Gene: TGFBR1

7046
AAT5|ACVRLK4|ALK-5|ALK5|ESS1|LDS1|LDS1A|LDS2A|MSSE|SKR4|TBR-i|TBRI|TGFR-1|tbetaR-I
transforming growth factor beta receptor 1
protein-coding
9q22.33
Ensembl:ENSG00000106799 MIM:190181 Vega:OTTHUMG00000020353 UniprotKB:P36897
NG_007461.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.923e-2 (AD)  3.364e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IKZF10.899
LILRA10.883
PTPRC0.873
HCK0.872
SCIN0.866
RUNX10.864
TBXAS10.862
LPCAT20.862
ARHGAP300.861
FCGR3A0.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.437
MAGIX-0.43
GSG1-0.414
ASPDH-0.413
KCNG1-0.408
RTN4R-0.407
KCNK4-0.406
MARCH4-0.404
CORT-0.4
WNT7A-0.399

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB039214-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)QuinolineSmall MoleculeExperimentalTarget
DB04434Naphthyridine InhibitorSmall MoleculeExperimentalTarget
DB044803-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]PyrazoleSmall MoleculeExperimentalTarget
DB07152N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamideSmall MoleculeExperimentalTarget
DB072672-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amineSmall MoleculeExperimentalTarget
DB08450N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TGFBR1 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TGFBR1 mRNA"19167446
C0292162-amino-3-methylimidazo(4,5-f)quinoline"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of TGFBR1 protein"22094457
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]17531121
C5029712-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine results in decreased phosphorylation of and results in decreased activity of TGFBR1 protein15723089
C0163923,3'-diindolylmethane"3,3'-diindolylmethane affects the methylation of TGFBR1 promoter"24466240
C5099274-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide results in decreased activity of TGFBR1 protein16570917
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased expression of TGFBR1 protein]"20458730
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of TGFBR1 protein"15811853|2436754
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of TGFBR1 protein] inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of VEGFA protein]"23618901
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of TGFBR1 protein"20852150
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of TGFBR1 protein"21613822|2361890
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TGFBR1 mRNA19191707
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of TGFBR1 mRNA20829426
D000082AcetaminophenAcetaminophen results in decreased expression of TGFBR1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TGFBR1 mRNA22230336
D000111AcetylcysteineAcetylcysteine results in decreased expression of TGFBR1 mRNA17602960
D000111AcetylcysteineAcetylcysteine results in decreased expression of TGFBR1 protein17602960
D000111AcetylcysteineButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]17602960
D000111AcetylcysteineButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]17602960
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TGFBR1 mRNA21641981
C006463allyl alcoholallyl alcohol results in increased expression of TGFBR1 mRNA18564211
C006463allyl alcoholTamoxifen inhibits the reaction [allyl alcohol results in increased expression of TGFBR1 mRNA]18564211
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TGFBR1 mRNA21298039
C010845aluminum chloridealuminum chloride results in decreased expression of TGFBR1 mRNA26658030|2772069
C010845aluminum chlorideTGFB1 protein inhibits the reaction [aluminum chloride results in decreased expression of TGFBR1 mRNA]27720690
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TGFBR1 mRNA16483693
C044946benazeprilbenazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]11798618
C044946benazeprilbenazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein]11798618
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TGFBR1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGFBR1 mRNA22228805
D004958EstradiolEstradiol inhibits the reaction [nitrofen results in increased expression of TGFBR1 mRNA]21129541
D001688Biological ProductsBiological Products results in decreased expression of TGFBR1 protein23624380
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of TGFBR1 mRNA"20162321
C006780bisphenol Abisphenol A results in increased expression of TGFBR1 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of TGFBR1 gene28505145
D001761BleomycinMIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28726637
D001761BleomycinBleomycin results in increased expression of TGFBR1 mRNA28726637
D001761Bleomycin[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28434932
D001761Bleomycin[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28434932
D001761Bleomycin[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28434932
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]17602960
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]17602960
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]17602960
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]17602960
D002101Cacodylic AcidCacodylic Acid results in decreased expression of TGFBR1 mRNA17441966
D002104CadmiumCadmium results in increased expression of TGFBR1 mRNA21120746
D002104CadmiumCadmium results in increased expression of TGFBR1 mRNA26187450
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TGFBR1 mRNA12160620
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TGFBR1 mRNA26778414
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGFBR1 mRNA27477297
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGFBR1 protein27477297
D002251Carbon TetrachlorideNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]27477297
D002251Carbon TetrachlorideNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]27477297
D002251Carbon Tetrachloridetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]27477297
D002251Carbon Tetrachloridetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]27477297
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of TGFBR1 mRNA18636392
C007020chlorophyllin"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 mRNA]"22485181
C007020chlorophyllin"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 protein]"22485181
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TGFBR1 mRNA20350560
D003042CocaineCocaine results in increased expression of TGFBR1 mRNA20056891
D003042CocaineEHMT2 inhibits the reaction [Cocaine results in increased expression of TGFBR1 mRNA]20056891
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TGFBR1 mRNA"19167446
D003471CuprizoneCuprizone results in increased expression of TGFBR1 mRNA27523638
D003474Curcumin2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]17531121
D003474CurcuminButhionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]17602960
D003474CurcuminButhionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]17602960
D003474CurcuminCurcumin results in decreased expression of TGFBR1 mRNA17602960
D003474CurcuminCurcumin results in decreased expression of TGFBR1 protein16959952|1753112
D016572CyclosporineCyclosporine results in decreased expression of TGFBR1 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of TGFBR1 mRNA16980036
D016572CyclosporineCyclosporine results in increased expression of TGFBR1 protein16980036
D016572Cyclosporine[Thioacetamide co-treated with Cyclosporine] results in increased expression of TGFBR1 protein15770714
D003907DexamethasoneDexamethasone results in increased expression of TGFBR1 mRNA21041162
D003975DiazepamDiazepam results in increased expression of TGFBR1 mRNA19114084
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of TGFBR1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of TGFBR1 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of TGFBR1 mRNA]27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TGFBR1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of TGFBR1 mRNA25016146
D004052Diethylnitrosamine[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TGFBR1 mRNA26778414
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR1 mRNA8001232
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR1 protein8001232
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR1 mRNA8565130
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 protein"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 mRNA]"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 protein]"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 protein]"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TGFBR1 protein16009107
D004128Dimethylnitrosaminesalvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR1 protein]16009107
C024629dimethyl phthalatedimethyl phthalate affects the expression of TGFBR1 mRNA26924002
D004610Ellagic Acid"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR1 protein]"22485181
D004656EnalaprilEnalapril results in decreased expression of TGFBR1 mRNA12883979
D004656EnalaprilEnalapril results in decreased expression of TGFBR1 protein12883979
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGFBR1 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TGFBR1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of TGFBR1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of TGFBR1 mRNA23649840
D005665FurosemideFurosemide results in increased expression of TGFBR1 mRNA16526316
C037032galangingalangin results in increased expression of TGFBR1 mRNA25268046
D005897GlafenineGlafenine results in decreased expression of TGFBR1 mRNA24136188
D005944Glucosamine"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased expression of TGFBR1 protein]"20458730
D005944GlucosamineGlucosamine analog results in increased expression of TGFBR1 protein20458730
D005947GlucoseGlucose results in increased expression of TGFBR1 protein21367880
D005947Glucoseisoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR1 protein]21367880
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of TGFBR1 mRNA28923513
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGFBR1 mRNA25613284
C551631isoangustone Aisoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR1 protein]21367880
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of TGFBR1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of TGFBR1 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of TGFBR1 mRNA27392435
D007854LeadLead affects the expression of TGFBR1 mRNA28903495
C467567lenalidomidelenalidomide results in decreased expression of TGFBR1 mRNA15618473
C467567lenalidomidelenalidomide results in decreased expression of TGFBR1 protein15618473
D017705LignansLignans results in decreased expression of TGFBR1 mRNA26678224
D008070Lipopolysaccharides[Thioacetamide co-treated with Lipopolysaccharides] results in increased expression of TGFBR1 mRNA17621560
D008095Lithocholic AcidLithocholic Acid results in increased expression of TGFBR1 mRNA23034213
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TGFBR1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TGFBR1 mRNA26378955
D008345ManganeseManganese results in decreased expression of TGFBR1 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of TGFBR1 mRNA17175027
D008694MethamphetamineMethamphetamine results in increased expression of TGFBR1 mRNA12766323
D008731MethoxychlorMethoxychlor results in increased methylation of TGFBR1 gene23303685
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of TGFBR1 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TGFBR1 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TGFBR1 mRNA23649840
D0156551-Methyl-4-phenylpyridiniumTGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein]]26254549
D0156551-Methyl-4-phenylpyridiniumTGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]]26254549
D0156551-Methyl-4-phenylpyridiniumTGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]26254549
D0156551-Methyl-4-phenylpyridiniumTGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]26254549
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of TGFBR1 mRNA20886546
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TGFBR1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TGFBR1 mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TGFBR1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TGFBR1 mRNA"19836432
C000621033napabucasinnapabucasin results in decreased expression of TGFBR1 mRNA25605917
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased expression of TGFBR1 mRNA21487212
D009532NickelNickel results in increased expression of TGFBR1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of TGFBR1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of TGFBR1 mRNA18832182|2271453
C007350nitrofenEstradiol inhibits the reaction [nitrofen results in increased expression of TGFBR1 mRNA]21129541
C007350nitrofennitrofen results in decreased expression of TGFBR1 mRNA27822781
C007350nitrofennitrofen results in decreased expression of TGFBR1 protein27822781
C007350nitrofennitrofen results in increased expression of TGFBR1 mRNA21129541
C529989NP 40208NP 40208 binds to and results in decreased activity of TGFBR1 protein22025605
C529989NP 40208NP 40208 results in decreased activity of TGFBR1 protein18034274
C464660obeticholic acidobeticholic acid results in decreased expression of TGFBR1 mRNA27939613
D019815Oxalic AcidOxalic Acid results in increased expression of TGFBR1 protein24145091
D019815Oxalic Acidresveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR1 protein]24145091
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of TGFBR1 mRNA18636392
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of TGFBR1 mRNA28973697
D015232Dinoprostone[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28434932
D015232Dinoprostone[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28434932
D015232Dinoprostone[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]28434932
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR1 mRNA8001232
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR1 protein8001232
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR1 mRNA8565130
D010656PhenylephrinePhenylephrine results in increased expression of TGFBR1 mRNA19443575
C008922piperinepiperine binds to TGFBR1 protein28341137
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGFBR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TGFBR1 mRNA22079256
D011791QuartzQuartz results in increased expression of TGFBR1 mRNA19836432
D011794QuercetinQuercetin results in decreased expression of TGFBR1 protein15580028
C059514resveratrolresveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR1 protein]24145091
C059514resveratrolresveratrol results in increased expression of TGFBR1 protein20637737
D012406RoxarsoneRoxarsone results in increased expression of TGFBR1 protein21652273
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR1 protein]16009107
C009277sodium arsenatesodium arsenate results in increased expression of TGFBR1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of TGFBR1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of TGFBR1 mRNA22714537
D053260SootSoot results in decreased expression of TGFBR1 mRNA23634900
D013311StreptozocinStreptozocin affects the expression of TGFBR1 mRNA26073000
D013311Streptozocinbenazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]11798618
D013311Streptozocinbenazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein]11798618
D013311StreptozocinStreptozocin results in increased expression of TGFBR1 mRNA11798618
D013311StreptozocinStreptozocin results in increased expression of TGFBR1 protein11798618
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TGFBR1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TGFBR1 mRNA26378955
C016766sulforafansulforafan affects the methylation of TGFBR1 promoter24466240
D016559TacrolimusTacrolimus results in increased expression of TGFBR1 mRNA16980036
D016559TacrolimusTacrolimus results in increased expression of TGFBR1 protein16980036
D013629TamoxifenTamoxifen inhibits the reaction [allyl alcohol results in increased expression of TGFBR1 mRNA]18564211
D043343Testosterone PropionateTestosterone Propionate results in increased expression of TGFBR1 mRNA20858754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFBR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGFBR1 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGFBR1 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFBR1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGFBR1 mRNA25613284
C017953tetramethylpyrazineNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]27477297
C017953tetramethylpyrazineNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]27477297
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]27477297
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]27477297
D013792ThalidomideThalidomide results in decreased expression of TGFBR1 mRNA15618473
D013792ThalidomideThalidomide results in decreased expression of TGFBR1 protein15618473
D013853ThioacetamideTGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of CTGF mRNA]28560358
D013853ThioacetamideTGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of PDGFA mRNA]28560358
D013853ThioacetamideTGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of PDGFB mRNA]28560358
D013853ThioacetamideTGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]28560358
D013853ThioacetamideTGFBR1 protein results in increased susceptibility to Thioacetamide28560358
D013853Thioacetamide[TGFBR1 protein results in increased susceptibility to Thioacetamide] which results in increased cleavage of CASP3 protein28560358
D013853Thioacetamide[TGFBR1 protein results in increased susceptibility to Thioacetamide] which results in increased expression of GPT protein28560358
D013853Thioacetamide[Thioacetamide co-treated with Cyclosporine] results in increased expression of TGFBR1 protein15770714
D013853Thioacetamide[Thioacetamide co-treated with Lipopolysaccharides] results in increased expression of TGFBR1 mRNA17621560
D013853ThioacetamideThioacetamide results in increased expression of TGFBR1 mRNA28181416
D014028Tobacco Smoke Pollution"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of TGFBR1 protein] inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of VEGFA protein]"23618901
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TGFBR1 mRNA20133372
D014212TretinoinTretinoin affects the expression of TGFBR1 mRNA16235736
D014212TretinoinTretinoin results in decreased expression of TGFBR1 mRNA15389595
D014212TretinoinTretinoin results in decreased expression of TGFBR1 mRNA24977338
C032910triadimefontriadimefon results in decreased expression of TGFBR1 mRNA18976680
C012589trichostatin Atrichostatin A results in increased expression of TGFBR1 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TGFBR1 mRNA23537331
D014635Valproic AcidValproic Acid results in decreased expression of TGFBR1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of TGFBR1 mRNA26705709
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TGFBR1 gene25560391
D014801Vitamin AVitamin A results in decreased expression of TGFBR1 mRNA17225872
D002762CholecalciferolCholecalciferol results in increased expression of TGFBR1 mRNA17170073
C000588914WJ1376-1WJ1376-1 inhibits the reaction [TGFB1 protein results in increased phosphorylation of TGFBR1 protein]24727557
C000588915WJ1398-1WJ1398-1 inhibits the reaction [TGFB1 protein results in increased phosphorylation of TGFBR1 protein]24727557

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA19736306  
GO:0004674protein serine/threonine kinase activity-IDA12065756  18625725  
GO:0005024transforming growth factor beta-activated receptor activity-IBA21873635  
GO:0005024transforming growth factor beta-activated receptor activity-IC1326540  
GO:0005024transforming growth factor beta-activated receptor activity-IDA12015308  14633705  
GO:0005024transforming growth factor beta-activated receptor activity-IMP18625725  
GO:0005024transforming growth factor beta-activated receptor activitycontributes_toIMP1333888  
GO:0005025transforming growth factor beta receptor activity, type I-IBA21873635  
GO:0005025transforming growth factor beta receptor activity, type I-IDA8752209  
GO:0005114type II transforming growth factor beta receptor binding-IDA11157754  
GO:0005114type II transforming growth factor beta receptor binding-IPI1333888  
GO:0005515protein binding-IPI8622651  10025408  11278302  11279102  12015308  14517293  
14580334  15702480  15761148  17099224  18243111  18625725  
18758450  18974388  19732720  20856203  22344298  24263861  
24658140  25893292  
GO:0005524ATP binding-IDA12065756  
GO:0019838growth factor binding-IBA21873635  
GO:0019838growth factor bindingcontributes_toIPI14517293  
GO:0046332SMAD binding-IBA21873635  
GO:0046332SMAD binding-IDA12065756  18625725  
GO:0046332SMAD binding-IPI8980228  9311995  
GO:0046872metal ion binding-IEA-  
GO:0048185activin binding-IBA21873635  
GO:0050431transforming growth factor beta binding-IDA11157754  14633705  
GO:0050431transforming growth factor beta bindingcontributes_toIMP1333888  
GO:0050431transforming growth factor beta binding-IPI1326540  
GO:0070411I-SMAD binding-IPI11278251  
GO ID GO Term Qualifier Evidence PubMed
GO:0000186activation of MAPKK activity-IDA18625725  
GO:0001501skeletal system development-ISS-  
GO:0001701in utero embryonic development-ISS-  
GO:0001822kidney development-ISS-  
GO:0001824blastocyst development-IEA-  
GO:0001837epithelial to mesenchymal transition-IDA15761148  
GO:0001937negative regulation of endothelial cell proliferation-IEA-  
GO:0001938positive regulation of endothelial cell proliferation-ISS-  
GO:0002088lens development in camera-type eye-IEA-  
GO:0003222ventricular trabecula myocardium morphogenesis-ISS-  
GO:0003223ventricular compact myocardium morphogenesis-ISS-  
GO:0003342proepicardium developmentNOTISS-  
GO:0006355regulation of transcription, DNA-templated-IDA14517293  
GO:0006355regulation of transcription, DNA-templated-IMP15702480  
GO:0006468protein phosphorylation-IDA12015308  12065756  
GO:0006915apoptotic process-IEA-  
GO:0007050cell cycle arrest-TAS9759503  
GO:0007165signal transduction-IDA14633705  
GO:0007179transforming growth factor beta receptor signaling pathway-IBA21873635  
GO:0007179transforming growth factor beta receptor signaling pathway-IC1326540  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA9389648  11157754  
GO:0007179transforming growth factor beta receptor signaling pathway-IMP1333888  
GO:0007179transforming growth factor beta receptor signaling pathway-ISS-  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007389pattern specification process-IBA21873635  
GO:0007507heart development-ISS-  
GO:0008284positive regulation of cell proliferation-IMP14633705  
GO:0008354germ cell migration-ISS-  
GO:0008584male gonad development-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0009952anterior/posterior pattern specification-ISS-  
GO:0010628positive regulation of gene expression-IMP27162619  
GO:0010717regulation of epithelial to mesenchymal transition-ISS-  
GO:0010718positive regulation of epithelial to mesenchymal transition-ISS-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IDA9311995  9389648  
GO:0016579protein deubiquitination-TAS-  
GO:0018105peptidyl-serine phosphorylation-IDA15761148  
GO:0018107peptidyl-threonine phosphorylation-IDA19736306  
GO:0030199collagen fibril organization-ISS-  
GO:0030307positive regulation of cell growth-IDA18625725  
GO:0030335positive regulation of cell migration-IDA19736306  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0031396regulation of protein ubiquitination-IDA18758450  
GO:0032331negative regulation of chondrocyte differentiation-ISS-  
GO:0032924activin receptor signaling pathway-IBA21873635  
GO:0032924activin receptor signaling pathway-ISS-  
GO:0035556intracellular signal transduction-ISS-  
GO:0042060wound healing-TAS9759503  
GO:0042118endothelial cell activation-ISS-  
GO:0043062extracellular structure organization-TAS9759503  
GO:0043393regulation of protein binding-IEA-  
GO:0043542endothelial cell migration-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA9311995  9389648  
GO:0048538thymus development-ISS-  
GO:0048663neuron fate commitment-ISS-  
GO:0048701embryonic cranial skeleton morphogenesis-ISS-  
GO:0048705skeletal system morphogenesis-ISS-  
GO:0048762mesenchymal cell differentiation-TAS9759503  
GO:0048844artery morphogenesis-ISS-  
GO:0048870cell motility-IMP18625725  
GO:0051272positive regulation of cellular component movement-IMP18625725  
GO:0051491positive regulation of filopodium assembly-IEA-  
GO:0051496positive regulation of stress fiber assembly-ISS-  
GO:0051897positive regulation of protein kinase B signaling-IDA18625725  
GO:0060017parathyroid gland development-ISS-  
GO:0060021roof of mouth development-ISS-  
GO:0060037pharyngeal system development-ISS-  
GO:0060043regulation of cardiac muscle cell proliferation-ISS-  
GO:0060317cardiac epithelial to mesenchymal transition-ISS-  
GO:0060389pathway-restricted SMAD protein phosphorylation-IDA11157754  12015308  18625725  19736306  
GO:0060391positive regulation of SMAD protein signal transduction-IDA9389648  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0060978angiogenesis involved in coronary vascular morphogenesis-ISS-  
GO:0060982coronary artery morphogenesis-ISS-  
GO:0070723response to cholesterol-IDA17878231  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA19494318  
GO:1905007positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation-ISS-  
GO:1905075positive regulation of occluding junction disassembly-ISS-  
GO:1905223epicardium morphogenesis-ISS-  
GO:2001235positive regulation of apoptotic signaling pathway-IDA18758450  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IMP18625725  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IEA-  
GO:0005886plasma membrane-IDA17878231  25893292  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005923bicellular tight junction-IDA15761148  
GO:0009986cell surface-IDA25893292  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA8774881  14517293  
GO:0045121membrane raft-IDA25893292  
GO:0048179activin receptor complex-IBA21873635  
GO:0070022transforming growth factor beta receptor complex-IC1326540  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04520Adherens junction
hsa05142Chagas disease (American trypanosomiasis)
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsIEA
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)TAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)IEA
R-HSA-3304349Loss of Function of SMAD2/3 in CancerTAS
R-HSA-3304351Signaling by TGF-beta Receptor Complex in CancerTAS
R-HSA-3304356SMAD2/3 Phosphorylation Motif Mutants in CancerTAS
R-HSA-3315487SMAD2/3 MH2 Domain Mutants in CancerTAS
R-HSA-3642278Loss of Function of TGFBR2 in CancerTAS
R-HSA-3645790TGFBR2 Kinase Domain Mutants in CancerTAS
R-HSA-3656532TGFBR1 KD Mutants in CancerTAS
R-HSA-3656534Loss of Function of TGFBR1 in CancerTAS
R-HSA-3656535TGFBR1 LBD Mutants in CancerTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5688426DeubiquitinationIEA
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesIEA
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23275154Genetic variations in the TGFbeta signaling pathway, smoking and risk of colorectal cancer in a Chinese population. (2013 Apr)Zhong RCarcinogenesis
19004027TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis. (2009 Feb 1)Castillejo AInt J Cancer
16835078How valid is single nucleotide polymorphism (SNP) diagnosis for the individual risk assessment of breast cancer? (2006 Mar)Tempfer CBGynecol Endocrinol
29614203Changes in the expression of matrix extracellular genes and TGFB family members in rotator cuff tears. (2018 Apr 3)Belangero PSJ Orthop Res
26027897Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms. (2015 Jul)Zuo SEur J Vasc Endovasc Surg