Gene: THBS2

7058
TSP2
thrombospondin 2
protein-coding
6q27
Ensembl:ENSG00000186340 MIM:188061 Vega:OTTHUMG00000045408 UniprotKB:P35442
NG_022911.1
PubMed
0   ANCO-SNPs
ND|AD
4   
1.518e-1 (AD)  3.026e-1 (ND)   (Frontal_Cortex)
6.423e-1 (AD)  8.141e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14225450chr6:169637832THBS2Gene body5.553e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TF0.814
UGT80.807
ENPP20.806
KLK60.804
TMEM2060.802
CNDP10.801
FA2H0.8
SLC45A30.792
TMC70.79
CAPN30.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.323
OR4F29-0.296
OLFM4-0.266
GRB14-0.257
PAEP-0.244
DIO3-0.238
GLP2R-0.222
TRIML2-0.218
C3orf22-0.213
NEUROD1-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of THBS2 mRNA25827057
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of THBS2 mRNA25827057
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of THBS2 mRNA"25710175
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of THBS2 mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of THBS2 mRNA"26644586
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of THBS2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
D020106AcrylamideAcrylamide affects the expression of THBS2 mRNA28959563
C016601afimoxifeneafimoxifene results in decreased expression of THBS2 mRNA16514628
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of THBS2 mRNA28522335
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of THBS2 mRNA"22863853
C015001arsenitearsenite results in increased methylation of THBS2 promoter23974009
D001379AzathioprineAzathioprine results in increased expression of THBS2 mRNA19192274
C547126AZM551248AZM551248 results in increased expression of THBS2 mRNA22323515
D004958EstradiolEstradiol affects the expression of THBS2 mRNA22574217
D004958EstradiolEstradiol results in increased expression of THBS2 mRNA16514628
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of THBS2 mRNA20226447
D004958EstradiolEstradiol results in increased expression of THBS2 mRNA19484750|2314475
C006780bisphenol Abisphenol A results in increased expression of THBS2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of THBS2 mRNA25594700|2606340
C006780bisphenol Abisphenol A results in decreased expression of THBS2 mRNA25181051
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS2 mRNA19840844
D002220CarbamazepineCarbamazepine affects the expression of THBS2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of THBS2 mRNA17484886
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of THBS2 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of THBS2 mRNA25827057
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBS2 mRNA20938992
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of THBS2 mRNA15467011
D003471CuprizoneCuprizone results in increased expression of THBS2 mRNA26577399
D000069439DasatinibDasatinib results in increased expression of THBS2 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of THBS2 mRNA25047013
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS2 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of THBS2 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of THBS2 mRNA24893172
D002945CisplatinCisplatin results in decreased expression of THBS2 mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of THBS2 mRNA22609946
C058705diethyl malatediethyl malate affects the expression of THBS2 mRNA24814887
D002117CalcitriolCalcitriol results in decreased expression of THBS2 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of THBS2 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of THBS2 mRNA"19480007
D004237DiuronDiuron results in increased expression of THBS2 mRNA21551480
C118739entinostatentinostat results in increased expression of THBS2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C061365flusilazoleflusilazole affects the expression of THBS2 mRNA21195148
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBS2 mRNA20938992
C070081fulvestrantfulvestrant results in decreased expression of THBS2 mRNA16514628
C039281furanfuran results in increased expression of THBS2 mRNA27387713
D005665FurosemideFurosemide results in increased expression of THBS2 mRNA16526316
D005947GlucoseGlucose results in increased expression of THBS2 protein23723366
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of THBS2 mRNA19192274
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of THBS2 mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of THBS2 mRNA26644586
C409722hexaconazolehexaconazole affects the expression of THBS2 mRNA21195148
D017313FenretinideFenretinide results in decreased expression of THBS2 mRNA28973697
D007069IfosfamideIfosfamide results in decreased expression of THBS2 mRNA25596134
C051890irinotecanirinotecan results in increased expression of THBS2 mRNA20097248
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS2 mRNA16054899
D007545IsoproterenolIsoproterenol results in increased expression of THBS2 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of THBS2 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THBS2 mRNA26644586
D007854LeadLead affects the expression of THBS2 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of THBS2 mRNA11578147
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of THBS2 mRNA15665042
C106335macrophage stimulatory lipopeptide 2[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of THBS2 mRNA18832182
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THBS2 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to THBS2 promoter]20348232
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of THBS2 mRNA28001369
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS2 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS2 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA19840844
C029938nickel sulfate[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of THBS2 mRNA18832182
C029938nickel sulfatenickel sulfate results in increased expression of THBS2 mRNA18832182
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS2 mRNA19840844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of THBS2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of THBS2 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of THBS2 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of THBS2 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of THBS2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THBS2 mRNA19710929
D010894PiroxicamPiroxicam results in increased expression of THBS2 mRNA19192274
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of THBS2 mRNA20226447
C513428pyrachlostrobinpyrachlostrobin results in increased expression of THBS2 mRNA27029645
D011794QuercetinQuercetin results in increased expression of THBS2 mRNA15309432
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of THBS2 mRNA16514628
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of THBS2 mRNA23723366
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of THBS2 protein23723366
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS2 mRNA16054899
C541923sandostatinLARsandostatinLAR results in increased expression of THBS2 mRNA17210224
D012834SilverSilver results in decreased expression of THBS2 mRNA27131904
D012906SmokeSmoke results in increased expression of THBS2 mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of THBS2 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of THBS2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of THBS2 mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of THBS2 mRNA18175754
D013311StreptozocinStreptozocin results in increased expression of THBS2 protein23723366
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of THBS2 mRNA"26680231
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA23519560
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA19840844
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of THBS2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of THBS2 mRNA"19682533
C032910triadimefontriadimefon affects the expression of THBS2 mRNA21195148
C012589trichostatin Atrichostatin A results in increased expression of THBS2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THBS2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of THBS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of THBS2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of THBS2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of THBS2 gene29154799
C111237vorinostatvorinostat results in decreased expression of THBS2 mRNA27188386
C111237vorinostatvorinostat results in increased expression of THBS2 mRNA20060208

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI19818485  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0016525negative regulation of angiogenesis-IDA20714802  
GO:0051965positive regulation of synapse assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0031091platelet alpha granule-IDA1737102  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04350TGF-beta signaling pathway
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19631562Decreased frequency of the 3'UTR T>G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion. (2010 May-Jun)Burke ACardiovasc Pathol
26137247Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study. (2015 May)Yamada YBiomed Rep
23747354Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. (2013 Sep 10)Manzardo AMGene
17334638Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. (2007 Apr)Yamaguchi SInt J Mol Med