Gene info: ID 7077

Gene: TIMP2

GENE ID: 7077

Synonyms: CSC-21K|DDC8

Description: TIMP metallopeptidase inhibitor 2

Gene type: protein-coding

Location: 17q25.3

dbXrefs: Ensembl:ENSG00000035862 MIM:188825 Vega:OTTHUMG00000154517 UniprotKB:P16035

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.337e-1 (AD) 1.148e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08012219	chr17:76913036	TIMP2	Gene body	7.239e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EIF4G2	0.885
CTNNB1	0.879
MSL1	0.876
ZNF512	0.876
ARMCX3	0.875
CBX1	0.873
KHDRBS1	0.871
YWHAQ	0.869
BTBD1	0.868
HDLBP	0.868

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.761
OR4F29	-0.744
MTRNR2L6	-0.219
MTRNR2L10	-0.198
C8orf74	-0.193
TTLL10	-0.179
MTRNR2L9	-0.173
KRTAP19-1	-0.172
PPBP	-0.17
NANOGNB	-0.168

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of TIMP2 mRNA"	19162173
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]"	11682029
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of TIMP2 mRNA	25827057
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TIMP2 mRNA	25827057
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TIMP2 mRNA"	19167446
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of TIMP2 mRNA"	25710175
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in decreased expression of TIMP2 mRNA"	22016648
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene results in decreased expression of TIMP2 mRNA"	16917068
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
C079315	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16033810
C488288	2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid	"[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with VEGFA protein] results in increased expression of TIMP2 protein"	25447407
C026308	3,4-dihydrocoumarin	"3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA"	22016648
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TIMP2 mRNA	16788091
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of TIMP2 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of TIMP2 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP2 mRNA"	27188386
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of TIMP2 mRNA	20829426
C080669	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein"	22245252
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP2 mRNA"	27188386
D000079	Acetaldehyde	Acetaldehyde results in increased expression of TIMP2 protein	12524413
D000082	Acetaminophen	Acetaminophen results in increased expression of TIMP2 mRNA	22230336
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine results in decreased expression of TIMP2 protein	19770485
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TIMP2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TIMP2 mRNA	19770486
D000393	Air Pollutants	[Glucose co-treated with Air Pollutants] results in decreased expression of TIMP2 mRNA	26179980
D019804	Mesalamine	Mesalamine results in increased expression of TIMP2 mRNA	10743803
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TIMP2 mRNA	16483693
D001151	Arsenic	Arsenic affects the expression of TIMP2 protein	24675094
D001151	Arsenic	Arsenic affects the methylation of TIMP2 gene	25304211
D001151	Arsenic	Arsenic results in decreased expression of TIMP2 mRNA	19654921
C025657	arsenic acid	arsenic acid results in increased expression of TIMP2 mRNA	18296743
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TIMP2 mRNA	15962302\|1662439
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TIMP2 protein	15962302\|1662439
C015001	arsenite	arsenite results in decreased expression of TIMP2 mRNA	18296743
D001194	Asbestos	TIMP2 gene SNP affects the susceptibility to Asbestos	24142982
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TIMP2"	16574944
D001241	Aspirin	Aspirin results in decreased expression of TIMP2 mRNA	15928584
D001241	Aspirin	Aspirin results in increased expression of TIMP2 mRNA	18971601
D001280	Atrazine	Atrazine results in decreased expression of TIMP2 mRNA	25929836
C547126	AZM551248	AZM551248 results in increased expression of TIMP2 mRNA	22323515
C080985	batimastat	batimastat results in decreased activity of TIMP2 protein	15632106
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]	16732983\|2082193
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein]	16732983\|2082193
D001542	Benomyl	Benomyl results in increased expression of TIMP2 mRNA	25530041
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TIMP2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TIMP2 protein	20719421
D001564	Benzo(a)pyrene	[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of TIMP2 protein	20719421
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
D004958	Estradiol	Estradiol results in decreased expression of TIMP2 mRNA	19167446\|1995687
D004958	Estradiol	Estradiol results in decreased expression of TIMP2 protein	19956873
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
C002503	betulin	betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
C002070	betulinic acid	betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
D001629	Bezafibrate	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]	18513333
C034786	bis(4-hydroxycinnamoyl)methane	bis(4-hydroxycinnamoyl)methane results in decreased expression of TIMP2 protein	18495463
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 mRNA	19956873
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 protein	19956873
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C006780	bisphenol A	bisphenol A results in decreased expression of TIMP2 mRNA	12233820
C006780	bisphenol A	bisphenol A results in decreased expression of TIMP2 mRNA	27925325
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 mRNA	25181051
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TIMP2 mRNA]	19228888
D000551	Ambroxol	Ambroxol affects the reaction [Paraquat results in increased expression of TIMP2 mRNA]	21921364
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA	19840844
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of TIMP2 protein	20719421
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TIMP2 protein	20719421
C081643	candesartan	candesartan results in decreased expression of TIMP2 mRNA	19047581
D002211	Capsaicin	Capsaicin results in increased expression of TIMP2 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D002220	Carbamazepine	Carbamazepine affects the expression of TIMP2 mRNA	25979313
C006698	carbendazim	carbendazim results in increased expression of TIMP2 mRNA	25530041
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TIMP2 mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TIMP2 mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 mRNA	14999682\|1505680
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 protein	16539848
D002251	Carbon Tetrachloride	IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16539848
D002251	Carbon Tetrachloride	IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 protein]	16539848
D002251	Carbon Tetrachloride	OSMR protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	14999682
D002251	Carbon Tetrachloride	POMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16508911
D002251	Carbon Tetrachloride	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16033810
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TIMP2 mRNA	15963342
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA	16420518
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 mRNA	15860571\|1603381
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 protein	17094476\|1715688
D002251	Carbon Tetrachloride	obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	15860571
C054133	casticin	casticin results in increased expression of TIMP2 mRNA	28444820
D000068579	Celecoxib	[Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA	16420518
C007020	chlorophyllin	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 mRNA]"	22485181
C007020	chlorophyllin	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]"	22485181
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D002794	Choline	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]	18513333
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA	18513333
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TIMP2 mRNA	17553155\|1932097
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TIMP2 protein	17553155
D005576	Colforsin	Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]	21832167
D005576	Colforsin	Colforsin results in increased expression of TIMP2 protein	21832167
D003300	Copper	Copper results in decreased expression of TIMP2 mRNA	24403277
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TIMP2 mRNA	15467011
D003300	Copper	[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein	11045606
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TIMP2 mRNA	19549813
C423222	cotylenin A	cotylenin A results in increased expression of TIMP2 mRNA	16129123
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TIMP2 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of TIMP2 mRNA	19167446
D003474	Curcumin	Curcumin results in decreased expression of TIMP2 protein	17996675
D003474	Curcumin	Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
C009160	cyclonite	cyclonite results in increased expression of TIMP2 mRNA	25559034
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of TIMP2 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of TIMP2 mRNA	20106945\|2163298
D003545	Cysteine	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TIMP2 mRNA	23640034
C107676	deguelin	deguelin results in increased expression of TIMP2 protein	25322282
C050229	demethoxycurcumin	demethoxycurcumin results in decreased expression of TIMP2 protein	18495463
D003907	Dexamethasone	Dexamethasone results in increased expression of TIMP2 mRNA	21247626
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of TIMP2 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of TIMP2 mRNA]	20032058
C028009	diallyl disulfide	diallyl disulfide results in increased expression of TIMP2 mRNA	20600798
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of TIMP2 mRNA	24084732
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of TIMP2 protein	24084732
D003976	Diazinon	Diazinon results in increased methylation of TIMP2 gene	22964155
D002945	Cisplatin	Cisplatin results in increased expression of TIMP2 mRNA	21151649
D002945	Cisplatin	Cisplatin results in decreased expression of TIMP2 mRNA	22023808
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA	16931933
D004041	Dietary Fats	Dietary Fats results in increased expression of TIMP2 mRNA	18296743
D004041	Dietary Fats	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of TIMP2 mRNA	19891982
D004051	Diethylhexyl Phthalate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
D004051	Diethylhexyl Phthalate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA	19956873
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of TIMP2 protein	19956873
D004051	Diethylhexyl Phthalate	fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
D004051	Diethylhexyl Phthalate	fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TIMP2 mRNA	28943392
D004052	Diethylnitrosamine	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 mRNA	12015029
D004052	Diethylnitrosamine	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 protein	12015029
D002117	Calcitriol	Calcitriol results in increased expression of TIMP2 mRNA	16002434
D015650	24,25-Dihydroxyvitamin D 3	"24,25-Dihydroxyvitamin D 3 results in decreased expression of TIMP2 protein"	18379402
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 mRNA"	21294050\|2248518
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 protein"	21294050\|2248518
D015127	9,10-Dimethyl-1,2-benzanthracene	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 mRNA]"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 mRNA]"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 protein]"	21294050
D004128	Dimethylnitrosamine	Dimethylnitrosamine affects the expression of TIMP2 mRNA	16042886
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased activity of TIMP2 protein	15161499
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TIMP2 mRNA	17036385\|1837115
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TIMP2 protein	16965748\|1734819
D004128	Dimethylnitrosamine	"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 mRNA]"	17036385\|1837115
D004128	Dimethylnitrosamine	"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]"	16965748
D004128	Dimethylnitrosamine	Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]	17348192
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11682029
D004237	Diuron	Diuron results in decreased expression of TIMP2 mRNA	21551480\|2515243
D004317	Doxorubicin	Doxorubicin results in decreased expression of TIMP2 mRNA	15033991
D004317	Doxorubicin	Doxorubicin results in increased expression of TIMP2 mRNA	22016648
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 mRNA]"	17036385\|1837115
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]"	16965748
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of TIMP2 protein"	17526172
D004610	Ellagic Acid	"Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]"	22485181
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of TIMP2 mRNA	12655031
D000431	Ethanol	betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
D000431	Ethanol	betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
D000431	Ethanol	Ethanol results in increased expression of TIMP2 protein	12524413\|2117240
D000431	Ethanol	Ethanol results in increased expression of TIMP2 mRNA	28069986
D005054	Eugenol	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]	20434464
D005054	Eugenol	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]	20434464
C093323	farnesylthiosalicylic acid	farnesylthiosalicylic acid results in increased expression of TIMP2 mRNA	15288472
D011345	Fenofibrate	Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]	28871336
C017690	fenvalerate	fenvalerate affects the expression of TIMP2 mRNA	20003521
C000499	ferric oxide	ferric oxide results in increased expression of TIMP2 protein	24885771
C093230	fexofenadine	fexofenadine inhibits the reaction [TNF protein results in increased expression of TIMP2 protein]	15663564
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA	20938992
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in increased expression of TIMP2 mRNA	12400877
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C070081	fulvestrant	fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
C070081	fulvestrant	fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
C039281	furan	furan results in increased expression of TIMP2 mRNA	27387713
D005665	Furosemide	Furosemide affects the expression of TIMP2 mRNA	16526316
D005707	Gallic Acid	Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TIMP2 mRNA]	24309158
D019833	Genistein	Genistein results in decreased expression of TIMP2 mRNA	15754008
D005944	Glucosamine	Glucosamine affects the expression of TIMP2 mRNA	17109745
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in decreased expression of TIMP2 mRNA]	17109745
D005947	Glucose	[Glucose co-treated with Air Pollutants] results in decreased expression of TIMP2 mRNA	26179980
D005947	Glucose	[Glucose co-treated with Particulate Matter] results in decreased expression of TIMP2 mRNA	26179980
D005947	Glucose	Glucose results in increased expression of TIMP2 protein	21367880
D005947	Glucose	isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]	21367880
C424943	glutamyl-Se-methylselenocysteine	glutamyl-Se-methylselenocysteine results in decreased expression of TIMP2 mRNA	11306469
C071834	glycidamide	glycidamide results in decreased expression of TIMP2 mRNA	17822822
C020905	glycyl-histidyl-lysine	[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein	11045606
C010176	halofuginone	halofuginone inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11172339\|1217562
C010176	halofuginone	halofuginone results in increased expression of TIMP2 mRNA	17180598
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of TIMP2 mRNA	15159207
D017313	Fenretinide	Fenretinide results in decreased expression of TIMP2 mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of TIMP2 mRNA	17183730
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TIMP2 mRNA	20044591
C031927	hydroquinone	[MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]	18055817
D019469	Indinavir	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA	16931933
D007213	Indomethacin	Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D007213	Indomethacin	Indomethacin results in increased expression of TIMP2 protein	16934674
D007213	Indomethacin	Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D007213	Indomethacin	Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TIMP2 mRNA	25613284
D019266	Iron, Dietary	"Iron, Dietary affects the reaction [Thioacetamide affects the expression of TIMP2 mRNA]"	18032466
C551631	isoangustone A	isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]	21367880
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TIMP2 mRNA	25961927
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of TIMP2 mRNA	26752646
D007657	Ketone Bodies	Ketone Bodies results in increased expression of TIMP2 mRNA	15469884
D007854	Lead	Lead affects the expression of TIMP2 mRNA	28903495
D019808	Losartan	Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]	20137537
D019808	Losartan	Losartan results in decreased expression of TIMP2 mRNA	20137537
D019808	Losartan	Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]	20137537
D008550	Melatonin	Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of TIMP2 mRNA	20353558
D008694	Methamphetamine	Methamphetamine results in increased activity of TIMP2 protein	18198472
D008694	Methamphetamine	TIMP2 protein results in decreased susceptibility to Methamphetamine	18198472
D008715	Methionine	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]	18513333
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA	18513333
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA	20938992
D008715	Methionine	Methionine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 mRNA	12015029
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 protein	12015029
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TIMP2 mRNA	23179753\|2800136
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]	20434464
D008769	Methylnitronitrosoguanidine	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]	20434464
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA	20434464
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein	20434464
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TIMP2 mRNA	19883732
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TIMP2 protein	19883732
D015655	1-Methyl-4-phenylpyridinium	TIMP2 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	19883732
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of TIMP2 mRNA	29191790
D008790	Metoprolol	Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 mRNA	21832167
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein	21832167
C016599	mono-(2-ethylhexyl)phthalate	Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]	21832167
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 mRNA	21832167
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein	21832167
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TIMP2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TIMP2 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TIMP2 mRNA	25380136
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
C433446	N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine	N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	22841774
C029938	nickel sulfate	nickel sulfate results in increased expression of TIMP2 mRNA	15020194
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of TIMP2 mRNA	18796497
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of TIMP2 protein	18796497
C007350	nitrofen	nitrofen results in decreased expression of TIMP2 mRNA	20638522
C025256	nonylphenol	nonylphenol results in decreased expression of TIMP2 mRNA	22982499
C069741	norcantharidin	norcantharidin results in increased expression of TIMP2 mRNA	16681930
C069741	norcantharidin	norcantharidin results in increased expression of TIMP2 protein	16681930
D009638	Norepinephrine	Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
D009638	Norepinephrine	Norepinephrine results in increased expression of TIMP2 mRNA	14577597\|1532608
D009638	Norepinephrine	Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
C464660	obeticholic acid	obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	15860571
C025589	ochratoxin A	ochratoxin A results in increased acetylation of TIMP2 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of TIMP2 promoter] which results in increased expression of TIMP2 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of TIMP2 mRNA	29098329
C025589	ochratoxin A	[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of TIMP2 mRNA	28710020
C025589	ochratoxin A	ochratoxin A results in increased expression of TIMP2 mRNA	14994279
D016627	Oxidopamine	Oxidopamine results in decreased expression of TIMP2 mRNA	19883732
D016627	Oxidopamine	Oxidopamine results in decreased expression of TIMP2 protein	19883732
D016627	Oxidopamine	TIMP2 protein results in decreased susceptibility to Oxidopamine	19883732
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA	19840844
D000069463	Olive Oil	Olive Oil promotes the reaction [Streptozocin results in increased activity of TIMP2 protein]	25246140
D009853	Omeprazole	Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D009930	Organic Chemicals	Organic Chemicals results in increased expression of TIMP2 mRNA	20526952
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of TIMP2 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of TIMP2 mRNA	16980344
D010126	Ozone	Ozone results in increased expression of TIMP2 mRNA	20980218
D010269	Paraquat	Paraquat results in decreased expression of TIMP2 mRNA	17215068
D010269	Paraquat	Paraquat results in decreased expression of TIMP2 protein	26988026
D010269	Paraquat	Ambroxol affects the reaction [Paraquat results in increased expression of TIMP2 mRNA]	21921364
D010269	Paraquat	Paraquat affects the expression of TIMP2 mRNA	16854511
D052638	Particulate Matter	[Glucose co-treated with Particulate Matter] results in decreased expression of TIMP2 mRNA	26179980
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of TIMP2 mRNA	18593933
C074968	pentaacetyl geniposide	pentaacetyl geniposide results in increased expression of TIMP2 mRNA	19464279
D010634	Phenobarbital	Phenobarbital affects the expression of TIMP2 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TIMP2 mRNA	26272509
D010862	Pilocarpine	Pilocarpine results in increased expression of TIMP2 mRNA	14656328
D010936	Plant Extracts	Plant Extracts results in decreased expression of TIMP2 mRNA	22144737
D010936	Plant Extracts	Plant Extracts results in increased expression of TIMP2 mRNA	23232078
D028321	Plant Preparations	Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]	17348192
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of TIMP2 mRNA	25716161
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TIMP2 protein	23718831
D017035	Pravastatin	Pravastatin results in decreased expression of TIMP2 mRNA	16935385
D011224	Prazosin	Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
D011374	Progesterone	[Progesterone co-treated with Triclosan] results in decreased expression of TIMP2 mRNA	26604029
D011372	Progestins	Progestins results in decreased expression of TIMP2 mRNA	19609016
C005556	propionaldehyde	propionaldehyde results in increased expression of TIMP2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TIMP2 mRNA	24780913
D015237	Dinoprost	Dinoprost results in increased expression of TIMP2 mRNA	21247626
C526689	punarnavine	punarnavine results in increased expression of TIMP2 protein	24060680
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	15078482
D011794	Quercetin	Quercetin results in increased expression of TIMP2 mRNA	15309432\|2163298
D011794	Quercetin	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 mRNA]"	21294050
D011794	Quercetin	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 protein]"	21294050
C059514	resveratrol	resveratrol results in decreased expression of TIMP2 mRNA	25394648
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D012402	Rotenone	Rotenone results in increased expression of TIMP2 mRNA	22016648
D019258	Saquinavir	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA	16931933
C093642	SB 203580	SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C410733	scriptaid	scriptaid affects the expression of TIMP2 mRNA	18813790
D012643	Selenium	Selenium inhibits the reaction [T-2 Toxin results in decreased expression of TIMP2 protein]	21144892
D012643	Selenium	Selenium results in decreased expression of TIMP2 mRNA	17390030
D012715	Sesame Oil	Sesame Oil results in increased expression of TIMP2 mRNA	29191790
D019821	Simvastatin	Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]	20137537
D019821	Simvastatin	Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]	20137537
D019821	Simvastatin	Simvastatin results in decreased expression of TIMP2 mRNA	20137537
C012037	solasodine	solasodine results in increased expression of TIMP2 mRNA	28283413
D012999	Soman	Soman results in increased expression of TIMP2 mRNA	19281266
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]	16732983\|2082193
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein]	16732983\|2082193
D013311	Streptozocin	Olive Oil promotes the reaction [Streptozocin results in increased activity of TIMP2 protein]	25246140
D013311	Streptozocin	Streptozocin results in increased activity of TIMP2 protein	25246140
D013311	Streptozocin	Streptozocin results in increased expression of TIMP2 mRNA	16732983\|2082193
D013311	Streptozocin	Streptozocin results in increased expression of TIMP2 protein	16732983\|2082193
D013427	Sulfapyridine	Sulfapyridine results in increased expression of TIMP2 mRNA	10743803
D012460	Sulfasalazine	Sulfasalazine results in increased expression of TIMP2 mRNA	22016648
C016766	sulforafan	sulforafan results in increased expression of TIMP2 mRNA	26833863
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
C446685	systhane	systhane results in increased expression of TIMP2 mRNA	16643972
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TIMP2 mRNA]	19228888
D014284	Triiodothyronine	Triiodothyronine results in increased expression of TIMP2 mRNA	19228888
D013605	T-2 Toxin	Selenium inhibits the reaction [T-2 Toxin results in decreased expression of TIMP2 protein]	21144892
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of TIMP2 protein	21144892
D013605	T-2 Toxin	T-2 Toxin affects the expression of TIMP2 mRNA	21112371
C087114	tebuconazole	tebuconazole results in increased expression of TIMP2 mRNA	26852204
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of TIMP2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TIMP2 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIMP2 mRNA	19684285\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TIMP2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIMP2 mRNA	15667827\|1758670
C117155	tetracycline CMT-3	tetracycline CMT-3 results in decreased secretion of TIMP2 protein	11857423
C117155	tetracycline CMT-3	tetracycline CMT-3 results in decreased secretion of TIMP2 protein	11857423
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TIMP2 protein	19969058
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA	19840844
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TIMP2 mRNA	25613284
D013792	Thalidomide	Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15464241
D013853	Thioacetamide	IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	16126171
D013853	Thioacetamide	Thioacetamide results in increased expression of TIMP2 mRNA	16126171
D013853	Thioacetamide	"1,3-dimethylthiourea inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]"	11682029
D013853	Thioacetamide	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TIMP2 mRNA	28943392
D013853	Thioacetamide	Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11682029
D013853	Thioacetamide	halofuginone inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11172339\|1217562
D013853	Thioacetamide	"Iron, Dietary affects the reaction [Thioacetamide affects the expression of TIMP2 mRNA]"	18032466
D013853	Thioacetamide	Methionine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
D013853	Thioacetamide	pyrrolidine dithiocarbamic acid inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	15078482
D013853	Thioacetamide	Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15464241
D013853	Thioacetamide	Thioacetamide results in increased expression of TIMP2 mRNA	15158331\|1546424
D013853	Thioacetamide	Thioacetamide results in increased expression of TIMP2 protein	11172339\|1168202
C003466	thymoquinone	pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C003466	thymoquinone	SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C003466	thymoquinone	thymoquinone results in increased expression of TIMP2 protein	27060453
C009495	titanium dioxide	titanium dioxide results in decreased expression of TIMP2 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TIMP2 mRNA	27404394\|2786577
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of TIMP2 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TIMP2 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of TIMP2 mRNA	24374174
D014212	Tretinoin	Tretinoin results in increased expression of TIMP2 mRNA	16129123
D014212	Tretinoin	Tretinoin results in increased expression of TIMP2 mRNA	16788091
D014260	Triclosan	[Progesterone co-treated with Triclosan] results in decreased expression of TIMP2 mRNA	26604029
D014260	Triclosan	Triclosan results in decreased expression of TIMP2 mRNA	26604029
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of TIMP2 mRNA	29024780
C057693	troglitazone	troglitazone results in increased expression of TIMP2 mRNA	28973697
C113580	U 0126	U 0126 inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	22841774
D014520	Urethane	Urethane results in increased expression of TIMP2 mRNA	28818685
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in increased expression of TIMP2 mRNA	12400877
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of TIMP2 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of TIMP2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TIMP2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of TIMP2 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of TIMP2 gene	29154799
D001335	Vehicle Emissions	[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of TIMP2 mRNA	19150882
D001335	Vehicle Emissions	[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of TIMP2 protein	19150882
D001335	Vehicle Emissions	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of TIMP2 mRNA	19891982
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of TIMP2 mRNA	17065432\|2019724
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of TIMP2 mRNA	20980218
C573672	VI-14 flavonoid	VI-14 flavonoid results in increased expression of TIMP2 protein	22538171
C025643	vinclozolin	vinclozolin affects the expression of TIMP2 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TIMP2 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TIMP2 mRNA	20044591
C111237	vorinostat	vorinostat results in increased expression of TIMP2 protein	19509267
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of TIMP2 mRNA"	20526952
C009687	wortmannin	wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	22841774
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA	16931933
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of TIMP2 mRNA	18593933
C088658	zoledronic acid	zoledronic acid results in increased expression of TIMP2 mRNA	28871336
C088658	zoledronic acid	zoledronic acid results in increased expression of TIMP2 protein	28871336
C088658	zoledronic acid	Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]	28871336
C088658	zoledronic acid	SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]	28871336
C088658	zoledronic acid	zoledronic acid results in increased expression of TIMP2 mRNA	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IBA	21873635
GO:0002020	protease binding	-	IPI	9573338
GO:0005178	integrin binding	-	IEA	-
GO:0005515	protein binding	-	IPI	24112707
GO:0008191	metalloendopeptidase inhibitor activity	-	IBA	21873635
GO:0008191	metalloendopeptidase inhibitor activity	-	IEA	-
GO:0008270	zinc ion binding	-	IDA	24073280
GO:0030414	peptidase inhibitor activity	-	IDA	9573338

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007417	central nervous system development	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009725	response to hormone	-	IBA	21873635
GO:0010033	response to organic substance	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0032487	regulation of Rap protein signal transduction	-	IEA	-
GO:0034097	response to cytokine	-	IBA	21873635
GO:0042493	response to drug	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043410	positive regulation of MAPK cascade	-	IEA	-
GO:0045666	positive regulation of neuron differentiation	-	IEA	-
GO:0045762	positive regulation of adenylate cyclase activity	-	IEA	-
GO:0045930	negative regulation of mitotic cell cycle	-	IEA	-
GO:0046580	negative regulation of Ras protein signal transduction	-	IEA	-
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	-	IBA	21873635
GO:1905049	negative regulation of metallopeptidase activity	-	IDA	9573338

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0009986	cell surface	-	IEA	-
GO:0030426	growth cone	-	IEA	-
GO:0035580	specific granule lumen	-	TAS	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707
GO:1904724	tertiary granule lumen	-	TAS	-
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16919984	Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. (2007)	Tomaki M	Pulm Pharmacol Ther
23536957	The role of MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants in age-related macular degeneration. (2013 Dec)	Ortak H	Ophthalmic Genet
26846412	Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. (2016 Feb 5)	Ramos BR	BMC Pregnancy Childbirth
22888638	[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. (2012 May-Jun)	Korytina GF	Mol Biol (Mosk)
23146278	Heavy smoking before coronary surgical procedures affects the native matrix metalloproteinase-2 and matrix metalloproteinase-9 gene expression in saphenous vein conduits. (2013 Jan)	Yongxin S	Ann Thorac Surg
22209925	Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications. (2011 Dec)	Mocchegiani E	Curr Opin Pulm Med