Gene: TGIF1

7050
HPE4|TGIF
TGFB induced factor homeobox 1
protein-coding
18p11.31
Ensembl:ENSG00000177426 MIM:602630 Vega:OTTHUMG00000131511 UniprotKB:Q15583
NG_007447.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.338e-1 (AD)  4.357e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFKB20.868
RAB200.857
PLIN20.855
TRAF3IP20.855
MSN0.853
CSF10.851
PNP0.847
YBX30.846
TNFRSF1A0.846
TEAD30.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.656
MARCH4-0.65
ABCC12-0.65
PPEF1-0.649
CALHM1-0.646
NEUROD6-0.643
LHX6-0.639
GPR61-0.627
CHRNB2-0.616
SLC32A1-0.614

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TGIF1 mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TGIF1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TGIF1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TGIF1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]25791921
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]21649584
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]"21649584|2579192
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]"21649584
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TGIF1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF1 mRNA"27188386
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of TGIF1 mRNA26975756
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TGIF1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TGIF1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TGIF1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TGIF1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TGIF1 mRNA]17585979
D015766Albendazole[Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA16861626
C103303alitretinoinalitretinoin results in increased expression of TGIF1 protein16192631
C103303alitretinoinalitretinoin inhibits the reaction [TGIF1 protein binds to RXRA protein]16428452
C103303alitretinoinalitretinoin inhibits the reaction [TGIF1 protein results in increased activity of RXRA protein]16428452
C006632arsenic trioxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]25791921
C006632arsenic trioxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]21649584
C006632arsenic trioxide"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]"21649584|2579192
C006632arsenic trioxide"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]"21649584
C006632arsenic trioxideAKT1 protein promotes the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]21649584
C006632arsenic trioxidearsenic trioxide promotes the reaction [ELAVL1 protein binds to TGIF1 promoter]21649584
C006632arsenic trioxide[arsenic trioxide promotes the reaction [ELAVL1 protein binds to TGIF1 promoter]] which results in decreased degradation of TGIF1 promoter21649584
C006632arsenic trioxidearsenic trioxide promotes the reaction [JUN protein binds to TGIF1 protein]20074581
C006632arsenic trioxidearsenic trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] binds to CDKN1A promoter]18210215
C006632arsenic trioxidearsenic trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] results in decreased expression of CDKN1A mRNA]18210215
C006632arsenic trioxidearsenic trioxide results in increased expression of TGIF1 mRNA21649584|2579192
C006632arsenic trioxidearsenic trioxide results in increased expression of TGIF1 protein21649584|2579192
C006632arsenic trioxideTGIF1 mutant form promotes the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]25791921
C006632arsenic trioxideTGIF1 protein inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]25791921
C006632arsenic trioxideTGIF1 protein inhibits the reaction [arsenic trioxide results in increased expression of CDKN1A mRNA]21649584
C006632arsenic trioxideTGIF1 protein inhibits the reaction [arsenic trioxide results in increased expression of CDKN1A protein]21649584
C006632arsenic trioxidewortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]21649584
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TGIF1 mRNA"25757056
D001241AspirinAspirin results in decreased expression of TGIF1 mRNA15928584
D001280AtrazineAtrazine results in increased expression of TGIF1 mRNA22378314
D001554BenzeneBenzene results in decreased expression of TGIF1 mRNA15120971|1512265
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TGIF1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGIF1 mRNA22228805
D004958EstradiolEstradiol affects the expression of TGIF1 mRNA14699072
D004958EstradiolEstradiol affects the expression of TGIF1 mRNA15598610
C044887beta-methylcholinebeta-methylcholine affects the expression of TGIF1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of TGIF1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of TGIF1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of TGIF1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of TGIF1 mRNA25979313
D002220CarbamazepineCarbamazepine affects the expression of TGIF1 mRNA22634333
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGIF1 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TGIF1 gene20938992
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of TGIF1 mRNA16197558
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TGIF1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TGIF1 mRNA]17585979
D002995Clofibric AcidClofibric Acid affects the expression of TGIF1 mRNA17602206
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TGIF1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of TGIF1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TGIF1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of TGIF1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of TGIF1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of TGIF1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of TGIF1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of TGIF1 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TGIF1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of TGIF1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TGIF1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TGIF1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of TGIF1 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TGIF1 mRNA19638242
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of TGIF1 mRNA17374397
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGIF1 mRNA22079256
D000431EthanolEthanol affects the expression of TGIF1 mRNA24355176
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TGIF1 mRNA28329830
C061365flusilazoleflusilazole affects the expression of TGIF1 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TGIF1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of TGIF1 mRNA20655997|2364984
D005839GentamicinsGentamicins results in increased expression of TGIF1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of TGIF1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGIF1 mRNA25613284
D007501IronIron deficiency results in increased expression of TGIF1 mRNA16629162
D007559Ivermectin[Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA16861626
C544151jinfukangjinfukang results in increased expression of TGIF1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TGIF1 mRNA27432991
C410337K 7174K 7174 results in increased expression of TGIF1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of TGIF1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGIF1 mRNA"18930950
D008627Mercuric ChlorideMercuric Chloride affects the expression of TGIF1 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TGIF1 mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TGIF1 gene20938992
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of TGIF1 mRNA17412507
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TGIF1 mRNA"29244179
C064769N-acetylsphingosineN-acetylsphingosine results in increased expression of TGIF1 mRNA18270325
C029938nickel sulfatenickel sulfate results in increased expression of TGIF1 mRNA17374397
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TGIF1 mRNA20971185
C030110oxaliplatinoxaliplatin results in decreased expression of TGIF1 mRNA17762391
D010081OxazoloneOxazolone results in increased expression of TGIF1 mRNA17374397
D000073878Palm OilPalm Oil results in decreased expression of TGIF1 mRNA18042831
C016030pantogabpantogab results in increased expression of TGIF1 mRNA17379144
D052638Particulate MatterParticulate Matter results in increased expression of TGIF1 mRNA21703343
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in decreased expression of TGIF1 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of TGIF1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of TGIF1 mRNA19270015
D019800PhenolPhenol results in increased expression of TGIF1 mRNA17547211
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TGIF1 mRNA19710929
D010894PiroxicamPiroxicam results in decreased expression of TGIF1 mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGIF1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TGIF1 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of TGIF1 mRNA18037150
D011441PropylthiouracilPropylthiouracil results in increased expression of TGIF1 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of TGIF1 mRNA19167446
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of TGIF1 mRNA"16678137
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TGIF1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in increased expression of TGIF1 mRNA19073995
C017947sodium arsenitesodium arsenite results in decreased expression of TGIF1 mRNA28595984
C016104sodium bichromatesodium bichromate results in increased expression of TGIF1 mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of TGIF1 mRNA18175754
D012999SomanSoman results in increased expression of TGIF1 mRNA19281266
C061133tamibarotenetamibarotene results in decreased expression of TGIF1 mRNA15498508
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of TGIF1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGIF1 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGIF1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGIF1 mRNA25613284
D013806TheophyllineTheophylline results in increased expression of TGIF1 mRNA16083514
D013853ThioacetamideThioacetamide results in increased expression of TGIF1 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of TGIF1 mRNA15498508
D014212TretinoinTGIF1 gene mutant form results in increased susceptibility to Tretinoin16428452
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of TGIF1 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of TGIF1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TGIF1 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGIF1 mRNA"18930950
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TGIF1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of TGIF1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of TGIF1 mRNA21427059
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]19225232
D014640VancomycinVancomycin results in decreased expression of TGIF1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TGIF1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of TGIF1 mRNA26682919
C009687wortmanninwortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]21649584
D015032Zinc[PCI 5002 co-treated with Zinc] results in decreased expression of TGIF1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10764806  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10764806  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP10764806  
GO:0003700DNA-binding transcription factor activity-TAS8537382  
GO:0003714transcription corepressor activity-TAS10764806  
GO:0005515protein binding-IPI10995736  16189514  18511908  21516116  25416956  25873176  
GO:0070410co-SMAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10764806  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP10764806  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-TAS8537382  
GO:0042493response to drug-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24869959Intrinsic and extrinsic risk factors for sagging eyelids. (2014 Aug)Jacobs LCJAMA Dermatol