Gene: TGFBR3

7049
BGCAN|betaglycan
transforming growth factor beta receptor 3
protein-coding
1p22.1
Ensembl:ENSG00000069702 MIM:600742 Vega:OTTHUMG00000010097 UniprotKB:Q03167
NG_027757.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.071e-1 (AD)  2.975e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2489188chr1:91866932 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17074704chr1:92350430TGFBR32.740e-8Maternal smoking in pregnancy27040690
cg17074704chr1:92350430TGFBR34.500e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YAP10.905
CDC14A0.897
LRP100.89
PLSCR40.889
ARHGAP310.88
CYBRD10.877
FERMT20.868
MAML20.868
TGFB20.86
PALLD0.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.55
PPEF1-0.539
SLC7A4-0.536
DUSP27-0.531
ADRA1D-0.526
DLK2-0.525
SMIM18-0.523
SST-0.523
HAS1-0.523
VGF-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TGFBR3 mRNA"19114083
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR3 mRNA]"26443840
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of TGFBR3 mRNA25716159
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of TGFBR3 mRNA"27567155
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of TGFBR3 mRNA20829426
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TGFBR3 mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TGFBR3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TGFBR3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of TGFBR3 mRNA26705709
D001379AzathioprineAzathioprine results in decreased expression of TGFBR3 mRNA22623647
D001554BenzeneBenzene results in increased expression of TGFBR3 mRNA16188089|2003664
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TGFBR3 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TGFBR3 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGFBR3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TGFBR3 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGFBR3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TGFBR3 mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of TGFBR3 mRNA21632981
D004958Estradiol[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA15878966
D004958Estradiolfulvestrant inhibits the reaction [[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA]15878966
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of TGFBR3 promoter22457795
D002251Carbon Tetrachloride"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR3 mRNA]"26443840
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TGFBR3 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGFBR3 mRNA26443840
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TGFBR3 mRNA16644059|1705623
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFBR3 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of TGFBR3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TGFBR3 mRNA20106945|2163298
D003561CytarabineCytarabine results in decreased expression of TGFBR3 mRNA21198554
C014347decitabinedecitabine results in increased expression of TGFBR3 mRNA27915011
D003907DexamethasoneDexamethasone results in increased expression of TGFBR3 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of TGFBR3 mRNA22733784
D003975DiazepamDiazepam results in decreased expression of TGFBR3 mRNA19114084
D002945CisplatinCisplatin results in decreased expression of TGFBR3 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of TGFBR3 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TGFBR3 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR3 mRNA8001232
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR3 protein8001232
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR3 mRNA8565130
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TGFBR3 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGFBR3 mRNA22079256
D005419FlavonoidsFlavonoids results in increased expression of TGFBR3 mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of TGFBR3 mRNA16557594
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFBR3 gene20938992
C070081fulvestrantfulvestrant inhibits the reaction [[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA]15878966
C039281furanfuran results in increased expression of TGFBR3 mRNA27387713
D019833GenisteinGenistein results in increased expression of TGFBR3 mRNA22228119
D017313FenretinideFenretinide results in decreased expression of TGFBR3 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of TGFBR3 mRNA17440234
C410337K 7174K 7174 results in decreased expression of TGFBR3 mRNA24086573
C008261lead acetatelead acetate results in increased expression of TGFBR3 mRNA22641619
C045463leflunomideleflunomide results in increased expression of TGFBR3 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFBR3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TGFBR3 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TGFBR3 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased expression of TGFBR3 mRNA12517777|1854812
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of TGFBR3 mRNA25145660
C523799MRK 003TGFBR3 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TGFBR3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TGFBR3 mRNA"25554681
C007350nitrofennitrofen results in decreased expression of TGFBR3 mRNA20638522
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TGFBR3 mRNA26705709
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TGFBR3 protein26879310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TGFBR3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of TGFBR3 mRNA19482888
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR3 mRNA8001232
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR3 protein8001232
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR3 mRNA8565130
D010852PicrotoxinPicrotoxin results in increased expression of TGFBR3 mRNA15170462
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGFBR3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TGFBR3 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of TGFBR3 mRNA20726854
D012643SeleniumSelenium results in decreased expression of TGFBR3 mRNA19244175
D020123SirolimusSirolimus results in increased expression of TGFBR3 mRNA11355896
C017947sodium arsenitesodium arsenite results in decreased expression of TGFBR3 mRNA23732083
D010042OuabainOuabain results in increased expression of TGFBR3 mRNA28795476
D020058StyreneStyrene affects the expression of TGFBR3 mRNA16705669
D020058StyreneStyrene affects the expression of TGFBR3 protein16705669
C013690styrene oxidestyrene oxide affects the expression of TGFBR3 mRNA16705669
C013690styrene oxidestyrene oxide affects the expression of TGFBR3 protein16705669
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFBR3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGFBR3 mRNA20106945
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TGFBR3 mRNA]14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGFBR3 mRNA14728982
D013853ThioacetamideThioacetamide results in decreased expression of TGFBR3 mRNA17621560
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TGFBR3 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TGFBR3 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TGFBR3 mRNA28111298
D014118Toxins, Biological"Toxins, Biological affects the expression of TGFBR3 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of TGFBR3 mRNA15389595
C012589trichostatin Atrichostatin A results in increased expression of TGFBR3 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TGFBR3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TGFBR3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TGFBR3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of TGFBR3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TGFBR3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of TGFBR3 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of TGFBR3 mRNA24896083
D014638VanadatesVanadates results in increased expression of TGFBR3 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of TGFBR3 mRNA23034163
D014750VincristineVincristine results in decreased expression of TGFBR3 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005024transforming growth factor beta-activated receptor activity-IDA12958365  
GO:0005114type II transforming growth factor beta receptor binding-IDA11157754  
GO:0005160transforming growth factor beta receptor binding-ISS1333192  
GO:0005515protein binding-IPI10746731  11157754  11546783  12958365  18184661  20856203  
GO:0005515protein bindingcontributes_toIPI10746731  
GO:0005539glycosaminoglycan binding-ISS-  
GO:0005539glycosaminoglycan binding-TAS1333192  
GO:0008201heparin binding-ISS1333192  
GO:0015026coreceptor activity-IDA10746731  
GO:0017134fibroblast growth factor binding-IEA-  
GO:0030165PDZ domain binding-ISS-  
GO:0046332SMAD binding-IMP11157754  
GO:0048185activin binding-IEA-  
GO:0050431transforming growth factor beta binding-IDA11157754  12958365  
GO:0050431transforming growth factor beta bindingcontributes_toIPI11157754  
GO:0070123transforming growth factor beta receptor activity, type III-IDA10746731  11157754  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0001837epithelial to mesenchymal transition-IDA18184661  
GO:0001889liver development-ISS-  
GO:0003007heart morphogenesis-ISS-  
GO:0003150muscular septum morphogenesis-ISS-  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0003223ventricular compact myocardium morphogenesis-ISS-  
GO:0006955immune response-IMP16886151  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA12958365  
GO:0007179transforming growth factor beta receptor signaling pathway-IMP11157754  
GO:0007179transforming growth factor beta receptor signaling pathway-ISS-  
GO:0007181transforming growth factor beta receptor complex assembly-IEA-  
GO:0016477cell migration-ISS-  
GO:0030509BMP signaling pathway-IDA18184661  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0032354response to follicle-stimulating hormone-IDA14557487  
GO:0034695response to prostaglandin E-IDA14557487  
GO:0034699response to luteinizing hormone-IDA14557487  
GO:0035556intracellular signal transduction-IMP14557487  
GO:0043393regulation of protein binding-IEA-  
GO:0046328regulation of JNK cascadeNOTISS-  
GO:0050680negative regulation of epithelial cell proliferation-ISS-  
GO:0051271negative regulation of cellular component movement-IDA17999987  
GO:0055010ventricular cardiac muscle tissue morphogenesis-ISS-  
GO:0060038cardiac muscle cell proliferation-ISS-  
GO:0060045positive regulation of cardiac muscle cell proliferation-ISS-  
GO:0060216definitive hemopoiesis-ISS-  
GO:0060317cardiac epithelial to mesenchymal transition-IDA18184661  
GO:0060318definitive erythrocyte differentiation-ISS-  
GO:0060347heart trabecula formation-ISS-  
GO:0060389pathway-restricted SMAD protein phosphorylation-IMP11157754  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0060939epicardium-derived cardiac fibroblast cell development-ISS-  
GO:0060979vasculogenesis involved in coronary vascular morphogenesis-ISS-  
GO:0061384heart trabecula morphogenesis-ISS-  
GO:0062009secondary palate development-ISS-  
GO:0070372regulation of ERK1 and ERK2 cascadeNOTISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-TAS18184661  
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0009897external side of plasma membrane-IDA12958365  
GO:0009986cell surface-ISS-  
GO:0034673inhibin-betaglycan-ActRII complex-IDA10746731  
GO:0043235receptor complex-IDA11157754  
GO:0070062extracellular exosome-HDA19056867  19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24451080Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)Szymanowska-Narloch AAdv Med Sci