Gene: TIAM1

7074
TIAM-1
T cell lymphoma invasion and metastasis 1
protein-coding
21q22.11
Ensembl:ENSG00000156299 MIM:600687 Vega:OTTHUMG00000084869 UniprotKB:Q13009
NC_000021.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.106e-2 (AD)  7.000e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL420.897
PBX10.896
PNMA20.896
KDM2B0.896
UBQLN20.893
DYRK1A0.893
GSK3B0.892
IPO90.891
MTMR40.891
UBE2K0.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.579
OR4F29-0.525
CSAG1-0.357
PPBP-0.341
PDZK1IP1-0.324
WDR38-0.32
RAI14-0.312
S100A14-0.311
TNFRSF12A-0.311
MYL3-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TIAM1 mRNA19933214
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of TIAM1 mRNA24140754
D000082AcetaminophenAcetaminophen affects the expression of TIAM1 mRNA25458485
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TIAM1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TIAM1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TIAM1 gene27153756
D000447AldehydesAldehydes results in increased expression of TIAM1 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TIAM1 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of TIAM1 mRNA18585445
C015001arsenitearsenite results in decreased expression of TIAM1 mRNA18191166
D001280AtrazineAtrazine results in decreased expression of TIAM1 mRNA25929836
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of TIAM1 mRNA18585445
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TIAM1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TIAM1 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TIAM1 mRNA"20382639
C038328BEP protocolBEP protocol results in increased expression of TIAM1 mRNA18987330
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of TIAM1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIAM1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TIAM1 mRNA19619570|2118537
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TIAM1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased methylation of TIAM1 gene22576693
C006780bisphenol Abisphenol A results in increased expression of TIAM1 mRNA22576693
C006780bisphenol Abisphenol A affects the expression of TIAM1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TIAM1 mRNA26496021
C018475butyraldehydebutyraldehyde results in increased expression of TIAM1 mRNA26079696
D002235CarbofuranCarbofuran results in increased expression of TIAM1 mRNA20211217
D002737ChloropreneChloroprene results in decreased expression of TIAM1 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TIAM1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TIAM1 mRNA]17585979
D003300CopperCopper affects the expression of TIAM1 mRNA23825565
D003471CuprizoneCuprizone results in decreased expression of TIAM1 mRNA26577399|2752363
D003703DemecolcineDemecolcine results in increased expression of TIAM1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TIAM1 mRNA17361019
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of TIAM1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of TIAM1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of TIAM1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of TIAM1 mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of TIAM1 mRNA26924002
D004317DoxorubicinDoxorubicin results in increased expression of TIAM1 mRNA20211217
C118739entinostatentinostat results in increased expression of TIAM1 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TIAM1 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIAM1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TIAM1 mRNA23550701
C004312glycidolglycidol results in decreased expression of TIAM1 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of TIAM1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TIAM1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of TIAM1 mRNA20211217
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TIAM1 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TIAM1 mRNA24796395
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of TIAM1 mRNA12634122
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TIAM1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TIAM1 mRNA"19836432
C028007nickel monoxidenickel monoxide results in increased expression of TIAM1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of TIAM1 mRNA16780908
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TIAM1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of TIAM1 mRNA18042831
C046012pentanalpentanal results in increased expression of TIAM1 mRNA26079696
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of TIAM1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of TIAM1 mRNA17950772
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TIAM1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TIAM1 mRNA22079256
C005556propionaldehydepropionaldehyde results in increased expression of TIAM1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of TIAM1 mRNA24780913
D011791QuartzQuartz results in increased expression of TIAM1 mRNA19836432
D012402RotenoneTIAM1 protein affects the susceptibility to Rotenone18480073
D012822Silicon DioxideSilicon Dioxide results in increased expression of TIAM1 mRNA22431001
D012999SomanSoman results in decreased expression of TIAM1 mRNA19281266
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIAM1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TIAM1 mRNA19619570|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TIAM1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIAM1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TIAM1 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TIAM1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TIAM1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TIAM1 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of TIAM1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of TIAM1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TIAM1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of TIAM1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TIAM1 gene25560391
C025643vinclozolinvinclozolin affects the expression of TIAM1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of TIAM1 mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of TIAM1 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-EXP15721239  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI15324660  17353931  17440041  23109420  23395182  
GO:0008017microtubule binding-IEA-  
GO:0008289lipid binding-IEA-  
GO:0019900kinase binding-IPI23109420  
GO:0030676Rac guanyl-nucleotide exchange factor activity-IDA23109420  
GO:0030676Rac guanyl-nucleotide exchange factor activity-IMP20361982  
GO:0030971receptor tyrosine kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003300cardiac muscle hypertrophy-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0007160cell-matrix adhesion-IMP20361982  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0008284positive regulation of cell proliferation-IDA25032858  
GO:0010717regulation of epithelial to mesenchymal transition-IDA20826792  
GO:0010718positive regulation of epithelial to mesenchymal transition-NAS17086355  
GO:0016477cell migration-IMP20361982  
GO:0016601Rac protein signal transduction-IMP20361982  
GO:0030335positive regulation of cell migration-IDA25032858  
GO:0032092positive regulation of protein binding-IDA23109420  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0042220response to cocaine-IEA-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0050772positive regulation of axonogenesis-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO:0061003positive regulation of dendritic spine morphogenesis-IEA-  
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus-IEA-  
GO:0070372regulation of ERK1 and ERK2 cascade-IEA-  
GO:0072657protein localization to membrane-IEA-  
GO:0090630activation of GTPase activity-IDA23109420  
GO:0098989NMDA selective glutamate receptor signaling pathway-IEA-  
GO:1904268positive regulation of Schwann cell chemotaxis-IEA-  
GO:1904338regulation of dopaminergic neuron differentiation-ISS-  
GO:1905274regulation of modification of postsynaptic actin cytoskeleton-IEA-  
GO:1990138neuron projection extension-IEA-  
GO:2000050regulation of non-canonical Wnt signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA23109420  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-IDA23109420  
GO:0005911cell-cell junction-IDA20332120  
GO:0014069postsynaptic density-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA20361982  
GO:0032587ruffle membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0044291cell-cell contact zone-IDA20361982  
GO:0044295axonal growth cone-IEA-  
GO:0044304main axon-IEA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9032845Activated NTRK2 signals through CDK5IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22027789[Quantitative analysis of Tiam1 expression in lung cancer and its clinical significance]. (2011 Oct)Li YMNan Fang Yi Ke Da Xue Xue Bao