Gene: KLF10

7071
EGR-alpha|EGRA|TIEG|TIEG1
Kruppel like factor 10
protein-coding
8q22.3
Ensembl:ENSG00000155090 MIM:601878 Vega:OTTHUMG00000164735 UniprotKB:Q13118
NG_033271.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.436e-1 (AD)  2.012e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ETV30.742
ARC0.727
ZBTB210.722
EGR20.709
EGR10.704
DUSP60.683
RARA0.677
ETS20.673
AMOTL10.667
FOXJ20.667

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.334
RFTN2-0.324
NPFFR1-0.315
DIAPH3-0.309
OR4F29-0.306
FXYD3-0.295
PDE11A-0.276
TPPP2-0.275
KLF15-0.275
ALDH1L1-AS2-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of KLF10 mRNA"19162173
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of KLF10 mRNA23792671
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF10 mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KLF10 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of KLF10 mRNA"20638727
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KLF10 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of KLF10 mRNA"12097258
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of KLF10 mRNA]"11179685
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KLF10 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KLF10 mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of KLF10 mRNA"19561079
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of KLF10 mRNA"19936915
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of KLF10 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KLF10 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of KLF10 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLF10 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of KLF10 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of KLF10 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of KLF10 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLF10 mRNA19770486|2171566
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of KLF10 mRNA]"11179685
D004958EstradiolEstradiol affects the expression of KLF10 mRNA14699072
D004958EstradiolEstradiol results in decreased expression of KLF10 mRNA11179685
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of KLF10 mRNA]11179685
D004958EstradiolEstradiol affects the expression of KLF10 mRNA15598610
D001622BetaineBetaine results in increased expression of KLF10 mRNA26391144
C095105bexarotenebexarotene results in decreased expression of KLF10 mRNA17178900
C006780bisphenol Abisphenol A results in increased expression of KLF10 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of KLF10 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of KLF10 mRNA17553608
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of KLF10 mRNA23410634
D002220CarbamazepineCarbamazepine affects the expression of KLF10 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KLF10 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KLF10 mRNA27339419
C522245CHF 5022CHF 5022 results in decreased expression of KLF10 mRNA17292621
D002737ChloropreneChloroprene results in increased expression of KLF10 mRNA23125180
D002857ChromiumChromium results in increased expression of KLF10 mRNA17547211
D002922CiguatoxinsCiguatoxins affects the expression of KLF10 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of KLF10 mRNA17585979
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of KLF10 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of KLF10 mRNA19549813
D003474CurcuminCurcumin results in decreased expression of KLF10 mRNA17999991
D016572CyclosporineCyclosporine results in increased expression of KLF10 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of KLF10 mRNA23640034
C017180decamethrindecamethrin results in decreased expression of KLF10 mRNA19017407
C014347decitabine[decitabine co-treated with TGFB1 protein] promotes the reaction [KLF10 protein binds to FOXP3 promoter]19109157
D003976DiazinonDiazinon affects the expression of KLF10 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KLF10 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of KLF10 mRNA28962523
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of KLF10 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of KLF10 mRNA27392435
D002945CisplatinCisplatin results in increased expression of KLF10 mRNA27594783
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of KLF10 mRNA]27392435
D002945CisplatinCisplatin results in increased expression of KLF10 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of KLF10 mRNA28302478
D004026DieldrinDieldrin results in increased expression of KLF10 mRNA20438755
D004026DieldrinDieldrin affects the expression of KLF10 mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of KLF10 mRNA18042831
D004041Dietary Fats"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of KLF10 mRNA"12097258
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KLF10 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of KLF10 mRNA]19850644
C014476diethyl maleatediethyl maleate results in decreased expression of KLF10 mRNA25270620
C014476diethyl maleatediethyl maleate results in decreased expression of KLF10 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KLF10 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KLF10 mRNA]17942915
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KLF10 mRNA"12097258
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of KLF10 mRNA24690739
D017292DoxazosinDoxazosin results in increased expression of KLF10 mRNA12771931
D017292DoxazosinDoxazosin results in increased expression of KLF10 protein12771931
D004317DoxorubicinDoxorubicin affects the expression of KLF10 mRNA15033991
D004317DoxorubicinDoxorubicin results in increased oxidation of KLF10 protein28818578
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of KLF10 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of KLF10 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of KLF10 mRNA21233418
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KLF10 mRNA23649840
D011345FenofibrateFenofibrate results in increased expression of KLF10 mRNA25572481
D011345FenofibrateFenofibrate results in decreased expression of KLF10 mRNA11798191
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF10 mRNA28329830
D005473FluoxetineFluoxetine results in increased expression of KLF10 mRNA18301726
D005485FlutamideFlutamide results in decreased expression of KLF10 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of KLF10 mRNA23649840
D005944GlucosamineGlucosamine results in increased expression of KLF10 mRNA17178593
D005947GlucoseGlucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]19225232
D005947GlucoseValsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]19225232
D005947GlucoseGlucose results in increased expression of KLF10 mRNA17178593
C029424hydrazinehydrazine results in decreased expression of KLF10 mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KLF10 mRNA20044591|2341063
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of KLF10 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of KLF10 mRNA25613284
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of KLF10 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of KLF10 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of KLF10 mRNA27392435
D007608Kainic AcidKainic Acid results in decreased expression of KLF10 mRNA17997037
C045463leflunomideleflunomide results in increased expression of KLF10 mRNA28988120
D008627Mercuric ChlorideMercuric Chloride affects the expression of KLF10 mRNA20353558
D008694MethamphetamineMethamphetamine results in increased expression of KLF10 mRNA19564919
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KLF10 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KLF10 mRNA"20188158
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of KLF10 mRNA15120970
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of KLF10 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of KLF10 mRNA21195148
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KLF10 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLF10 mRNA"25620056
C022838nickel chloridenickel chloride results in increased expression of KLF10 mRNA17547211
C022838nickel chloridenickel chloride affects the expression of KLF10 mRNA22546817
D009538NicotineNicotine results in decreased expression of KLF10 mRNA17997037
D009538NicotineNicotine results in increased expression of KLF10 mRNA17456735
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of KLF10 mRNA17616710
D009966OrphenadrineOrphenadrine affects the expression of KLF10 mRNA23665939
D010081OxazoloneOxazolone results in increased expression of KLF10 mRNA23999411
D000073878Palm OilPalm Oil results in decreased expression of KLF10 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of KLF10 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of KLF10 mRNA19162173
D026023PermethrinKLF10 gene SNP affects the susceptibility to Permethrin25622337
D010634PhenobarbitalPhenobarbital results in decreased expression of KLF10 mRNA19270015|2133504
D010634PhenobarbitalPhenobarbital results in increased expression of KLF10 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of KLF10 mRNA19162173
D019800PhenolPhenol results in increased expression of KLF10 mRNA17547211
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLF10 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLF10 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of KLF10 mRNA11798191|1844570
C006253pirinixic acidpirinixic acid results in increased expression of KLF10 mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of KLF10 mRNA19162173
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of KLF10 mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of KLF10 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KLF10 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of KLF10 mRNA17547211
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KLF10 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of KLF10 mRNA18037150
D011374ProgesteroneProgesterone results in decreased expression of KLF10 mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of KLF10 mRNA21278054
C045950propiconazolepropiconazole results in decreased expression of KLF10 mRNA28970091
D011441PropylthiouracilPropylthiouracil results in increased expression of KLF10 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of KLF10 mRNA14699072
D012312RitodrineRitodrine results in decreased expression of KLF10 mRNA23370008
C541923sandostatinLARsandostatinLAR results in increased expression of KLF10 mRNA17210224
D012822Silicon DioxideSilicon Dioxide results in increased expression of KLF10 mRNA25351596
D012834SilverSilver results in increased expression of KLF10 mRNA26014281
D019821Simvastatin[Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]19225232
C017947sodium arsenitesodium arsenite results in decreased expression of KLF10 mRNA25270620
C016104sodium bichromatesodium bichromate results in increased expression of KLF10 mRNA22561333
C016766sulforafansulforafan results in increased expression of KLF10 mRNA26833863
C061133tamibarotenetamibarotene results in decreased expression of KLF10 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of KLF10 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of KLF10 mRNA]11179685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of KLF10 mRNA]16891777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF10 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of KLF10 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of KLF10 mRNA]15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLF10 mRNA16891777|1869160
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF10 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLF10 mRNA20959002|2121527
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of KLF10 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of KLF10 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of KLF10 mRNA23557971|2776080
D014118Toxins, Biological"Toxins, Biological affects the expression of KLF10 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of KLF10 mRNA15498508
D014212TretinoinTretinoin results in increased expression of KLF10 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased expression of KLF10 mRNA28973375
C012589trichostatin Atrichostatin A results in increased expression of KLF10 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of KLF10 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLF10 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of KLF10 mRNA22378314
D014520UrethaneUrethane results in increased expression of KLF10 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of KLF10 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of KLF10 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of KLF10 mRNA15901671
D000068756Valsartan[Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]19225232
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]19225232
D000068756ValsartanValsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]19225232
D014638VanadatesVanadates results in increased expression of KLF10 protein17874149
C029297vinylidene chloridevinylidene chloride results in increased expression of KLF10 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of KLF10 mRNA20044591|2341063
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of KLF10 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15087465  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001046core promoter sequence-specific DNA binding-ISS-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15087465  
GO:0003700DNA-binding transcription factor activity-TAS9748269  10816551  
GO:0005515protein binding-IPI10976766  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS9748269  
GO:0001501skeletal system development-TAS10816551  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS10816551  
GO:0007267cell-cell signaling-TAS8532536  
GO:0007623circadian rhythm-IEA-  
GO:0008283cell proliferation-TAS10816551  
GO:0008285negative regulation of cell proliferation-TAS9748269  
GO:0009267cellular response to starvation-ISS-  
GO:0030282bone mineralization-IEA-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0045672positive regulation of osteoclast differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15087465  
GO:1901653cellular response to peptide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One