23726867
D003545	Cysteine	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TGFB2 mRNA]	15158331
D003609	Dactinomycin	Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]	18253093
D003609	Dactinomycin	Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA]	18253093
C515055	darinaparsin	darinaparsin results in increased expression of TGFB2 mRNA	22535156
D000069439	Dasatinib	Dasatinib results in increased expression of TGFB2 mRNA	20579391
D013759	Dronabinol	Dronabinol promotes the reaction [Estradiol results in increased expression of TGFB2 mRNA]	8390853
D003907	Dexamethasone	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB2 mRNA	16997883
D003907	Dexamethasone	Dexamethasone results in decreased expression of TGFB2 mRNA	16997883
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TGFB2 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of TGFB2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TGFB2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TGFB2 mRNA	21151649
D004008	Diclofenac	Diclofenac results in decreased expression of TGFB2 mRNA	17379860
C027118	didecyldimethylammonium	didecyldimethylammonium results in decreased expression of TGFB2 mRNA	23537712
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of TGFB2 protein	26042203
D004041	Dietary Fats	Dietary Fats results in increased expression of TGFB2 mRNA	18042831
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in increased expression of TGFB2 mRNA	21852083
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of TGFB2 protein	26042203
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of TGFB2 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of TGFB2 mRNA	20920545
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of TGFB2 protein	20920545
C058705	diethyl malate	diethyl malate affects the expression of TGFB2 mRNA	24814887
C058705	diethyl malate	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]	24814887
D004052	Diethylnitrosamine	AHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB2 mRNA]	19996281
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TGFB2 mRNA	18282651\|1999628
D004052	Diethylnitrosamine	TGFB2 gene mutant form results in increased susceptibility to Diethylnitrosamine	11559531
D004052	Diethylnitrosamine	TGFB2 gene mutant form results in increased susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]	11526486
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA	23830814
D002117	Calcitriol	Calcitriol results in increased expression of TGFB2 mRNA	16002434\|2159239
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of TGFB2 mRNA	21592394
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of TGFB2 mRNA	19945496\|2088654
D004221	Disulfiram	Disulfiram affects the expression of TGFB2 mRNA	19088833
D004280	Dobutamine	Dobutamine results in increased expression of TGFB2 mRNA	16760913
C076946	donepezil	donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]]	26114860
D004298	Dopamine	Dopamine results in increased expression of TGFB2 mRNA	16760913
D004317	Doxorubicin	Doxorubicin results in increased expression of TGFB2 mRNA	20211217\|2355851
D004656	Enalapril	Enalapril results in decreased expression of TGFB2 mRNA	17164399
D020536	Enzyme Activators	[Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 mRNA]	25707573
D020536	Enzyme Activators	[Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 protein]	25707573
D020536	Enzyme Activators	[Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of EP300 protein]	25707573
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TGFB2 mRNA	20170705
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TGFB2 mRNA	18936297
D015025	Zearalenone	Zearalenone results in decreased expression of TGFB2 mRNA	27862621
C001209	fenamic acid	fenamic acid results in increased expression of TGFB2 mRNA	23558518
C540355	fenamidone	fenamidone results in increased expression of TGFB2 mRNA	27029645
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased expression of TGFB2 mRNA	23208426
C082360	fipronil	fipronil results in increased methylation of TGFB2 gene	28536466
D005472	Fluorouracil	TGFB2 protein affects the susceptibility to Fluorouracil	16217747
D005472	Fluorouracil	TGFB2 gene polymorphism results in decreased susceptibility to Fluorouracil	18941179
C061365	flusilazole	flusilazole affects the expression of TGFB2 mRNA	22634333
D005620	Freund's Adjuvant	Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of TGFB2 mRNA]	12810352
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA	28123933
C039281	furan	furan results in decreased expression of TGFB2 mRNA	26194646
D005665	Furosemide	Furosemide results in increased expression of TGFB2 mRNA	16526316
C001277	geldanamycin	geldanamycin results in increased expression of TGFB2 mRNA	26705709
C056507	gemcitabine	gemcitabine results in increased expression of TGFB2 mRNA	17039268
D019833	Genistein	Genistein results in decreased expression of TGFB2 mRNA	16474171\|2222811
D005839	Gentamicins	Gentamicins results in increased expression of TGFB2 mRNA	22061828
D006820	Hyaluronic Acid	MAP3K3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]	20633555
D006820	Hyaluronic Acid	MAPK1 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]	20633555
D006820	Hyaluronic Acid	MAPK3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]	20633555
D006820	Hyaluronic Acid	MAPK7 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]	20633555
D006820	Hyaluronic Acid	TGFB2 protein results in increased abundance of Hyaluronic Acid	20633555
D006861	Hydrogen Peroxide	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA	20606027
D006861	Hydrogen Peroxide	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein	20606027
D006861	Hydrogen Peroxide	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA	20606027
D006861	Hydrogen Peroxide	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein	20606027
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in increased expression of TGFB2 protein	21948866
C474021	indirubin-3'-monoxime	Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB2 protein]	21948866
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of TGFB2 mRNA	21948866
C016517	indole-3-carbinol	Lipopolysaccharides affects the susceptibility to [indole-3-carbinol results in increased expression of TGFB2 mRNA]	21948866
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGFB2 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB2 mRNA	16997883
D007545	Isoproterenol	Isoproterenol results in increased expression of TGFB2 mRNA	20211217\|2355851
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of TGFB2 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of TGFB2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TGFB2 mRNA	24796395\|2675264
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TGFB2 mRNA	26644586
D007854	Lead	Lead affects the expression of TGFB2 mRNA	28903495
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TGFB2 mRNA	12634122
C038753	leptomycin B	leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
C038753	leptomycin B	leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
C038753	leptomycin B	leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
C038753	leptomycin B	leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
C000589733	leukadherin-1	FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]]	26921287
C000589733	leukadherin-1	leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	26921287
D008070	Lipopolysaccharides	Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB2 protein]	21948866
D008070	Lipopolysaccharides	Lipopolysaccharides affects the susceptibility to [indole-3-carbinol results in increased expression of TGFB2 mRNA]	21948866
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TGFB2 mRNA	21131560
D008628	Mercury	Mercury results in increased expression of TGFB2 mRNA	16823088
D009921	Metaproterenol	Metaproterenol results in increased expression of TGFB2 mRNA	23558518
D008701	Methapyrilene	Methapyrilene results in increased expression of TGFB2 mRNA	23558518
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB2 mRNA	22915297
D008715	Methionine	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB2 mRNA]	22915297
D008715	Methionine	Methionine inhibits the reaction [Thioacetamide results in increased expression of TGFB2 mRNA]	15158331
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TGFB2 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of TGFB2 mRNA	21664453
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]	26114860
D015655	1-Methyl-4-phenylpyridinium	donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]]	26114860
C008493	methylselenic acid	methylselenic acid results in increased expression of TGFB2 mRNA	18548127
D015735	Mifepristone	Mifepristone results in decreased expression of TGFB2 mRNA	25972201
D008911	Minocycline	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA	20606027
D008911	Minocycline	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein	20606027
D008911	Minocycline	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA	20606027
D008911	Minocycline	[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein	20606027
D008942	Mitoxantrone	Mitoxantrone results in increased expression of TGFB2 mRNA	23558518
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of TGFB2 mRNA	19945496
C406082	monomethylarsonous acid	leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
C406082	monomethylarsonous acid	leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]	26354774
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]	26354774
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [TGFB2 protein results in increased localization of MAPK7 protein]	25145660
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [TGFB2 protein results in increased localization of SMAD2 protein]	25145660
C406082	monomethylarsonous acid	monomethylarsonous acid inhibits the reaction [TGFB2 protein results in increased localization of SMAD3 protein]	25145660
C406082	monomethylarsonous acid	Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
C406082	monomethylarsonous acid	Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
C500085	muraglitazar	muraglitazar results in increased expression of TGFB2 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in decreased expression of TGFB2 mRNA	18955075
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA	24633426\|2692128
D015058	1-Naphthylisothiocyanate	FGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	26921287
D015058	1-Naphthylisothiocyanate	FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]]	26921287
D015058	1-Naphthylisothiocyanate	IFNG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	26921287
D015058	1-Naphthylisothiocyanate	leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	26921287
D015058	1-Naphthylisothiocyanate	RAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	28049044
D015058	1-Naphthylisothiocyanate	Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	24633426
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA	23558518
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
D009532	Nickel	Nickel results in decreased expression of TGFB2 mRNA	24768652\|2558310
D009582	Nitrofurantoin	Nitrofurantoin results in increased expression of TGFB2 mRNA	23558518
D009638	Norepinephrine	Norepinephrine results in increased expression of TGFB2 mRNA	15326086
D009638	Norepinephrine	Norepinephrine results in increased expression of TGFB2 protein	15326086
D009638	Norepinephrine	Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA]	15326086
C464660	obeticholic acid	obeticholic acid results in decreased expression of TGFB2 mRNA	27939613
C025589	ochratoxin A	ochratoxin A metabolite results in increased expression of TGFB2 mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in increased expression of TGFB2 mRNA	26314263
C025589	ochratoxin A	NFE2L2 protein affects the reaction [ochratoxin A results in decreased expression of TGFB2 mRNA]	28710020
C025589	ochratoxin A	ochratoxin A results in decreased expression of TGFB2 mRNA	28710020
C025589	ochratoxin A	ochratoxin A results in increased expression of TGFB2 mRNA	28710020
C025589	ochratoxin A	ochratoxin A results in increased expression of TGFB2 mRNA	23208426\|2335814
C016340	o,p'-DDT	"o,p'-DDT results in decreased expression of TGFB2 mRNA"	19371625
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TGFB2 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of TGFB2 mRNA	21531777
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of TGFB2 mRNA]	21531777
D000073878	Palm Oil	Palm Oil results in increased expression of TGFB2 mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of TGFB2 mRNA	16854511
D015232	Dinoprostone	[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D015232	Dinoprostone	[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D010634	Phenobarbital	TGFB2 gene mutant form results in increased susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]	11526486
D010653	Phenylbutazone	Phenylbutazone results in increased expression of TGFB2 mRNA	23558518
D010656	Phenylephrine	Phenylephrine results in increased expression of TGFB2 mRNA	19443575
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGFB2 mRNA"	27188386
D010672	Phenytoin	Phenytoin results in decreased expression of TGFB2 mRNA	9118846
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TGFB2 mRNA	19710929
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of TGFB2 mRNA	21334430
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of TGFB2 mRNA	16474171
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of TGFB2 mRNA	24583197
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of TGFB2 mRNA	22714537
D011224	Prazosin	Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA]	15326086
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of TGFB2 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of TGFB2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of TGFB2	17510236
C005556	propionaldehyde	propionaldehyde results in increased expression of TGFB2 mRNA	26079696
C006068	propylparaben	[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of TGFB2 mRNA	25086368
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TGFB2 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TGFB2 mRNA	27029645
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of TGFB2 mRNA"	21152443
D011794	Quercetin	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB2 mRNA]	22915297
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of TGFB2 mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA	19059307
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TGFB2 mRNA	21185374
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TGFB2 mRNA	19167446
C059514	resveratrol	Niacinamide inhibits the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]]	25707573
C059514	resveratrol	Niacinamide inhibits the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A2 mRNA]]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein promotes the reaction [EP300 protein binds to COL1A2 promoter]]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 mRNA]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 protein]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A2 mRNA]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein results in increased expression of EP300 protein]	25707573
C059514	resveratrol	resveratrol inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA alternative form]	25707573
C059514	resveratrol	resveratrol results in decreased expression of TGFB2 mRNA	19371625
C059514	resveratrol	resveratrol results in increased expression of TGFB2 mRNA	12002526
C059514	resveratrol	SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA alternative form]]	25707573
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in increased expression of TGFB2 mRNA	21852083
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of TGFB2 mRNA]	21531777
C089730	rosiglitazone	rosiglitazone results in decreased expression of TGFB2 mRNA	21531777
D012402	Rotenone	Rotenone results in increased expression of TGFB2 mRNA	23186747
C093642	SB 203580	SB 203580 inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]	18253093
C093642	SB 203580	SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein]	18253093
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]	24814887
D012834	Silver	Silver results in decreased expression of TGFB2 mRNA	27131904
D012906	Smoke	Smoke results in increased expression of TGFB2 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of TGFB2 mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of TGFB2 mRNA	21795629
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TGFB2 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of TGFB2 mRNA	20886546\|2219929
C017947	sodium arsenite	sodium arsenite results in increased expression of TGFB2 mRNA	12634122
C017947	sodium arsenite	sodium arsenite inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein]	23732083
C017947	sodium arsenite	sodium arsenite inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein]	23732083
C017947	sodium arsenite	sodium arsenite results in decreased expression of TGFB2 mRNA	23732083
D012965	Sodium Chloride	Sodium Chloride results in increased expression of TGFB2 mRNA	26800359
C025399	sodium tungstate(VI)	sodium tungstate(VI) affects the expression of TGFB2 mRNA	26164860
C525422	SRT1720	SRT1720 inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 mRNA]	25707573
D010042	Ouabain	Ouabain results in decreased expression of TGFB2 mRNA	28795476
D020058	Styrene	Styrene affects the expression of TGFB2 mRNA	16705669
D020058	Styrene	Styrene affects the expression of TGFB2 protein	16705669
C013690	styrene oxide	styrene oxide affects the expression of TGFB2 mRNA	16705669
C013690	styrene oxide	styrene oxide affects the expression of TGFB2 protein	16705669
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]	22150557
C061133	tamibarotene	tamibarotene results in increased secretion of TGFB2 protein	17611697
C061133	tamibarotene	TGFB2 results in increased susceptibility to tamibarotene	17611697
D013629	Tamoxifen	Tamoxifen affects the expression of TGFB2 mRNA	14699072
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA	19059307
C501413	tesaglitazar	tesaglitazar results in increased expression of TGFB2 mRNA	21515302
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of TGFB2 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of TGFB2 mRNA	21592394
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TGFB2 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGFB2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased chemical synthesis of TGFB2 mRNA	1447203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNA	1447203\|19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGFB2 protein	9787404
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TGFB2 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNA	19933214\|2109775
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGFB2 protein	17056225
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGFB2 mRNA	14728982\|2756255
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TGFB2 mRNA	16979875
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGFB2 mRNA	25613284
D013853	Thioacetamide	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TGFB2 mRNA]	15158331
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA	23830814
D013853	Thioacetamide	Methionine inhibits the reaction [Thioacetamide results in increased expression of TGFB2 mRNA]	15158331
D013853	Thioacetamide	Thioacetamide results in increased expression of TGFB2 mRNA	15158331\|1729241
D008063	Thioctic Acid	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA	23830814
D013893	Thiram	Thiram results in decreased expression of TGFB2 mRNA	20530235
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TGFB2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of TGFB2 mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of TGFB2 mRNA	23228038
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TGFB2 mRNA"	19682533
D014148	Tranexamic Acid	Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]	24633426
C528105	trans-3,4'-dimethyl-3-hydroxyflavanone	"trans-3,4'-dimethyl-3-hydroxyflavanone results in decreased activity of TGFB2 protein"	18310908
D014212	Tretinoin	Tretinoin results in increased expression of TGFB2 mRNA	20530235
D014212	Tretinoin	IFNG protein inhibits the reaction [Tretinoin results in increased expression of TGFB2 mRNA]	16007204
D014212	Tretinoin	Tretinoin results in increased expression of TGFB2 mRNA	15955085\|1600720
D014212	Tretinoin	Tretinoin results in increased expression of TGFB2 protein	15955085\|1597067
D014212	Tretinoin	Tretinoin results in increased secretion of TGFB2 protein	15970678\|1647392
D014212	Tretinoin	Tretinoin affects the expression of TGFB2 mRNA	16235736
C032910	triadimefon	triadimefon results in decreased expression of TGFB2 mRNA	26705709
C032910	triadimefon	triadimefon results in decreased expression of TGFB2 mRNA	18976680
D014241	Trichloroethylene	Trichloroethylene results in increased expression of TGFB2 mRNA	15363585
C012589	trichostatin A	trichostatin A results in decreased expression of TGFB2 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of TGFB2 mRNA	24935251\|2670570
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of TGFB2 mRNA	25307695
C057693	troglitazone	troglitazone inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]	18253093
C057693	troglitazone	troglitazone inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA]	18253093
C057693	troglitazone	troglitazone inhibits the reaction [TGFB2 protein results in increased expression of FN1 protein]	18253093
C057693	troglitazone	troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein]	18253093
C057693	troglitazone	troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein]	18253093
C057693	troglitazone	troglitazone results in decreased susceptibility to TGFB2 protein	18253093
C057693	troglitazone	troglitazone results in increased expression of TGFB2 mRNA	17569031
C057693	troglitazone	troglitazone results in increased expression of TGFB2 mRNA	21515302
D014520	Urethane	Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of TGFB2 mRNA]	12810352
D014520	Urethane	IFNG protein inhibits the reaction [Urethane results in decreased expression of TGFB2 mRNA]	12810352
D014520	Urethane	Urethane results in decreased expression of TGFB2 mRNA	12810352
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGFB2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of TGFB2 mRNA	24935251\|2915479
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TGFB2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of TGFB2 mRNA	23179753\|2627250
C066075	vanadium pentoxide	vanadium pentoxide results in decreased expression of TGFB2 mRNA	17459161
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of TGFB2 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of TGFB2 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TGFB2 mRNA	26682919
D014800	Vitallium	Vitallium analog results in decreased expression of TGFB2 mRNA	23825117
D009536	Niacinamide	Niacinamide inhibits the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]]	25707573
D009536	Niacinamide	Niacinamide inhibits the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A2 mRNA]]	25707573
D002762	Cholecalciferol	Cholecalciferol results in increased expression of TGFB2 mRNA	17170073
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TGFB2 mRNA	16979875
D015032	Zinc	Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
D015032	Zinc	Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
D015032	Zinc	Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]	26354774
D015032	Zinc	Zinc inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]	26354774
D015034	Zinc Oxide	Zinc Oxide affects the expression of TGFB2 mRNA	28648595
C088658	zoledronic acid	zoledronic acid results in increased expression of TGFB2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001540	amyloid-beta binding	-	IDA	16227582
GO:0005102	signaling receptor binding	-	IMP	16227582
GO:0005114	type II transforming growth factor beta receptor binding	-	IBA	21873635
GO:0005114	type II transforming growth factor beta receptor binding	-	IDA	11157754
GO:0005114	type II transforming growth factor beta receptor binding	-	IMP	8167376
GO:0005114	type II transforming growth factor beta receptor binding	-	IPI	1333888 7852346 11157754
GO:0005125	cytokine activity	-	IBA	21873635
GO:0005125	cytokine activity	-	TAS	9611771
GO:0005160	transforming growth factor beta receptor binding	-	IBA	21873635
GO:0005160	transforming growth factor beta receptor binding	-	IDA	10092230 16227582
GO:0005515	protein binding	-	IPI	2119582 10930463 11157754 16227582 17827158 25241761
GO:0008083	growth factor activity	-	IEA	-
GO:0034714	type III transforming growth factor beta receptor binding	-	IMP	8167376
GO:0034714	type III transforming growth factor beta receptor binding	-	IPI	7852346 11157754
GO:0042803	protein homodimerization activity	-	IDA	2119582
GO:0046982	protein heterodimerization activity	-	TAS	9611771

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IDA	15896309
GO:0001501	skeletal system development	-	ISS	-
GO:0001525	angiogenesis	-	TAS	9611771
GO:0001654	eye development	-	IDA	15944186
GO:0001666	response to hypoxia	-	IMP	12411310
GO:0001822	kidney development	-	ISS	-
GO:0001837	epithelial to mesenchymal transition	-	IDA	10092230 18223299
GO:0001837	epithelial to mesenchymal transition	-	TAS	14679171
GO:0001843	neural tube closure	-	ISS	-
GO:0001942	hair follicle development	-	IDA	10433821
GO:0001942	hair follicle development	-	ISS	-
GO:0002576	platelet degranulation	-	TAS	-
GO:0003007	heart morphogenesis	-	IDA	10092230
GO:0003148	outflow tract septum morphogenesis	-	ISS	-
GO:0003149	membranous septum morphogenesis	-	ISS	-
GO:0003179	heart valve morphogenesis	-	ISS	-
GO:0003181	atrioventricular valve morphogenesis	-	ISS	-
GO:0003184	pulmonary valve morphogenesis	-	ISS	-
GO:0003203	endocardial cushion morphogenesis	-	ISS	-
GO:0003215	cardiac right ventricle morphogenesis	-	ISS	-
GO:0003222	ventricular trabecula myocardium morphogenesis	-	ISS	-
GO:0003274	endocardial cushion fusion	-	ISS	-
GO:0003289	atrial septum primum morphogenesis	-	ISS	-
GO:0003407	neural retina development	-	ISS	-
GO:0006468	protein phosphorylation	-	IDA	18358889
GO:0007050	cell cycle arrest	-	IDA	18223299
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IBA	21873635
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IDA	11157754 18358889
GO:0007267	cell-cell signaling	-	TAS	3322813
GO:0007435	salivary gland morphogenesis	-	IEP	18080134
GO:0007507	heart development	-	IDA	15896309
GO:0008219	cell death	-	IDA	16227582
GO:0008283	cell proliferation	-	TAS	3322813
GO:0008284	positive regulation of cell proliferation	-	IDA	15896309
GO:0008285	negative regulation of cell proliferation	-	IDA	15944186
GO:0008347	glial cell migration	-	IDA	18431253
GO:0008584	male gonad development	-	ISS	-
GO:0009611	response to wounding	-	IEP	16891397 18040277
GO:0009792	embryo development ending in birth or egg hatching	-	TAS	2119582
GO:0010002	cardioblast differentiation	-	IDA	15896309
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010629	negative regulation of gene expression	-	IDA	25217442
GO:0010634	positive regulation of epithelial cell migration	-	IDA	17960115
GO:0010693	negative regulation of alkaline phosphatase activity	-	IDA	18358889
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IDA	17999987 18505915
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	-	IBA	21873635
GO:0010936	negative regulation of macrophage cytokine production	-	IDA	20875417
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	IDA	18223299
GO:0016477	cell migration	-	IDA	10092230
GO:0016525	negative regulation of angiogenesis	-	IDA	25217442 28977001
GO:0030097	hemopoiesis	-	ISS	-
GO:0030199	collagen fibril organization	-	IDA	16891397
GO:0030307	positive regulation of cell growth	-	IDA	15896309 20573232
GO:0030308	negative regulation of cell growth	-	IDA	18358889
GO:0030326	embryonic limb morphogenesis	-	ISS	-
GO:0030593	neutrophil chemotaxis	-	ISS	-
GO:0030593	neutrophil chemotaxis	-	TAS	9611771
GO:0031069	hair follicle morphogenesis	-	ISS	-
GO:0032147	activation of protein kinase activity	-	IDA	17192487 17960115
GO:0032570	response to progesterone	-	IDA	18039789
GO:0032874	positive regulation of stress-activated MAPK cascade	-	IDA	17192487
GO:0032909	regulation of transforming growth factor beta2 production	-	IMP	12411310
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	IDA	17960115 18223299
GO:0035910	ascending aorta morphogenesis	-	ISS	-
GO:0042060	wound healing	-	ISS	-
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0042416	dopamine biosynthetic process	-	ISS	-
GO:0042476	odontogenesis	-	NAS	18078367
GO:0042493	response to drug	-	IDA	20573232
GO:0042704	uterine wall breakdown	-	TAS	18039789
GO:0042981	regulation of apoptotic process	-	IBA	21873635
GO:0043408	regulation of MAPK cascade	-	IBA	21873635
GO:0043525	positive regulation of neuron apoptotic process	-	IDA	16227582
GO:0045216	cell-cell junction organization	-	IDA	18505915
GO:0045726	positive regulation of integrin biosynthetic process	-	IDA	17960115
GO:0045747	positive regulation of Notch signaling pathway	-	IDA	25217442
GO:0045778	positive regulation of ossification	-	IEP	17401695
GO:0045787	positive regulation of cell cycle	-	ISS	-
GO:0045823	positive regulation of heart contraction	-	IDA	15896309
GO:0046580	negative regulation of Ras protein signal transduction	-	ISS	-
GO:0048103	somatic stem cell division	-	ISS	-
GO:0048468	cell development	-	IBA	21873635
GO:0048566	embryonic digestive tract development	-	IEP	20875417
GO:0048666	neuron development	-	ISS	-
GO:0048699	generation of neurons	-	TAS	15944186
GO:0048839	inner ear development	-	ISS	-
GO:0050680	negative regulation of epithelial cell proliferation	-	IDA	17217916
GO:0050680	negative regulation of epithelial cell proliferation	-	IMP	16943770
GO:0050714	positive regulation of protein secretion	-	IDA	18505915
GO:0050777	negative regulation of immune response	-	TAS	9611771
GO:0050778	positive regulation of immune response	-	ISS	-
GO:0051781	positive regulation of cell division	-	IEA	-
GO:0051794	regulation of timing of catagen	-	IDA	15955085
GO:0051795	positive regulation of timing of catagen	-	IDA	15955085
GO:0051891	positive regulation of cardioblast differentiation	-	IDA	15896309
GO:0060038	cardiac muscle cell proliferation	-	IDA	15896309
GO:0060065	uterus development	-	ISS	-
GO:0060317	cardiac epithelial to mesenchymal transition	-	IDA	10092230
GO:0060389	pathway-restricted SMAD protein phosphorylation	-	IDA	11157754 18358889
GO:0060395	SMAD protein signal transduction	-	IBA	21873635
GO:0060395	SMAD protein signal transduction	-	IDA	17192487
GO:0060412	ventricular septum morphogenesis	-	ISS	-
GO:0060413	atrial septum morphogenesis	-	ISS	-
GO:0061626	pharyngeal arch artery morphogenesis	-	ISS	-
GO:0062009	secondary palate development	-	ISS	-
GO:0097191	extrinsic apoptotic signaling pathway	-	IDA	17217916
GO:1902256	regulation of apoptotic process involved in outflow tract morphogenesis	-	ISS	-
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	-	IDA	25217442
GO:1903659	regulation of complement-dependent cytotoxicity	NOT	IMP	16034134
GO:1903701	substantia propria of cornea development	-	ISS	-
GO:1904888	cranial skeletal system development	-	ISS	-
GO:1905006	negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	-	ISS	-
GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	16227582
GO:0005576	extracellular region	-	TAS	2119582
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	24263861
GO:0030424	axon	-	ISS	-
GO:0031093	platelet alpha granule lumen	-	TAS	-
GO:0043025	neuronal cell body	-	ISS	-
GO:0062023	collagen-containing extracellular matrix	-	IDA	18049952

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04110	Cell cycle
hsa04144	Endocytosis
hsa04350	TGF-beta signaling pathway
hsa04380	Osteoclast differentiation
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia
hsa05323	Rheumatoid arthritis
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-3000178	ECM proteoglycans	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27609985	Seminal plasma transforming growth factor-beta, activin A and follistatin fluctuate within men over time. (2016 Oct)	Sharkey DJ	Hum Reprod
27698889	TGFB2 and BCL2L11 methylation in male laryngeal cancer patients. (2016 Oct)	Shen Z	Oncol Lett