Gene: THBD

7056
AHUS6|BDCA3|CD141|THPH12|THRM|TM
thrombomodulin
protein-coding
20p11.21
Ensembl:ENSG00000178726 MIM:188040 Vega:OTTHUMG00000032053 UniprotKB:P07204
NG_012027.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.741e-1 (AD)  2.012e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B4GALT10.832
CD930.8
TNFRSF10A0.799
ITGA50.793
F11R0.779
ITGB30.774
THBS10.768
TNFAIP30.766
SVIL0.764
NOS30.763

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLL1-0.413
MYADML2-0.409
BCL11A-0.406
NEUROD6-0.396
ASIC2-0.388
TMEM179-0.384
AMER3-0.384
RTN4R-0.381
RS1-0.381
PVALB-0.375

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00055Drotrecogin alfaBiotechDrug98530-76-8Approved|Investigational|WithdrawnTarget
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTarget
DB09213DexibuprofenSmall Molecule51146-56-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of THBD mRNA28329830
C0326681-nitropyrene1-nitropyrene results in increased expression of THBD mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of THBD mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of THBD mRNA]15020266
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of THBD mRNA]15020266
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of THBD mRNA25088246
C0127962-butenal2-butenal results in decreased expression of THBD mRNA20471460
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of THBD mRNA"20702594
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of THBD protein"28973532
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of THBD protein"28973532
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of THBD mRNA"25380136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of THBD mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBD mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of THBD protein12654133
D000082AcetaminophenAcetaminophen affects the expression of THBD mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of THBD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of THBD gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of THBD mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of THBD mRNA19770486
D000393Air PollutantsAir Pollutants analog results in increased expression of THBD mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of THBD mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of THBD mRNA24449571
C026987aroclor 1260[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of THBD protein28163111
C006632arsenic trioxidearsenic trioxide affects the expression of THBD mRNA25873331
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tretinoin results in increased expression of THBD mRNA]10803529
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tretinoin results in increased expression of THBD protein]10803529
C006632arsenic trioxidearsenic trioxide results in decreased expression of THBD mRNA26705709
C015001arsenitearsenite results in decreased expression of THBD mRNA11864708
C015001arsenitearsenite results in decreased expression of THBD protein11864708
C015001arsenitearsenite results in increased methylation of THBD promoter23974009
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of THBD mRNA"22352330
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of THBD mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of THBD mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to THBD promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of THBD mRNA19770486|2071347
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of THBD mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of THBD mRNA19619570
D004958EstradiolEstradiol results in increased expression of THBD mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of THBD mRNA17404688
D004958EstradiolEstradiol results in increased expression of THBD mRNA19484750
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of THBD mRNA15912405
C006780bisphenol Abisphenol A affects the expression of THBD mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of THBD mRNA15336504
D002101Cacodylic Acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of THBD mRNA23192986
C081643candesartancandesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]16778335
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of THBD mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of THBD mRNA19395590
D002330CarmustineTHBD mRNA affects the susceptibility to Carmustine16365179
D002794Choline"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of THBD protein"28973532
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of THBD protein28163111
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBD mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of THBD mRNA18353800
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of THBD mRNA18078969
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in increased expression of THBD protein19038792
C018021cobaltous chloridecobaltous chloride results in decreased expression of THBD mRNA19376846
D003078ColchicineColchicine results in increased expression of THBD mRNA20624997
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of THBD mRNA]11007951
D016572CyclosporineCyclosporine results in decreased expression of THBD mRNA19770486
C014347decitabinedecitabine results in increased expression of THBD mRNA16367923
D003907DexamethasoneDexamethasone results in decreased expression of THBD mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of THBD mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of THBD mRNA21266533
D002945CisplatinCisplatin results in decreased expression of THBD mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of THBD mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of THBD mRNA26485663
C062856dimethylarsine[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of THBD mRNA25873331
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of THBD mRNA25380136
D004237DiuronDiuron results in decreased expression of THBD mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of THBD mRNA17172434
D004317DoxorubicinDoxorubicin results in increased expression of THBD protein17172434
D004317DoxorubicinDoxorubicin affects the expression of THBD mRNA15033991
D000431EthanolEthanol results in decreased expression of THBD mRNA17920746
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of THBD protein8950781
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of THBD protein8950781
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of THBD mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBD mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of THBD mRNA17557909
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of THBD mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of THBD mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBD mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of THBD mRNA20655997|2893796
C039281furanfuran results in increased expression of THBD mRNA27387713
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of THBD protein8950781
D017313FenretinideFenretinide results in decreased expression of THBD mRNA28973697
D006830HydralazineHydralazine inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]16778335
D007213IndomethacinIndomethacin results in decreased expression of THBD mRNA16984733
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THBD mRNA24435446
C008261lead acetatelead acetate results in increased expression of THBD mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of THBD mRNA25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of THBD mRNA10975854|2733941
D008715Methionine"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of THBD protein"28973532
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of THBD protein28163111
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBD mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of THBD mRNA24449571
D008727MethotrexateMethotrexate affects the expression of THBD mRNA18502557
C543395methylarsine[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of THBD mRNA25873331
D008748MethylcholanthreneMethylcholanthrene results in increased expression of THBD mRNA20713471
D020366MethylmethacrylateMethylmethacrylate results in increased expression of THBD mRNA16916219
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of THBD mRNA26011545
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA]20493886
C020300monomethylarsonic acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of THBD mRNA23192986
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of THBD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of THBD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of THBD mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of THBD mRNA25380136
D009532NickelNickel results in increased expression of THBD mRNA24768652|2558310
D009569Nitric Oxidecandesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]16778335
D009569Nitric OxideHydralazine inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]16778335
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of THBD protein16778335
C109079norgestimate, ethinyl estradiol drug combination"norgestimate, ethinyl estradiol drug combination results in decreased expression of THBD protein"8950781
C016340o,p'-DDT"o,p'-DDT results in increased expression of THBD mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of THBD mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of THBD mRNA26516004
D010126OzoneOzone results in decreased expression of THBD mRNA12763052|1838168
D010126OzoneOzone results in increased expression of THBD mRNA20980218
D017239PaclitaxelTHBD protein results in decreased susceptibility to Paclitaxel27474498
C016030pantogabpantogab results in increased expression of THBD mRNA17379144
D010269ParaquatParaquat results in increased expression of THBD mRNA21371552
D010269ParaquatParaquat results in increased expression of THBD mRNA20095324
D010269ParaquatUnithiol inhibits the reaction [Paraquat results in increased expression of THBD mRNA]20095324
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of THBD mRNA17715259
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of THBD protein17715259
D052638Particulate MatterParticulate Matter results in increased expression of THBD mRNA15046786|2170334
D010416PentachlorophenolPentachlorophenol results in increased expression of THBD mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of THBD mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBD mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of THBD mRNA26272509
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of THBD mRNA17715259
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of THBD protein17715259
C006253pirinixic acidpirinixic acid results in increased expression of THBD mRNA18445702
D010938Plant OilsPlant Oils results in increased expression of THBD mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of THBD mRNA22714537
D017035PravastatinPravastatin results in increased expression of THBD mRNA27225895
D017035PravastatinPravastatin affects the expression of THBD mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of THBD mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of THBD mRNA20631399
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of THBD mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of THBD mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of THBD mRNA17404688|1807036
D011374ProgesteroneProgesterone results in decreased expression of THBD mRNA20726854
D011372ProgestinsProgestins results in decreased expression of THBD mRNA19609016
C005556propionaldehydepropionaldehyde results in increased expression of THBD mRNA26079696
C502851quinocetonequinocetone results in decreased expression of THBD mRNA27046791
C059514resveratrolKLF2 protein promotes the reaction [resveratrol results in increased expression of THBD mRNA]19815564
C059514resveratrolMAP2K5 protein promotes the reaction [resveratrol results in increased expression of THBD mRNA]19815564
C059514resveratrolresveratrol results in increased expression of THBD mRNA19815564
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of THBD mRNA25905778
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of THBD mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of THBD mRNA"16251409
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of THBD mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of THBD mRNA25351596
D019821SimvastatinSimvastatin results in increased expression of THBD mRNA16375908
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA]20493886
D019821SimvastatinSimvastatin results in increased expression of THBD mRNA14630613|2049388
D019821SimvastatinSimvastatin results in increased expression of THBD protein16375908
C017947sodium arsenite[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of THBD mRNA25873331
C017947sodium arsenite[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of THBD mRNA23192986
D053260SootSoot results in decreased expression of THBD mRNA22461453
C075117squalestatin 1squalestatin 1 affects the expression of THBD mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of THBD mRNA27225895
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of THBD mRNA25905778
C061133tamibarotene2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of THBD mRNA]15020266
C061133tamibarotene2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of THBD mRNA]15020266
C061133tamibarotenetamibarotene results in increased expression of THBD mRNA15020266
D013629TamoxifenTamoxifen affects the expression of THBD mRNA20937368
C047246temozolomideTHBD mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of THBD mRNA]11007951
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of THBD mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of THBD mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of THBD mRNA11007951|1237799
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of THBD mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of THBD mRNA20702594|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBD mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of THBD mRNA15667827|1993321
C009495titanium dioxidetitanium dioxide results in decreased expression of THBD mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of THBD mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of THBD mRNA25729387
D014212Tretinoinarsenic trioxide inhibits the reaction [Tretinoin results in increased expression of THBD mRNA]10803529
D014212Tretinoinarsenic trioxide inhibits the reaction [Tretinoin results in increased expression of THBD protein]10803529
D014212TretinoinTretinoin results in decreased expression of THBD mRNA23830798
D014212TretinoinTretinoin results in increased expression of THBD mRNA10803529|1605412
D014212TretinoinTretinoin results in increased expression of THBD protein10803529
D014212TretinoinTretinoin results in increased expression of THBD16757074
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of THBD mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of THBD mRNA28973697
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of THBD mRNA18078969
D017973Tungsten CompoundsTungsten Compounds results in increased expression of THBD mRNA28666766
D014494UnithiolUnithiol inhibits the reaction [Paraquat results in increased expression of THBD mRNA]20095324
D014635Valproic AcidValproic Acid results in decreased methylation of THBD gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of THBD mRNA15046786
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of THBD mRNA19165385
D001335Vehicle EmissionsVehicle Emissions results in increased expression of THBD mRNA20980218
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of THBD mRNA25423262
D014747VinblastineVinblastine results in increased expression of THBD mRNA20624997
C025643vinclozolinvinclozolin affects the expression of THBD mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of THBD mRNA20566332|2303416
D014750VincristineTHBD protein results in decreased susceptibility to Vincristine27474498
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of THBD mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of THBD mRNA19244175
D015032ZincZinc results in decreased expression of THBD mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of THBD mRNA17074742
D015054ZymosanZymosan results in decreased expression of THBD mRNA12707536
D015054ZymosanZymosan results in decreased expression of THBD protein12707536

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI14691232  17379830  
GO:0038023signaling receptor activity-TAS2822087  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0010165response to X-ray-IEA-  
GO:0010544negative regulation of platelet activation-TAS17379830  
GO:0030195negative regulation of blood coagulation-TAS17379830  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0051918negative regulation of fibrinolysis-TAS17379830  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005774vacuolar membrane-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009986cell surface-IDA17379830  
GO:0016327apicolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-202733Cell surface interactions at the vascular wallTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15135268Genetic risk for restenosis after coronary balloon angioplasty. (2004 May)Horibe HAtherosclerosis