Gene: TSPO

706
BPBS|BZRP|DBI|IBP|MBR|PBR|PBS|PKBS|PTBR|mDRC|pk18
translocator protein
protein-coding
22q13.2
Ensembl:ENSG00000100300 MIM:109610 Vega:OTTHUMG00000150573 UniprotKB:B1AH88
NC_000022.11
PubMed
0   ANCO-SNPs
CD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.930e-1 (AD)  2.232e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPC20.905
VAMP50.898
RHOC0.896
RAB130.895
HMG20B0.887
ROM10.883
EMP30.868
SERPINB60.868
PSMB80.866
GNG50.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.583
GRIN2B-0.583
GPR61-0.583
PPEF1-0.575
MARCH4-0.572
CALHM1-0.571
PTPN3-0.57
KCNB2-0.57
GABRG3-0.568
OTOGL-0.567

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00186LorazepamSmall Molecule846-49-1ApprovedTarget
DB00231TemazepamSmall Molecule846-50-4Approved|InvestigationalTarget
DB00402EszopicloneSmall Molecule138729-47-2Approved|InvestigationalTarget
DB00628ClorazepateSmall Molecule23887-31-2Approved|IllicitTarget
DB00829DiazepamSmall Molecule439-14-5Approved|Illicit|InvestigationalTarget
DB00897TriazolamSmall Molecule28911-01-5Approved|InvestigationalTarget
DB00962ZaleplonSmall Molecule151319-34-5Approved|Illicit|InvestigationalTarget
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitTarget
DB01178ChlormezanoneSmall Molecule80-77-3Approved|Investigational|WithdrawnTarget
DB01198ZopicloneSmall Molecule43200-80-2ApprovedTarget
DB01544FlunitrazepamSmall Molecule1622-62-4Approved|IllicitTarget
DB01587KetazolamSmall Molecule27223-35-4ApprovedTarget
ID Drug Name Action PubMed
C0400811-hydroxymethylmidazolam1-hydroxymethylmidazolam binds to TSPO protein7603229
C0400811-hydroxymethylmidazolam1-hydroxymethylmidazolam metabolite binds to TSPO protein7603229
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TSPO mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TSPO mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TSPO mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TSPO mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C0285134'-chlorodiazepam4'-chlorodiazepam binds to TSPO protein11266385|1978206
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C5294318-2 fluorotelomer alcohol8-2 fluorotelomer alcohol results in decreased expression of TSPO mRNA23142464
D000082AcetaminophenAcetaminophen affects the expression of TSPO mRNA17562736
D020106AcrylamideAcrylamide affects the expression of TSPO mRNA28959563
C096064acteinactein results in increased expression of TSPO mRNA19527300
C052036alpidemSSR180575 inhibits the reaction [alpidem binds to TSPO protein]12023539
D000577AmidesAmides analog binds to TSPO protein16495062
D000577AmidesAmides analog binds to TSPO protein16495062
D000641AmmoniaAmmonia results in increased expression of TSPO protein10206825
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TSPO mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the metabolism of TSPO protein11923223
D000643Ammonium ChlorideTSPO protein affects the susceptibility to Ammonium Chloride17893919
D001205Ascorbic AcidAscorbic Acid results in increased expression of TSPO mRNA15372504
D001280AtrazineAtrazine results in decreased expression of TSPO mRNA19541795
D001569BenzodiazepinesBenzodiazepines binds to and affects the activity of TSPO protein7862733
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TSPO mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TSPO mRNA19770486
D004958EstradiolEstradiol results in decreased expression of TSPO mRNA20144698
C099952bifenthrinbifenthrin results in decreased expression of TSPO mRNA23994515|2444916
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of TSPO mRNA]21871944
C006780bisphenol Abisphenol A affects the expression of TSPO mRNA21786754|2355768
C006780bisphenol Abisphenol A affects the expression of TSPO mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TSPO mRNA18804290
C038091butylparabenbutylparaben results in decreased expression of TSPO mRNA18648085
D019256Cadmium ChlorideCadmium Chloride affects the expression of TSPO mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TSPO mRNA17484886
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of TSPO mRNA19395590
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TSPO mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of TSPO mRNA26352163|2847649
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TSPO mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of TSPO mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of TSPO mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of TSPO mRNA19320972
D003345CorticosteroneCorticosterone results in increased expression of TSPO mRNA15755911
D003471CuprizoneCuprizone results in increased expression of TSPO mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of TSPO mRNA25562108
D003561CytarabineCytarabine results in decreased expression of TSPO mRNA21198554
C118941DAA 1097DAA 1097 analog binds to TSPO protein16640334
C118941DAA 1097DAA 1097 binds to TSPO protein16640334
C014347decitabinedecitabine affects the expression of TSPO mRNA23300844
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of TSPO mRNA26873546
D003975DiazepamTSPO protein affects the susceptibility to Diazepam19782064
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TSPO mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TSPO protein15141095|2174549
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TSPO mRNA15141095|2174549
D002945CisplatinCisplatin affects the expression of TSPO mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TSPO mRNA27392435
D002945CisplatinCisplatin results in increased expression of TSPO mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of TSPO mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TSPO mRNA19245819
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TSPO mRNA16690193|2503135
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TSPO protein16690193
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TSPO mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TSPO mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TSPO protein23873838
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TSPO mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [PK 11195 binds to TSPO protein]"21037200
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TSPO mRNA25380136
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of TSPO mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of TSPO mRNA26873546
C118739entinostatentinostat results in increased expression of TSPO mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C024565ethylene dichlorideethylene dichloride affects the expression of TSPO mRNA28973639
D005442Flumazenil[Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine7862733
D005442FlumazenilFlumazenil binds to and results in decreased activity of TSPO protein10723632|1627218
D005445FlunitrazepamFlunitrazepam binds to TSPO protein1946580
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of TSPO mRNA]15016801
D005485FlutamideFlutamide results in increased expression of TSPO mRNA24136188
C094127FOE 5043FOE 5043 affects the activity of TSPO protein23611293
C056933fumonisin B1fumonisin B1 results in increased expression of TSPO mRNA16221962
C039281furanfuran results in increased expression of TSPO mRNA25539665|2619464
D019833Genistein[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of TSPO mRNA27181934
D005839GentamicinsGentamicins results in decreased expression of TSPO mRNA22061828
D005897GlafenineGlafenine results in increased expression of TSPO mRNA24136188
D006533HeptachlorHeptachlor results in increased expression of TSPO14699885
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of TSPO14699885
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of TSPO mRNA25447410
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of TSPO mRNA25447410
D017313FenretinideFenretinide results in decreased expression of TSPO mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of TSPO mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TSPO mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TSPO mRNA21179406
C492448ICG 001ICG 001 results in increased expression of TSPO mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TSPO mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TSPO mRNA27392435
C544151jinfukangjinfukang results in increased expression of TSPO mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TSPO mRNA23086925
D048628KetolidesKetolides analog results in increased expression of TSPO mRNA24967691
D007854LeadLead affects the expression of TSPO mRNA28903495
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of TSPO mRNA"21745355
D008345ManganeseManganese results in increased expression of TSPO12106778
D008345ManganeseManganese results in increased expression of TSPO protein10206825
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TSPO mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TSPO mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TSPO mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of TSPO mRNA17412507
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TSPO mRNA24810058
D008874MidazolamMidazolam results in increased expression of TSPO protein19857560
D008874MidazolamMidazolam binds to TSPO protein7603229
D015735MifepristoneMifepristone results in decreased expression of TSPO mRNA25972201
C016599mono-(2-ethylhexyl)phthalate[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of TSPO mRNA27181934
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of TSPO mRNA27181934
C568376MT19c compoundMT19c compound results in decreased expression of TSPO mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TSPO mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TSPO mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TSPO mRNA25380136
C502525N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide"N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide binds to TSPO protein"21790126
C502525N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide"N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide binds to TSPO protein"21790126
C545830N-benzyl-N-methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide"N-benzyl-N-methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide binds to TSPO protein"19720292
D018377Neurotransmitter AgentsTSPO protein results in increased chemical synthesis of Neurotransmitter Agents10206825
D009538Nicotine[Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine7862733
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of TSPO mRNA17616710
C522838olesoximeolesoxime binds to TSPO protein17496168
C030110oxaliplatinoxaliplatin results in decreased expression of TSPO mRNA17762391
D000073878Palm OilPalm Oil results in decreased expression of TSPO mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TSPO mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of TSPO mRNA22861003
D010416PentachlorophenolPentachlorophenol results in increased expression of TSPO mRNA23892564
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of TSPO mRNA22790973
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TSPO mRNA20136073
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TSPO mRNA18804290
D026023PermethrinPermethrin analog results in decreased expression of TSPO mRNA21745691
D026023PermethrinPermethrin results in decreased expression of TSPO mRNA17463061|1845585
D010634PhenobarbitalPhenobarbital affects the expression of TSPO mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TSPO mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TSPO mRNA19482888
D010705PhosgenePhosgene affects the expression of TSPO mRNA16300373
C556557picoxystrobinpicoxystrobin results in decreased activity of TSPO protein23611293
C556557picoxystrobinpicoxystrobin results in decreased activity of TSPO protein23611293
C006253pirinixic acidpirinixic acid results in increased expression of TSPO mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of TSPO mRNA19162173|2211250
C037850PK 11195PK 11195 binds to TSPO protein15519653
C037850PK 11195"9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [PK 11195 binds to TSPO protein]"21037200
C037850PK 11195PK 11195 binds to TSPO protein16495062|2103720
C037850PK 11195TSPO protein affects the susceptibility to PK 1119511266385
C037850PK 11195PK 11195 binds to and results in decreased activity of TSPO protein12730627|1616631
C037850PK 11195PK 11195 binds to TSPO protein11266385|1978206
D011166PorphyrinsTSPO protein affects the transport of Porphyrins11020479
C035988procymidoneprocymidone results in decreased expression of TSPO mRNA15686871
C028025protoporphyrin IXTSPO protein results in decreased abundance of protoporphyrin IX11020479
C513428pyrachlostrobinpyrachlostrobin results in decreased activity of TSPO protein21251949
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TSPO mRNA27029645
C513428pyrachlostrobinpyrachlostrobin results in decreased activity of TSPO protein21251949
D011804QuinolinesQuinolines analog binds to TSPO protein16495062
D011804QuinolinesQuinolines analog binds to TSPO protein16495062|1829485
C059514resveratrolresveratrol results in increased expression of TSPO mRNA22610192
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of TSPO mRNA25905778
C076809Ro 19-8022Ro 19-8022 binds to and results in increased activity of TSPO protein10771294
D020156Salicylic AcidSalicylic Acid results in decreased expression of TSPO mRNA16551645
D012524SarinSarin results in increased expression of TSPO mRNA27639427
D012524SarinSarin results in increased expression of TSPO protein27639427
D012645SelenomethionineSelenomethionine results in increased expression of TSPO mRNA21963595
D012906SmokeSmoke affects the expression of TSPO mRNA23693141
C016104sodium bichromatesodium bichromate results in increased expression of TSPO mRNA25993096
D012999SomanSoman results in increased expression of TSPO mRNA19281266
C456740SSR180575SSR180575 binds to TSPO protein12023539
C456740SSR180575SSR180575 binds to TSPO protein12023539
C456740SSR180575SSR180575 inhibits the reaction [alpidem binds to TSPO protein]12023539
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of TSPO mRNA25905778
C004648testosterone enanthatetestosterone enanthate results in decreased expression of TSPO mRNA21427060|2560346
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TSPO mRNA12377990|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSPO mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TSPO mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TSPO mRNA20959002|2121527
D013752TetracyclineTetracycline results in decreased expression of TSPO mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TSPO mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of TSPO mRNA22378314
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TSPO mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of TSPO mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TSPO mRNA27255386|2811129
C011559tributyltintributyltin affects the expression of TSPO protein28707438
C011559tributyltintributyltin results in increased expression of TSPO mRNA21683754
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TSPO mRNA24935251|2627250
D014303TrinitrotolueneTrinitrotoluene affects the expression of TSPO mRNA21346803
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of TSPO mRNA26183808
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of TSPO mRNA26049154
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of TSPO mRNA26049154
D014415TunicamycinTunicamycin results in decreased expression of TSPO mRNA22378314
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of TSPO mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSPO mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TSPO mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TSPO mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TSPO mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of TSPO gene29154799
D014640VancomycinVancomycin results in decreased expression of TSPO mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TSPO mRNA22861003
C025643vinclozolinvinclozolin results in decreased expression of TSPO mRNA15686871
C111237vorinostatvorinostat results in increased expression of TSPO mRNA27188386
C017802zinc hematoporphyrinTSPO protein results in increased abundance of zinc hematoporphyrin11020479
D015039ZiramZiram results in decreased expression of TSPO mRNA28973382

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005497androgen binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008503benzodiazepine receptor activity-IEA-  
GO:0015485cholesterol binding-IBA21873635  
GO:0015485cholesterol binding-TAS16822554  
GO:0017127cholesterol transporter activity-TAS-  
GO:0044325ion channel binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006626protein targeting to mitochondrion-TAS1326278  
GO:0006700C21-steroid hormone biosynthetic process-TAS-  
GO:0006783heme biosynthetic process-TAS16822554  
GO:0006820anion transport-TAS16822554  
GO:0006821chloride transport-IEA-  
GO:0006915apoptotic process-TAS16822554  
GO:0007165signal transduction-IEA-  
GO:0007568aging-IEA-  
GO:0008202steroid metabolic process-TAS16822554  
GO:0008283cell proliferation-TAS16822554  
GO:0008347glial cell migration-IEA-  
GO:0010042response to manganese ion-IEA-  
GO:0010266response to vitamin B1-IEA-  
GO:0010940positive regulation of necrotic cell death-IEA-  
GO:0014012peripheral nervous system axon regeneration-IEA-  
GO:0030301cholesterol transport-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0031397negative regulation of protein ubiquitination-IEA-  
GO:0032374regulation of cholesterol transport-TAS16822554  
GO:0032570response to progesterone-IEA-  
GO:0032720negative regulation of tumor necrosis factor production-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0045019negative regulation of nitric oxide biosynthetic process-IEA-  
GO:0048266behavioral response to pain-IEA-  
GO:0050810regulation of steroid biosynthetic process-IEA-  
GO:0051901positive regulation of mitochondrial depolarization-IEA-  
GO:0051928positive regulation of calcium ion transport-IEA-  
GO:0060242contact inhibition-IEA-  
GO:0060252positive regulation of glial cell proliferation-IEA-  
GO:0060253negative regulation of glial cell proliferation-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071294cellular response to zinc ion-IEA-  
GO:0071476cellular hypotonic response-IEA-  
GO:0072656maintenance of protein location in mitochondrion-IEA-  
GO:1903147negative regulation of autophagy of mitochondrion-IEA-  
GO:1903579negative regulation of ATP metabolic process-IEA-  
GO:2000379positive regulation of reactive oxygen species metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-IBA21873635  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043229intracellular organelle-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-196108Pregnenolone biosynthesisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28738332Neuroprogression and Immune Activation in Major Depressive Disorder. (2017)Meyer JHMod Trends Pharmacopsychiatry
28811616Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and (64)CuCl2. (2017 Aug 15)Yang JSci Rep
28242869In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence. (2017 Dec)Hillmer ATMol Psychiatry
28262740Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [(11)C]DAA1106 Positron Emission Tomography Study. (2017 Jul)Brody ALNeuropsychopharmacology
29777199Influence of alcoholism and cholesterol on TSPO binding in brain: PET [(11)C]PBR28 studies in humans and rodents. (2018 May 3)Kim SWNeuropsychopharmacology
25057196Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28. (2014 Jul 23)Narendran RJ Neurosci
20085808Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis. (2010 May)Nagler RBiochim Biophys Acta
28072413Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. (2017 Jan 10)Kalk NJTransl Psychiatry