Gene: TGFB3

7043
ARVD|ARVD1|LDS5|RNHF|TGF-beta3
transforming growth factor beta 3
protein-coding
14q24.3
Ensembl:ENSG00000119699 MIM:190230 Vega:OTTHUMG00000171489 UniprotKB:P10600
NG_011715.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.561e-1 (AD)  7.345e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF1C0.893
LPAR10.856
MAP4K40.851
BCAS10.851
ANP32B0.85
SGMS20.846
FGF10.844
HIPK20.838
PAIP2B0.832
SMARCC10.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.609
CDH22-0.591
KCNQ4-0.591
KCNK3-0.583
FBLN7-0.581
CNTN5-0.578
PCDH8-0.573
NDST3-0.573
CBLN4-0.57
IGSF3-0.567

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB033161,4-Diethylene DioxideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of TGFB3 mRNA25827057
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TGFB3 mRNA25827057
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TGFB3 mRNA19933214
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of TGFB3 mRNA]"19414516
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of TGFB3 mRNA16460773
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TGFB3 mRNA"23196670
C0312853-xylene3-xylene results in decreased expression of TGFB3 mRNA12815608
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD3 protein]"21586554
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD3 protein modified form]"21586554
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein affects the localization of SMAD4 protein]"21586554
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein results in increased secretion of Estradiol]"21586554
D000082AcetaminophenAcetaminophen affects the expression of TGFB3 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of TGFB3 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of TGFB3 mRNA]21233418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of TGFB3 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TGFB3 mRNA16483693
D001104ArbutinArbutin results in decreased expression of TGFB3 mRNA17103032
D001151ArsenicArsenic affects the methylation of TGFB3 gene25304211
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of TGFB3 mRNA19962721
D001151ArsenicArsenic results in decreased expression of TGFB3 mRNA19962721
C015001arsenitearsenite results in increased expression of TGFB3 mRNA18191166
D001205Ascorbic AcidIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]26526931
D001205Ascorbic AcidIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]26526931
D001205Ascorbic AcidIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]26526931
D001205Ascorbic AcidIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]26526931
D001205Ascorbic AcidIL1B protein results in decreased susceptibility to [TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone]26526931
D001205Ascorbic Acidresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]26526931
D001205Ascorbic Acidresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]]26526931
D001205Ascorbic Acidresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]26526931
D001205Ascorbic Acid[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA26526931
D001205Ascorbic Acid[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA26526931
D001205Ascorbic Acid[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA26526931
D001205Ascorbic Acid[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA26526931
C547126AZM551248AZM551248 results in increased expression of TGFB3 mRNA22323515
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of TGFB3 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGFB3 mRNA15034205|2222880
D004958Estradiol[Estradiol co-treated with EGF protein] results in decreased expression of TGFB3 mRNA24758408
D004958EstradiolEstradiol results in decreased expression of TGFB3 mRNA16202921|2475840
D004958EstradiolEstradiol results in increased expression of TGFB3 mRNA10811566|1133165
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of TGFB3 mRNA17404688
D004958EstradiolTGFB3 protein inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]26224478
D004958EstradiolTGFB3 protein inhibits the reaction [Estradiol results in increased expression of FOS mRNA]26224478
D004958Estradiol"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB3 protein results in increased secretion of Estradiol]"21586554
D004958EstradiolDronabinol affects the reaction [Estradiol results in increased expression of TGFB3 mRNA]8390853
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB3 mRNA11861973
D004958EstradiolEstradiol results in increased expression of TGFB3 mRNA19484750|8390853
D004958EstradiolFSHB protein promotes the reaction [TGFB3 protein results in increased secretion of Estradiol]21586554
D004958EstradiolTGFB3 protein results in increased secretion of Estradiol21586554
C095105bexarotenebexarotene results in increased expression of TGFB3 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of TGFB3 mRNA11331657
C006780bisphenol ATGFB3 protein inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]26224478
C006780bisphenol ATGFB3 protein inhibits the reaction [bisphenol A results in increased expression of FOS mRNA]26224478
C006780bisphenol Abisphenol A affects the expression of TGFB3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TGFB3 mRNA17052851
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TGFB3 mRNA28628672
D001761BleomycinBleomycin results in increased expression of TGFB3 mRNA28434932
D001761BleomycinCCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]28434932
D001761BleomycinDinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]28434932
D001761BleomycinHIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]28434932
D001761BleomycinMMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]28434932
C546611brevetoxin 2brevetoxin 2 results in increased expression of TGFB3 mRNA20498034
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB3 mRNA16997883
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of TGFB3 mRNA16460773
D020148Butyric AcidButyric Acid results in increased expression of TGFB3 mRNA17928716
D002104CadmiumCadmium results in decreased expression of TGFB3 mRNA20570719
D002104CadmiumCadmium results in increased expression of TGFB3 protein26424772
D002104Cadmiumflavocoxid inhibits the reaction [Cadmium results in increased expression of TGFB3 protein]26424772
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TGFB3 protein26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TGFB3 protein26424772
D019256Cadmium Chlorideflavocoxid inhibits the reaction [Cadmium Chloride results in increased expression of TGFB3 protein]26424772
D002211CapsaicinCapsaicin results in increased expression of TGFB3 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TGFB3 mRNA17484886
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TGFB3 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGFB3 mRNA25827057
D002251Carbon Tetrachloride[Quercetin co-treated with Carbon Tetrachloride] results in increased expression of TGFB3 mRNA22989100
D002752ChlorthalidoneChlorthalidone results in decreased expression of TGFB3 mRNA20625077
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFB3 mRNA20938992
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein results in decreased secretion of TGFB3 protein]21954917
C018021cobaltous chloridecobaltous chloride results in decreased expression of TGFB3 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of TGFB3 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TGFB3 mRNA23640034
D013759DronabinolDronabinol affects the expression of TGFB3 mRNA18454173
D013759DronabinolDronabinol affects the reaction [Estradiol results in increased expression of TGFB3 mRNA]8390853
C007262deoxynivalenoldeoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TGFB3 mRNA]14644621
C007262deoxynivalenoldeoxynivalenol results in increased expression of TGFB3 mRNA14644621
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB3 mRNA16997883
D003907DexamethasoneDexamethasone results in increased expression of TGFB3 mRNA16144937
D003907DexamethasoneIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]26526931
D003907DexamethasoneIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]26526931
D003907DexamethasoneIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]26526931
D003907DexamethasoneIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]26526931
D003907DexamethasoneIL1B protein results in decreased susceptibility to [TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone]26526931
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TGFB3 mRNA28628672
D003907Dexamethasoneresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]26526931
D003907Dexamethasoneresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]]26526931
D003907Dexamethasoneresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]26526931
D003907Dexamethasone[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA26526931
D003907Dexamethasone[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA26526931
D003907Dexamethasone[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA26526931
D003907Dexamethasone[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA26526931
D003975DiazepamDiazepam results in decreased expression of TGFB3 mRNA19114084
D003976DiazinonDiazinon results in increased expression of TGFB3 mRNA16758764
D003976DiazinonDiazinon affects the expression of TGFB3 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TGFB3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TGFB3 mRNA19464577
D002945CisplatinCisplatin results in increased expression of TGFB3 mRNA19561079
C027118didecyldimethylammoniumdidecyldimethylammonium results in decreased expression of TGFB3 mRNA23537712
D004026DieldrinDieldrin affects the expression of TGFB3 mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of TGFB3 mRNA20920545
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TGFB3 mRNA15765122|1828265
D004052DiethylnitrosamineRB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of TGFB3 mRNA]18282651
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TGFB3 mRNA10811566|1133165
D002117CalcitriolCalcitriol results in increased expression of TGFB3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TGFB3 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TGFB3 mRNA25380136
D004237DiuronDiuron results in decreased expression of TGFB3 mRNA25152437
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of TGFB3 mRNA24412560
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of TGFB3 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of TGFB3 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TGFB3 mRNA15885639
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TGFB3 mRNA12538720
C540355fenamidonefenamidone results in increased expression of TGFB3 mRNA27029645
C504383fenbuconazolefenbuconazole results in increased expression of TGFB3 mRNA15942997
C544478flavocoxidflavocoxid inhibits the reaction [Cadmium Chloride results in increased expression of TGFB3 protein]26424772
C544478flavocoxidflavocoxid inhibits the reaction [Cadmium results in increased expression of TGFB3 protein]26424772
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of TGFB3 mRNA19962721
D005459FluoridesFluorides results in decreased expression of TGFB3 mRNA19962721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFB3 mRNA20938992
D005620Freund's AdjuvantFreund's Adjuvant inhibits the reaction [Urethane results in decreased expression of TGFB3 mRNA]12810352
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in decreased expression of TGFB3 mRNA12400877
C039281furanfuran results in increased expression of TGFB3 mRNA27387713
D019833GenisteinGenistein results in increased expression of TGFB3 mRNA11331657
C004312glycidolglycidol results in increased expression of TGFB3 mRNA24915197
C010176halofuginonehalofuginone results in increased expression of TGFB3 mRNA17180598
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of TGFB3 mRNA24680724
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of TGFB3 mRNA15159207
D017313FenretinideFenretinide results in decreased expression of TGFB3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TGFB3 mRNA20044591
C474021indirubin-3'-monoximeindirubin-3'-monoxime results in increased expression of TGFB3 protein21948866
C474021indirubin-3'-monoximeLipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB3 protein]21948866
C016517indole-3-carbinolindole-3-carbinol results in increased expression of TGFB3 mRNA21948866
C016517indole-3-carbinolLipopolysaccharides affects the susceptibility to [indole-3-carbinol results in increased expression of TGFB3 mRNA]21948866
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TGFB3 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of TGFB3 mRNA18299717
D007213Indomethacinrebamipide inhibits the reaction [Indomethacin results in increased expression of TGFB3 mRNA]18299717
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TGFB3 mRNA16997883
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TGFB3 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of TGFB3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TGFB3 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TGFB3 mRNA26644586
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TGFB3 mRNA"24972896
D008070Lipopolysaccharidesdeoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TGFB3 mRNA]14644621
D008070LipopolysaccharidesLipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB3 protein]21948866
D008070LipopolysaccharidesLipopolysaccharides affects the susceptibility to [indole-3-carbinol results in increased expression of TGFB3 mRNA]21948866
D008070Lipopolysaccharides[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB3 mRNA21097750
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TGFB3 mRNA14644621
C520284Ly-364947Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]25566828
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA]25566828
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CTGF mRNA]25566828
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]25566828
C520284Ly-364947Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form]25566828
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of TGFB3 mRNA20843944
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFB3 mRNA20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of TGFB3 mRNA21061450
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of TGFB3 mRNA25234470
D008777MethyltestosteroneMethyltestosterone results in decreased expression of TGFB3 mRNA29191790
C500085muraglitazarmuraglitazar results in decreased expression of TGFB3 mRNA21515302
D009151Mustard GasMustard Gas results in decreased expression of TGFB3 mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TGFB3 mRNA"25554681
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TGFB3 mRNA19812364
D009532NickelNickel results in decreased expression of TGFB3 mRNA24084258
C022838nickel chloridenickel chloride affects the expression of TGFB3 mRNA22546817
C007350nitrofennitrofen results in decreased expression of TGFB3 mRNA20638522
C025256nonylphenolTGFB3 protein inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA]26224478
C025256nonylphenolTGFB3 protein inhibits the reaction [nonylphenol results in increased expression of FOS mRNA]26224478
D009638NorepinephrineNorepinephrine results in increased expression of TGFB3 mRNA15326086
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA]15326086
C464660obeticholic acidobeticholic acid results in increased expression of TGFB3 mRNA27939613
C474055octylphenolTGFB3 protein inhibits the reaction [octylphenol results in increased expression of ESR1 mRNA]26224478
C474055octylphenolTGFB3 protein inhibits the reaction [octylphenol results in increased expression of FOS mRNA]26224478
D000069463Olive OilOlive Oil results in increased expression of TGFB3 mRNA26240151
C508548ormeloxifeneormeloxifene affects the expression of TGFB3 mRNA16797179
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in increased expression of TGFB3 mRNA19176365
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of TGFB3 mRNA19176365
D010100OxygenOxygen deficiency results in increased expression of TGFB3 mRNA21531777
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of TGFB3 mRNA]21531777
D010269ParaquatParaquat results in increased expression of TGFB3 mRNA18198484
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of TGFB3 mRNA17715259
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in increased expression of TGFB3 mRNA19176365
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of TGFB3 mRNA19176365
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TGFB3 mRNA28511854
D010578PetroleumPetroleum affects the expression of TGFB3 mRNA25208076
D015232DinoprostoneCCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]28434932
D015232DinoprostoneDinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]28434932
D015232DinoprostoneHIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]28434932
D015232DinoprostoneMMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]28434932
D010656PhenylephrinePhenylephrine results in increased expression of TGFB3 mRNA18158353
D010672PhenytoinPhenytoin results in increased expression of TGFB3 mRNA14741686
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of TGFB3 mRNA17715259
D010795Phthalic AcidsPhthalic Acids results in increased expression of TGFB3 mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of TGFB3 mRNA15268973
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA]15326086
D011374ProgesteroneProgesterone results in decreased expression of TGFB3 mRNA23012394
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of TGFB3 mRNA17404688
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TGFB3 mRNA27029645
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of TGFB3 mRNA"21152443
D011794Quercetin[Quercetin co-treated with Carbon Tetrachloride] results in increased expression of TGFB3 mRNA22989100
D020849Raloxifene HydrochlorideESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TGFB3 mRNA]14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TGFB3 mRNA14699072
C052785rebamipiderebamipide inhibits the reaction [Indomethacin results in increased expression of TGFB3 mRNA]18299717
C059514resveratrolresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]26526931
C059514resveratrolresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]]26526931
C059514resveratrolresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]26526931
C071721Ro 41-0960Ro 41-0960 results in decreased expression of TGFB3 mRNA21896544
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of TGFB3 mRNA]21531777
C089730rosiglitazonerosiglitazone results in decreased expression of TGFB3 mRNA21531777
C089730rosiglitazonerosiglitazone results in decreased expression of TGFB3 mRNA21515302
D012715Sesame OilSesame Oil results in increased expression of TGFB3 mRNA29191790
C017947sodium arsenitesodium arsenite results in increased expression of TGFB3 mRNA12016162
C017947sodium arsenitesodium arsenite results in decreased expression of TGFB3 mRNA16014739
C017947sodium arsenitesodium arsenite results in increased expression of TGFB3 mRNA11241755
C538809sodium pentaboratesodium pentaborate analog results in increased expression of TGFB3 protein27206737
D010042OuabainOuabain results in decreased expression of TGFB3 mRNA28795476
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]22150557
D013629TamoxifenTamoxifen results in decreased expression of TGFB3 mRNA26908177
C501413tesaglitazartesaglitazar results in decreased expression of TGFB3 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TGFB3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TGFB3 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of TGFB3 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGFB3 mRNA9787404
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFB3 mRNA7755487
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFB3 protein9787404
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFB3 mRNA]14728982
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB3 mRNA11861973
D013749Tetrachlorodibenzodioxin[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB3 mRNA21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFB3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFB3 mRNA14728982|1758670
D013749TetrachlorodibenzodioxinTGFB3 protein affects the susceptibility to Tetrachlorodibenzodioxin15668235
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFB3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and affects the localization of TGFB3 protein11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFB3 mRNA15358164
D013853ThioacetamideThioacetamide results in increased expression of TGFB3 mRNA17292413
D013893ThiramThiram results in decreased expression of TGFB3 mRNA20530235
C078041tin sulfidetin sulfide results in increased expression of TGFB3 mRNA29069489
D014212TretinoinTGFB3 protein inhibits the reaction [Tretinoin results in decreased expression of FBN2]24374174
D014212TretinoinTGFB3 protein inhibits the reaction [Tretinoin results in decreased expression of FN1]24374174
D014212TretinoinTGFB3 protein inhibits the reaction [Tretinoin results in decreased expression of TNC]24374174
D014212TretinoinTretinoin results in decreased expression of TGFB324374174
D014212TretinoinTretinoin results in decreased expression of TGFB3 mRNA23830798
D014212TretinoinTretinoin affects the expression of TGFB3 mRNA16235736
D014212TretinoinTretinoin results in increased expression of TGFB3 mRNA12834868|1641007
C057693troglitazonetroglitazone results in decreased expression of TGFB3 mRNA21515302
D014520UrethaneFreund's Adjuvant inhibits the reaction [Urethane results in decreased expression of TGFB3 mRNA]12810352
D014520UrethaneIFNG protein inhibits the reaction [Urethane results in decreased expression of TGFB3 mRNA]12810352
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in decreased expression of TGFB3 mRNA12400877
D014520UrethaneUrethane results in decreased expression of TGFB3 mRNA12400877|1281035
D014635Valproic AcidValproic Acid results in decreased expression of TGFB3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of TGFB3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TGFB3 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of TGFB3 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of TGFB3 mRNA19165385
D014801Vitamin AVitamin A results in increased expression of TGFB3 mRNA17225872
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of TGFB3 mRNA"25208076
D015029ZeranolZeranol results in increased expression of TGFB3 mRNA10811566|1133165
D015034Zinc OxideZinc Oxide affects the expression of TGFB3 mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005114type II transforming growth factor beta receptor binding-IBA21873635  
GO:0005114type II transforming growth factor beta receptor binding-IDA11157754  18243111  
GO:0005114type II transforming growth factor beta receptor binding-IMP8167376  
GO:0005114type II transforming growth factor beta receptor binding-IPI1333888  
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0005515protein binding-IPI1326540  7852346  9872992  10930463  11157754  11850637  
17827158  18243111  21423151  
GO:0008083growth factor activity-IEA-  
GO:0034713type I transforming growth factor beta receptor binding-IDA18243111  
GO:0034714type III transforming growth factor beta receptor binding-IMP8167376  
GO:0042802identical protein binding-IDA18243111  
GO:0042802identical protein binding-IPI19073914  21423151  
GO:0046982protein heterodimerization activity-IEA-  
GO:0050431transforming growth factor beta binding-IDA18243111  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0001666response to hypoxia-IDA18156205  
GO:0001701in utero embryonic development-ISS-  
GO:0002576platelet degranulation-TAS-  
GO:0007179transforming growth factor beta receptor signaling pathway-IBA21873635  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA11157754  18718461  
GO:0007435salivary gland morphogenesis-IEP18080134  
GO:0007565female pregnancy-IEA-  
GO:0007568aging-IEA-  
GO:0008284positive regulation of cell proliferation-IMP11158066  
GO:0008285negative regulation of cell proliferation-IMP11158066  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010718positive regulation of epithelial to mesenchymal transition-IDA18505915  18718461  
GO:0010718positive regulation of epithelial to mesenchymal transition-ISS-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-ISS-  
GO:0010936negative regulation of macrophage cytokine production-IDA20875417  
GO:0030501positive regulation of bone mineralization-IEP17401695  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0030879mammary gland development-ISS-  
GO:0032570response to progesterone-IDA18039789  
GO:0032967positive regulation of collagen biosynthetic process-IMP11158066  
GO:0034616response to laminar fluid shear stress-IEA-  
GO:0042060wound healing-IEA-  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0042476odontogenesis-NAS18078367  
GO:0042704uterine wall breakdown-TAS18039789  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0043627response to estrogen-IEA-  
GO:0043932ossification involved in bone remodeling-IEP17401695  
GO:0045216cell-cell junction organization-IDA18505915  
GO:0045893positive regulation of transcription, DNA-templated-IDA18156205  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048286lung alveolus development-ISS-  
GO:0048468cell development-IBA21873635  
GO:0048565digestive tract development-IEA-  
GO:0048702embryonic neurocranium morphogenesis-IEA-  
GO:0048839inner ear development-IEA-  
GO:0050714positive regulation of protein secretion-IDA18505915  
GO:0051491positive regulation of filopodium assembly-ISS-  
GO:0051496positive regulation of stress fiber assembly-IDA18718461  
GO:0051781positive regulation of cell division-IEA-  
GO:0060325face morphogenesis-IMP12651933  
GO:0060364frontal suture morphogenesis-IEA-  
GO:0060391positive regulation of SMAD protein signal transduction-ISS-  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0062009secondary palate development-ISS-  
GO:0070483detection of hypoxia-IDA18156205  
GO:1904706negative regulation of vascular smooth muscle cell proliferation-IDA26315405  
GO:1905005regulation of epithelial to mesenchymal transition involved in endocardial cushion formationNOTISS-  
GO:1905075positive regulation of occluding junction disassembly-IDA18718461  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-IC11157754  
GO:0009986cell surface-IEA-  
GO:0030315T-tubule-IEA-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0062023collagen-containing extracellular matrix-IDA18049952  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04110Cell cycle
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05144Malaria
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05323Rheumatoid arthritis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-3000178ECM proteoglycansIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9988882Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts. (1999 Jan)Romitti PATeratology
22409215Genetic and environmental risk factors for submucous cleft palate. (2012 Apr)Reiter REur J Oral Sci
27356075Associations Between TGFA/TGFB3/MSX1 Gene Polymorphisms and Congenital Non-Syndromic Hearing Impairment in a Chinese Population. (2016 Jun 29)Du JMed Sci Monit
9415696Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. (1997 Dec 19)Maestri NEAm J Med Genet
18698632Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft. (2008 Sep 15)Chevrier CAm J Med Genet A
27609985Seminal plasma transforming growth factor-beta, activin A and follistatin fluctuate within men over time. (2016 Oct)Sharkey DJHum Reprod