Gene info: ID 7048

Gene: TGFBR2

GENE ID: 7048

Description: transforming growth factor beta receptor 2

Gene type: protein-coding

Location: 3p24.1

dbXrefs: Ensembl:ENSG00000163513 MIM:190182 Vega:OTTHUMG00000130569 UniprotKB:P37173

RefSeq: NG_007490.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.995e-2 (AD) 8.778e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg24719910	chr3:30691493	TGFBR2		3.600e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GIMAP6	0.916
FLI1	0.909
MECOM	0.9
MYOF	0.895
FOXC1	0.889
GIMAP8	0.884
EMCN	0.883
CARD6	0.882
MYCT1	0.882
CFH	0.881

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC7A4	-0.467
SPEF1	-0.454
TMEM121	-0.453
ZSCAN1	-0.452
CHST8	-0.45
HAS1	-0.449
MYADML2	-0.449
TMEM179	-0.446
ASPDH	-0.445
MARCH4	-0.442

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB09462	Glycerin	Small Molecule	56-81-5	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TGFBR2 mRNA"	22698814\|2890350
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFBR2 mRNA]"	21851831
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TGFBR2 mRNA"	21851831
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TGFBR2 mRNA]"	21851831
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	"TGFBR2 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of IGFBP3 mRNA]"	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	"TGFBR2 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of IGFBP3 protein]"	29108245
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of TGFBR2 protein"	22094457
C029955	2-nitrotoluene	2-nitrotoluene results in increased expression of TGFBR2 mRNA	16460773
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of TGFBR2 mRNA"	18648102
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of TGFBR2 mRNA"	27567155
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Fluoride results in increased expression of TGFBR2 mRNA]"	29127033
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of TGFBR2 mRNA	20829426
D000079	Acetaldehyde	Acetaldehyde results in increased expression of TGFBR2 mRNA	12223100
D000079	Acetaldehyde	JUN protein promotes the reaction [Acetaldehyde results in increased expression of TGFBR2 mRNA]	12223100
D000079	Acetaldehyde	KLF9 protein promotes the reaction [Acetaldehyde results in increased expression of TGFBR2 mRNA]	12223100
D000079	Acetaldehyde	TGFBR2 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]	12223100
D000082	Acetaminophen	Acetaminophen affects the expression of TGFBR2 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of TGFBR2 mRNA	17602960
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of TGFBR2 protein	17602960
D000111	Acetylcysteine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 mRNA]	17602960
D000111	Acetylcysteine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 protein]	17602960
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TGFBR2 mRNA	28943387
C010845	aluminum chloride	aluminum chloride results in decreased expression of TGFBR2 mRNA	26658030\|2772069
C010845	aluminum chloride	TGFB1 protein inhibits the reaction [aluminum chloride results in decreased expression of TGFBR2 mRNA]	27720690
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of TGFBR2 mRNA	19464052
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TGFBR2 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of TGFBR2 mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of TGFBR2 mRNA]	12205029
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TGFBR2 mRNA	25339124
D001151	Arsenic	Arsenic affects the expression of TGFBR2 protein	24675094
D001151	Arsenic	Arsenic affects the methylation of TGFBR2 gene	25304211
C058317	arsenic disulfide	arsenic disulfide results in decreased expression of TGFBR2 mRNA	12890387
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TGFBR2 mRNA	12852829\|2252195
D001194	Asbestos	"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of TGFBR2 mRNA"	25358858
C547126	AZM551248	AZM551248 results in increased expression of TGFBR2 mRNA	22323515
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of TGFBR2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TGFBR2 mRNA	20106945\|2163298
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TGFBR2 mRNA"	19150397
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in increased expression of TGFBR2 mRNA	24758408
D004958	Estradiol	Estradiol results in increased expression of TGFBR2 mRNA	19484750
D004958	Estradiol	Estradiol results in decreased expression of TGFBR2 mRNA	7585526
D001688	Biological Products	Biological Products results in decreased expression of TGFBR2 protein	23624380
C006780	bisphenol A	bisphenol A affects the expression of TGFBR2 mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TGFBR2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of TGFBR2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of TGFBR2 gene	28505145
D001761	Bleomycin	[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D001761	Bleomycin	[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of TGFBR2 mRNA	22079614
C099813	bromochloroacetic acid	bromochloroacetic acid results in increased expression of TGFBR2 mRNA	16460773
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 mRNA]	17602960
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 protein]	17602960
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]	17602960
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein]	17602960
C584509	C646 compound	C646 compound results in decreased expression of TGFBR2 mRNA	26921506
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of TGFBR2 mRNA	17481689
D002104	Cadmium	Cadmium results in increased expression of TGFBR2 mRNA	22562489
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TGFBR2 mRNA	26472689
C077793	candesartan cilexetil	candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of TGFBR2 protein]	27889505
D002220	Carbamazepine	Carbamazepine affects the expression of TGFBR2 mRNA	25979313
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TGFBR2 mRNA	26778414
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TGFBR2 mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TGFBR2 mRNA	15818738\|1687230
D002251	Carbon Tetrachloride	"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]"	15818738\|1716359
D002251	Carbon Tetrachloride	Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]	16872305
D002251	Carbon Tetrachloride	Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]	16872305
C007020	chlorophyllin	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 mRNA]"	22485181
C007020	chlorophyllin	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 protein]"	22485181
C100187	chloropicrin	chloropicrin results in decreased expression of TGFBR2 mRNA	26352163\|2847649
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of TGFBR2 mRNA	28472532
C418118	CI 1044	CI 1044 results in increased expression of TGFBR2 mRNA	17569694
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TGFBR2 mRNA	19320972
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TGFBR2 mRNA	15467011
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TGFBR2 mRNA	19549813
D003474	Curcumin	Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]	17602960
D003474	Curcumin	Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein]	17602960
D003474	Curcumin	Curcumin results in decreased expression of TGFBR2 mRNA	17602960
D003474	Curcumin	Curcumin results in decreased expression of TGFBR2 protein	16959952\|1760296
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of TGFBR2 mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in decreased expression of TGFBR2 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of TGFBR2 protein	16980036
C093628	cyproconazole	cyproconazole results in increased expression of TGFBR2 mRNA	22334560
D003545	Cysteine	Cysteine results in decreased expression of TGFBR2 protein	15158331
C014347	decitabine	decitabine results in increased expression of TGFBR2 mRNA	27915011
C014347	decitabine	[decitabine affects the methylation of TGFBR2 protein] which affects the expression of TGFBR2 mRNA	18381416\|1838141
D003907	Dexamethasone	Dexamethasone results in increased expression of TGFBR2 mRNA	12732289\|1278212
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TGFBR2 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of TGFBR2 mRNA	21041162
D003975	Diazepam	Diazepam results in increased expression of TGFBR2 mRNA	19114084
D002945	Cisplatin	Cisplatin results in increased expression of TGFBR2 mRNA	21151649
D004041	Dietary Fats	Dietary Fats results in decreased expression of TGFBR2 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of TGFBR2 mRNA	22609946
D004052	Diethylnitrosamine	[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TGFBR2 mRNA	26778414
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TGFBR2 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR2 mRNA	8001232
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR2 protein	8001232
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR2 mRNA	8565130
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of TGFBR2 mRNA	21041162
D002117	Calcitriol	Calcitriol results in increased expression of TGFBR2 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of TGFBR2 mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 mRNA"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 protein"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 mRNA]"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 protein]"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 mRNA]"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 protein]"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TGFBR2 mRNA	23197195
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TGFBR2 protein	16009107
D004128	Dimethylnitrosamine	salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR2 protein]	16009107
D004237	Diuron	Diuron results in decreased expression of TGFBR2 mRNA	21551480
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of TGFBR2 mRNA	21040762
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA]	18089841
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]"	15818738\|1716359
D004610	Ellagic Acid	"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 mRNA]"	22485181
D004610	Ellagic Acid	"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFBR2 protein]"	22485181
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [IL1B protein results in decreased expression of TGFBR2 mRNA]	16206353
C109476	epoxiconazole	epoxiconazole results in increased expression of TGFBR2 mRNA	22334560
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TGFBR2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBR2 mRNA	17942748
D005665	Furosemide	Furosemide results in increased expression of TGFBR2 mRNA	16526316
C037032	galangin	galangin results in increased expression of TGFBR2 mRNA	25268046
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of TGFBR2 mRNA	21782745
D019833	Genistein	Genistein results in increased expression of TGFBR2 mRNA	21782745
D005839	Gentamicins	Gentamicins results in increased expression of TGFBR2 mRNA	22061828
D005947	Glucose	Glucose results in increased expression of TGFBR2 protein	21367880
D005947	Glucose	isoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR2 protein]	21367880
D006581	Hexachlorobenzene	Hexachlorobenzene affects the expression of TGFBR2 mRNA	28923513
D006581	Hexachlorobenzene	Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]	28923513
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TGFBR2 mRNA	20044591
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TGFBR2 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGFBR2 mRNA	25613284
C551631	isoangustone A	isoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR2 protein]	21367880
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TGFBR2 mRNA	28628672
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of TGFBR2 mRNA	18089841\|2000320
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to TGFBR2 promoter]	27432991
C561695	(+)-JQ1 compound	(+)-JQ1 compound promotes the reaction [TRIM33 protein binds to TGFBR2 promoter]	27432991
C561695	(+)-JQ1 compound	TGFBR2 protein affects the reaction [TRIM33 mutant form results in decreased susceptibility to (+)-JQ1 compound]	27432991
C045463	leflunomide	leflunomide results in decreased expression of TGFBR2 mRNA	28988120
D008070	Lipopolysaccharides	[Thioacetamide co-treated with Lipopolysaccharides] results in decreased expression of TGFBR2 mRNA	17621560
D008070	Lipopolysaccharides	[Thioacetamide co-treated with Lipopolysaccharides] results in decreased expression of TGFBR2 protein	17621560
D018021	Lithium Chloride	Lithium Chloride results in increased expression of TGFBR2 mRNA	23527032
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of TGFBR2 mRNA	23034213
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TGFBR2 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TGFBR2 mRNA	26378955
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of TGFBR2 mRNA	20843944
D008694	Methamphetamine	Methamphetamine results in increased expression of TGFBR2 mRNA	12766323
D008694	Methamphetamine	Methamphetamine results in increased expression of TGFBR2 mRNA	15644446
D008715	Methionine	Methionine results in decreased expression of TGFBR2 protein	15158331
D008727	Methotrexate	Methotrexate results in decreased expression of TGFBR2 mRNA	25339124
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of TGFBR2 mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of TGFBR2 mRNA	21782745
D008746	Methylazoxymethanol Acetate	Methylazoxymethanol Acetate results in increased expression of TGFBR2 mRNA	28349193
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TGFBR2 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TGFBR2 mRNA"	20188158
C008493	methylselenic acid	methylselenic acid results in increased expression of TGFBR2 mRNA	18548127
C020300	monomethylarsonic acid	monomethylarsonic acid results in increased expression of TGFBR2 mRNA	17481689
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of TGFBR2 mRNA	20886546
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TGFBR2 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TGFBR2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TGFBR2 mRNA"	25554681\|2562005
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of TGFBR2 mRNA	19812364
C029938	nickel sulfate	nickel sulfate results in decreased expression of TGFBR2 mRNA	22714537
C007350	nitrofen	nitrofen results in decreased expression of TGFBR2 mRNA	20638522\|2782278
C007350	nitrofen	nitrofen results in decreased expression of TGFBR2 protein	27822781
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TGFBR2 mRNA"	12756304
C042670	N-vinyl-2-pyrrolidinone	[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TGFBR2 mRNA	22037397
D019815	Oxalic Acid	resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR2 protein]	24145091
D010100	Oxygen	Oxygen deficiency results in increased expression of TGFBR2 mRNA	16373842
D010100	Oxygen	Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of TGFBR2 mRNA]	16373842
D010269	Paraquat	Paraquat affects the expression of TGFBR2 mRNA	16854511
D010269	Paraquat	Paraquat results in increased expression of TGFBR2 mRNA	17077588\|1819848
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TGFBR2 protein	26879310
D020913	Perindopril	Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]	16872305
D020913	Perindopril	Perindopril results in decreased expression of TGFBR2 mRNA	15619341
D015232	Dinoprostone	[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D015232	Dinoprostone	[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of TGFBR2 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of TGFBR2 mRNA	19482888
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR2 mRNA	8001232
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR2 protein	8001232
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR2 mRNA	8565130
D010634	Phenobarbital	Phenobarbital results in increased expression of TGFBR2 mRNA	22037397
D010656	Phenylephrine	Phenylephrine results in increased expression of TGFBR2 mRNA	19443575
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TGFBR2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of TGFBR2 mRNA	19162173
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of TGFBR2 mRNA	22714537
D011374	Progesterone	Progesterone results in increased expression of TGFBR2 mRNA	21795739
C045950	propiconazole	propiconazole results in increased expression of TGFBR2 mRNA	21278054\|2233456
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TGFBR2 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of TGFBR2 protein	15580028
D011794	Quercetin	Quercetin results in increased expression of TGFBR2 mRNA	14715546
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of TGFBR2 mRNA	14699072
C059514	resveratrol	resveratrol inhibits the reaction [Oxalic Acid results in increased expression of TGFBR2 protein]	24145091
C059514	resveratrol	resveratrol results in increased expression of TGFBR2 protein	20637737
D015474	Isotretinoin	Isotretinoin results in increased expression of TGFBR2 mRNA	20436886
C076944	salvianolic acid B	salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR2 protein]	16009107
D012645	Selenomethionine	Selenomethionine inhibits the reaction [IL1B protein results in decreased expression of TGFBR2 mRNA]	16206353
D017632	Asbestos, Serpentine	"[Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of TGFBR2 mRNA"	25358858
D019821	Simvastatin	Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of TGFBR2 mRNA]	16373842
D019821	Simvastatin	Simvastatin results in decreased expression of TGFBR2 mRNA	16320597
C017947	sodium arsenite	sodium arsenite results in decreased expression of TGFBR2 mRNA	20886546
C017947	sodium arsenite	candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of TGFBR2 protein]	27889505
C017947	sodium arsenite	sodium arsenite results in increased expression of TGFBR2 protein	27889505
D012969	Sodium Fluoride	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Fluoride results in increased expression of TGFBR2 mRNA]"	29127033
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of TGFBR2 mRNA	29127033
D013311	Streptozocin	Streptozocin results in decreased expression of TGFBR2 protein	15496156
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TGFBR2 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TGFBR2 mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in increased expression of TGFBR2 mRNA	16980036
D016559	Tacrolimus	Tacrolimus results in increased expression of TGFBR2 protein	16980036
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of TGFBR2 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of TGFBR2 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of TGFBR2 mRNA	22138414
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGFBR2 mRNA	16443690
D013749	Tetrachlorodibenzodioxin	"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TGFBR2 mRNA]"	21851831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TGFBR2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBR2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	"Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TGFBR2 mRNA]"	21851831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGFBR2 mRNA	21851831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGFBR2 mRNA	20959002
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGFBR2 mRNA	25613284
D013853	Thioacetamide	[Thioacetamide co-treated with Lipopolysaccharides] results in decreased expression of TGFBR2 mRNA	17621560
D013853	Thioacetamide	[Thioacetamide co-treated with Lipopolysaccharides] results in decreased expression of TGFBR2 protein	17621560
D013853	Thioacetamide	Thioacetamide results in decreased expression of TGFBR2 mRNA	17621560
D013853	Thioacetamide	Thioacetamide results in increased expression of TGFBR2 mRNA	28181416
C402769	tipifarnib	tipifarnib results in increased expression of TGFBR2 mRNA	16403772
D014028	Tobacco Smoke Pollution	EGR affects the reaction [Tobacco Smoke Pollution results in decreased expression of TGFBR2 mRNA]	20621662
D014028	Tobacco Smoke Pollution	EGR affects the reaction [Tobacco Smoke Pollution results in decreased expression of TGFBR2 protein]	20621662
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TGFBR2 mRNA	20621662\|2806579
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TGFBR2 protein	20621662
C483909	torcetrapib	torcetrapib results in increased expression of TGFBR2 mRNA	23228038
D014212	Tretinoin	Tretinoin results in decreased expression of TGFBR2 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of TGFBR2	24374174
D014212	Tretinoin	Tretinoin affects the expression of TGFBR2 mRNA	16235736
D014212	Tretinoin	Tretinoin results in decreased expression of TGFBR2 mRNA	15389595\|1641007
D014212	Tretinoin	Tretinoin results in increased expression of TGFBR2 mRNA	24977338
C012589	trichostatin A	trichostatin A promotes the reaction [EP300 protein binds to TGFBR2 promoter]	15647279
C012589	trichostatin A	trichostatin A promotes the reaction [KAT2B protein binds to TGFBR2 promoter]	15647279
C012589	trichostatin A	trichostatin A results in increased expression of TGFBR2 mRNA	15647279
C012589	trichostatin A	trichostatin A results in increased expression of TGFBR2 protein	15647279
C057693	troglitazone	troglitazone results in decreased expression of TGFBR2 mRNA	25572481
D014635	Valproic Acid	Valproic Acid results in increased expression of TGFBR2 mRNA	24896083
D000068756	Valsartan	Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]	16872305
D000068756	Valsartan	Valsartan results in decreased expression of TGFBR2 mRNA	15619341
D014638	Vanadates	Vanadates results in increased expression of TGFBR2 mRNA	22714537
D014640	Vancomycin	Vancomycin results in decreased expression of TGFBR2 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of TGFBR2 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of TGFBR2 mRNA	19015723
D014801	Vitamin A	Vitamin A results in increased expression of TGFBR2 mRNA	17225872
D002762	Cholecalciferol	Cholecalciferol results in increased expression of TGFBR2 mRNA	17170073
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TGFBR2 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	-	IDA	12015308
GO:0005024	transforming growth factor beta-activated receptor activity	-	IBA	21873635
GO:0005024	transforming growth factor beta-activated receptor activity	-	IC	1326540
GO:0005024	transforming growth factor beta-activated receptor activity	-	IDA	7852346 18453574
GO:0005024	transforming growth factor beta-activated receptor activity	-	IMP	1333888
GO:0005026	transforming growth factor beta receptor activity, type II	-	IBA	21873635
GO:0005026	transforming growth factor beta receptor activity, type II	-	IEA	-
GO:0005515	protein binding	-	IPI	7852346 8242742 8622651 9865696 11278302 11279102 11483955 11850637 12015308 15702480 16530041 18243111 20856203 20860622 21054789 21423151 21441952 23178117 24263861
GO:0005524	ATP binding	-	IEA	-
GO:0005539	glycosaminoglycan binding	-	IDA	7852346
GO:0019838	growth factor binding	-	IBA	21873635
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IEA	-
GO:0034713	type I transforming growth factor beta receptor binding	-	IBA	21873635
GO:0034713	type I transforming growth factor beta receptor binding	-	IPI	1333888
GO:0046332	SMAD binding	-	IBA	21873635
GO:0046332	SMAD binding	-	IDA	11157754 18453574
GO:0046872	metal ion binding	-	IEA	-
GO:0048185	activin binding	-	IBA	21873635
GO:0050431	transforming growth factor beta binding	-	IDA	7852346 18243111 18453574
GO:0050431	transforming growth factor beta binding	-	IPI	1326540 1333888
GO:0050431	transforming growth factor beta binding	contributes_to	IPI	7852346

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001568	blood vessel development	-	TAS	10092230
GO:0001569	branching involved in blood vessel morphogenesis	-	ISS	-
GO:0001570	vasculogenesis	-	ISS	-
GO:0001666	response to hypoxia	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001947	heart looping	-	ISS	-
GO:0002053	positive regulation of mesenchymal cell proliferation	-	ISS	-
GO:0002088	lens development in camera-type eye	-	IEA	-
GO:0002651	positive regulation of tolerance induction to self antigen	-	ISS	-
GO:0002663	positive regulation of B cell tolerance induction	-	ISS	-
GO:0002666	positive regulation of T cell tolerance induction	-	ISS	-
GO:0003148	outflow tract septum morphogenesis	-	ISS	-
GO:0003149	membranous septum morphogenesis	-	ISS	-
GO:0003151	outflow tract morphogenesis	-	ISS	-
GO:0003181	atrioventricular valve morphogenesis	-	ISS	-
GO:0003186	tricuspid valve morphogenesis	-	ISS	-
GO:0003214	cardiac left ventricle morphogenesis	-	ISS	-
GO:0003274	endocardial cushion fusion	-	ISS	-
GO:0003430	growth plate cartilage chondrocyte growth	-	IEA	-
GO:0006468	protein phosphorylation	-	IDA	12015308
GO:0006898	receptor-mediated endocytosis	-	IEA	-
GO:0006915	apoptotic process	-	IDA	17471240
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IBA	21873635
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IC	1326540
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IDA	18453574
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IMP	1333888
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	-
GO:0007182	common-partner SMAD protein phosphorylation	-	IEA	-
GO:0007219	Notch signaling pathway	-	IEA	-
GO:0007224	smoothened signaling pathway	-	IEA	-
GO:0007369	gastrulation	-	IEA	-
GO:0007389	pattern specification process	-	IBA	21873635
GO:0007420	brain development	-	ISS	-
GO:0007507	heart development	-	IBA	21873635
GO:0007507	heart development	-	ISS	-
GO:0007566	embryo implantation	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0007584	response to nutrient	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	TAS	7761852
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0009749	response to glucose	-	IEA	-
GO:0010468	regulation of gene expression	-	IEA	-
GO:0010634	positive regulation of epithelial cell migration	-	IEA	-
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IDA	26459119
GO:0018105	peptidyl-serine phosphorylation	-	IDA	12015308
GO:0018107	peptidyl-threonine phosphorylation	-	IDA	12015308
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	TAS	-
GO:0031100	animal organ regeneration	-	IEA	-
GO:0032147	activation of protein kinase activity	-	ISS	-
GO:0032924	activin receptor signaling pathway	-	IBA	21873635
GO:0035162	embryonic hemopoiesis	-	ISS	-
GO:0042060	wound healing	-	IEA	-
GO:0042127	regulation of cell proliferation	-	ISS	-
GO:0042493	response to drug	-	IDA	17878231
GO:0043011	myeloid dendritic cell differentiation	-	ISS	-
GO:0043415	positive regulation of skeletal muscle tissue regeneration	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0048545	response to steroid hormone	-	IEA	-
GO:0048565	digestive tract development	-	IEA	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0048701	embryonic cranial skeleton morphogenesis	-	ISS	-
GO:0051138	positive regulation of NK T cell differentiation	-	ISS	-
GO:0060044	negative regulation of cardiac muscle cell proliferation	-	IEA	-
GO:0060389	pathway-restricted SMAD protein phosphorylation	-	IDA	18453574
GO:0060412	ventricular septum morphogenesis	-	ISS	-
GO:0060434	bronchus morphogenesis	-	IEA	-
GO:0060440	trachea formation	-	IEA	-
GO:0060443	mammary gland morphogenesis	-	IEA	-
GO:0060463	lung lobe morphogenesis	-	IEA	-
GO:0062009	secondary palate development	-	ISS	-
GO:0070723	response to cholesterol	-	IDA	17878231
GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	-	ISS	-
GO:1905315	cell proliferation involved in endocardial cushion morphogenesis	NOT	ISS	-
GO:1905316	superior endocardial cushion morphogenesis	NOT	ISS	-
GO:1905317	inferior endocardial cushion morphogenesis	-	ISS	-
GO:1990086	lens fiber cell apoptotic process	-	IEA	-
GO:1990428	miRNA transport	-	ISS	-
GO:2000379	positive regulation of reactive oxygen species metabolic process	-	IMP	20160708
GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	-	IDA	17164348

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	25893292
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005901	caveola	-	IDA	17878231
GO:0009897	external side of plasma membrane	-	IDA	18453574
GO:0016021	integral component of membrane	-	IDA	7852346
GO:0043235	receptor complex	-	IBA	21873635
GO:0043235	receptor complex	-	IDA	7852346 8774881
GO:0045121	membrane raft	-	IDA	25893292
GO:0048179	activin receptor complex	-	IBA	21873635
GO:0070022	transforming growth factor beta receptor complex	-	IC	1326540

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04144	Endocytosis
hsa04350	TGF-beta signaling pathway
hsa04380	Osteoclast differentiation
hsa04520	Adherens junction
hsa05142	Chagas disease (American trypanosomiasis)
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	IEA
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	IEA
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	TAS
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	TAS
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	IEA
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	TAS
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	IEA
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	TAS
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	TAS
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	TAS
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	TAS
R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	TAS
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	TAS
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	TAS
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	TAS
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	TAS
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5688426	Deubiquitination	IEA
R-HSA-5689603	UCH proteinases	IEA
R-HSA-597592	Post-translational protein modification	IEA
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9006936	Signaling by TGF-beta family members	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24451080	Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)	Szymanowska-Narloch A	Adv Med Sci
25365407	Association study of TGFBR2 and miR-518 gene polymorphisms with age at natural menopause, premature ovarian failure, and early menopause among Chinese Han women. (2014 Oct)	Ma X	Medicine (Baltimore)
23157888	[An association study between transforming growth factor-beta1 receptor 2 gene polymorphisms and essential hypertension]. (2012 Sep)	Chen JF	Zhonghua Yu Fang Yi Xue Za Zhi
26027897	Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms. (2015 Jul)	Zuo S	Eur J Vasc Endovasc Surg