Gene: TH

7054
DYT14|DYT5b|TYH
tyrosine hydroxylase
protein-coding
11p15.5
Ensembl:ENSG00000180176 MIM:191290 Vega:OTTHUMG00000009559 UniprotKB:P07101
NG_008128.1
PubMed
CD|OD|ND|AD
137   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.325e-2 (AD)  4.161e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF10.864
CRNDE0.828
NTS0.827
IRX20.826
C5orf380.824
SLITRK60.824
HCRT0.819
OTP0.819
HMX20.812
LHX50.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXF2-0.345
FGD6-0.336
THSD1-0.334
PDGFRB-0.333
MCF2L2-0.331
SLC38A11-0.318
GJC1-0.301
RGS5-0.3
ADRB2-0.291
PRELP-0.288

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00120L-PhenylalanineSmall Molecule63-91-2Approved|Investigational|NutraceuticalTarget
DB00135L-TyrosineSmall Molecule60-18-4Approved|Investigational|NutraceuticalTarget
DB00360SapropterinSmall Molecule62989-33-7Approved|InvestigationalTarget
DB00765MetyrosineSmall Molecule672-87-7ApprovedTarget
DB035523-TyrosineSmall Molecule587-33-7ExperimentalTarget
DB04400L-erythro-7,8-dihydrobiopterinSmall Molecule6779-87-9ExperimentalTarget
ID Drug Name Action PubMed
C5348801,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
C5452551,1-bis(3'-indolyl)-1-(p-anisyl)methane"1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [epibatidine results in increased expression of TH mRNA]"15588622
C5031021-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate"1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"18573265
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TH protein"15212945
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TH protein"21856379
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"AKT1 protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TH protein]"21856379
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"NRF1 protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TH protein]"21856379
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"TFAM protein inhibits the reaction [1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of TH protein]"21856379
C0849811-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene"[1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]"10661506
C0849811-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene"1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]"10661506
C0849811-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene"Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]"10661506
C0329042,2',3,5',6-pentachlorobiphenyl"2,2',3,5',6-pentachlorobiphenyl results in increased expression of TH mRNA"29233657
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcholine results in increased phosphorylation of and results in increased activity of TH protein]9288946
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of TH mRNA18950629
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TH mRNA"29233657
C04456324-hydroxycholesterol24-hydroxycholesterol results in increased expression of and results in increased phosphorylation of TH protein19014385
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0210082',5'-dideoxyadenosine"2',5'-dideoxyadenosine inhibits the reaction [epibatidine results in increased expression of TH mRNA]"15588622
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of TH mRNA"12641731
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA"17540007
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"17540007
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased expression of TH mRNA]"18992715
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA"18992715
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"bisindolylmaleimide I inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18992715
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18992715
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"Pertussis Toxin affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18992715
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA"18950629
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"pyrazolanthrone inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"U 0126 affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C0081103,3'-iminodipropionitrile"3,3'-iminodipropionitrile results in increased expression of TH protein"19244277
C0081103,3'-iminodipropionitrile"Acrylonitrile inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TH protein]"19244277
C0074303,4-dihydroxyphenylacetaldehyde"3,4-dihydroxyphenylacetaldehyde binds to TH protein"21238438
C0074303,4-dihydroxyphenylacetaldehyde"3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein"21514317
C0074303,4-dihydroxyphenylacetaldehyde"[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa"21514317
C5495413-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23062100
C5495413-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"23062100
C1065923,9-bis((ethylthio)methyl)-K-252a"3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [methylmercuric chloride results in decreased expression of TH mRNA]"21385734
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of TH protein"2904812|7931246
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased expression of TH mRNA"8103199
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in increased expression of TH mRNA"8103199
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TH protein"2904812
C5239643-iodotyrosine3-iodotyrosine results in decreased activity of TH protein17498763
C0259463-methyladenine3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]28802652
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of TH mRNA"26186136
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
C0415944-nonylphenol4-nonylphenol promotes the reaction [Acetylcholine results in increased activity of TH protein]15486222
C0415944-nonylphenol4-nonylphenol results in increased activity of TH protein15486222
C0415944-nonylphenolU 0126 inhibits the reaction [4-nonylphenol results in increased activity of TH protein]15486222
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of TH protein21372141
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [carnosol results in increased expression of TH protein]"17047462
C0801227-nitroindazole7-nitroindazole affects the reaction [Methamphetamine results in decreased expression of TH protein]8931477
C0162768-bromocyclic GMP8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]16023617
C0162768-bromocyclic GMP8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]16023617
D019342Acetic AcidAcetic Acid results in decreased expression of TH protein21296659
C056165acetovanilloneacetovanillone results in decreased expression of TH mRNA25217652
D000109Acetylcholine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcholine results in increased phosphorylation of and results in increased activity of TH protein]9288946
D000109Acetylcholine4-nonylphenol promotes the reaction [Acetylcholine results in increased activity of TH protein]15486222
D000109AcetylcholineAcetylcholine results in increased activity of TH protein15486222
D000109AcetylcholineAcetylcholine results in increased expression of TH mRNA1970506
D000109AcetylcholineAcetylcholine results in increased phosphorylation of and results in increased activity of TH protein9288946
D000109AcetylcholineSB 203580 inhibits the reaction [Acetylcholine results in increased phosphorylation of and results in increased activity of TH protein]9288946
D000109AcetylcholineAcetylcholine results in increased expression of TH mRNA29246838
D000109Acetylcholineconotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]29246838
D000109Acetylcholineconotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]29246838
D000109Acetylcholineimidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]29246838
D000109Acetylcholinetriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]29246838
D000109Acetylcholinetriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]29246838
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]22714038
D000111AcetylcysteineAcetylcysteine results in decreased expression of TH protein25891525
D000111Acetylcysteine[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein25891525
D020106AcrylamideAcrylamide results in increased expression of TH mRNA25943760
D020106AcrylamideAcrylamide results in increased expression of TH protein25943760
D000181Acrylonitrile"Acrylonitrile inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TH protein]"19244277
C072610adenosine-N(6)-methyl-propylthioether-N-pyridoxamineadenosine-N(6)-methyl-propylthioether-N-pyridoxamine results in decreased activity of TH protein15765258
D000336AerosolsAerosols affects the expression of TH mRNA25265048
D000376AgmatineAgmatine inhibits the reaction [Morphine results in increased expression of TH protein]15541421
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TH protein"20224926|2208560
C014959albiflorinalbiflorin affects the expression of TH26475043
D000447AldehydesAldehydes results in decreased expression of TH mRNA25014914
D053959Alpha-AmanitinAlpha-Amanitin inhibits the reaction [Tetrabenazine results in increased expression of TH mRNA]1970506
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of TH mRNA16543374
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein]15790535
D024502alpha-Tocopherol[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein25891525
C011164amentoflavone"amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"28185818
C011164amentoflavone"amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"28185818
D000640Amitrole"Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein]"25891026
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TH mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of TH protein16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of TH mRNA18681898
D000661AmphetamineAmphetamine results in decreased expression of TH protein20620199
D000661AmphetamineAmphetamine results in increased expression of TH mRNA16916582
D000661AmphetamineAmphetamine results in increased expression of TH protein19059431
D000661AmphetaminePTN protein inhibits the reaction [Amphetamine results in decreased expression of TH protein]20620199
D000661AmphetamineAmphetamine results in decreased expression of TH protein12468030|1583691
D000661AmphetamineAmphetamine results in increased expression of TH mRNA16126238
D047310ApigeninApigenin inhibits the reaction [Rotenone results in decreased expression of TH protein]28389404
C027423aroclor 1242[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein17324953
C028617aroclor 1248[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein17324953
C026987aroclor 1260[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein17324953
D001151ArsenicArsenic results in increased expression of TH protein27413109
D001151ArsenicArsenic results in decreased expression of TH protein22704994
D001151Arsenic[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]22704994
C006632arsenic trioxidearsenic trioxide results in decreased expression of TH protein11027660
C006632arsenic trioxidearsenic trioxide results in decreased expression of TH mRNA23392890|2351822
C006632arsenic trioxideTaurine inhibits the reaction [arsenic trioxide results in decreased expression of TH mRNA]23392890
D001205Ascorbic AcidAscorbic Acid results in decreased expression of TH protein22285708
D001205Ascorbic Acid[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein25891525
D001205Ascorbic AcidAscorbic Acid results in decreased expression of TH protein25891525
D001205Ascorbic AcidAscorbic Acid results in increased expression of TH mRNA15372504
D001280AtrazineAtrazine results in decreased expression of TH mRNA25929836
D001280AtrazineAtrazine results in decreased expression of TH mRNA23123945|2486396
D001280AtrazineAtrazine results in decreased expression of TH protein14550852|2486396
C005177benserazide, levodopa drug combination"benserazide, levodopa drug combination inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"28185818
C005177benserazide, levodopa drug combination"benserazide, levodopa drug combination inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"28185818
C012768benzanthronebenzanthrone results in increased expression of TH protein28029781
C006029benzonaphthyridonebenzonaphthyridone analog results in decreased activity of TH protein854479
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TH promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TH protein28049045
D004958EstradiolEstradiol results in decreased expression of TH mRNA16543374
D004958EstradiolEstradiol affects the expression of TH mRNA14699072
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of TH mRNA]20404318
D004958EstradiolEstradiol results in increased expression of and results in increased secretion of TH protein27271280
D004958EstradiolEstradiol results in increased expression of TH mRNA27271280
D004958EstradiolEstradiol affects the expression of TH protein16427766
D001640BicucullineBicuculline promotes the reaction [Reserpine affects the activity of TH protein]1981253
D001640BicucullineBicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]1981253
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of TH mRNA26186136
C070515bisindolylmaleimide I"bisindolylmaleimide I inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18992715
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C006780bisphenol Abisphenol A results in increased activity of TH protein15486222
C006780bisphenol Abisphenol A results in decreased expression of TH mRNA27271280
C006780bisphenol Abisphenol A results in decreased expression of TH protein27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH protein]27271280
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein]19481886
C006780bisphenol A[bisphenol A co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of TH protein]19481886
C006780bisphenol Abisphenol A results in decreased expression of TH protein19481886
C006780bisphenol A[Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [bisphenol A results in decreased expression of TH protein]19481886
C006780bisphenol Abisphenol A results in decreased expression of TH mRNA28079927
C006780bisphenol Abisphenol A affects the expression of TH protein16427766
C006780bisphenol Abisphenol A results in decreased expression of TH mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of TH protein16909604|1768903
C006780bisphenol Abisphenol A results in increased expression of TH mRNA26141625
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TH mRNA1970506
C099813bromochloroacetic acidbromochloroacetic acid affects the expression of TH protein21296659
C018475butyraldehydebutyraldehyde results in increased expression of TH mRNA26079696
D002104CadmiumCadmium results in increased expression of TH mRNA21694771
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TH promoter22457795
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA20360939
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TH mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"20230807
D002110CaffeineCaffeine promotes the reaction [Methamphetamine results in decreased activity of TH protein]7996441
D002211CapsaicinCapsaicin results in decreased activity of TH protein17028848
D002330CarmustineCarmustine results in increased activity of TH protein14670008
D002330CarmustineCarmustine results in increased expression of TH mRNA14670008
D002330CarmustineCarmustine results in increased expression of TH protein14670008
C068623carnosol"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [carnosol results in increased expression of TH protein]"17047462
C068623carnosolcarnosol inhibits the reaction [Rotenone results in decreased expression of TH protein]17047462
C068623carnosolcarnosol results in increased expression of TH protein17047462
C068623carnosolU 0126 inhibits the reaction [carnosol results in increased expression of TH protein]17047462
C043211carvedilolcarvedilol inhibits the reaction [Ethanol results in increased expression of TH protein]22413959
C043211carvedilolcarvedilol results in decreased expression of TH mRNA20359859
C043211carvedilolcarvedilol results in decreased expression of TH protein20359859
C070295catalase-polyethylene glycol"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in increased expression of TH protein]"25891026
D002395CatecholaminesTH protein results in increased chemical synthesis of Catecholamines11911850
C016299chelerythrine"chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18992715
C016299chelerythrinechelerythrine inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
D048271Chitosan[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]22704994
D002698Chloralose[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein12088752
D002714ChlorisondamineChlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]1714554
D002714ChlorisondamineChlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]1714554
D002714ChlorisondamineChlorisondamine results in increased expression of TH mRNA1714554
D002719ChlormethiazoleChlormethiazole inhibits the reaction [Methamphetamine results in decreased activity of TH protein]1381816
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TH protein22094459
D020111Chlorodiphenyl (54% Chlorine)[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH protein17324953
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TH protein24793810
D004390ChlorpyrifosAcetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]22714038
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TH protein22714038
D004390ChlorpyrifosChlorpyrifos results in increased expression of TH mRNA18812211
D003000ClonidineClonidine results in decreased activity of and results in decreased expression of TH protein19067675
D003000Clonidine[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine19067675
D003000Clonidine[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine19067675
D003000ClonidineClonidine results in increased activity of and results in increased expression of TH protein19067675
D003000Clonidine[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine19067675
D003000Clonidine[Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine19067675
D003024Clozapine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]"16402076
D003024ClozapineClozapine results in increased activity of TH protein16415089
D003024Clozapine[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine16415089
D003024ClozapineClozapine results in decreased activity of TH protein15983997
D003024ClozapineClozapine results in decreased expression of TH mRNA12645084|1598399
D003024ClozapineClozapine results in decreased expression of TH protein12645084|1598399
D003024ClozapineClozapine results in increased expression of TH protein17028028
D003024ClozapineEthylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]15983997
C018021cobaltous chloride[cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein16772336
C018021cobaltous chloridecobaltous chloride results in increased expression of TH mRNA9458725
D003042CocaineCocaine results in decreased phosphorylation of TH protein23499958
D003042Cocaineresveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein]23499958
D003042CocaineCocaine affects the expression of TH protein12787079
D003042CocaineCocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]20729865
D003042CocaineCocaine results in decreased expression of TH protein11391778
D003042CocaineCocaine results in increased expression of TH protein18992788
D003042CocaineSpiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]20729865
D005576ColforsinColforsin results in increased expression of TH mRNA1970506
D005576Colforsin"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased expression of TH mRNA]"18992715
D005576Colforsinbisindolylmaleimide I inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
D005576ColforsinColforsin results in increased activity of TH protein9288946
D005576ColforsinColforsin results in increased expression of TH mRNA18992715
D005576ColforsinColforsin results in increased expression of TH protein14550852
D005576ColforsinHU 211 inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
D005576ColforsinKT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
C115558conotoxin AuIB[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C115558conotoxin AuIB[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C115558conotoxin AuIB[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
C115558conotoxin AuIBconotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]29246838
C115558conotoxin AuIBconotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]29246838
C115558conotoxin AuIBconotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C115558conotoxin AuIBconotoxin AuIB inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C115558conotoxin AuIBconotoxin AuIB inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D019327Copper SulfateCopper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of TH protein]20184101
D019327Copper SulfateCopper Sulfate results in decreased expression of TH mRNA18369385
C470995corexit 9500corexit 9500 results in decreased expression of TH protein21916746
D003345CorticosteroneCorticosterone results in increased expression of TH protein28186389
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]24398105
D003471CuprizoneCuprizone results in decreased expression of TH mRNA27523638
D003474Curcumin[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]22704994
D003474CurcuminCurcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]19631675
C007168cyanazinecyanazine results in increased expression of TH protein14550852
D003513CycloheximideCycloheximide inhibits the reaction [Histamine results in increased expression of TH mRNA]2229066
D016572CyclosporineCyclosporine results in decreased methylation of TH promoter27989131
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein]11911850
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]11911850
C037304cyhalothrincyhalothrin results in decreased expression of TH protein22366556|2849560
D003561CytarabineCytarabine results in decreased expression of TH protein21198554
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein"16931444
C017180decamethrindecamethrin results in increased expression of TH mRNA25912032
C017180decamethrindecamethrin results in decreased expression of TH protein27553674
C017180decamethrindecamethrin results in decreased activity of TH protein16673815
C017180decamethrindecamethrin results in decreased expression of and results in decreased activity of TH protein15461254
C017180decamethrindecamethrin results in decreased expression of TH mRNA15461254|1622997
C017180decamethrindecamethrin results in decreased expression of TH protein16229977|1667381
C014347decitabinedecitabine results in increased expression of TH mRNA23441691
D003676DeferoxamineDeferoxamine results in increased expression of TH mRNA9458725
D013759DronabinolDronabinol affects the activity of and affects the expression of TH7776847
D013759DronabinolDronabinol affects the expression of and affects the activity of TH protein9188039
D013759DronabinolDronabinol affects the reaction [PRKN mutant form affects the activity of TH protein]15882845
D013759DronabinolDronabinol results in increased activity of TH protein7776847|9188039
D013759DronabinolDronabinol results in increased expression of and results in increased activity of TH protein10700552|8968950
D013759DronabinolDronabinol results in increased expression of TH mRNA7776847|8968950
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein]10700552|9188039
D003891DesipramineDesipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]1717808
D003907DexamethasoneDexamethasone results in increased expression of TH mRNA1970506
D003907DexamethasoneDexamethasone results in decreased expression of TH mRNA11072875
D003907DexamethasoneDexamethasone results in increased expression of TH protein14550852
C020733diadenosine tetraphosphatediadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19442829
D003976DiazinonDiazinon results in decreased expression of and results in decreased activity of TH protein11757738
D003976DiazinonDiazinon results in decreased expression of TH mRNA11757738
D003976DiazinonDiazinon results in increased expression of TH mRNA17452286|1881221
D003994BucladesineBucladesine results in increased expression of TH protein15486222
D003994BucladesineBucladesine results in increased expression of TH mRNA19912776
C100106dicarbinedicarbine inhibits the reaction [Dopamine results in decreased activity of TH protein]2884129
C100106dicarbinedicarbine results in decreased activity of TH protein2884129
C100106dicarbinedicarbine results in increased activity of TH protein2884129
D002945CisplatinCisplatin results in increased expression of TH mRNA15464296|1547189
D004006DichlorvosDichlorvos results in increased activity of TH protein12186780
D004006DichlorvosNimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]12186780
D004026DieldrinDieldrin results in decreased expression of TH mRNA23041725
D004026DieldrinDieldrin results in increased expression of TH mRNA18812211
D004041Dietary FatsDietary Fats results in decreased phosphorylation of TH protein25637688
D004041Dietary Fats"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein]"25637688
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein]19481886
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of TH protein]19481886
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [bisphenol A results in decreased expression of TH protein]19481886
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TH protein19481886
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TH gene23968726
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TH protein16329116
D002117Calcitriol[Calcitriol co-treated with VDR protein] results in increased expression of TH mRNA26210580
D002117Calcitriol[Calcitriol co-treated with VDR protein] results in increased expression of TH protein26210580
D004176DipyridamoleDipyridamole results in decreased expression of TH protein17568153
D004050DitiocarbDitiocarb results in decreased expression of and results in increased phosphorylation of TH protein22874009
D007980Levodopa[Paraquat co-treated with Levodopa] results in decreased expression of TH protein16321246
D007980Levodopa"[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa"21514317
D007980Levodopa"Drugs, Chinese Herbal inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]]"12585172
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]25129099
D007980LevodopaLevodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]12585172
D007980LevodopaLevodopa results in increased phosphorylation of TH protein25044243
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]15659429
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]15659429
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]15659429
D004298DopamineTH protein results in increased chemical synthesis of Dopamine19815691
D004298Dopamine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]"16402076
D004298Dopamine[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine16415089
D004298DopamineTH protein affects the abundance of Dopamine10984662|8707341
D004298Dopamine[TH protein affects the abundance of Dopamine] which affects the susceptibility to Methamphetamine10984662
D004298DopamineTH protein affects the chemical synthesis of Dopamine9822156
D004298Dopamine[TH protein affects the chemical synthesis of Dopamine] which affects the susceptibility to Methamphetamine9822156
D004298Dopamine"[1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]"10661506
D004298Dopamine"1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]"10661506
D004298Dopamine[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine19067675
D004298DopamineCocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]20729865
D004298Dopaminedicarbine inhibits the reaction [Dopamine results in decreased activity of TH protein]2884129
D004298DopamineDopamine results in decreased activity of TH protein2884129
D004298DopamineParaquat promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]24743698
D004298Dopamine[Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine11113527
D004298DopamineSpiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]20729865
D004298DopamineSulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]2884129
D004298DopamineTH affects the abundance of Dopamine20615977
D004298DopamineTH protein results in increased chemical synthesis of Dopamine10661506
D004298Dopamine"Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]"10661506
D004298DopamineTH protein results in increased chemical synthesis of Dopamine21310168
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]]"12585172
D015773EnalaprilatEnalaprilat inhibits the reaction [AGT protein modified form results in increased expression of TH]24342267
C082748epibatidine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [epibatidine results in increased expression of TH mRNA]"15588622
C082748epibatidine"2',5'-dideoxyadenosine inhibits the reaction [epibatidine results in increased expression of TH mRNA]"15588622
C082748epibatidineepibatidine results in increased expression of TH mRNA15588622
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of TH protein27659729
D004837EpinephrineTH protein results in increased chemical synthesis of Epinephrine9822156
D004837Epinephrine[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine19067675
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of TH protein16329116
D004967EstrogensEstrogens results in decreased expression of TH protein19744546
D000431EthanolEthanol promotes the reaction [mephedrone results in decreased expression of TH protein]26747301
D000431EthanolEthanol results in decreased expression of TH protein26747301
D000431Ethanolcarvedilol inhibits the reaction [Ethanol results in increased expression of TH protein]22413959
D000431EthanolEthanol results in increased expression of TH protein22413959
D005033EthylmaleimideEthylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]15983997
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of TH gene16495775
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [imidacloprid results in increased expression of TH mRNA]"29246838
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [Nicotine results in increased expression of TH mRNA]"29246838
C063007exoenzyme C3, Clostridium botulinum"[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]"29246838
C063007exoenzyme C3, Clostridium botulinum"[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]"29246838
D015025ZearalenoneZearalenone results in decreased expression of TH mRNA24412706
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated deficiency results in increased expression of TH protein"11916751
C533349FG 0041FG 0041 results in increased expression of TH protein19156859
C082360fipronilfipronil results in decreased expression of TH protein21296133
D005419FlavonoidsFlavonoids results in increased expression of TH mRNA18035473
D005472FluorouracilFluorouracil affects the expression of TH protein21296659
D005473FluoxetineFluoxetine results in decreased expression of TH mRNA20857517
D005473FluoxetineFluoxetine results in increased expression of TH mRNA20374287
D005473FluoxetineFluoxetine affects the expression of TH26475043
D005473FluoxetineFluoxetine results in decreased expression of TH mRNA15936043
D005473FluoxetineFluoxetine results in increased expression of TH mRNA1351783|20626387
D005557FormaldehydeFormaldehyde results in increased expression of TH protein15064152
D005632FructoseFructose results in increased expression of TH mRNA16843071
D019833GenisteinGenistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D019833GenisteinGenistein affects the expression of TH protein16427766
C077458ginkgetin"ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"25968939
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of TH mRNA22634610
D005905Glyburide"Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"16725203
D006145GuanethidineGuanethidine results in decreased expression of TH protein9460767
C120099GW 1929[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
C120099GW 1929GW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
D006220HaloperidolHaloperidol results in increased expression of TH protein17028028
D006533HeptachlorHeptachlor results in increased expression of TH protein16112329
D006540HerbicidesHerbicides results in decreased expression of TH mRNA23123945
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of TH protein28214749
D006632HistamineCycloheximide inhibits the reaction [Histamine results in increased expression of TH mRNA]2229066
D006632HistamineHistamine results in increased expression of TH mRNA2229066
C062018HU 2112-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C062018HU 2112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C062018HU 211CNR1 protein affects the reaction [HU 211 results in decreased expression of TH mRNA]17540007
C062018HU 211HU 211 results in decreased expression of TH mRNA17540007|1895062
C062018HU 211HU 211 results in decreased expression of TH protein17540007
C062018HU 211U 0126 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C062018HU 211wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C062018HU 211bisindolylmaleimide I inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C062018HU 211chelerythrine inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C062018HU 211HU 211 inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
C062018HU 211HU 211 results in decreased expression of TH mRNA18992715
C062018HU 211KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C062018HU 211N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C062018HU 211Pertussis Toxin inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
D006861Hydrogen PeroxideTH protein affects the susceptibility to Hydrogen Peroxide19815691
D006861Hydrogen PeroxideTH protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]19815691
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TH mRNA9458725
D006861Hydrogen PeroxideTH protein affects the abundance of Hydrogen Peroxide9458725
D019329IdazoxanIdazoxan results in increased expression of TH mRNA1351783
C082359imidacloprid[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C082359imidacloprid[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C082359imidaclopridconotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]29246838
C082359imidaclopridconotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C082359imidaclopridconotoxin AuIB inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C082359imidacloprid"exoenzyme C3, Clostridium botulinum inhibits the reaction [imidacloprid results in increased expression of TH mRNA]"29246838
C082359imidaclopridimidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]29246838
C082359imidaclopridimidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]29246838
C082359imidaclopridimidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]29246838
C082359imidaclopridimidacloprid results in increased expression of TH mRNA29246838
C082359imidaclopridimidacloprid results in increased expression of TH protein29246838
C082359imidacloprid"[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]"29246838
C082359imidaclopridN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C082359imidaclopridtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]29246838
C082359imidaclopridtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C082359imidaclopridtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C082359imidaclopridZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C082359imidaclopridZM 241385 inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C016527isoquercitrinisoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]25129099
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TH mRNA23430699
C005134juglone"juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"23754278
D007608Kainic AcidKainic Acid results in increased activity of TH protein3024077
D007649KetamineKetamine results in decreased expression of TH protein22178134
D007654KetoconazoleKetoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]22334051
D007654Ketoconazole"Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]"19594327
D007654KetoconazoleKetoconazole inhibits the reaction [Paraquat results in decreased expression of TH protein]22334051
C057416KT 5720KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
C057416KT 5720KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C057416KT 5720KT 5720 results in decreased expression of TH mRNA18992715
D007854LeadLead results in decreased expression of TH protein21703292
C018584linaloollinalool results in decreased expression of TH mRNA20536181
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TH protein"17573159
D008070LipopolysaccharidesLipopolysaccharides results in decreased methylation of TH gene21212295
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TH gene21212295
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of TH protein23483921
D008094LithiumLithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19149911
D008148LovastatinLovastatin results in increased expression of TH protein20694854
D008148LovastatinMevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]20694854
D008148LovastatinLovastatin results in increased expression of TH protein20694854
D008148LovastatinMevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]20694854
D008344Maneb4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D008344ManebGenistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D008344ManebKetoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]22334051
D008344ManebManeb results in decreased expression of TH protein22334051
D008344ManebMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]20964710
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of TH protein11124998|1838618
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of TH protein20455021
D008344Manebpimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D008344Manebprolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D008344ManebSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]20964710
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of TH24376148
D008345ManganeseManganese results in decreased expression of TH mRNA16943606|1978156
D008345ManganeseManganese results in decreased expression of TH protein20224926|2079824
C025340manganese chloridemanganese chloride results in decreased expression of TH mRNA27913844
C025340manganese chloridemanganese chloride results in increased methylation of TH gene27913844
C025340manganese chloridemanganese chloride results in decreased expression of TH protein24969583|2853924
C025340manganese chlorideMelatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]24969583
C025340manganese chloridemanganese chloride results in decreased activity of TH protein21310168
C025340manganese chloridemanganese chloride results in decreased expression of TH protein20798247|2360496
C025340manganese chloridemanganese chloride results in increased activity of and results in increased phosphorylation of TH protein21310168
C025340manganese chloridemanganese chloride results in increased expression of TH mRNA12106697
C025340manganese chloridemanganese chloride results in increased expression of TH protein12106697
C025340manganese chloriderottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein]21310168
C025340manganese chloride[wortmannin co-treated with manganese chloride] results in decreased expression of TH protein23604964
C039798manganese sulfatemanganese sulfate results in decreased expression of TH protein17347134
C039798manganese sulfatemanganese sulfate results in increased expression of TH mRNA17347134
C039798manganese sulfatemanganese sulfate results in decreased expression of TH mRNA16943606
C057383MDL 201053MDL 201053 inhibits the reaction [Oxidopamine results in decreased expression of TH protein]28802652
D008550MelatoninMelatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]24969583
D008550MelatoninMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]20964710
D008550MelatoninMelatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19409439
D008550MelatoninMelatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]18289173
C548233mephedroneEthanol promotes the reaction [mephedrone results in decreased expression of TH protein]26747301
C548233mephedronemephedrone results in decreased expression of TH protein26747301
C548233mephedronemephedrone results in decreased expression of TH protein25817894
D015122Mercaptopurine[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
D015122MercaptopurineMercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
D008694MethamphetamineMethamphetamine results in decreased expression of TH protein10958525
D008694MethamphetamineMethamphetamine results in decreased expression of TH protein16622715
D008694Methamphetamine7-nitroindazole affects the reaction [Methamphetamine results in decreased expression of TH protein]8931477
D008694MethamphetamineCaffeine promotes the reaction [Methamphetamine results in decreased activity of TH protein]7996441
D008694MethamphetamineChlormethiazole inhibits the reaction [Methamphetamine results in decreased activity of TH protein]1381816
D008694MethamphetamineMethamphetamine results in decreased activity of TH protein1381816|22512859
D008694MethamphetamineMethamphetamine results in decreased expression of TH mRNA22329540
D008694MethamphetamineMethamphetamine results in decreased expression of TH protein12871582|1608894
D008694MethamphetamineNR4A2 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]21151937
D008694MethamphetamineOPRM1 protein affects the susceptibility to [Methamphetamine results in decreased expression of TH mRNA]22329540
D008694MethamphetamineOPRM1 protein affects the susceptibility to [Methamphetamine results in decreased expression of TH protein]22329540
D008694MethamphetaminePhencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein]1381816
D008694MethamphetaminePRKCD protein affects the reaction [Methamphetamine results in decreased activity of TH protein]22512859
D008694MethamphetaminePRKCD protein affects the reaction [Methamphetamine results in decreased expression of TH protein]22512859
D008694MethamphetamineRaclopride inhibits the reaction [Methamphetamine results in decreased expression of TH protein]16088948
D008694Methamphetamine[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]22512859
D008694Methamphetamine[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]22512859
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of TH protein]16088948
D008694MethamphetamineTAAR1 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]28919515
D008694Methamphetaminetalipexole inhibits the reaction [Methamphetamine results in decreased activity of TH protein]9655613
D008694Methamphetamine[TH protein affects the abundance of Dopamine] which affects the susceptibility to Methamphetamine10984662
D008694Methamphetamine[TH protein affects the chemical synthesis of Dopamine] which affects the susceptibility to Methamphetamine9822156
D008694MethamphetamineTH protein affects the susceptibility to Methamphetamine9822156
D008694Methamphetaminediadenosine tetraphosphate inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19442829
D008694MethamphetamineLithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19149911
D008694MethamphetamineMelatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19409439
D008694MethamphetamineMethamphetamine affects the expression of TH mRNA24042092
D008694MethamphetamineMethamphetamine results in decreased activity of TH protein2579200
D008694MethamphetamineMethamphetamine results in decreased expression of TH protein10773198|1527687
D008694Methamphetamineolanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein]15276877
D008694MethamphetamineValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19149911
D008694MethamphetamineMethamphetamine results in decreased activity of TH protein20722968
D008731MethoxychlorMethoxychlor results in increased methylation of TH gene23303685
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein]"25637688
C054634methyllycaconitine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]17498763
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TH mRNA23103053
C004925methylmercuric chloride"3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [methylmercuric chloride results in decreased expression of TH mRNA]"21385734
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TH mRNA21385734
D008767Methylmercury CompoundsTH protein results in decreased susceptibility to Methylmercury Compounds20650311
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TH mRNA26056851|2655846
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TH protein26056851
D008774MethylphenidateMethylphenidate results in decreased expression of TH mRNA22470460
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA26364587
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TH protein26364587
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TH mRNA24810058
D0156551-Methyl-4-phenylpyridiniumBMP2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]20007850
D0156551-Methyl-4-phenylpyridiniumINS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA]26364587
D0156551-Methyl-4-phenylpyridiniumINS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]26364587
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased activity of TH protein20184101
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TH mRNA23665943|2605685
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TH protein20007850|2366594
D0156551-Methyl-4-phenylpyridiniumCopper Sulfate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of TH protein]20184101
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TH protein19794909|2320148
D0156551-Methyl-4-phenylpyridinium[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
D0156551-Methyl-4-phenylpyridiniumGW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
D0156551-Methyl-4-phenylpyridiniumMercaptopurine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]27435855
D0156551-Methyl-4-phenylpyridiniumsesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]19794909
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein"16026462
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA"23062100
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein"23062100
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23062100
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"23062100
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"PRKN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH]"25447324
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"24140863
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein"16029219|2045242
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"18573265
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein"19653878|2540616
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]"16402076
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH"25447324
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA"15329391|2023080
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein"16725203|1755555
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"28185818
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"amentoflavone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"28185818
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"benserazide, levodopa drug combination inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"28185818
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"benserazide, levodopa drug combination inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"28185818
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TH mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"CSF3 protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"27044752
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"25968939
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"16725203
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"23754278
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]"19594327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TH mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"20230807|2393322
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"19594327|2023080
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH protein"19948168
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"19199078
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]20694854
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]20694854
D015735MifepristoneMifepristone results in decreased expression of TH mRNA17584828
D015735MifepristoneMifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein]22305719
D008920MisonidazoleMisonidazole results in increased activity of TH protein2875048
D008920MisonidazoleMisonidazole results in increased expression of TH protein2875048
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of TH mRNA22401849
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of TH mRNA21145954
D008999MonocrotophosMifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein]22305719
D008999MonocrotophosMonocrotophos results in increased activity of TH protein22305719
D005677G(M1) GangliosideG(M1) Ganglioside results in increased activity of TH protein14552908
D009020MorphineCRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]25582704
D009020Morphine[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein25582704
D009020MorphineAgmatine inhibits the reaction [Morphine results in increased expression of TH protein]15541421
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]24398105
D009020Morphine[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein25308750
D009020MorphineMorphine deficiency results in increased phosphorylation of TH protein24398105
D009020MorphineMorphine promotes the reaction [CREB1 protein modified form binds to TH promoter]25643298
D009020MorphineMorphine results in decreased expression of TH protein26386147
D009020MorphineMorphine results in increased expression of TH protein15541421
D009151Mustard GasMustard Gas results in increased expression of TH mRNA15674843
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide"[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]"29246838
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide"[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]"29246838
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of TH mRNA]18992715
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of TH mRNA18992715
D009270NaloxoneCRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]25582704
D009270Naloxone[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein25582704
D009270Naloxone[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]24398105
D009270Naloxone[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein25308750
D009270NaloxoneNaloxone results in increased phosphorylation of TH protein24398105
C407426neurotensin 69Lneurotensin 69L results in increased expression of TH mRNA17113052
D009532NickelNickel results in increased expression of TH mRNA18812211
C022838nickel chloridenickel chloride inhibits the reaction [Tretinoin results in increased expression of TH protein]25614230
D009538NicotineNicotine results in increased expression of TH mRNA1970506
D009538Nicotine[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]17498763
D009538NicotineNicotine results in increased expression of TH mRNA17498763
D009538NicotineNicotine results in increased expression of TH protein17498763
D009538Nicotine"Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]"19594327
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TH mRNA"20230807
D009538Nicotine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23933227
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"20230807|2393322
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"19594327|2023080
D009538Nicotine[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
D009538Nicotine[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D009538Nicotineconotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
D009538Nicotineconotoxin AuIB inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D009538Nicotine"exoenzyme C3, Clostridium botulinum inhibits the reaction [Nicotine results in increased expression of TH mRNA]"29246838
D009538Nicotineimidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]29246838
D009538Nicotineimidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]29246838
D009538Nicotine"[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]"29246838
D009538NicotineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D009538NicotineNicotine results in increased expression of TH mRNA29246838
D009538NicotineNicotine results in increased expression of TH protein29246838
D009538Nicotinetriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
D009538Nicotinetriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D009538NicotineZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
D009538NicotineZM 241385 inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D009553NimodipineNimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]12186780
D009585Nitrogen DioxideNitrogen Dioxide results in decreased activity of TH protein12771134
D009599Nitroprusside[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein12088752
D009599NitroprussideNitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]16023617
D009599NitroprussideNitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]16023617
D009599NitroprussideNitroprusside results in increased expression of TH protein12088752
D009638NorepinephrineTH protein results in increased chemical synthesis of Norepinephrine9822156
D009638Norepinephrine[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine19067675
D009638Norepinephrine[Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine19067675
C474055octylphenoloctylphenol results in decreased expression of TH protein15620428
D016627OxidopamineTH protein affects the susceptibility to Oxidopamine19815691
D016627OxidopamineTH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]19815691
D016627OxidopamineOxidopamine results in decreased expression of TH mRNA17803225
D016627OxidopamineOxidopamine results in decreased expression of TH protein15899244|1691438
D016627OxidopaminePARK2 protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]16914382
D016627Oxidopaminesulforafan inhibits the reaction [Oxidopamine results in decreased expression of TH protein]23518299
D016627Oxidopamine3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]28802652
D016627Oxidopamine"Drugs, Chinese Herbal inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]]"12585172
D016627Oxidopamineisoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]25129099
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]25129099
D016627OxidopamineLevodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]12585172
D016627OxidopamineMDL 201053 inhibits the reaction [Oxidopamine results in decreased expression of TH protein]28802652
D016627OxidopamineOxidopamine results in decreased expression of TH mRNA11730701|1258517
D016627OxidopamineOxidopamine results in decreased expression of TH protein14696016|1570327
D016627Oxidopaminerosiglitazone inhibits the reaction [Oxidopamine results in decreased expression of TH protein]22842585
D016627OxidopamineRutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]25129099
D016627Oxidopaminesalvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein]25446857
D016627OxidopamineTea inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]16480889
D016627OxidopamineTea inhibits the reaction [Oxidopamine results in decreased expression of TH protein]16480889
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]15659429
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]15659429
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]15659429
C076029olanzapineolanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein]15276877
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of TH mRNA19793540
D010100OxygenOxygen deficiency results in increased expression of TH mRNA10486562|1157707
D010269ParaquatTH protein results in decreased susceptibility to Paraquat25158689
D010269ParaquatParaquat results in increased expression of TH protein26498265
D010269Paraquat4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the expression of TH protein]28428137
D010269ParaquatGenistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D010269ParaquatKetoconazole inhibits the reaction [Paraquat results in decreased expression of TH protein]22334051
D010269ParaquatMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]20964710
D010269ParaquatParaquat affects the expression of TH protein28428137
D010269Paraquat[Paraquat co-treated with Levodopa] results in decreased expression of TH protein16321246
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of TH protein11124998|1838618
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of TH protein20455021
D010269ParaquatParaquat results in decreased expression of TH protein22334051
D010269Paraquatpimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D010269Paraquatprolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D010269ParaquatSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]20964710
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of TH24376148
D010269ParaquatParaquat promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]24743698
D010269ParaquatParaquat promotes the reaction [Zinc Sulfate results in decreased expression of TH protein]20553223
D010269ParaquatParaquat results in decreased expression of TH mRNA24521700|2846789
D010269ParaquatParaquat results in decreased expression of TH protein16190885|2055322
D010269ParaquatParaquat results in increased activity of TH protein24743698
D010269ParaquatZinc Sulfate promotes the reaction [Paraquat results in decreased expression of TH protein]20553223
D052638Particulate Matter[Particulate Matter co-treated with Volatile Organic Compounds] affects the expression of TH mRNA25265048
C046012pentanalpentanal results in decreased expression of TH mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TH mRNA26686188
D026023PermethrinPermethrin results in decreased expression of and results in decreased activity of TH protein15461254
D026023PermethrinPermethrin results in decreased expression of TH mRNA15461254
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of TH protein12771134
D037342Pertussis Toxin"Pertussis Toxin affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18992715
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18992715
D037342Pertussis ToxinPertussis Toxin results in increased expression of TH mRNA18992715
C031181phenanthrenephenanthrene results in decreased expression of TH mRNA19781795
D010622PhencyclidinePhencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein]1381816
D010622PhencyclidinePhencyclidine results in increased expression of TH mRNA12105081
D010624PhenelzinePhenelzine results in increased expression of TH mRNA1351783
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [Rotenone results in decreased expression of TH protein]27108097
C004479pimagedinepimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TH gene23968726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TH mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of TH mRNA23557933
D028321Plant PreparationsPlant Preparations results in decreased activity of TH protein27697540
C043435polylactic acid-polyglycolic acid copolymer"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23933227
D045542PQQ CofactorPQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TH protein]26276080|2710809
D000069583PregabalinPregabalin affects the expression of TH mRNA22017514
D000069583PregabalinPregabalin results in increased expression of TH mRNA22489711
D011339Probenecid"1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
D011339Probenecid"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
D011339Probenecid"1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]"25406165
D011339Probenecid"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein"19653878|2540616
D011374ProgesteroneProgesterone results in decreased activity of TH protein18096660
D011374ProgesteroneProgesterone results in decreased phosphorylation of TH protein18096660
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]20455021
C005556propionaldehydepropionaldehyde results in decreased expression of TH mRNA26079696
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C432165pyrazolanthronepyrazolanthrone results in increased expression of TH mRNA18950629
D011794QuercetinQuercetin inhibits the reaction [Rotenone results in decreased expression of TH protein]23357119
D020891RacloprideRaclopride inhibits the reaction [Methamphetamine results in decreased expression of TH protein]16088948
D012110ReserpineReserpine results in increased expression of TH mRNA1970506
D012110ReserpineReserpine results in increased expression of TH mRNA9263596
D012110ReserpineReserpine results in increased expression of TH mRNA1717819
D012110ReserpineReserpine results in increased expression of TH mRNA8666980
D012110ReserpineBicuculline promotes the reaction [Reserpine affects the activity of TH protein]1981253
D012110ReserpineBicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]1981253
D012110ReserpineChlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]1714554
D012110ReserpineChlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]1714554
D012110ReserpineDesipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]1717808
D012110ReserpineReserpine affects the activity of TH protein1981253
D012110ReserpineReserpine promotes the reaction [CREM protein binds to TH promoter]11438978
D012110ReserpineReserpine results in decreased expression of TH mRNA20504635
D012110ReserpineReserpine results in increased activity of TH protein1978789|2862954|
D012110ReserpineReserpine results in increased expression of and results in increased activity of TH protein1687822
D012110ReserpineReserpine results in increased expression of TH mRNA11438978|1350653
D012110ReserpineReserpine results in increased expression of TH protein1976760
D012110ReserpineReserpine results in increased stability of TH mRNA11161478
C059514resveratrolresveratrol promotes the reaction [Cocaine results in decreased phosphorylation of TH protein]23499958
C089032rimonabantrimonabant affects the reaction [PRKN mutant form affects the activity of TH protein]15882845
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in increased activity of TH protein]10700552|9188039
C089032rimonabantrimonabant results in increased activity of TH protein15882845
D018967RisperidoneRisperidone results in increased expression of TH protein17028028
C085989Ro 32-0432Ro 32-0432 inhibits the reaction [EDN1 protein results in increased activity of TH protein]11911850
C085989Ro 32-0432Ro 32-0432 inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]11911850
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxidopamine results in decreased expression of TH protein]22842585
D012402RotenoneRotenone results in increased expression of TH mRNA23639798
D012402Rotenonecarnosol inhibits the reaction [Rotenone results in decreased expression of TH protein]17047462
D012402RotenoneRotenone results in decreased expression of TH protein17047462
D012402Rotenonealpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein]15790535
D012402RotenoneApigenin inhibits the reaction [Rotenone results in decreased expression of TH protein]28389404
D012402RotenoneMelatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]18289173
D012402Rotenonephenylmethylpyrazolone inhibits the reaction [Rotenone results in decreased expression of TH protein]27108097
D012402RotenonePQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TH protein]26276080|2710809
D012402RotenoneQuercetin inhibits the reaction [Rotenone results in decreased expression of TH protein]23357119
D012402RotenoneRotenone results in decreased expression of TH protein12385818|1579053
D012402Rotenonesaxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein]25446674
D012402RotenoneSelegiline inhibits the reaction [Rotenone results in decreased expression of TH protein]16490285
D012402RotenoneSNCA protein promotes the reaction [Rotenone results in decreased expression of TH protein]26075822
D012402RotenoneSulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein]18289173
D012402RotenoneTH protein results in increased susceptibility to Rotenone14622122
C085746rottlerin[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]22512859
C085746rottlerin[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]22512859
C085746rottlerinrottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein]21310168
D012431RutinRutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]25129099
C018381salvinsalvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein]25446857
C502994saxagliptinsaxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein]25446674
C093642SB 203580SB 203580 inhibits the reaction [Acetylcholine results in increased phosphorylation of and results in increased activity of TH protein]9288946
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein]9288946
C093642SB 203580SB 203580 inhibits the reaction [Sorbitol results in increased activity of TH protein]9288946
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein]9288946
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of TH protein]16088948
D012642SelegilineSelegiline inhibits the reaction [Rotenone results in decreased expression of TH protein]16490285
D012642SelegilineSelegiline results in decreased expression of TH mRNA11862330
D012643SeleniumSelenium deficiency results in increased activity of TH protein11113527
D012643Selenium[Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine11113527
D012643SeleniumSelenium deficiency results in increased expression of TH mRNA11113527
D012715Sesame OilSesame Oil results in decreased expression of TH mRNA29191790
C054125sesaminsesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]19794909
D012838SilymarinSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]20964710
D012839SimazineSimazine results in increased expression of TH mRNA27513680
D012839SimazineSimazine results in decreased expression of TH protein14550852
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein]9288946
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of TH protein9288946
C017947sodium arsenite[sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of TH mRNA]23283970
C017947sodium arsenitesodium arsenite results in decreased expression of TH mRNA19121333|2328397
C017947sodium arsenitesodium arsenite results in increased expression of TH protein27413109
C017947sodium arseniteCurcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]19631675
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of TH protein]9288946
C017947sodium arsenitesodium arsenite results in decreased expression of TH protein19631675
C017947sodium arsenitesodium arsenite results in increased expression of TH protein25179238
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of TH protein9288946
D012965Sodium ChlorideSodium Chloride results in increased expression of TH mRNA10613505
D017673Sodium Chloride, Dietary"Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein]"25891026
D017673Sodium Chloride, Dietary"catalase-polyethylene glycol inhibits the reaction [Sodium Chloride, Dietary results in increased expression of TH protein]"25891026
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of TH protein"25891026
D012989Soil PollutantsSoil Pollutants results in increased expression of TH protein23953925
D013012SorbitolSB 203580 inhibits the reaction [Sorbitol results in increased activity of TH protein]9288946
D013012SorbitolSorbitol results in increased activity of TH protein9288946
D013134SpiperoneSpiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]20729865
C016766sulforafansulforafan inhibits the reaction [Oxidopamine results in decreased expression of TH protein]23518299
D013469SulpirideSulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]2884129
D013469SulpirideSulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein]18289173
D013469SulpirideSulpiride results in increased activity of TH protein2884129
C024763talipexoletalipexole inhibits the reaction [Methamphetamine results in decreased activity of TH protein]9655613
D013654TaurineTaurine inhibits the reaction [arsenic trioxide results in decreased expression of TH mRNA]23392890
D013662TeaTea inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]16480889
D013662TeaTea inhibits the reaction [Oxidopamine results in decreased expression of TH protein]16480889
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]"23747572
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"23747572
D013739TestosteroneTestosterone results in increased expression of TH mRNA16543374
D013739TestosteroneTestosterone results in decreased expression of TH protein11883789
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of TH protein16329116
D013747TetrabenazineAlpha-Amanitin inhibits the reaction [Tetrabenazine results in increased expression of TH mRNA]1970506
D013747TetrabenazineTetrabenazine results in increased expression of TH mRNA1970506
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TH mRNA]19500377
D013749Tetrachlorodibenzodioxin[bisphenol A co-treated with Diethylhexyl Phthalate] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TH protein]19481886
D013749Tetrachlorodibenzodioxin[bisphenol A co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of TH protein]19481886
D013749Tetrachlorodibenzodioxin[Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [bisphenol A results in decreased expression of TH protein]19481886
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of TH gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TH protein19481886
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased methylation of TH gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of TH protein19500377
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TH mRNA19500377
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TH protein19500377|2802978
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TH mRNA22808131
D013755Tetradecanoylphorbol Acetate[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TH protein24101030
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TH mRNA18992715
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TH protein25891525
C052342topiramatetopiramate affects the expression of TH mRNA22017514
C052342topiramatetopiramate results in increased expression of TH mRNA22489711
D014212Tretinoinnickel chloride inhibits the reaction [Tretinoin results in increased expression of TH protein]25614230
D014212Tretinoin[Tretinoin co-treated with CNTF protein] results in increased expression of TH17017122
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH mRNA17085092
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH protein17085092
D014212Tretinoin[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TH protein24101030
D014212Tretinoin[Tretinoin co-treated with VDR protein] results in increased expression of TH protein26210580
D014212TretinoinTretinoin results in increased expression of TH mRNA25614230
D014212TretinoinTretinoin results in increased expression of TH protein15464216|2561423
C118602triethyl-(beta-4-stilbenoxyethyl)ammonium[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammonium[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammonium[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C118602triethyl-(beta-4-stilbenoxyethyl)ammoniumtriethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
D014311Triprolidine"Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]"10661506
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TH mRNA29024780
C113580U 0126U 0126 inhibits the reaction [4-nonylphenol results in increased activity of TH protein]15486222
C113580U 0126U 0126 inhibits the reaction [carnosol results in increased expression of TH protein]17047462
C113580U 0126U 0126 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C113580U 0126U 0126 inhibits the reaction [CCK protein results in increased phosphorylation of TH protein]19176891
C113580U 0126"U 0126 affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C113580U 0126U 0126 results in decreased expression of TH mRNA18950629
D014520Urethane[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein12088752
D014635Valproic AcidValproic Acid affects the expression of TH mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of TH mRNA17963808
D014635Valproic AcidCREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA]18976638
D014635Valproic AcidValproic Acid affects the expression of TH protein19460635
D014635Valproic AcidValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein]19149911
D014635Valproic AcidValproic Acid results in decreased expression of TH mRNA18976638
D014635Valproic AcidValproic Acid results in decreased expression of TH protein18976638
D014635Valproic AcidValproic Acid results in increased expression of TH mRNA18976638
D014635Valproic AcidValproic Acid results in increased expression of TH protein18976638
C044616vindeburnolvindeburnol results in increased expression of TH protein7903186
D014807Vitamin DVitamin D deficiency results in decreased expression of TH mRNA28365874
D014807Vitamin DVitamin D deficiency results in decreased expression of TH protein28365874
D055549Volatile Organic Compounds[Particulate Matter co-treated with Volatile Organic Compounds] affects the expression of TH mRNA25265048
C111237vorinostatvorinostat results in decreased expression of TH mRNA27188386
C009687wortmanninwortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA]18950629
C009687wortmannin[wortmannin co-treated with manganese chloride] results in decreased expression of TH protein23604964
C009687wortmannin"wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"18950629
C108830Y 27632[cobaltous chloride co-treated with Y 27632] results in increased expression of TH protein16772336
D015032ZincZinc results in decreased expression of TH mRNA20932299
D015032ZincZinc results in decreased expression of TH protein22367497
D015032ZincZinc results in increased expression of TH protein11165868
D015034Zinc OxideZinc Oxide analog results in decreased expression of TH mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of TH mRNA27215404
D019287Zinc SulfateParaquat promotes the reaction [Zinc Sulfate results in decreased expression of TH protein]20553223
D019287Zinc SulfateZinc Sulfate promotes the reaction [Paraquat results in decreased expression of TH protein]20553223
D019287Zinc SulfateZinc Sulfate results in decreased expression of TH protein20553223
C097270ZM 241385[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C097270ZM 241385[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C097270ZM 241385[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
C097270ZM 241385ZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]29246838
C097270ZM 241385ZM 241385 inhibits the reaction [imidacloprid results in increased expression of TH mRNA]29246838
C097270ZM 241385ZM 241385 inhibits the reaction [Nicotine results in increased expression of TH mRNA]29246838
C022189zonisamidezonisamide results in increased expression of TH mRNA20196486
C022189zonisamidezonisamide results in increased expression of TH protein20196486
C022189zonisamide"[zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH protein"19948168
C022189zonisamide"zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]"19199078
C022189zonisamidezonisamide results in increased expression of TH protein19199078
D015054ZymosanZymosan results in increased expression of TH mRNA18178496

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004511tyrosine 3-monooxygenase activity-IDA2896667  11943812  12631248  16338639  19703902  
GO:0004511tyrosine 3-monooxygenase activity-TAS-  
GO:0005515protein binding-IPI11943812  19703902  
GO:0008198ferrous iron binding-IEA-  
GO:0008199ferric iron binding-IEA-  
GO:0016597amino acid binding-IEA-  
GO:0019825oxygen binding-IEA-  
GO:0019899enzyme binding-IPI19703902  
GO:0019904protein domain specific binding-IEA-  
GO:0034617tetrahydrobiopterin binding-IEA-  
GO:0035240dopamine binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA17520326  
GO:0001963synaptic transmission, dopaminergic-ISS-  
GO:0001975response to amphetamine-IEA-  
GO:0003007heart morphogenesis-NAS12113410  
GO:0006585dopamine biosynthetic process from tyrosine-NAS10907721  
GO:0006631fatty acid metabolic process-IEA-  
GO:0006665sphingolipid metabolic process-IEA-  
GO:0007507heart development-ISS-  
GO:0007601visual perception-ISS-  
GO:0007605sensory perception of sound-IEA-  
GO:0007612learning-ISS-  
GO:0007613memory-ISS-  
GO:0007617mating behavior-IEA-  
GO:0007626locomotory behavior-ISS-  
GO:0008016regulation of heart contraction-ISS-  
GO:0009414response to water deprivation-IEA-  
GO:0009416response to light stimulus-IEA-  
GO:0009635response to herbicide-IEA-  
GO:0009651response to salt stress-IEA-  
GO:0009653anatomical structure morphogenesis-TAS7715703  
GO:0009887animal organ morphogenesis-ISS-  
GO:0010043response to zinc ion-IEA-  
GO:0010259multicellular organism aging-IEA-  
GO:0014823response to activity-IEA-  
GO:0015842aminergic neurotransmitter loading into synaptic vesicle-IEA-  
GO:0016137glycoside metabolic process-IEA-  
GO:0018963phthalate metabolic process-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0033076isoquinoline alkaloid metabolic process-IEA-  
GO:0035176social behavior-IEA-  
GO:0035900response to isolation stress-IEA-  
GO:0035902response to immobilization stress-IEA-  
GO:0042136neurotransmitter biosynthetic process-IEA-  
GO:0042214terpene metabolic process-IEA-  
GO:0042416dopamine biosynthetic process-IDA12457228  
GO:0042418epinephrine biosynthetic process-IDA12457228  
GO:0042421norepinephrine biosynthetic process-IDA12457228  
GO:0042423catecholamine biosynthetic process-TAS-  
GO:0042462eye photoreceptor cell development-ISS-  
GO:0042745circadian sleep/wake cycle-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0043473pigmentation-TAS12631248  
GO:0045471response to ethanol-IDA18343820  
GO:0045472response to ether-IEA-  
GO:0046684response to pyrethroid-IEA-  
GO:0048596embryonic camera-type eye morphogenesis-ISS-  
GO:0051412response to corticosterone-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0052314phytoalexin metabolic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0071287cellular response to manganese ion-IEA-  
GO:0071312cellular response to alkaloid-IEA-  
GO:0071316cellular response to nicotine-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IDA10907721  
GO:0005739mitochondrion-IEA-  
GO:0005790smooth endoplasmic reticulum-IDA12457228  
GO:0005829cytosol-TAS-  
GO:0008021synaptic vesicle-IEA-  
GO:0009898cytoplasmic side of plasma membrane-IDA12457228  
GO:0030425dendrite-IEA-  
GO:0031410cytoplasmic vesicle-IDA12457228  
GO:0033162melanosome membrane-IDA12631248  
GO:0043005neuron projection-IDA17135716  
GO:0043195terminal bouton-IEA-  
GO:0043204perikaryon-ISS-  
KEGG ID KEGG Term
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209905Catecholamine biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
7494448Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration. (1995 Aug)Hiremagalur BBrain Res Mol Brain Res
29544861Self-initiated physical activity is associated with high sensitivity C-reactive protein: A longitudinal study in 5,030 adults. (2018 Jun)Fernandes RAAtherosclerosis
27596289Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness. (2016 Dec)Arenas MCPsychopharmacology (Berl)
23142009Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease. (2013 May)King PTJ Allergy Clin Immunol
23030796The Holy Grail of outer space: pluralism, Druidry, and the religion of cinema in The Sky Ship. (2012 Oct)Bjornvig TAstrobiology
25869478Serum periostin in smokers and never smokers with asthma. (2015 Jun)Thomson NCRespir Med
21589866Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. (2011 May 12)Fonseca FPLoS One
18489797Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance. (2008 May 20)Van Hove CLRespir Res
26573493[Alcohol Abuse and Associated Factors in Student Children and Adolescents]. (2012 Jun)Rueda-Jaimes GERev Colomb Psiquiatr
20383631Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. (2011 Jan)Tamaki JOsteoporos Int
16266866Inflammatory cytokine profile and circulating cortisol levels in malnourished children with necrotizing ulcerative gingivitis. (2005 Sep)Enwonwu COEur Cytokine Netw
8735864The effect of inhaled thiorphan on allergen-induced airway responses in asthmatic subjects. (1996 May)Diamant ZClin Exp Allergy
23661909A comparison of cognitive functions in non-hypoxemic chronic obstructive pulmonary disease (COPD) patients and age-matched healthy volunteers using mini-mental state examination questionnaire and event-related potential, P300 analysis. (2013 Jan)Gupta PPLung India
25415831Occupational Chronic Obstructive Pulmonary Disease in a Danish Population-Based Study. (2015 Aug)Wurtz ETCOPD
28286467Smoking exposure, loss of forced expiratory volume in one second and the risk of lung cancer among patients with malignant disease who present with cardiac or pulmonary symptoms: a cross-sectional study. (2017)Wieshammer STob Induc Dis
18728743Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims. (2008 Apr)Sanchez-Bahillo ANeuropsychiatr Dis Treat
12007527Thyroid hormones in the pathogenesis and treatment of obesity. (2002 Apr 12)Krotkiewski MEur J Pharmacol
25375131Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression. (2014)Zhang MQPLoS One
27653240Bone Density Loss Is Associated With Blood Cell Counts. (2017 Feb)Valderrabano RJJ Bone Miner Res
29024786Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. (2017 Dec 16)Pahng ARNeuroscience
18940290Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study). (2008 Nov 1)Parikh NIAm J Cardiol
26007670Prospective risk of rheumatologic disease associated with occupational exposure in a cohort of male construction workers. (2015 Oct)Blanc PDAm J Med
29736066Prevalence and correlates of sexual dysfunction in male patients with alcohol dependence syndrome: A cross-sectional study. (2018 Jan-Mar)Prabhakaran DKIndian J Psychiatry
19748248Normal weight obesity: relationship with lipids, glycaemic status, liver enzymes and inflammation. (2010 Nov)Marques-Vidal PNutr Metab Cardiovasc Dis
24527678Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. (2014 Jun)Echeverry-Alzate VBr J Pharmacol
20538817Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. (2010 Nov)Doe CChest
16344718A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. (2006 Jan)Rodriguez SPharmacogenet Genomics
24250589A pilot study of polymorphism of adrenergic Beta-2 receptor and mild asthma: a clinical and pharmacogenetic study. (2013 Winter)Adimi Naghan PIran J Pharm Res
28704413Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25-35: The Korean National Health and Nutrition Examination Survey 2008-2010. (2017)Choo MSPLoS One
28468077[Changes and the impact on immune function of opioid-dependent subjects by Jitai tabelets during the withdrawal stage]. (2017 Apr 10)Li XXZhonghua Liu Xing Bing Xue Za Zhi
29407532The involvement of CRF1 receptor within the basolateral amygdala and dentate gyrus in the naloxone-induced conditioned place aversion in morphine-dependent mice. (2018 Jun 8)Valero EProg Neuropsychopharmacol Biol Psychiatry
15213845Impaired fibrinolysis in retinal vein occlusion: a role for genetic determinants of PAI-1 levels. (2004 Jul)Gori AMThromb Haemost
9046370Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandinavian chronic alcoholics. (1997 Feb)Geijer TAlcohol Clin Exp Res
24803805Vitamin D improves inflammatory bowel disease outcomes: basic science and clinical review. (2014 May 7)Reich KMWorld J Gastroenterol
19180564Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. (2009 Oct 5)Pergadia MLAm J Med Genet B Neuropsychiatr Genet
22690831Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare exceptions. (2013 Feb)Sakurai AClin Endocrinol (Oxf)
8788983[Effect of pharmacotherapy of affective disorders on the psycho-semantics of alcoholic patients]. (1995)Krupitskii EMZh Nevrol Psikhiatr Im S S Korsakova
22467995PER3 polymorphism and insomnia severity in alcohol dependence. (2012 Apr 1)Brower KJSleep
25626992Effects of Jitai tablet, a traditional Chinese medicine, on spontaneous withdrawal symptoms and modulation of dopaminergic functions in morphine-dependent rats. (2015 May)Tu SPhytother Res
7638233Functional and developmental studies of the peripheral arterial chemoreceptors in rat: effects of nicotine and possible relation to sudden infant death syndrome. (1995 Aug 1)Holgert HProc Natl Acad Sci U S A
17175982[Efficacy and safety of levofloxacin treatment of community--acquired pneumonia in hospitalized patients]. (2006)Karwat KJPneumonol Alergol Pol
19616447Cigarette smoking enhances T cell activation and a Th2 immune response; an aspect of the pathophysiology in periodontal disease. (2009 Sep)de Heens GLCytokine
26846589First-trimester screening with specific algorithms for early- and late-onset fetal growth restriction. (2016 Sep)Crovetto FUltrasound Obstet Gynecol
11593897[Interactions of fibroblasts, adipocytes and immunocompeent cells in the pathogenesis of endocrine ophthalmopathy]. (2001)Heufelder AEActa Med Austriaca
11431599Heterogeneity of fetal growth in type 1 diabetic pregnancy. (2001 Jun)Lepercq JDiabetes Metab
29751286The prevalence and correlates of subclinical atherosclerosis among adults with low-density lipoprotein cholesterol <70mg/dL: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). (2018 Apr 28)Al Rifai MAtherosclerosis
27626030Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia. (2016)Mathai AJFront Public Health
17466074Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (2007 Apr 28)Ton TGBehav Brain Funct
28488840Bladder cancer and Th1 chemokines (2017 Jan-Feb)Paparo SRClin Ter
18815253Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration. (2008 Sep 24)Lane DAJ Neurosci
23317798Pathophysiology of the human locus coeruleus complex in fetal/neonatal sudden unexplained death. (2013 Jan)Lavezzi AMNeurol Res
17581257Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action. (2007 Jul)Park HJEur J Neurosci
26447226Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)Celorrio DAlcohol Alcohol
24086088Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men. (2013 Dec)Roef GEur J Endocrinol
1391883[Effects of neuropeptide Y on rat body temperature in normal conditions and after ethanol administration]. (1992 Apr)Timofeeva LVBiull Eksp Biol Med
14596023[Etiopathogenesis of inflammatory bowel diseases]. (2003 Sep 21)Lakatos LOrv Hetil
10470972Chronic alcoholism is associated with an imbalanced production of Th-1/Th-2 cytokines by peripheral blood T cells. (1999 Aug)Laso FJAlcohol Clin Exp Res
21253362Urine Albumin Creatinine Ratio is Associated with Carotid Atherosclerosis in a Community Based Cohort: Atherosclerosis Risk of Rural Area in Korean General Population Study. (2010 Dec)Sung JKJ Cardiovasc Ultrasound
21289608Prenatal exposure to nicotine impairs performance of the 5-choice serial reaction time task in adult rats. (2011 Apr)Schneider TNeuropsychopharmacology
22235250Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height. (2012)Williams PTPLoS One
23688675T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. (2013 May 20)Tracy RPJ Am Heart Assoc
9695129Effects of chronic nicotine treatment and withdrawal on hypothalamic proopiomelanocortin gene expression and neuroendocrine regulation. (1998 Apr)Rasmussen DDPsychoneuroendocrinology
10517993Factors contributing to biomarker responses in exposed workers. (1999 Jul 16)Anderson DMutat Res
29285859Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population. (2018 Mar)Dekkers IAJ Thromb Haemost
25632333A comparison of risk factors and severity of ischemic stroke in female and male genders in North-West Iran: A cross-sectional study. (2014 Oct 6)Talebi MIran J Neurol
24205156Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. (2013)Bi WPLoS One
2967138Impairments in functional subsets of T-suppressor (CD8) lymphocytes, monocytes, and natural killer cells among asbestos-exposed workers. (1988 Jun)Tsang PHClin Immunol Immunopathol
8899098Similarities and dissimilarities between asthma and inflammatory bowel diseases. (1996)Collins SMAliment Pharmacol Ther
23817165Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine. (2013 Nov)Navarrete FNeuropsychopharmacology
15077008Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. (2004 Feb)Anney RJPharmacogenetics
25134609An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats. (2014 Aug 19)Gao JLBMC Complement Altern Med
28176939Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease. (2017)Kim SWInt J Chron Obstruct Pulmon Dis
28461299Th-2 signature in chronic airway diseases: towards the extinction of asthma-COPD overlap syndrome? (2017 May)Cosio BGEur Respir J
12783120PAI-1 level and the PAI-1 4G/5G polymorphism in relation to risk of non-fatal myocardial infarction: results from the Stockholm Heart Epidemiology Program (SHEEP). (2003 Jun)Leander KThromb Haemost
26740650Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. (2016 Jan 6)Srinivasan RJ Neurosci
8869159Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. (1995 Dec)Ortiz JSynapse
19736493Prevalence of cigarette smoking and khat chewing among Aden university medical students and their relationship to BP and body mass index. (2009 Sep)Laswar AKSaudi J Kidney Dis Transpl
29544524Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease. (2018 Mar 15)Chen YCJ Transl Med
12486492Associations of plasma homocysteine concentration in subjects with type 2 diabetes mellitus. (2002 Dec)Abdella NAActa Diabetol
15665988Th-1 and Th-2 cytokine production in infants with virus-associated wheezing. (2005 Jan)Pitrez PMBraz J Med Biol Res
28457624High miR-124-3p expression identifies smoking individuals susceptible to atherosclerosis. (2017 Aug)de Ronde MWJAtherosclerosis
23328587Effect of maternal smoking on colostrum and breast milk cytokines. (2012 Oct-Dec)Etem Piskin IEur Cytokine Netw
25432502The reference values for semen parameters of 1213 fertile men in Guangdong Province in China. (2015 Mar-Apr)Tang YGAsian J Androl
22414816Decreased cocaine motor sensitization and self-administration in mice overexpressing cannabinoid CB(2) receptors. (2012 Jun)Aracil-Fernandez ANeuropsychopharmacology
25329073Treg/IL-17 ratio and Treg differentiation in patients with COPD. (2014)Jin YPLoS One
25932076Spinal cord compression: an unusual presentation of hepatocellular carcinoma. (2014)Nangolo HTPan Afr Med J
11356013Cigarette smoking depletes cells spontaneously secreting Th(1) cytokines in the human airway. (2001 Apr 21)Hagiwara ECytokine
28597181Clinical Signs, Pathophysiology and Management of Cutaneous Side Effects of Anti-Tumor Necrosis Factor Agents. (2017 Dec)Segaert SAm J Clin Dermatol
19675120Altered innate immune response in farmers and smokers. (2010 Feb)Sahlander KInnate Immun
26484878Urban-Rural Differences in Bone Mineral Density: A Cross Sectional Analysis Based on the Hyderabad Indian Migration Study. (2015)Viljakainen HTPLoS One
24421748Cardiovascular responses induced by Catalase Inhibitior into the Fourth Cerebral Ventricle is changed in Wistar rats exposed to sidestream cigarette smoke. (2013 Jun)Valenti VEInt J Health Sci (Qassim)
28940393Clinical features and prognosis of thymic neuroendocrine tumours associated with multiple endocrine neoplasia type 1: A single-centre study, systematic review and meta-analysis. (2017 Dec)Ye LClin Endocrinol (Oxf)
15345197The relationship of atopy, smoking, and sensitization to methyltetrahydrophthalic anhydride. (2004 May-Aug)Yokota KInt J Immunopathol Pharmacol
9184313Cladistic analysis of disease association with tyrosine hydroxylase: application to manic-depressive disease and alcoholism. (1997 May 31)Lobos EAAm J Med Genet
26220216Chronic obstructive pulmonary disease induced by exposure to biomass smoke is associated with a Th2 cytokine production profile. (2015 Dec)Solleiro-Villavicencio HClin Immunol
29573501First-trimester and combined first- and second-trimester prediction of small-for-gestational age and fetuses with late growth restriction. (2018 Mar 24)Sotiriadis AUltrasound Obstet Gynecol
17481661Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. (2008 Apr)Karolewicz BJ Psychiatr Res
28492360Resveratrol Inhibits Periodontitis-Related Bone Loss in Rats Subjected to Cigarette Smoke Inhalation. (2017 Aug)Ribeiro FVJ Periodontol
27187237TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation. (2016 May 17)Aurelian LTransl Psychiatry
9754624Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism. (1998 Sep 7)Ishiguro HAm J Med Genet
21083670Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (2011 Feb)Hack LMAlcohol Clin Exp Res
10980691Thyroid-associated eye disease. (2000 Jun)Heufelder AEStrabismus
26810137Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder. (2017 Jan)Pagerols MPharmacogenomics J
26246178Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis. (2015 Dec)Patterson KAArthritis Rheumatol
9603607Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. (1998 May 8)Long JCAm J Med Genet
21822476Modulation of tyrosine hydroxylase, neuropeptide y, glutamate, and substance p in Ganglia and brain areas involved in cardiovascular control after chronic exposure to nicotine. (2011)Ferrari MFInt J Hypertens
17044860Refined association mapping for a quantitative trait: weight in the H19-IGF2-INS-TH region. (2006 Nov)Zhang WAnn Hum Genet
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