Gene: TIMP3

7078
HSMRK222|K222|K222TA2|SFD
TIMP metallopeptidase inhibitor 3
protein-coding
22q12.3
Ensembl:ENSG00000100234 MIM:188826 Vega:OTTHUMG00000030784 UniprotKB:P35625
NG_009117.1
PubMed
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.986e-1 (AD)  7.910e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LEPROT0.868
STOM0.865
S1PR10.858
PDLIM50.856
EPS80.843
FOXO10.835
PON20.829
MAOA0.826
CYBRD10.825
LIX1L0.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALHM1-0.49
ABCC12-0.479
OR4F29-0.478
RTP1-0.472
KCNB2-0.464
OR4F5-0.457
CDCA5-0.446
OPRD1-0.443
CACNA1F-0.441
TYRP1-0.44

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05383PimagedineSmall Molecule79-17-4InvestigationalTarget
ID Drug Name Action PubMed
C0523831,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in decreased expression of TIMP3 mRNA"23373633
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of TIMP3 mRNA25827057
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TIMP3 mRNA"15215175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TIMP3 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"27188386
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in increased expression of TIMP3 mRNA15135645
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TIMP3 mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of TIMP3 mRNA27761495
D000082AcetaminophenAcetaminophen results in increased expression of TIMP3 mRNA21420995|2776149
D000082AcetaminophenAcetaminophen affects the expression of TIMP3 mRNA17562736
D000171AcroleinAcrolein results in decreased expression of TIMP3 mRNA15531749|2174278
D000171AcroleinTIMP3 protein inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]15531749
D000171AcroleinAcrolein results in decreased expression of TIMP3 mRNA18006877
D020106AcrylamideAcrylamide results in decreased expression of TIMP3 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TIMP3 mRNA16483693
D003504AncitabineTIMP3 protein affects the susceptibility to Ancitabine18202788
C023650anilineaniline results in increased expression of TIMP3 mRNA22016648
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TIMP3 mRNA24449571
C068151aphidicolin glycinateTIMP3 gene modified form results in decreased susceptibility to aphidicolin glycinate18202788
C006632arsenic trioxidearsenic trioxide results in increased expression of TIMP3 mRNA17530438
D017639Asbestos, Amosite"Asbestos, Amosite results in decreased expression of TIMP3 mRNA"23917077
C547126AZM551248AZM551248 results in decreased expression of TIMP3 mRNA22323515
C487081belinostatbelinostat results in decreased expression of TIMP3 mRNA26272509
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of TIMP3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TIMP3 mRNA26238291
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of TIMP3 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TIMP3 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TIMP3 mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TIMP3 mRNA"20018196
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of TIMP3 mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TIMP3 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP3 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of TIMP3 mRNA16474171|1916744
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of TIMP3 mRNA20226447
C006780bisphenol Abisphenol A results in decreased expression of TIMP3 mRNA16474171|2660402
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TIMP3 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of TIMP3 mRNA15866537
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TIMP3 mRNA15336504
D002087ButyratesButyrates results in increased expression of TIMP3 mRNA14674679
C584509C646 compoundC646 compound results in increased expression of TIMP3 mRNA23698071
D002104CadmiumCadmium results in increased expression of TIMP3 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TIMP3 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TIMP3 mRNA25993096
C081643candesartancandesartan results in decreased expression of TIMP3 mRNA19047581
C459604candoxincandoxin results in decreased expression of TIMP3 mRNA16309724
D002211CapsaicinCapsaicin results in increased expression of TIMP3 mRNA21310942
D002211CapsaicinCapsaicin results in increased expression of TIMP3 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TIMP3 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TIMP3 mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TIMP3 mRNA19784758
D004390ChlorpyrifosChlorpyrifos results in increased expression of TIMP3 mRNA20350560
D002784CholesterolCholesterol results in increased expression of TIMP3 mRNA26296894
D002784CholesterolCLEC4E protein inhibits the reaction [Cholesterol results in increased expression of TIMP3 mRNA]26296894
D002809Chondroitin Sulfates[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA17605605
C038142chondroitin sulfate glycosaminoglycan[N6L peptide binds to chondroitin sulfate glycosaminoglycan] which results in increased secretion of TIMP3 protein23109338
D002857ChromiumChromium results in increased expression of TIMP3 mRNA21437242
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of TIMP3 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of TIMP3 mRNA18353800
D002994ClofibrateClofibrate affects the expression of TIMP3 mRNA16081524
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TIMP3 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of TIMP3 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of TIMP3 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of TIMP3 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of TIMP3 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of TIMP318462866
D016572CyclosporineCyclosporine results in decreased expression of TIMP3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of TIMP3 mRNA27989131
D003561CytarabineTIMP3 gene modified form results in decreased susceptibility to Cytarabine18202788
D003561CytarabineTIMP3 protein affects the susceptibility to Cytarabine18202788
C017180decamethrindecamethrin results in increased expression of TIMP3 mRNA19017407
C014347decitabinedecitabine affects the methylation of TIMP3 promoter17671114
C014347decitabinedecitabine results in increased expression of TIMP3 mRNA16367923|1921582
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of TIMP3 promoter] which affects the expression of TIMP3 mRNA18836996|1883699
C014347decitabinedecitabine results in increased expression of TIMP3 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP3 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of TIMP3 mRNA22733784
D003907DexamethasoneDexamethasone inhibits the reaction [sephadex results in decreased expression of TIMP3 mRNA]25878373
D016264Dextran SulfateADAM17 protein affects the reaction [Dextran Sulfate results in decreased expression of TIMP3 mRNA]24548422
D016264Dextran SulfateDextran Sulfate results in decreased expression of TIMP3 mRNA24548422
D016264Dextran Sulfateresveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of TIMP3 mRNA]24548422
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TIMP3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TIMP3 mRNA21266533
D002945CisplatinCisplatin affects the expression of TIMP3 mRNA21151649
D004026DieldrinDieldrin affects the expression of TIMP3 mRNA22546817
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of TIMP3 mRNA17490981
D004041Dietary FatsDietary Fats results in increased expression of TIMP3 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of TIMP3 mRNA]21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of TIMP3 protein21163286
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of TIMP3 gene21163286
D002117CalcitriolCalcitriol results in decreased expression of TIMP3 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of TIMP3 mRNA26485663
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TIMP3 mRNA23197195
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of TIMP3 mRNA16314067
D004237DiuronDiuron results in decreased expression of TIMP3 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of TIMP3 mRNA22016648
D004317DoxorubicinDoxorubicin results in increased expression of TIMP3 protein17609194
C118739entinostatentinostat results in increased expression of TIMP3 mRNA27188386
C045651epigallocatechin gallate[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA12628509
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TIMP3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TIMP3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMP3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TIMP3 mRNA15866537|1735126
C540355fenamidonefenamidone results in increased expression of TIMP3 mRNA27029645
D005467FloxuridineTIMP3 gene modified form results in decreased susceptibility to Floxuridine18202788
D005467FloxuridineTIMP3 protein affects the susceptibility to Floxuridine18202788
D005557FormaldehydeFormaldehyde results in decreased expression of TIMP3 mRNA17285311
D005707Gallic AcidGallic Acid inhibits the reaction [ALB modified form results in decreased expression of TIMP3 mRNA]24309158
D019833GenisteinGenistein results in decreased expression of TIMP3 mRNA15754008|1647417
D005897GlafenineGlafenine results in increased expression of TIMP3 mRNA24136188
D005944Glucosamine[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA17605605
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in decreased expression of TIMP3 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of TIMP3 mRNA17109745
D005944GlucosamineIL1B affects the reaction [Glucosamine results in increased expression of TIMP3 mRNA]17109745
C065632glucosamine 3-O-sulfateglucosamine 3-O-sulfate results in decreased expression of TIMP3 mRNA16300972
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TIMP3 mRNA22634610
C424943glutamyl-Se-methylselenocysteineglutamyl-Se-methylselenocysteine results in decreased expression of TIMP3 mRNA11306469
C071834glycidamideglycidamide results in decreased expression of TIMP3 mRNA17822822
C010974glyphosateglyphosate results in increased expression of TIMP3 mRNA17984146
C121944HB-19 peptideHB-19 peptide results in increased secretion of TIMP3 protein23109338
D006497Heparitin Sulfate[N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein23109338
D007166Immunosuppressive AgentsImmunosuppressive Agents affects the expression of TIMP3 protein19652986
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIMP3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP3 mRNA16054899
D007545IsoproterenolIsoproterenol results in increased expression of TIMP3 protein24286936
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TIMP3 mRNA25961927
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TIMP3 mRNA26644586
C410337K 7174K 7174 results in decreased expression of TIMP3 mRNA24086573
C045463leflunomideleflunomide results in increased expression of TIMP3 mRNA28988120
D008044LinuronLinuron affects the expression of TIMP3 mRNA12730624
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 affects the expression of TIMP3 mRNA"18986645
C433788lipopolysaccharide, E. coli O26-B6"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA"18986645
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TIMP3 mRNA"11578593
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TIMP3 mRNA26378955
D008294MalathionMalathion results in decreased expression of TIMP3 mRNA19784758
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of TIMP3 mRNA20843944
D008713MethimazoleMethimazole results in decreased expression of TIMP3 mRNA17403546
D008727MethotrexateMethotrexate results in increased expression of TIMP3 mRNA21678067
C005219methyl cellosolvemethyl cellosolve results in increased expression of TIMP3 mRNA21061450
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of TIMP3 protein21163286
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of TIMP3 gene21163286
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TIMP3 mRNA28001369
D008743Methyl ParathionMethyl Parathion affects the expression of TIMP3 mRNA19784758
D008743Methyl ParathionMethyl Parathion results in increased expression of TIMP3 mRNA19784758
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]"20230807
C000873methylprednisolone acetatemethylprednisolone acetate results in increased expression of TIMP3 mRNA15693093
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of TIMP3 mRNA"25461557
C580583N6L peptide[N6L peptide binds to chondroitin sulfate glycosaminoglycan] which results in increased secretion of TIMP3 protein23109338
C580583N6L peptide[N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein23109338
C580583N6L peptideN6L peptide results in increased secretion of TIMP3 protein23109338
C580583N6L peptide[N6L peptide results in increased secretion of TIMP3 protein] which results in decreased activity of ADAM17 protein23109338
C580583N6L peptide[N6L peptide results in increased secretion of TIMP3 protein] which results in decreased activity of MMP2 protein23109338
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TIMP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TIMP3 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of TIMP3 mRNA18978301
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TIMP3 mRNA19812364
D009532NickelNickel results in decreased expression of TIMP3 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of TIMP3 mRNA22546817
C029938nickel sulfatenickel sulfate results in decreased expression of TIMP3 mRNA22714537
C029938nickel sulfatenickel sulfate results in increased expression of TIMP3 mRNA16314067
D009538NicotineNicotine affects the expression of TIMP3 mRNA18986645
D009538Nicotine"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA"18986645
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]"20230807
C007350nitrofennitrofen results in decreased expression of TIMP3 mRNA20638522
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA"18778698
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA]"18778698
C025589ochratoxin Aochratoxin A results in decreased expression of TIMP3 mRNA18417182
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP3 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TIMP3 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of TIMP3 mRNA16980344
D010269ParaquatParaquat results in increased expression of TIMP3 mRNA16854511
D052638Particulate MatterTIMP3 protein inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]18474546
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased secretion of TIMP3 protein10968687
C494474perchlorateperchlorate results in decreased expression of TIMP3 mRNA17403546
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TIMP3 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TIMP3 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of TIMP3 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of TIMP3 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of TIMP3 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of TIMP3 mRNA16474171
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TIMP3 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TIMP3 mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TIMP3 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of TIMP3 mRNA20226447
D011374ProgesteroneProgesterone results in decreased expression of TIMP3 mRNA26604029
D011374ProgesteroneProgesterone results in increased expression of TIMP3 mRNA20864642
D011374ProgesteroneProgesterone affects the expression of TIMP3 mRNA21291521
D011374ProgesteroneProgesterone results in increased expression of TIMP3 mRNA20726854
D011372ProgestinsProgestins results in decreased expression of TIMP3 mRNA19609016
D011441PropylthiouracilPropylthiouracil results in decreased expression of TIMP3 mRNA17403546
D015237DinoprostDinoprost results in decreased expression of TIMP3 mRNA11517196
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TIMP3 mRNA27029645
C037219quinolinequinoline analog results in decreased methylation of TIMP3 promoter19417133
C037219quinolinequinoline analog results in increased expression of TIMP3 mRNA19417133
C037219quinolinequinoline analog results in increased expression of TIMP3 protein19417133
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of TIMP3 mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of TIMP3 mRNA]24548422
C059514resveratrolresveratrol results in decreased expression of TIMP3 mRNA25394648
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of TIMP3 mRNA]21852083
D015474IsotretinoinIsotretinoin results in increased expression of TIMP3 mRNA20436886
C009166retinol acetateretinol acetate results in increased expression of TIMP3 mRNA16772331
C116926rofecoxibrofecoxib results in decreased expression of TIMP3 mRNA16580899
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP3 mRNA16054899
D012402RotenoneRotenone results in increased expression of TIMP3 mRNA22016648
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TIMP3 mRNA21427059
C010327salinomycinsalinomycin results in decreased expression of TIMP3 mRNA19682730
D012643SeleniumSelenium results in decreased expression of TIMP3 mRNA17390030
D012643SeleniumSelenium results in increased expression of TIMP3 mRNA19244175
C025614sephadexDexamethasone inhibits the reaction [sephadex results in decreased expression of TIMP3 mRNA]25878373
C025614sephadexsephadex results in decreased expression of TIMP3 mRNA25878373
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of TIMP3 mRNA"24160326
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TIMP3 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TIMP3 mRNA25351596
D012834SilverSilver results in increased expression of TIMP3 mRNA28959546
D012834SilverSilver results in decreased expression of TIMP3 mRNA27131904
D020123SirolimusSirolimus results in decreased expression of TIMP3 mRNA21742783
D020123SirolimusSirolimus results in decreased expression of TIMP3 protein21742783
D012906SmokeSmoke results in decreased expression of TIMP3 mRNA21095227|2174278
D012906SmokeSmoke results in decreased expression of TIMP3 protein21742783
D012906Smoke[Smoke co-treated with AGT protein modified form] results in decreased expression of TIMP3 mRNA20937366
D012906Smoke[Smoke results in decreased expression of MTOR] which affects the expression of TIMP321742783
C009277sodium arsenatesodium arsenate results in increased expression of TIMP3 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of TIMP3 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of TIMP3 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of TIMP3 mRNA12634122
D053260SootSoot results in increased expression of TIMP3 mRNA26551751
C471405sorafenibsorafenib results in decreased expression of TIMP3 mRNA21360571
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TIMP3 mRNA26378955
D012460SulfasalazineSulfasalazine results in increased expression of TIMP3 mRNA22016648
D013467Sulindac[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA12628509
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]22150557
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of TIMP3 mRNA22467014
D013629TamoxifenTamoxifen affects the expression of TIMP3 mRNA17555576
C112765tanespimycintanespimycin results in increased expression of TIMP3 mRNA19514085
D013739TestosteroneTestosterone results in increased expression of TIMP3 mRNA15788153
C004648testosterone enanthatetestosterone enanthate affects the expression of TIMP3 mRNA17440010
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TIMP3 mRNA12377990|1669712
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TIMP3 mRNA19465110|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TIMP3 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMP3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA15034205|1758670
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TIMP3 mRNA18172886|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA20959002|2121527
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of TIMP3 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIMP3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of TIMP3 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of TIMP3 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP3 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of TIMP3 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of TIMP3 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TIMP3 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of TIMP3 mRNA24935251
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of TIMP3 promoter] which affects the expression of TIMP3 mRNA18836996|1883699
D014260TriclosanTriclosan results in decreased expression of TIMP3 mRNA26604029
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TIMP3 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of TIMP3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TIMP3 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased methylation of TIMP3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TIMP3 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of TIMP3 mRNA21427059|2489608
D014640VancomycinVancomycin results in increased expression of TIMP3 mRNA18930951
D001335Vehicle EmissionsTIMP3 protein inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]18474546
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of TIMP3 mRNA15541757
C025643vinclozolinvinclozolin affects the expression of TIMP3 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of TIMP3 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of TIMP3 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of TIMP3 mRNA26272509
D015032ZincZinc results in increased expression of TIMP3 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of TIMP3 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IBA21873635  
GO:0005515protein binding-IPI18344519  18638486  
GO:0008191metalloendopeptidase inhibitor activity-IBA21873635  
GO:0008191metalloendopeptidase inhibitor activity-TAS18638486  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0007601visual perception-IEA-  
GO:0009725response to hormone-IBA21873635  
GO:0010033response to organic substance-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0034097response to cytokine-IBA21873635  
GO:0051045negative regulation of membrane protein ectodomain proteolysis-IBA21873635  
GO:0051045negative regulation of membrane protein ectodomain proteolysis-IMP18383040  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IMP19962668  
GO:0071310cellular response to organic substance-IEA-  
GO:1903984positive regulation of TRAIL-activated apoptotic signaling pathway-IMP19962668  
GO:1904684negative regulation of metalloendopeptidase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-HDA21630459  
GO:0031089platelet dense granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27601084A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene. (2016 Sep 7)Meunier ISci Rep
26197083MMP, VEGF and TIMP as prognostic factors in recurring bladder cancer. (2015 Dec)Wieczorek EClin Biochem
28421310Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)Strzelczyk JKBiochem Genet
26116372MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)Melnik BCJ Transl Med
18676844RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. (2008 Aug 1)Wolff EMCancer Res
15911247CpG island methylation and expression of tumour-associated genes in lung carcinoma. (2005 May)Dammann REur J Cancer
22649395Association of Cigarette Smoking with Aberrant Methylation of the Tumor Suppressor Gene RARbeta2 in Papillary Thyroid Cancer. (2011)Kiseljak-Vassiliades KFront Endocrinol (Lausanne)
23838140Aberrant promoter methylation of cell adhesion-related genes associated with clinicopathologic features in non-small cell lung cancer in China. (2013)Xu PWCancer Biomark
20572039Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. (2010 Oct 1)Paun BCCancer
22888638[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. (2012 May-Jun)Korytina GFMol Biol (Mosk)
29487693Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants. (2018 Jan 30)Cascella ROncotarget