Gene: THBS1

7057
THBS|THBS-1|TSP|TSP-1|TSP1
thrombospondin 1
protein-coding
15q14
Ensembl:ENSG00000137801 MIM:188060 Vega:OTTHUMG00000133665 UniprotKB:P07996
NC_000015.10
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.144e-1 (AD)  2.469e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23849826chr15:39872186THBS12.810e-17Maternal smoking in pregnancy27040690
cg10078511chr15:39872032THBS11.020e-14Maternal smoking in pregnancy27040690
cg08293324chr15:39872037THBS12.150e-11Maternal smoking in pregnancy27040690
cg23849826chr15:39872186THBS14.280e-15Maternal smoking in pregnancy27040690
cg10078511chr15:39872032THBS11.810e-14Maternal smoking in pregnancy27040690
cg08293324chr15:39872037THBS11.280e-9Maternal smoking in pregnancy27040690
cg23849826chr15:39872186THBS19.020e-15Maternal smoking in pregnancy27040690
cg10078511chr15:39872032THBS18.160e-13Maternal smoking in pregnancy27040690
cg08293324chr15:39872037THBS11.560e-8Maternal smoking in pregnancy27040690
cg05886626chr15:39873553THBS13.600e-17Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STEAP40.775
MYC0.768
THBD0.768
FBLIM10.727
NFKBIZ0.711
IL60.709
COL4A10.705
CD930.694
PLAU0.693
ITGA50.69

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBA2-0.337
MYADML2-0.332
NEUROD6-0.33
E2F1-0.325
PVALB-0.321
FBLL1-0.319
ASPDH-0.318
TEX29-0.318
SLC22A18AS-0.317
BCL11A-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of THBS1 mRNA"26377693
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of THBS1 mRNA25827057
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of THBS1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of THBS1 mRNA"19167446
C5259212-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine"2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of THBS1 mRNA"24497940
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of THBS1 mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of THBS1 mRNA"26644586
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of THBS1 mRNA"19561079
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of THBS1 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of THBS1 mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of THBS1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of THBS1 mRNA29067470
D000082AcetaminophenAcetaminophen results in decreased expression of THBS1 mRNA17585979
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of THBS1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of THBS1 mRNA]17585979
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased secretion of THBS1 protein17303692
D016604Aflatoxin B1Aflatoxin B1 affects the expression of THBS1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of THBS1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of THBS1 mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of THBS1 mRNA"23195993
C103303alitretinoinalitretinoin results in decreased expression of THBS1 mRNA15982314
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of THBS1 mRNA17023530
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA19737545
C030419andrographolideandrographolide results in decreased expression of THBS1 mRNA19737545
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of THBS1 mRNA15894712
C015001arsenitearsenite results in decreased expression of THBS1 mRNA15894712
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of THBS1 protein]17303692
D001241AspirinAspirin results in increased expression of THBS1 mRNA15928584
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of THBS1 mRNA16410222
C503983axitinibaxitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]18202011
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of THBS1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THBS1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THBS1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of THBS1 mRNA26377693
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA19737545
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of THBS1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of THBS1 mRNA26238291
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of THBS1 mRNA]15034205
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of THBS1 mRNA15894712
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THBS1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of THBS1 mRNA15034205|1589471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of THBS1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of THBS1 mRNA"20018196
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of THBS1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of THBS1 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of THBS1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of THBS1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of THBS1 mRNA16474171|1916744
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of THBS1 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of THBS1 mRNA25210133
D004958EstradiolEstradiol results in decreased expression of THBS1 protein17283240
C006780bisphenol Abisphenol A results in increased expression of THBS1 mRNA16474171|1937162
C006780bisphenol Abisphenol A results in increased methylation of THBS1 gene22258036
C006780bisphenol Abisphenol A results in decreased expression of THBS1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of THBS1 mRNA25181051
D002066BusulfanBusulfan results in increased expression of THBS1 mRNA22286157
D002104CadmiumCadmium affects the expression of THBS1 mRNA21694771
D002104CadmiumCadmium results in increased expression of THBS1 mRNA15010501
D002104Cadmium"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of THBS1 mRNA]"15010501
D019256Cadmium ChlorideCadmium Chloride results in increased expression of THBS1 mRNA12160620
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS1 mRNA19840844
D002166CamptothecinCamptothecin results in decreased expression of THBS1 mRNA16962673
D002166CamptothecinCamptothecin results in decreased secretion of THBS1 protein16962673
D002166CamptothecinTHBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]16962673
D002166CamptothecinTHBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]16962673
C459604candoxincandoxin results in increased expression of THBS1 mRNA16309724
D002220CarbamazepineCarbamazepine affects the expression of THBS1 mRNA25979313
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of THBS1 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of THBS1 mRNA15056808|2582705
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of THBS1 mRNA26272509
C100187chloropicrinchloropicrin affects the expression of THBS1 mRNA26352163
C100187chloropicrinchloropicrin results in decreased expression of THBS1 mRNA28476498
D002737ChloropreneChloroprene results in decreased expression of THBS1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBS1 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THBS1 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of THBS1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of THBS1 mRNA]17585979
D002995Clofibric AcidClofibric Acid affects the expression of THBS1 mRNA17602206
C055162clopidogrelclopidogrel results in increased expression of THBS111875746
C055162clopidogrelclopidogrel results in increased expression of THBS1 mRNA9447704
C055162clopidogrelclopidogrel results in increased expression of THBS1 protein9447704
C018021cobaltous chloridecobaltous chloride results in decreased expression of THBS1 mRNA19320972
D003078ColchicineColchicine results in increased expression of THBS1 mRNA20624997
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of THBS1 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of THBS1 mRNA15467011
D003300CopperCopper results in increased expression of THBS1 mRNA16629173
D019327Copper SulfateCopper Sulfate results in increased expression of THBS1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of THBS1 mRNA"19167446
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]18200517
D003513CycloheximideCycloheximide inhibits the reaction [Testosterone results in decreased expression of THBS1 mRNA]16723184
D003520CyclophosphamideCyclophosphamide results in increased expression of THBS1 mRNA15331540
D003520Cyclophosphamideaxitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]18202011
D003520CyclophosphamideCyclophosphamide results in increased expression of THBS1 protein18202011
D016572CyclosporineCyclosporine results in decreased expression of THBS1 mRNA19159671|2798913
D016572CyclosporineCyclosporine results in increased expression of THBS1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of THBS1 mRNA19770486
D003561CytarabineCytarabine results in increased expression of THBS1 mRNA21198554
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of THBS1 mRNA]21095227
D013759DronabinolDronabinol results in decreased expression of THBS1 mRNA16616335
D003907DexamethasoneDexamethasone results in increased expression of THBS1 mRNA19853017
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS1 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of THBS1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of THBS1 mRNA17361019|2126653
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of THBS1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of THBS1 mRNA19561079|2739243
D002945CisplatinCisplatin results in increased expression of THBS1 mRNA21674241
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of THBS1 mRNA]27392435
D002945CisplatinCisplatin results in increased expression of THBS1 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of THBS1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of THBS1 mRNA21394550
D004041Dietary FatsDietary Fats results in increased expression of THBS1 protein21394550
D004041Dietary FatsGlucose inhibits the reaction [Dietary Fats results in increased expression of THBS1 protein]21394550
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of THBS1 mRNA27614199
C058705diethyl malatediethyl malate affects the expression of THBS1 mRNA24814887
C014476diethyl maleatediethyl maleate results in increased expression of THBS1 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of THBS1 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of THBS1 mRNA19638242
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of THBS1 protein18407596
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of THBS1 mRNA19371625
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of THBS1 mRNA16507463
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of THBS1 mRNA22302311
D004298DopamineDopamine results in increased expression of THBS1 mRNA21983523
C025034doxifluridineTHBS1 protein results in decreased susceptibility to doxifluridine16734730
D004317DoxorubicinDoxorubicin affects the expression of THBS1 mRNA15205334
D004317DoxorubicinDoxorubicin results in decreased expression of THBS1 mRNA16962673
D004317DoxorubicinDoxorubicin results in decreased secretion of THBS1 protein16962673
D004317DoxorubicinTHBS1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]16962673
D004317DoxorubicinTHBS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]16962673
D004317DoxorubicinDoxorubicin results in increased expression of THBS1 mRNA15033991
D004317Doxorubicin[THBS1 protein alternative form co-treated with Doxorubicin] results in increased expression of FASLG protein15818399
D004317Doxorubicin[THBS1 protein alternative form co-treated with Doxorubicin] results in increased expression of FAS protein15818399
D004391DustDust results in increased expression of THBS1 mRNA17805423
D060754EquolEquol results in decreased expression of THBS1 mRNA16865672
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of THBS1 mRNA18936297
D015025ZearalenoneZearalenone results in decreased expression of THBS1 mRNA28965971
D015025ZearalenoneZearalenone results in increased expression of THBS1 mRNA19371625
D015025ZearalenoneZearalenone results in decreased expression of THBS1 mRNA25455459
C540355fenamidonefenamidone results in increased expression of THBS1 mRNA27029645
D018818FenoldopamFenoldopam results in increased expression of THBS1 mRNA21983523
D005472FluorouracilEGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 mRNA]18757417
D005472FluorouracilEGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 protein]18757417
D005472FluorouracilFluorouracil affects the expression of THBS1 mRNA15205334
D005472FluorouracilFluorouracil promotes the reaction [EGR1 protein binds to THBS1 promoter]18757417
D005472FluorouracilFluorouracil results in increased expression of THBS1 mRNA18757417
D005472FluorouracilFluorouracil results in increased expression of THBS1 protein18757417
D005472FluorouracilSB 203580 inhibits the reaction [Fluorouracil results in increased expression of THBS1 mRNA]18757417
D005472FluorouracilTHBS1 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBS1 mRNA20938992
D005665FurosemideFurosemide affects the expression of THBS1 mRNA16526316
C546771gardiquimodgardiquimod results in decreased expression of THBS1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of THBS1 mRNA]28003376
C001277geldanamycingeldanamycin results in increased expression of THBS1 mRNA26705709
D019833GenisteinGenistein results in increased expression of THBS1 mRNA16474171|1937162
D019833GenisteinGenistein results in decreased expression of THBS1 mRNA21048042
D005839GentamicinsGentamicins results in increased expression of THBS1 mRNA22061828
D005947GlucoseGlucose inhibits the reaction [Dietary Fats results in increased expression of THBS1 protein]21394550
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of THBS1 mRNA19192274
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of THBS1 mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of THBS1 mRNA26644586
D006493HeparinTHBS1 protein alternative form binds to Heparin9309585
D006493HeparinTHBS1 protein binds to Heparin9309585
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde affects the expression of THBS1 mRNA22302311
D017313FenretinideFenretinide results in decreased expression of THBS1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of THBS1 mRNA26846883
D007052IbuprofenIbuprofen results in increased expression of THBS1 protein18261746
C056493imiquimodimiquimod results in increased expression of THBS116302556
D007213IndomethacinIndomethacin results in decreased expression of THBS1 mRNA16984733
D007213IndomethacinIndomethacin results in increased expression of THBS1 mRNA18261746
D007213IndomethacinIndomethacin results in increased expression of THBS1 protein16227405|1826174
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of THBS1 mRNA25613284
C051890irinotecanTHBS1 protein results in decreased susceptibility to irinotecan16734730
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS1 mRNA16054899
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of THBS1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of THBS1 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of THBS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of THBS1 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THBS1 mRNA22904298|2479639
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of THBS1 mRNA27432991
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THBS1 mRNA25982114
C008261lead acetatelead acetate results in increased expression of THBS1 mRNA22609695
C045463leflunomideleflunomide results in increased expression of THBS1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of THBS1 mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of THBS1 mRNA25613284
D008274MagnesiumMagnesium results in increased expression of THBS1 protein10397942
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of THBS1 mRNA26378955
C025340manganese chloridemanganese chloride results in increased expression of THBS1 mRNA17467022
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of THBS1 mRNA18497975
C042720mercuric bromidemercuric bromide results in increased expression of THBS1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of THBS1 mRNA16005714
D008627Mercuric ChlorideMercuric Chloride results in increased expression of THBS1 protein16005714
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBS1 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of THBS1 mRNA17400583
D008727MethotrexateMethotrexate results in increased expression of THBS1 mRNA19192274|2167806
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of THBS1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS1 mRNA19840844
D008775MethylprednisoloneMethylprednisolone results in increased expression of THBS1 mRNA19192274
D008790MetoprololMetoprolol results in decreased expression of THBS1 mRNA20353484
D015735MifepristoneMifepristone results in increased expression of THBS1 mRNA17584828
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of THBS1 mRNA16809437
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of THBS1 mRNA"28128526
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of THBS1 protein"28128526
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of THBS1 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of THBS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of THBS1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of THBS1 mRNA15913567
D0150581-Naphthylisothiocyanate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of THBS1 mRNA]"15913567
D009532NickelNickel results in increased expression of THBS1 mRNA23195993|2476865
C029938nickel sulfatenickel sulfate results in increased expression of THBS1 mRNA16100012
C069741norcantharidinnorcantharidin results in increased expression of THBS1 protein16681930
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of THBS1 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of THBS1 mRNA20971185
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of THBS1 mRNA]"15913567
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of THBS1 mRNA]"15010501
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS1 mRNA19840844
C016340o,p'-DDT"o,p'-DDT results in increased expression of THBS1 mRNA"19371625
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of THBS1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of THBS1 mRNA25658374
D010126OzoneOzone results in increased expression of THBS1 mRNA12763052|1955522
C084656paricalcitol[Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNA17715259
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 protein17715259
D052638Particulate MatterParticulate Matter results in increased expression of THBS1 mRNA21708214
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of THBS1 mRNA26705709
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of THBS1 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of THBS1 mRNA26272509
D010705PhosgenePhosgene affects the expression of THBS1 mRNA16300373
D010758Phosphorus[Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNA17715259
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 protein17715259
D009764o-Phthalaldehydeo-Phthalaldehyde affects the expression of THBS1 mRNA22302311
C060836pioglitazonepioglitazone inhibits the reaction [Streptozocin results in increased expression of THBS1 mRNA]17063547
C060836pioglitazonepioglitazone inhibits the reaction [Streptozocin results in increased expression of THBS1 protein]17063547
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THBS1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of THBS1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of THBS1 mRNA23232078
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of THBS1 mRNA16474171
D011239PrednisolonePrednisolone results in increased expression of THBS1 mRNA19192274
D011374ProgesteroneProgesterone results in decreased expression of THBS1 mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of THBS1 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of THBS1 mRNA18037150|1807036
D011374ProgesteroneProgesterone results in increased expression of THBS1 mRNA21795739
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of THBS1 mRNA]28003376
C513428pyrachlostrobinpyrachlostrobin results in increased expression of THBS1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of THBS1 mRNA19729006
D011794QuercetinQuercetin results in increased expression of THBS1 mRNA21632981|2667655
D011794QuercetinQuercetin results in increased expression of THBS1 protein26676551
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of THBS1 mRNA17010073
C059514resveratrolresveratrol results in decreased expression of THBS1 mRNA19228061
C059514resveratrolresveratrol results in increased expression of THBS1 mRNA23419489
D015474IsotretinoinIsotretinoin results in decreased expression of THBS1 mRNA15982314|1876912
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS1 mRNA16054899
C079198S 1 (combination)THBS1 protein results in decreased susceptibility to S 1 (combination)16734730
C093642SB 203580SB 203580 inhibits the reaction [Fluorouracil results in increased expression of THBS1 mRNA]18757417
C410733scriptaidscriptaid affects the expression of THBS1 mRNA18813790
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of THBS1 mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of THBS1 mRNA]"21514415
D012822Silicon DioxideSilicon Dioxide analog results in decreased secretion of THBS1 protein25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of THBS1 mRNA23221170
D012834SilverSilver results in decreased expression of THBS1 mRNA26551752
D012834SilverSilver results in increased expression of THBS1 mRNA28959546
D012834SilverSilver results in decreased expression of THBS1 mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of THBS1 mRNA17428261
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of THBS1 mRNA]21095227
C017947sodium arsenitesodium arsenite results in decreased expression of THBS1 mRNA16014739
D012969Sodium FluorideSodium Fluoride results in decreased expression of THBS1 mRNA27862939
D012999SomanSoman results in increased expression of THBS1 mRNA19281266
D053260SootSoot results in increased expression of THBS1 mRNA26551751
D013311Streptozocinpioglitazone inhibits the reaction [Streptozocin results in increased expression of THBS1 mRNA]17063547
D013311Streptozocinpioglitazone inhibits the reaction [Streptozocin results in increased expression of THBS1 protein]17063547
D013311StreptozocinStreptozocin results in increased expression of THBS1 mRNA17063547|1711755
D013311StreptozocinStreptozocin results in increased expression of THBS1 protein17063547|1711755
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of THBS1 mRNA26378955
C025462sulindac sulfideEGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]16227405
C025462sulindac sulfideRHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]18261746
C025462sulindac sulfide[sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein18261746
C025462sulindac sulfidesulindac sulfide results in increased expression of THBS1 mRNA16227405|1826174
C025462sulindac sulfidesulindac sulfide results in increased expression of THBS1 protein16227405|1826174
C025462sulindac sulfide[sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein18261746
C025462sulindac sulfide[sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein18261746
C025462sulindac sulfideU 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]18261746
C025462sulindac sulfideU 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]18261746
D013629TamoxifenTamoxifen affects the expression of THBS1 mRNA14699072
D013629TamoxifenTamoxifen results in increased expression of THBS1 mRNA19155303
D013629TamoxifenTamoxifen results in increased expression of THBS1 mRNA25123088
D013739TestosteroneCycloheximide inhibits the reaction [Testosterone results in decreased expression of THBS1 mRNA]16723184
D013739TestosteroneTestosterone results in decreased expression of THBS1 mRNA15788153|1672318
D013739TestosteroneTestosterone results in decreased expression of THBS1 protein16723184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of THBS1 mRNA18495758
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of THBS1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of THBS1 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of THBS1 mRNA]14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of THBS1 mRNA16962184|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of THBS1 mRNA14728982|1503420
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of THBS1 mRNA19770486|2629044
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS1 mRNA19840844
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of THBS1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of THBS1 mRNA23411599
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of THBS1 protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of THBS1 protein17303692
D013988TiclopidineTiclopidine affects the expression of THBS1 mRNA14687031
C009495titanium dioxidetitanium dioxide results in increased expression of THBS1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of THBS1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of THBS1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of THBS1 mRNA28111298
D014212TretinoinTretinoin metabolite results in increased expression of THBS1 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of THBS1 mRNA15982314
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of THBS1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of THBS1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride affects the expression of THBS1 mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of THBS1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA18200517
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of THBS1 mRNA"18930950
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of THBS1 mRNA28666766
C113580U 0126U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]18261746
C113580U 0126U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]18261746
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of THBS1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of THBS1 mRNA24935251|2915479
D014635Valproic AcidValproic Acid results in increased expression of THBS1 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of THBS1 gene25487561
D014747VinblastineVinblastine results in increased expression of THBS1 mRNA20624997
D014750VincristineVincristine results in increased expression of THBS1 mRNA20624997
D014800VitalliumVitallium analog results in decreased expression of THBS1 mRNA23825117
C111237vorinostatvorinostat results in increased expression of THBS1 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of THBS1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IDA18940719  
GO:0001968fibronectin binding-IDA6693501  
GO:0005178integrin binding-IMP17413041  18757424  
GO:0005509calcium ion binding-NAS9304800  
GO:0005515protein binding-IPI3402455  6438154  11134179  15700281  15864306  18042364  
18688696  19542224  24117177  26627825  
GO:0005515protein binding-NAS6438154  
GO:0008201heparin binding-IDA101549  8288588  
GO:0017134fibroblast growth factor binding-IDA17996481  
GO:0030169low-density lipoprotein particle binding-IDA6693501  
GO:0042802identical protein binding-NAS9304800  
GO:0043236laminin binding-IDA6693501  
GO:0043394proteoglycan binding-TAS9304800  
GO:0050431transforming growth factor beta binding-ISS-  
GO:0050431transforming growth factor beta binding-TAS9304800  
GO:0070051fibrinogen binding-IDA6693501  
GO:0070052collagen V binding-IDA6693501  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IMP17413041  
GO:0001666response to hypoxia-NAS9304800  
GO:0001937negative regulation of endothelial cell proliferation-IDA16150726  17996481  
GO:0001937negative regulation of endothelial cell proliferation-IMP17413041  
GO:0001953negative regulation of cell-matrix adhesion-IDA16150726  17416590  
GO:0002040sprouting angiogenesis-IMP17879962  
GO:0002544chronic inflammatory response-IEP18674744  
GO:0002576platelet degranulation-TAS-  
GO:0002581negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II-IDA16882710  
GO:0002605negative regulation of dendritic cell antigen processing and presentation-IDA16882710  
GO:0006954inflammatory response-IDA23144964  
GO:0006955immune response-IEP18674744  
GO:0006986response to unfolded protein-IEA-  
GO:0007050cell cycle arrest-IDA17596205  
GO:0007155cell adhesion-NAS9304800  
GO:0008284positive regulation of cell proliferation-IDA24615654  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009749response to glucose-IDA18096704  
GO:0010595positive regulation of endothelial cell migration-IDA18555217  
GO:0010596negative regulation of endothelial cell migration-IDA18555217  
GO:0010748negative regulation of plasma membrane long-chain fatty acid transport-IDA17416590  
GO:0010751negative regulation of nitric oxide mediated signal transduction-IDA16150726  17416590  
GO:0010754negative regulation of cGMP-mediated signaling-IDA17416590  
GO:0010757negative regulation of plasminogen activation-IDA6438154  
GO:0010759positive regulation of macrophage chemotaxis-ISS-  
GO:0010763positive regulation of fibroblast migration-IDA18555217  
GO:0016477cell migration-IDA18555217  
GO:0016525negative regulation of angiogenesis-IDA16150726  17596205  17996481  18726995  
GO:0016525negative regulation of angiogenesis-IMP24177325  
GO:0018149peptide cross-linking-IDA3997886  
GO:0030194positive regulation of blood coagulation-IDA3997886  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IDA15700281  
GO:0030335positive regulation of cell migration-IMP17413041  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IDA18555217  
GO:0032026response to magnesium ion-IDA6777381  
GO:0032570response to progesterone-TAS9304800  
GO:0032695negative regulation of interleukin-12 production-IDA16882710  
GO:0032914positive regulation of transforming growth factor beta1 production-ISS-  
GO:0033574response to testosterone-IEA-  
GO:0034605cellular response to heat-NAS9304800  
GO:0034976response to endoplasmic reticulum stress-ISS-  
GO:0040037negative regulation of fibroblast growth factor receptor signaling pathway-IDA17996481  
GO:0042327positive regulation of phosphorylation-IMP17413041  
GO:0042493response to drug-IEP19738618  
GO:0042535positive regulation of tumor necrosis factor biosynthetic process-IDA18726995  
GO:0043032positive regulation of macrophage activation-IDA18757424  
GO:0043066negative regulation of apoptotic process-IDA18653767  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA18653767  
GO:0043536positive regulation of blood vessel endothelial cell migration-IDA18555217  
GO:0043537negative regulation of blood vessel endothelial cell migration-IDA18555217  
GO:0043652engulfment of apoptotic cell-IDA16882710  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0045727positive regulation of translation-IDA15700281  
GO:0045766positive regulation of angiogenesis-IMP17413041  17879962  
GO:0048266behavioral response to pain-ISS-  
GO:0048661positive regulation of smooth muscle cell proliferation-IDA24615654  
GO:0050921positive regulation of chemotaxis-IDA18555217  
GO:0051592response to calcium ion-IDA6777381  18757424  
GO:0051895negative regulation of focal adhesion assembly-TAS9304800  
GO:0051897positive regulation of protein kinase B signaling-IDA18653767  
GO:0051918negative regulation of fibrinolysis-IDA6438154  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IMP25660232  
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA18726995  
GO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IMP25660232  
GO:1903671negative regulation of sprouting angiogenesis-IGI28124060  
GO:2000353positive regulation of endothelial cell apoptotic process-IDA18726995  
GO:2000379positive regulation of reactive oxygen species metabolic process-IDA18757424  
GO:2001027negative regulation of endothelial cell chemotaxis-IDA16150726  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-TAS17879962  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005577fibrinogen complex-IDA3997886  
GO:0005615extracellular space-HDA16502470  20551380  
GO:0005615extracellular space-IDA6777381  26395742  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0009897external side of plasma membrane-IDA6777381  
GO:0009986cell surface-IDA2435757  3084490  6777381  
GO:0016529sarcoplasmic reticulum-ISS-  
GO:0030141secretory granule-IDA101549  
GO:0031012extracellular matrix-HDA23658023  
GO:0031012extracellular matrix-IDA6341993  
GO:0031091platelet alpha granule-IDA6777381  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0062023collagen-containing extracellular matrix-TAS9304800  
GO:0070062extracellular exosome-HDA19056867  19199708  21362503  23533145  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
hsa04145Phagosome
hsa04350TGF-beta signaling pathway
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05144Malaria
hsa05219Bladder cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000170Syndecan interactionsIEA
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27344311MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. (2016 Sep)von Toerne CDiabetologia
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis
22982001Association between variations in coagulation system genes and carotid plaque. (2012 Dec 15)Della-Morte DJ Neurol Sci
26829059Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study. (2015)Sayols-Baixeras SEpigenetics