Gene info: ID 7045

Gene: TGFBI

GENE ID: 7045

Synonyms: BIGH3|CDB1|CDG2|CDGG1|CSD|CSD1|CSD2|CSD3|EBMD|LCD1

Description: transforming growth factor beta induced

Gene type: protein-coding

Location: 5q31.1

dbXrefs: Ensembl:ENSG00000120708 MIM:601692 Vega:OTTHUMG00000163213 UniprotKB:Q15582

RefSeq: NG_012646.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.237e-1 (AD) 4.822e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2107331	chr5:136041660 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg10187927	chr5:135364060	TGFBI		4.560e-11	Maternal smoking in pregnancy	27040690
cg18331412	chr5:135364986	TGFBI		1.900e-8	Maternal smoking in pregnancy	27040690
cg10187927	chr5:135364060	TGFBI		3.000e-12	Maternal smoking in pregnancy	27040690
cg18331412	chr5:135364986	TGFBI		7.080e-8	Maternal smoking in pregnancy	27040690
cg10187927	chr5:135364060	TGFBI		2.110e-14	Maternal smoking in pregnancy	27040690
cg18331412	chr5:135364986	TGFBI		2.480e-8	Maternal smoking in pregnancy	27040690
cg05838308	chr5:135367668	TGFBI		2.740e-15	Alcohol consumption per day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CTSC	0.786
GPR65	0.783
CYBB	0.77
MS4A4A	0.77
TLR1	0.768
TNFAIP8	0.763
DAPP1	0.76
LRRC25	0.76
LILRA1	0.759
IKZF1	0.756

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FEZF2	-0.456
HHATL	-0.444
MYH7B	-0.428
ASPDH	-0.401
NXPH3	-0.397
PNPLA7	-0.389
ATP2C2	-0.388
DBP	-0.384
PLA2G6	-0.384
MYADML2	-0.381

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TGFBI mRNA	19933214
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of TGFBI mRNA"	25710175
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TGFBI mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TGFBI mRNA"	22262711
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in decreased expression of TGFBI mRNA"	24172598
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGFBI mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGFBI mRNA"	27188386
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of TGFBI mRNA	17011747
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of TGFBI mRNA	17011747
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGFBI mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGFBI mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of TGFBI mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in decreased expression of TGFBI mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of TGFBI mRNA	17562736
D020106	Acrylamide	Acrylamide affects the expression of TGFBI mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TGFBI mRNA	19770486
D000638	Amiodarone	Amiodarone affects the expression of TGFBI mRNA	19483382
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of TGFBI mRNA"	22863853
D001151	Arsenic	Arsenic affects the methylation of TGFBI gene	25304211
C015001	arsenite	arsenite results in decreased methylation of TGFBI promoter	23974009
D001194	Asbestos	Asbestos results in decreased expression of TGFBI mRNA	16920672
C547126	AZM551248	AZM551248 results in increased expression of TGFBI mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in increased expression of TGFBI mRNA	23656298
D001553	Benzbromarone	Benzbromarone affects the expression of TGFBI mRNA	19483382
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TGFBI mRNA	25566086
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFBI mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of TGFBI mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of TGFBI mRNA	15289156
C006780	bisphenol A	bisphenol A affects the expression of TGFBI mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of TGFBI mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of TGFBI mRNA	27312807
C006780	bisphenol A	bisphenol A results in increased expression of TGFBI mRNA	24534842
C006780	bisphenol A	bisphenol A results in decreased expression of TGFBI mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of TGFBI gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of TGFBI promoter	22457795
D002220	Carbamazepine	Carbamazepine affects the expression of TGFBI mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TGFBI mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TGFBI mRNA	27339419
C100187	chloropicrin	chloropicrin results in decreased expression of TGFBI mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFBI mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of TGFBI mRNA	28472532
D002994	Clofibrate	Clofibrate affects the expression of TGFBI mRNA	19483382
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TGFBI mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased secretion of TGFBI protein	22079246
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TGFBI mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TGFBI mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of TGFBI mRNA	21072851
D003471	Cuprizone	Cuprizone results in decreased expression of TGFBI mRNA	27523638
D003471	Cuprizone	Cuprizone results in increased expression of TGFBI mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of TGFBI mRNA	27989131
C561627	dabrafenib	"dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]"	29042256
C561627	dabrafenib	"dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]"	29042256
C561627	dabrafenib	dabrafenib inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein]	29042256
C561627	dabrafenib	dabrafenib inhibits the reaction [TGFBI protein results in increased expression of SELE protein]	29042256
C561627	dabrafenib	dabrafenib inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein]	29042256
C014347	decitabine	decitabine results in increased expression of TGFBI mRNA	21856257
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TGFBI mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in decreased expression of TGFBI mRNA	25047013
D002945	Cisplatin	TGFBI mRNA results in decreased susceptibility to Cisplatin	25199881
C121718	dicyclanil	dicyclanil results in decreased expression of TGFBI mRNA	15664270
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of TGFBI mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of TGFBI mRNA	18042831\|1845759
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TGFBI mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of TGFBI mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of TGFBI mRNA	15289156
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of TGFBI mRNA	17011747
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of TGFBI mRNA	17011747
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of TGFBI mRNA	26924002
D004237	Diuron	Diuron metabolite results in decreased expression of TGFBI mRNA	24172598
D004237	Diuron	Diuron results in increased expression of TGFBI mRNA	21551480
D004317	Doxorubicin	Doxorubicin affects the expression of TGFBI protein	29385562
D004317	Doxorubicin	TGFBI mRNA results in decreased susceptibility to Doxorubicin	25199881
D004656	Enalapril	Enalapril results in decreased secretion of TGFBI protein	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein	18682491
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TGFBI mRNA	22079256
C414690	eplerenone	[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein	18682491
C414690	eplerenone	eplerenone results in decreased secretion of TGFBI protein	18682491
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBI mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TGFBI mRNA	16174780
D005001	Ethionine	Ethionine affects the expression of TGFBI mRNA	19483382
C000499	ferric oxide	ferric oxide analog results in increased expression of TGFBI mRNA	24525745
D005472	Fluorouracil	TGFBI protein affects the susceptibility to Fluorouracil	16217747
D005485	Flutamide	Flutamide results in decreased expression of TGFBI mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFBI mRNA	20938992
C069837	fullerene C60	fullerene C60 results in decreased expression of TGFBI mRNA	19167457
D019833	Genistein	Genistein results in decreased expression of TGFBI mRNA	15289156
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of TGFBI mRNA	22634610
C004312	glycidol	glycidol results in decreased expression of TGFBI mRNA	24915197
C412815	GW 4064	GW 4064 results in increased expression of TGFBI mRNA	26655953
D017313	Fenretinide	Fenretinide results in decreased expression of TGFBI mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGFBI mRNA	25613284
C051890	irinotecan	irinotecan analog results in decreased expression of TGFBI mRNA	18927307
C544151	jinfukang	jinfukang results in increased expression of TGFBI mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TGFBI mRNA	23086925
C410337	K 7174	K 7174 results in increased expression of TGFBI mRNA	24086573
D007854	Lead	Lead results in decreased expression of TGFBI mRNA	19921347
C533894	LG 100815	LG 100815 results in increased expression of TGFBI mRNA	16951191
C440499	lipopolysaccharide, Escherichia coli O111 B4	"dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]"	29042256
C440499	lipopolysaccharide, Escherichia coli O111 B4	"dabrafenib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]"	29042256
C440499	lipopolysaccharide, Escherichia coli O111 B4	"ITGB5 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]"	27287417\|2904225
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA"	27287417\|2904225
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein"	27287417\|2904225
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Triterpenes inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]"	27287417
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Triterpenes inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]"	27287417
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of TGFBI mRNA	28070326
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TGFBI mRNA	27887929
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of TGFBI protein	27887929
D008070	Lipopolysaccharides	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TGFBI mRNA]	28070326
D008070	Lipopolysaccharides	Triterpenes inhibits the reaction [Lipopolysaccharides results in increased expression of TGFBI mRNA]	27887929
D008070	Lipopolysaccharides	Triterpenes inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFBI protein]	27887929
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TGFBI mRNA	27339419
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in increased expression of TGFBI mRNA	24525745
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of TGFBI mRNA	20353558
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFBI mRNA	20938992
D008727	Methotrexate	TGFBI mRNA results in decreased susceptibility to Methotrexate	25199881
D016685	Mitomycin	Mitomycin results in decreased expression of TGFBI mRNA	18615204
D016685	Mitomycin	Mitomycin results in decreased expression of TGFBI protein	18615204
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of TGFBI mRNA	22108045
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of TGFBI mRNA	26924002
C523799	MRK 003	MRK 003 results in decreased expression of TGFBI mRNA	21169257
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TGFBI mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TGFBI mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of TGFBI mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of TGFBI mRNA	24136188
D009532	Nickel	Nickel results in increased expression of TGFBI mRNA	12540486
C022838	nickel chloride	nickel chloride results in decreased expression of TGFBI mRNA	24612858
C028007	nickel monoxide	nickel monoxide results in decreased expression of TGFBI mRNA	19167457
C012655	nimesulide	nimesulide results in decreased expression of TGFBI mRNA	24136188
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of TGFBI mRNA"	16951191
D009853	Omeprazole	Omeprazole affects the expression of TGFBI mRNA	19483382
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of TGFBI mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of TGFBI mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of TGFBI mRNA	26516004
D017239	Paclitaxel	TGFBI mRNA results in decreased susceptibility to Paclitaxel	25199881
D000073878	Palm Oil	Palm Oil results in decreased expression of TGFBI mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGFBI mRNA"	27188386
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of TGFBI mRNA	18692542
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TGFBI mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TGFBI mRNA	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGFBI mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of TGFBI mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of TGFBI mRNA	17426115
C006253	pirinixic acid	pirinixic acid affects the expression of TGFBI mRNA	19483382
D010936	Plant Extracts	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TGFBI mRNA]	28070326
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TGFBI mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of TGFBI mRNA	22714537
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of TGFBI mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of TGFBI protein	23718831
D011374	Progesterone	Progesterone results in decreased expression of TGFBI mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of TGFBI	17510236
D011441	Propylthiouracil	Propylthiouracil affects the expression of TGFBI mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TGFBI mRNA	24780913
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of TGFBI mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA	19059307
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFBI mRNA	19059307
C059514	resveratrol	resveratrol results in decreased expression of TGFBI mRNA	25888808
D012715	Sesame Oil	Sesame Oil results in decreased expression of TGFBI mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased secretion of TGFBI protein	25895662
D012906	Smoke	Smoke results in increased expression of TGFBI mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of TGFBI mRNA	16882884\|2392266
C016104	sodium bichromate	sodium bichromate results in decreased expression of TGFBI mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in decreased expression of TGFBI mRNA	17685462
D012999	Soman	Soman results in increased expression of TGFBI mRNA	19281266
D053260	Soot	Soot results in increased expression of TGFBI mRNA	22461453
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA	19059307
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of TGFBI mRNA	19059307
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of TGFBI mRNA	15885361
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TGFBI mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFBI mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNA	19619570\|2010694
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBI mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGFBI mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNA	15644576
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGFBI mRNA	25613284
D013792	Thalidomide	Thalidomide results in decreased expression of TGFBI mRNA	26006729\|2621778
D013853	Thioacetamide	Thioacetamide affects the expression of TGFBI mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in increased expression of TGFBI mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TGFBI mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TGFBI mRNA	18087596
D019772	Topotecan	TGFBI mRNA results in decreased susceptibility to Topotecan	25199881
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of TGFBI mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of TGFBI mRNA	25729387
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of TGFBI mRNA"	17951470
D014212	Tretinoin	Tretinoin results in decreased expression of TGFBI mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of TGFBI mRNA	16951191\|2383079
C012589	trichostatin A	trichostatin A results in increased expression of TGFBI mRNA	15901671
C012589	trichostatin A	trichostatin A results in decreased expression of TGFBI mRNA	24935251
C012589	trichostatin A	trichostatin A results in decreased expression of TGFBI mRNA	15901671
D014315	Triterpenes	"Triterpenes inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFBI mRNA]"	27287417
D014315	Triterpenes	"Triterpenes inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TGFBI protein]"	27287417
D014315	Triterpenes	Triterpenes inhibits the reaction [Lipopolysaccharides results in increased expression of TGFBI mRNA]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFBI protein]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased expression of ICAM1 protein]	27287417\|2788792
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased expression of SELE protein]	27287417\|2788792
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased expression of VCAM1 protein]	27287417\|2788792
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased phosphorylation of and affects the localization of RELA protein]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased phosphorylation of MAPK1 protein]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased phosphorylation of MAPK3 protein]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased secretion of IL6 protein]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased secretion of ITGAV protein alternative form]	27887929
D014315	Triterpenes	Triterpenes inhibits the reaction [TGFBI protein results in increased secretion of TNF protein]	27887929
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of TGFBI mRNA	15885361
D014635	Valproic Acid	Valproic Acid results in increased expression of TGFBI mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in decreased expression of TGFBI mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in increased expression of TGFBI mRNA	24896083
D014635	Valproic Acid	Valproic Acid results in decreased expression of TGFBI mRNA	15901671
D014638	Vanadates	Vanadates results in increased expression of TGFBI mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of TGFBI mRNA	19165385
D014750	Vincristine	TGFBI mRNA results in decreased susceptibility to Vincristine	25199881
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TGFBI mRNA	26682919
D014800	Vitallium	Vitallium analog results in decreased expression of TGFBI mRNA	23825117
D014810	Vitamin E	Vitamin E results in increased expression of TGFBI mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005178	integrin binding	-	IEA	-
GO:0005515	protein binding	-	IPI	19478074 25416956
GO:0005518	collagen binding	-	IPI	19478074
GO:0050839	cell adhesion molecule binding	-	IBA	21873635
GO:0050840	extracellular matrix binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEP	11866539
GO:0002062	chondrocyte differentiation	-	IEA	-
GO:0007155	cell adhesion	-	IBA	21873635
GO:0007155	cell adhesion	-	IEA	-
GO:0007162	negative regulation of cell adhesion	-	TAS	8024701
GO:0007601	visual perception	-	IEA	-
GO:0008283	cell proliferation	-	IEA	-
GO:0030198	extracellular matrix organization	-	IBA	21873635
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0050896	response to stimulus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	TAS	-
GO:0005604	basement membrane	-	IEA	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	19478074
GO:0005802	trans-Golgi network	-	IDA	19478074
GO:0005886	plasma membrane	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707 27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	ISS	22261194
GO:0070062	extracellular exosome	-	HDA	19199708 21362503

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-977225	Amyloid fiber formation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21071578	A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. (2011 Jan)	Balasenthil S	Cancer Prev Res (Phila)