Gene: TGM2

7052
TG(C)|TGC
transglutaminase 2
protein-coding
20q11.23
Ensembl:ENSG00000198959 MIM:190196 Vega:OTTHUMG00000032437 UniprotKB:P21980
NC_000020.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.164e-1 (AD)  7.378e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSL50.915
FGR0.882
IL4R0.88
STARD80.868
VWF0.866
ERG0.86
ICAM20.856
FLT10.856
PLA1A0.852
CFB0.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.488
CPLX3-0.447
SMIM18-0.442
ZSCAN1-0.437
ABCC12-0.427
CORT-0.424
MARCH4-0.419
NEUROD6-0.417
KCNIP3-0.411
SPEF1-0.411

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of TGM2 mRNA"16269432
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TGM2 mRNA"28903501
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to TGM2 protein16453347
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TGM2 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of TGM2 mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TGM2 mRNA"23196670
C0541893,5-di-tert-butylchalcone 4'-carboxylic acid"3,5-di-tert-butylchalcone 4'-carboxylic acid results in increased activity of TGM2 protein"2884032
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of TGM2 mRNA25716159
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 mRNA"10910994
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 protein"16158052
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"Tetrachlorodibenzodioxin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 mRNA]"10910994
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid co-treated with CD 2425] results in increased expression of TGM2 mRNA"9516142
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid co-treated with CD 2425] results in increased expression of TGM2 protein"9516142
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]"9516142
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGM2 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of TGM2 mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of TGM2 mRNA17034753
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGM2 mRNA"27188386
C0030017-ketocholesterol7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM2 mRNA]16480812
D000082AcetaminophenAcetaminophen results in decreased expression of TGM2 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TGM2 mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of TGM2 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter analog results in decreased activity of TGM2 protein]15541757
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Vehicle Emissions analog results in decreased activity of TGM2 protein]15541757
D020106AcrylamideAcrylamide results in decreased expression of TGM2 mRNA15749267
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TGM2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TGM2 mRNA19770486
C096920AGN 193109AGN 193109 inhibits the reaction [Tretinoin results in increased expression of TGM2 protein]16158052
C103303alitretinoin[alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [HIST3H3 protein modified form binds to TGM2 gene]15964820
C103303alitretinoin[alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [HIST4H4 protein modified form binds to TGM2 gene]15964820
C103303alitretinoinalitretinoin results in increased activity of TGM2 protein9516142
C103303alitretinoinalitretinoin results in increased expression of TGM2 mRNA15964820|1703475
C103303alitretinoinalitretinoin results in increased expression of TGM2 protein15964820|1615805
C103303alitretinoinDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]15964820
C103303alitretinoinDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 protein]15964820
C103303alitretinoinperiodate-oxidized adenosine inhibits the reaction [alitretinoin results in increased expression of TGM2 mRNA]15964820
C103303alitretinoinperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]]15964820
C103303alitretinoinVitamin D promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]15964820
C103303alitretinoinalitretinoin results in increased expression of TGM2 mRNA28689802
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of TGM2 mRNA28522335
C068073Am 580[Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein9516142
C068073Am 580Am 580 results in increased activity of TGM2 protein2884032
C068073Am 580Am 580 results in increased expression of TGM2 mRNA16982809
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TGM2 mRNA16483693
C102351apicidinapicidin inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]23946490
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tretinoin results in increased expression of TGM2 protein]11133770|9450572
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TGM2 mRNA"25351596
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]16964424
C547126AZM551248AZM551248 results in increased expression of TGM2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TGM2 mRNA22178795
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGM2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TGM2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGM2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TGM2 mRNA"26238291
D019207beta Carotenebeta Carotene results in increased expression of TGM2 mRNA17034753
D004958EstradiolESR1 protein affects the reaction [Estradiol results in increased expression of TGM2 mRNA]14699072
D004958EstradiolEstradiol affects the expression of TGM2 mRNA14699072
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGM2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TGM2 mRNA19619570|2532141
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of TGM2 mRNA17404688
D004958EstradiolEstradiol results in increased expression of TGM2 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TGM2 mRNA26496021
C095105bexarotenebexarotene results in increased expression of TGM2 mRNA17178900
C095105bexarotenebexarotene results in increased expression of TGM2 mRNA21622945|2593259
C095105bexarotenediazepinylbenzoic acid inhibits the reaction [bexarotene results in increased expression of TGM2 mRNA]25932594
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of TGM2 mRNA15912405
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of TGM2 mRNA15912405
C006780bisphenol Abisphenol A results in decreased expression of TGM2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of TGM2 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TGM2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TGM2 protein22649256
C006780bisphenol Abisphenol A results in increased expression of TGM2 mRNA25181051
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TGM2 mRNA]19228888
D019819BudesonideBudesonide results in increased expression of TGM2 protein21885873
D002065BuspironeBuspirone results in decreased expression of TGM2 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TGM2 mRNA15336504
D002087ButyratesButyrates inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]]10910994
D002087ButyratesButyrates results in increased expression of TGM2 mRNA10910994
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TGM2 mRNA26314618
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGM2 mRNA27339419
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]18038451
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGM2 mRNA17708605
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TGM2 protein17708605
D002251Carbon TetrachlorideCystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]17708605
D002251Carbon TetrachlorideCystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein]17708605
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of TGM2 mRNA19395590
C109628CD 2425"[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid co-treated with CD 2425] results in increased expression of TGM2 mRNA"9516142
C109628CD 2425"[4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid co-treated with CD 2425] results in increased expression of TGM2 protein"9516142
C109628CD 2425[Am 580 co-treated with CD 2425] results in increased activity of TGM2 protein9516142
C109628CD 2425CD 2425 promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]9516142
C109628CD 2425[CD 437 co-treated with CD 2425] results in increased activity of TGM2 protein9516142
C099555CD 437[CD 437 co-treated with CD 2425] results in increased activity of TGM2 protein9516142
C098137Ch 80Ch 80 results in increased activity of TGM2 protein2884032
D004390ChlorpyrifosChlorpyrifos results in increased activity of TGM2 protein20637855
D004390ChlorpyrifosChlorpyrifos results in increased activity of TGM2 protein20637855
C018021cobaltous chloridecobaltous chloride results in decreased expression of TGM2 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased expression of TGM2 mRNA23052192
C018021cobaltous chloridecobaltous chloride results in decreased expression of TGM2 mRNA24386269
D003345CorticosteroneCorticosterone results in increased expression of TGM2 mRNA15755911
D003471CuprizoneCuprizone results in increased expression of TGM2 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA]18200517
C057862cyanoginosin LRcyanoginosin LR results in increased expression of TGM2 mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of TGM2 mRNA19159671|2010694
D016572CyclosporineCyclosporine results in increased expression of TGM2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of TGM2 mRNA19770486
D003538CystamineCystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]17708605
D003538CystamineCystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein]17708605
C004742daidzeindaidzein results in increased expression of TGM2 mRNA24859791
C004742daidzeindaidzein results in increased expression of TGM2 protein24859791
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in increased expression of TGM2 mRNA26854739
D003907Dexamethasoneapicidin inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]23946490
D003907DexamethasoneDexamethasone results in increased expression of TGM2 mRNA23946490|2922923
D003907Dexamethasonetrichostatin A inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]23946490
D003907DexamethasoneValproic Acid inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]23946490
C438269diazepinylbenzoic aciddiazepinylbenzoic acid inhibits the reaction [bexarotene results in increased expression of TGM2 mRNA]25932594
C438269diazepinylbenzoic aciddiazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of TGM2 mRNA]25932594
C438269diazepinylbenzoic aciddiazepinylbenzoic acid results in decreased expression of TGM2 mRNA25932594
D003976DiazinonDiazinon results in increased methylation of TGM2 gene22964155
D003976DiazinonDiazinon affects the expression of TGM2 mRNA22546817
D002945Cisplatin[Hexylresorcinol results in decreased activity of TGM2 protein] which results in increased susceptibility to Cisplatin21424127
D004026DieldrinDieldrin affects the expression of TGM2 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of TGM2 mRNA22609946
C014476diethyl maleatediethyl maleate results in increased expression of TGM2 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TGM2 mRNA21527772
D002117CalcitriolCalcitriol results in increased expression of TGM2 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TGM2 mRNA21592394
D004121Dimethyl Sulfoxide[alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [HIST3H3 protein modified form binds to TGM2 gene]15964820
D004121Dimethyl Sulfoxide[alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [HIST4H4 protein modified form binds to TGM2 gene]15964820
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]15964820
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 protein]15964820
D004121Dimethyl Sulfoxideperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]]15964820
D004317DoxorubicinDoxorubicin results in increased expression of TGM2 mRNA15870702
D004317DoxorubicinTGM2 protein affects the susceptibility to Doxorubicin17073438
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of TGM2 mRNA25198161
C118739entinostatentinostat results in increased expression of TGM2 mRNA27188386
D000431Ethanol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D000431Ethanol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D000431EthanolEthanol promotes the reaction [RELA protein binds to TGM2 promoter]18295389
D000431EthanolEthanol results in increased activity of TGM2 protein18295389
D000431EthanolEthanol results in increased expression of TGM2 mRNA18295389
D000431Ethanolpinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D000431Ethanolpinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]18295389
D000431EthanolPropolis inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D000431EthanolPropolis inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]18295389
D000431EthanolTosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D000431EthanolTosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]18295389
D000431EthanolEthanol results in increased activity of TGM2 protein11696672
D000431EthanolEthanol results in increased expression of TGM2 mRNA11696672
D000431EthanolEthanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]10801782
D000431EthanolEthanol results in increased activity of TGM2 protein10801782
D000431EthanolEthanol results in increased expression of TGM2 mRNA10801782
D000431EthanolPutrescine inhibits the reaction [Ethanol results in increased activity of TGM2 protein]10801782
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TGM2 mRNA14976129|1755557
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TGM2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGM2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TGM2 mRNA23300682
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TGM2 mRNA15834898|1755790
C000499ferric oxideferric oxide analog results in increased expression of TGM2 mRNA25086211
D018120FinasterideFinasteride results in increased expression of TGM2 mRNA24136188
C007734flunisolideflunisolide results in increased expression of TGM2 protein21885873
C061365flusilazoleflusilazole results in increased expression of TGM2 mRNA28263823
D005485FlutamideFlutamide results in decreased expression of TGM2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of TGM2 mRNA28937961
C069837fullerene C60fullerene C60 results in decreased expression of TGM2 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of TGM2 mRNA22061828
D006118GriseofulvinGriseofulvin affects the expression of TGM2 mRNA12735108
D006160Guanosine TriphosphateGuanosine Triphosphate binds to TGM2 protein15556610
C010176halofuginonehalofuginone results in increased expression of TGM2 mRNA17180598
D006427Hemin[Hemin co-treated with Tretinoin] affects the localization of TGM2 protein15556610
D006533HeptachlorHeptachlor results in decreased expression of TGM2 mRNA23153324
D006604HexylresorcinolHexylresorcinol results in decreased activity of and affects the localization of TGM2 protein21424127
D006604Hexylresorcinol[Hexylresorcinol results in decreased activity of TGM2 protein] which results in increased susceptibility to Cisplatin21424127
D017313FenretinideFenretinide results in increased expression of TGM2 mRNA28973697
C029424hydrazinehydrazine results in increased expression of TGM2 mRNA15282401
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGM2 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of TGM2 mRNA20003209
D007555IsoxazolesIsoxazoles analog results in decreased activity of TGM2 protein15850984
D007555IsoxazolesIsoxazoles analog results in decreased activity of TGM2 protein15850984
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TGM2 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TGM2 mRNA24796395|2511904
C510621KCC 009KCC 009 results in decreased activity of TGM2 protein16170020
C510621KCC 009KCC 009 results in decreased activity of TGM2 protein17099729
C510621KCC 009[KCC 009 results in decreased activity of TGM2 protein] which affects the localization of FN1 protein17099729
C533894LG 100815LG 100815 results in increased expression of TGM2 mRNA16951191
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGM2 mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TGM2 mRNA27339419
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TGM2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TGM2 mRNA26378955
D008731MethoxychlorMethoxychlor results in increased methylation of TGM2 gene23303685
D016685MitomycinTGM2 protein affects the susceptibility to Mitomycin16217747
D000068656Mometasone FuroateMometasone Furoate results in increased expression of TGM2 protein21885873
C008542monodansylcadaverinemonodansylcadaverine results in decreased activity of TGM2 protein16382148
C008542monodansylcadaverinemonodansylcadaverine results in decreased activity of TGM2 protein16170020
C500085muraglitazarmuraglitazar results in increased expression of TGM2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TGM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TGM2 mRNA"25554681|2562005
C031721naphthalenenaphthalene metabolite binds to TGM2 protein16453347
C031721naphthalenenaphthalene analog results in decreased expression of TGM2 mRNA24976557
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TGM2 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of TGM2 mRNA24136188
D009532NickelNickel results in increased expression of TGM2 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of TGM2 mRNA24136188
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of TGM2 mRNA"16951191
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of TGM2 mRNA24888373
C016030pantogabpantogab results in increased expression of TGM2 mRNA17379144
D052638Particulate Matter[Particulate Matter co-treated with IL4 protein] results in increased expression of TGM2 mRNA27224998
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter analog results in decreased activity of TGM2 protein]15541757
D052638Particulate MatterParticulate Matter analog results in decreased activity of TGM2 protein15541757
D052638Particulate MatterParticulate Matter analog results in decreased expression of TGM2 mRNA15541757
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TGM2 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of TGM2 mRNA25119042
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TGM2 mRNA23948077
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of TGM2 mRNA23602845
C027579periodate-oxidized adenosineperiodate-oxidized adenosine inhibits the reaction [alitretinoin results in increased expression of TGM2 mRNA]15964820
C027579periodate-oxidized adenosineperiodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]]15964820
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TGM2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TGM2 mRNA19482888
D010656PhenylephrineADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]10801782
D010656PhenylephrineEthanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]10801782
D010656PhenylephrinePhenylephrine results in decreased activity of TGM2 protein10801782
D010656PhenylephrinePhenylephrine results in increased expression of TGM2 mRNA18158353
C046357phenylsaligenin cyclic phosphatephenylsaligenin cyclic phosphate affects the activity of TGM2 protein19735718
C046357phenylsaligenin cyclic phosphatephenylsaligenin cyclic phosphate results in increased expression of TGM2 protein19735718
C046357phenylsaligenin cyclic phosphatephenylsaligenin cyclic phosphate results in decreased activity of TGM2 protein19735718
C046357phenylsaligenin cyclic phosphatephenylsaligenin cyclic phosphate results in decreased expression of TGM2 protein19735718
D010798PhycocyaninPhycocyanin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of TGM2 mRNA]22986104
D010798PhycocyaninPhycocyanin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of TGM2 protein]22986104
C016063pinocembrinpinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
C016063pinocembrinpinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]18295389
C006253pirinixic acidpirinixic acid results in increased expression of TGM2 mRNA18301758|1844570
D010894PiroxicamPiroxicam results in decreased expression of TGM2 mRNA21858171
D010938Plant OilsPlant Oils results in decreased expression of TGM2 mRNA23370395
D028321Plant PreparationsPlant Preparations affects the expression of TGM2 mRNA16251609
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of TGM2 mRNA21334430
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of TGM2 mRNA24888373
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TGM2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TGM2 mRNA28903501
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of TGM2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of TGM2 mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of TGM2 mRNA20726854
C045950propiconazolepropiconazole results in increased expression of TGM2 mRNA21278054
D011429PropolisPropolis inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D011429PropolisPropolis inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]18295389
D011700PutrescinePutrescine inhibits the reaction [Ethanol results in increased activity of TGM2 protein]10801782
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TGM2 mRNA27029645
D011794QuercetinQuercetin binds to and results in decreased activity of TGM2 protein23117658
D011794Quercetin[TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin23117658
D011794QuercetinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]23117658
D011794QuercetinQuercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]23117658
C012526quercitrinquercitrin results in decreased expression of TGM2 mRNA25193878
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TGM2 mRNA14699072
D012176RetinoidsRARA protein promotes the reaction [Retinoids results in increased expression of TGM2 mRNA]12075115
D012176RetinoidsRetinoids results in increased expression of TGM2 mRNA12075115
C089730rosiglitazonerosiglitazone results in increased expression of TGM2 mRNA16982809
C089730rosiglitazonerosiglitazone results in increased expression of TGM2 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TGM2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of TGM2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of TGM2 mRNA23221170
D012834SilverSilver results in increased expression of TGM2 mRNA28959546
D020123SirolimusSirolimus results in decreased expression of TGM2 mRNA11355896
D012999SomanSoman results in increased expression of TGM2 mRNA19281266
D053260SootSoot results in increased expression of TGM2 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TGM2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TGM2 mRNA26378955
D013467SulindacSulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA]15190207
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TGM2 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in increased expression of TGM2 mRNA19228888
C061133tamibarotenetamibarotene results in increased activity of TGM2 protein2884032
D013629TamoxifenTamoxifen affects the expression of TGM2 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of TGM2 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of TGM2 mRNA15885361
C501413tesaglitazartesaglitazar results in increased expression of TGM2 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TGM2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TGM2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGM2 mRNA26854739
D013749Tetrachlorodibenzodioxin7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM2 mRNA]16480812
D013749TetrachlorodibenzodioxinButyrates inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]]10910994
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGM2 mRNA19619570
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 mRNA]"10910994
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]10910994|1207511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGM2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGM2 mRNA16480812
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGM2 mRNA19770486|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGM2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGM2 mRNA15652763
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGM2 mRNA27562557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TGM2 mRNA21215274
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of TGM2 mRNA26854739
D013755Tetradecanoylphorbol AcetatePhycocyanin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of TGM2 mRNA]22986104
D013755Tetradecanoylphorbol AcetatePhycocyanin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of TGM2 protein]22986104
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of TGM2 mRNA22986104
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of TGM2 protein22986104
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TGM2 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of and results in increased activity of TGM2 protein16382148
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]16140955
C009495titanium dioxidetitanium dioxide affects the expression of TGM2 mRNA17656681
C009495titanium dioxidetitanium dioxide results in increased expression of TGM2 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TGM2 mRNA25447457|2806579
C024746tobacco tartobacco tar results in decreased expression of TGM2 mRNA19559774
D014050TolueneToluene results in increased expression of TGM2 mRNA22967744
D019772TopotecanTGM2 protein affects the susceptibility to Topotecan16217747
D014107Tosyllysine Chloromethyl KetoneTosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased activity of TGM2 protein]18295389
D014107Tosyllysine Chloromethyl KetoneTosyllysine Chloromethyl Ketone inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]18295389
D014118Toxins, Biological"Toxins, Biological affects the expression of TGM2 mRNA"19682533
D014212Tretinoin"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]"9516142
D014212TretinoinAGN 193109 inhibits the reaction [Tretinoin results in increased expression of TGM2 protein]16158052
D014212Tretinoinarsenic trioxide inhibits the reaction [Tretinoin results in increased expression of TGM2 protein]11133770|9450572
D014212TretinoinButyrates inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]]10910994
D014212TretinoinCD 2425 promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]9516142
D014212Tretinoin[Hemin co-treated with Tretinoin] affects the localization of TGM2 protein15556610
D014212TretinoinTetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]10910994|1207511
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in increased expression of TGM2 mRNA]16140955
D014212TretinoinTretinoin results in increased activity of TGM2 protein2884032|9516142
D014212TretinoinTretinoin results in increased expression of and results in increased activity of TGM2 protein16158929
D014212TretinoinTretinoin results in increased expression of TGM2 mRNA10910994|1207511
D014212TretinoinTretinoin results in increased expression of TGM2 protein11133770|1615805
D014212TretinoinTretinoin results in increased expression of TGM2 mRNA16505366|1660451
D014212TretinoinTretinoin results in increased expression of TGM2 mRNA20488242
D014212TretinoinTretinoin results in increased expression of TGM2 mRNA28689802
C011559tributyltindiazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of TGM2 mRNA]25932594
C011559tributyltintributyltin results in increased expression of TGM2 mRNA21622945|2593259
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TGM2 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of TGM2 mRNA26705709
C012589trichostatin Atrichostatin A inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]23946490
C012589trichostatin Atrichostatin A results in decreased expression of TGM2 mRNA15901671
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of TGM2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TGM2 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of TGM2 mRNA21515302
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGM2 mRNA"18930950
C022884undecaneundecane results in increased expression of TGM2 protein17337753
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of TGM2 mRNA15885361
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TGM2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TGM2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of TGM2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TGM2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]23946490
D014635Valproic AcidValproic Acid results in decreased expression of TGM2 mRNA15901671
D014640VancomycinVancomycin results in decreased expression of TGM2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions analog inhibits the reaction [IL4 protein results in increased expression of TGM2 mRNA]27224998
D001335Vehicle Emissions[Vehicle Emissions co-treated with IL4 protein] results in increased expression of TGM2 mRNA27224998
D001335Vehicle EmissionsAcetylcysteine inhibits the reaction [Vehicle Emissions analog results in decreased activity of TGM2 protein]15541757
D001335Vehicle EmissionsVehicle Emissions analog results in decreased activity of TGM2 protein15541757
D001335Vehicle EmissionsVehicle Emissions analog results in decreased expression of TGM2 mRNA15541757
C025643vinclozolinvinclozolin affects the expression of TGM2 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of TGM2 mRNA26682919
D014801Vitamin AVitamin A results in increased expression of TGM2 mRNA17034753
D014801Vitamin AVitamin A affects the expression of TGM2 mRNA14529804
D014807Vitamin DVitamin D promotes the reaction [alitretinoin results in increased expression of TGM2 mRNA]15964820
D014812Vitamin KQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]23117658
D014812Vitamin K[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein23117658
D014859WarfarinTGM2 protein affects the susceptibility to Warfarin23117658
D014859Warfarin[TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin23117658
D014859WarfarinTGM2 protein results in increased susceptibility to Warfarin23117658
D014859WarfarinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]23117658
D014859WarfarinQuercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]23117658
D014859Warfarin[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein23117658
D014859WarfarinWarfarin results in increased expression of and results in increased activity of TGM2 protein23117658
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of TGM2 mRNA"25198161
D015032ZincZinc deficiency results in decreased expression of TGM2 mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in decreased expression of TGM2 mRNA]16140947
C088658zoledronic acidzoledronic acid results in increased expression of TGM2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003810protein-glutamine gamma-glutamyltransferase activity-IMP24349085  
GO:0003810protein-glutamine gamma-glutamyltransferase activity-ISS-  
GO:0005515protein binding-IPI9442029  14517264  16301118  16951195  19542224  19738201  
20080707  21625219  22442151  28106549  
GO:0005525GTP binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001974blood vessel remodeling-IEA-  
GO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine-IEA-  
GO:0032471negative regulation of endoplasmic reticulum calcium ion concentration-IMP24349085  
GO:0043065positive regulation of apoptotic process-IMP24349085  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043277apoptotic cell clearance-IDA19628791  
GO:0045785positive regulation of cell adhesion-ISS-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0050729positive regulation of inflammatory response-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IEA-  
GO:0051561positive regulation of mitochondrial calcium ion concentration-IMP24349085  
GO:0060445branching involved in salivary gland morphogenesis-IEA-  
GO:0060662salivary gland cavitation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA24349085  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IDA24349085  
GO:0005925focal adhesion-HDA21423176  
GO:0031226intrinsic component of plasma membrane-IDA2578891  
GO:0031226intrinsic component of plasma membrane-IMP8105889  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27084846Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease. (2016 Jun 1)Ohlmeier SAm J Physiol Lung Cell Mol Physiol