Gene: TIE1

7075
JTK14|TIE
tyrosine kinase with immunoglobulin like and EGF like domains 1
protein-coding
1p34.2
Ensembl:ENSG00000066056 MIM:600222 Vega:OTTHUMG00000007282 UniprotKB:P35590
NG_030673.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.395e-2 (AD)  8.489e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08928753chr1:43770707TIE1Gene body1.535e-4Alcohol use disorders26763658
cg03971454chr1:43770557TIE1Gene body5.298e-4Alcohol use disorders26763658
cg10965178chr1:43766752TIE12.500e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP10A0.851
ESAM0.841
FLT40.832
STARD80.818
VWF0.813
CLEC14A0.809
CXorf360.797
PKN30.794
PRKCH0.793
ERG0.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.358
SMIM18-0.343
CPLX3-0.336
C1orf53-0.327
SP9-0.304
KIT-0.299
DLX1-0.291
LYPD8-0.283
HNF1A-0.28
MARCH4-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased expression of TIE1 mRNA"15313899
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TIE1 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIE1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIE1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIE1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIE1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIE1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of TIE1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TIE1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TIE1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TIE1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TIE1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of TIE1 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TIE1 mRNA26377693
D004958EstradiolEstradiol affects the expression of TIE1 mRNA21826169
D004958EstradiolEstradiol affects the expression of TIE1 mRNA15598610
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of TIE1 mRNA18192240
C006780bisphenol Abisphenol A affects the expression of TIE1 mRNA21826169
C006780bisphenol Abisphenol A affects the expression of TIE1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TIE1 mRNA15336504
D002994ClofibrateClofibrate results in decreased expression of TIE1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TIE1 mRNA19320972
D003471CuprizoneCuprizone results in increased expression of TIE1 mRNA26577399
D016572CyclosporineCyclosporine results in increased methylation of TIE1 promoter27989131
D003634DDTDDT results in decreased expression of TIE1 mRNA25014179
C014347decitabinedecitabine affects the expression of TIE1 mRNA23300844
D002945CisplatinCisplatin affects the expression of TIE1 mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of TIE1 mRNA25016146
D004147DioxinsDioxins affects the expression of TIE1 mRNA20463971
C118739entinostatentinostat results in increased expression of TIE1 mRNA27188386
D004397FonofosFonofos results in increased methylation of TIE1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of TIE1 mRNA28937961
C069837fullerene C60fullerene C60 results in increased expression of TIE1 mRNA19167457
D005665FurosemideFurosemide results in increased expression of TIE1 mRNA16526316
D017313FenretinideFenretinide results in increased expression of TIE1 mRNA28973697
C025340manganese chloridemanganese chloride results in increased expression of TIE1 mRNA17467022
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of TIE1 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of TIE1 mRNA19564919
C028007nickel monoxidenickel monoxide affects the expression of TIE1 mRNA19167457
D010126OzoneOzone results in decreased expression of TIE1 mRNA12763052
D010278ParathionParathion results in increased methylation of TIE1 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TIE1 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TIE1 mRNA28511854
D010634PhenobarbitalPhenobarbital affects the expression of TIE1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TIE1 mRNA19482888
D010705PhosgenePhosgene affects the expression of TIE1 mRNA16300373
C006253pirinixic acidpirinixic acid results in increased expression of TIE1 mRNA17426115
C043680ptaquilosideptaquiloside results in decreased expression of TIE1 mRNA23274088
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of TIE1 mRNA19564919
D012969Sodium FluorideSodium Fluoride results in increased expression of TIE1 mRNA21340527
D013629TamoxifenTamoxifen results in increased expression of TIE1 mRNA15590111
C012568terbufosterbufos results in increased methylation of TIE1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TIE1 promoter]19654925
D014050TolueneToluene results in increased expression of TIE1 mRNA22967744
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of TIE1 mRNA]15363585
C012589trichostatin Atrichostatin A results in decreased expression of TIE1 mRNA15901671
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TIE1 mRNA29024780
D014635Valproic AcidValproic Acid results in decreased expression of TIE1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of TIE1 gene29154799
D014801Vitamin AVitamin A results in decreased expression of TIE1 mRNA17426644

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI21982860  25416956  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001570vasculogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0007165signal transduction-TAS1312667  
GO:0007275multicellular organism development-IBA21873635  
GO:0007498mesoderm development-TAS7596437  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0016525negative regulation of angiogenesis-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030336negative regulation of cell migration-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0045026plasma membrane fusion-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1312667  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20346360Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (2010 Jul)Roberts KEGastroenterology