Gene: THBS4

7060
TSP-4|TSP4
thrombospondin 4
protein-coding
5q14.1
Ensembl:ENSG00000113296 MIM:600715 Vega:OTTHUMG00000108173 UniprotKB:P35443
NG_047084.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.968e-1 (AD)  8.813e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST110.776
PTPRZ10.77
CAPN20.745
ARAF0.741
WLS0.738
ARHGEF60.729
TBL1X0.728
VANGL20.726
ARHGEF400.722
CPNE30.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.498
OR4F29-0.445
ABCC12-0.306
TYRP1-0.293
FBLN7-0.277
RHO-0.277
DUSP27-0.273
CALHM1-0.272
KCNS2-0.269
TRABD2A-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of THBS4 mRNA"25710175
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of THBS4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THBS4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THBS4 mRNA"27188386
C496492abrineabrine results in increased expression of THBS4 mRNA22595364
D020106AcrylamideAcrylamide affects the expression of THBS4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of THBS4 mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of THBS4 mRNA16483693
C015001arsenitearsenite results in decreased expression of THBS4 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of THBS4 mRNA]18929588
D001280AtrazineAtrazine results in increased expression of THBS4 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of THBS4 mRNA22378314
D004958EstradiolEstradiol results in increased expression of THBS4 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of THBS4 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of THBS4 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of THBS4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of THBS4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of THBS4 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of THBS4 mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of THBS4 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of THBS4 mRNA26577399|2752363
C014347decitabinedecitabine affects the expression of THBS4 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of THBS4 mRNA21266533
D002945CisplatinCisplatin affects the expression of THBS4 mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of THBS4 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of THBS4 mRNA28085963
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of THBS4 mRNA22302311
D004317DoxorubicinDoxorubicin results in increased expression of THBS4 mRNA28940058
C108024emamectin benzoateemamectin benzoate results in decreased expression of THBS4 mRNA18786259
D004656EnalaprilEnalapril results in increased expression of THBS4 mRNA25037058
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBS4 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of THBS4 mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of THBS4 mRNA19167457
C039281furanfuran results in increased expression of THBS4 mRNA25539665
D005665FurosemideFurosemide affects the expression of THBS4 mRNA16526316
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in decreased expression of THBS4 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of THBS4 mRNA17109745
D005944GlucosamineIL1B promotes the reaction [Glucosamine results in decreased expression of THBS4 mRNA]17109745
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde affects the expression of THBS4 mRNA22302311
D015122MercaptopurineMercaptopurine results in increased expression of THBS4 mRNA23358152
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of THBS4 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of THBS4 mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of THBS4 mRNA"20188158
C033069methyl salicylatemethyl salicylate affects the expression of THBS4 mRNA22302311
D008790MetoprololMetoprolol results in decreased expression of THBS4 mRNA20353484
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of THBS4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of THBS4 mRNA"25554681
D000073878Palm OilPalm Oil results in increased expression of THBS4 mRNA18042831
D010269ParaquatParaquat results in increased expression of THBS4 mRNA17275934
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THBS4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of THBS4 mRNA26272509
D009764o-Phthalaldehydeo-Phthalaldehyde affects the expression of THBS4 mRNA22302311
C006253pirinixic acidpirinixic acid results in increased expression of THBS4 mRNA20813756
D028321Plant PreparationsPlant Preparations results in increased expression of THBS4 protein28284660
D011192Potassium DichromatePotassium Dichromate results in decreased expression of THBS4 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of THBS4 mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of THBS4 mRNA20436886
C017947sodium arsenitesodium arsenite affects the methylation of THBS4 gene28589171
D053260SootSoot results in increased expression of THBS4 mRNA26551751
D013311StreptozocinStreptozocin results in increased expression of THBS4 mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of THBS4 mRNA]16684804
C004648testosterone enanthatetestosterone enanthate affects the expression of THBS4 mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBS4 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of THBS4 mRNA22363418
D014118Toxins, Biological"Toxins, Biological affects the expression of THBS4 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of THBS4 mRNA21934132
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of THBS4 mRNA]27469509
C012589trichostatin Atrichostatin A results in decreased expression of THBS4 mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of THBS4 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride affects the expression of THBS4 mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of THBS4 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of THBS4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of THBS4 mRNA15901671
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of THBS4 mRNA]16684804
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of THBS4 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of THBS4 mRNA19165385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IDA16099885  
GO:0005509calcium ion binding-IDA7852353  16246837  
GO:0005515protein binding-IPI22682248  
GO:0008083growth factor activity-IEA-  
GO:0008201heparin binding-IDA7852353  
GO ID GO Term Qualifier Evidence PubMed
GO:0001938positive regulation of endothelial cell proliferation-IDA12952849  
GO:0006986response to unfolded protein-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016525negative regulation of angiogenesis-IEP18802666  
GO:0034103regulation of tissue remodeling-ISS-  
GO:0034976response to endoplasmic reticulum stress-ISS-  
GO:0048266behavioral response to pain-ISS-  
GO:0048771tissue remodeling-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA16099885  
GO:0051451myoblast migration-IDA7519904  
GO:0051781positive regulation of cell division-IEA-  
GO:0071603endothelial cell-cell adhesion-IDA12952849  
GO:0090023positive regulation of neutrophil chemotaxis-IDA16099885  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IDA17927980  
GO:0005615extracellular space-IDA12952849  18802666  
GO:0005783endoplasmic reticulum-ISS-  
GO:0016529sarcoplasmic reticulum-ISS-  
GO:0031012extracellular matrix-ISS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04350TGF-beta signaling pathway
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27769059Microarray analysis on the lncRNA expression profile in male hepatocelluar carcinoma patients with chronic hepatitis B virus infection. (2016 Nov 15)Niu JOncotarget