Gene: THPO

7066
MGDF|MKCSF|ML|MPLLG|THCYT1|TPO
thrombopoietin
protein-coding
3q27.1
Ensembl:ENSG00000090534 MIM:600044 Vega:OTTHUMG00000156745 UniprotKB:P40225
NG_012136.1
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.285e-1 (AD)  9.038e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM540.84
CCDC570.831
SLC38A70.819
CRHR10.816
CHRD0.808
RNF2070.806
ANKRD240.806
ABCC80.805
SLC26A100.805
MOK0.801

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.43
SGMS2-0.425
WWTR1-0.424
GIMAP2-0.421
SH2D1A-0.421
GYPC-0.42
IGF2BP2-0.414
RAI14-0.413
REST-0.412
ACAP1-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]20523355
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of THPO mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of THPO mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of THPO mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of THPO mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of THPO mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of THPO mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of THPO mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THPO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THPO mRNA"27188386
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased abundance of Reactive Oxygen Species]"20523355
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of GP1BA protein]"20523355
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]"20523355
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]"20523355
D000082AcetaminophenAcetaminophen affects the expression of THPO protein12601353
D000082AcetaminophenAcetaminophen results in decreased expression of THPO mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of THPO mRNA17562736
C043377acetochloracetochlor results in increased expression of THPO mRNA26397822
D000111AcetylcysteineAcetylcysteine inhibits the reaction [THPO protein results in increased abundance of Reactive Oxygen Species]20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]20523355
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of GP1BA protein]"20523355
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]"20523355
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]"20523355
D000643Ammonium ChlorideAmmonium Chloride affects the expression of THPO mRNA16483693
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]20586925
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]20586925
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein]20586925
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]20586925
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]20586925
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA]20586925
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA]20586925
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of THPO mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of THPO mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of THPO mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of THPO gene28505145
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]16822543
D002104CadmiumCadmium results in decreased expression of THPO mRNA24376830
D019327Copper SulfateCopper Sulfate results in decreased expression of THPO mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of THPO mRNA26577399
C000944dicrotophosdicrotophos results in increased expression of THPO mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of THPO mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of THPO protein18379402
D004147DioxinsDioxins results in increased expression of THPO protein12948893
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT3 protein]20523355
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT5A protein]20523355
D004317DoxorubicinTHPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]16651473
D004317DoxorubicinTHPO protein inhibits the reaction [Doxorubicin results in increased expression of ANXA5 protein]16651473
C118739entinostatentinostat results in increased expression of THPO mRNA27188386
C024565ethylene dichlorideethylene dichloride results in increased expression of THPO mRNA28189721
D005419FlavonoidsFlavonoids results in decreased expression of THPO mRNA18035473
D005620Freund's AdjuvantFreund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]16822543
C039281furanfuran results in increased methylation of THPO gene22079235
C056507gemcitabinegemcitabine results in increased expression of THPO protein20531411
D019833GenisteinGenistein results in increased expression of THPO mRNA21048042
D005978GlutathioneGlutathione deficiency results in decreased expression of THPO mRNA20621112
C004312glycidolglycidol results in increased expression of THPO mRNA24915197
D008070Lipopolysaccharides[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of THPO protein18437699
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of THPO mRNA12057914
D008694MethamphetamineMethamphetamine results in increased expression of THPO mRNA25290377
D008770MethylnitrosoureaButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]16822543
D008770MethylnitrosoureaFreund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]16822543
D008770MethylnitrosoureaIFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]16822543
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of THPO protein16822543
C022838nickel chloride[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of THPO protein18437699
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of THPO mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of THPO mRNA23602845
C006253pirinixic acidpirinixic acid results in decreased expression of THPO mRNA20813756
D011441PropylthiouracilPropylthiouracil results in decreased expression of THPO mRNA24780913
C432165pyrazolanthronepyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C432165pyrazolanthronepyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
C432165pyrazolanthronepyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein]20523355
D017382Reactive Oxygen Species"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased abundance of Reactive Oxygen Species]"20523355
D017382Reactive Oxygen SpeciesAcetylcysteine inhibits the reaction [THPO protein results in increased abundance of Reactive Oxygen Species]20523355
D017382Reactive Oxygen SpeciesTHPO protein results in increased abundance of Reactive Oxygen Species20523355
C059514resveratrolresveratrol results in increased activity of [KITL protein co-treated with THPO protein co-treated with FLT3LG protein co-treated with IL6 protein]26160960
C552240StemRegenin 1StemRegenin 1 results in increased activity of [KITL protein co-treated with THPO protein co-treated with FLT3LG protein co-treated with IL6 protein]26160960
D014284TriiodothyronineTriiodothyronine results in increased expression of THPO mRNA26397822
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of THPO mRNA19074003
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of THPO mRNA16979875
D013849ThimerosalThimerosal results in decreased expression of THPO mRNA24675092
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of THPO mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C113580U 0126U 0126 inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]20523355
C113580U 0126U 0126 inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]20523355
D014520UrethaneUrethane results in decreased expression of THPO mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THPO mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of THPO mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of THPO mRNA23179753|2519280
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of THPO mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005125cytokine activity-IEA-  
GO:0005179hormone activity-IEA-  
GO:0008083growth factor activity-TAS8202159  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0002574thrombocyte differentiation-IBA21873635  
GO:0007275multicellular organism development-TAS8202159  
GO:0008283cell proliferation-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0038163thrombopoietin-mediated signaling pathway-IBA21873635  
GO:0038163thrombopoietin-mediated signaling pathway-ISS-  
GO:0045654positive regulation of megakaryocyte differentiation-ISS-  
GO:0051897positive regulation of protein kinase B signaling-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:1902035positive regulation of hematopoietic stem cell proliferation-IBA21873635  
GO:1902035positive regulation of hematopoietic stem cell proliferation-IDA21540074  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-76009Platelet Aggregation (Plug Formation)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal