Gene info: ID 7078

Gene: TIMP3

GENE ID: 7078

Synonyms: HSMRK222|K222|K222TA2|SFD

Description: TIMP metallopeptidase inhibitor 3

Gene type: protein-coding

Location: 22q12.3

dbXrefs: Ensembl:ENSG00000100234 MIM:188826 Vega:OTTHUMG00000030784 UniprotKB:P35625

RefSeq: NG_009117.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.986e-1 (AD) 7.910e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LEPROT	0.868
STOM	0.865
S1PR1	0.858
PDLIM5	0.856
EPS8	0.843
FOXO1	0.835
PON2	0.829
MAOA	0.826
CYBRD1	0.825
LIX1L	0.824

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CALHM1	-0.49
ABCC12	-0.479
OR4F29	-0.478
RTP1	-0.472
KCNB2	-0.464
OR4F5	-0.457
CDCA5	-0.446
OPRD1	-0.443
CACNA1F	-0.441
TYRP1	-0.44

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05383	Pimagedine	Small Molecule	79-17-4	Investigational	Target

ID	Drug Name	Action	PubMed
C052383	1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene	"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in decreased expression of TIMP3 mRNA"	23373633
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of TIMP3 mRNA	25827057
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TIMP3 mRNA"	15215175
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TIMP3 mRNA"	23196670
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"	27188386
C065250	4-hydroxy-equilenin	4-hydroxy-equilenin results in increased expression of TIMP3 mRNA	15135645
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TIMP3 mRNA"	19936915
D000082	Acetaminophen	Acetaminophen results in decreased expression of TIMP3 mRNA	27761495
D000082	Acetaminophen	Acetaminophen results in increased expression of TIMP3 mRNA	21420995\|2776149
D000082	Acetaminophen	Acetaminophen affects the expression of TIMP3 mRNA	17562736
D000171	Acrolein	Acrolein results in decreased expression of TIMP3 mRNA	15531749\|2174278
D000171	Acrolein	TIMP3 protein inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	Acrolein results in decreased expression of TIMP3 mRNA	18006877
D020106	Acrylamide	Acrylamide results in decreased expression of TIMP3 mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TIMP3 mRNA	16483693
D003504	Ancitabine	TIMP3 protein affects the susceptibility to Ancitabine	18202788
C023650	aniline	aniline results in increased expression of TIMP3 mRNA	22016648
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TIMP3 mRNA	24449571
C068151	aphidicolin glycinate	TIMP3 gene modified form results in decreased susceptibility to aphidicolin glycinate	18202788
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TIMP3 mRNA	17530438
D017639	Asbestos, Amosite	"Asbestos, Amosite results in decreased expression of TIMP3 mRNA"	23917077
C547126	AZM551248	AZM551248 results in decreased expression of TIMP3 mRNA	22323515
C487081	belinostat	belinostat results in decreased expression of TIMP3 mRNA	26272509
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of TIMP3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TIMP3 mRNA	26238291
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of TIMP3 mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TIMP3 mRNA	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TIMP3 mRNA	21569818\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TIMP3 mRNA"	20018196
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of TIMP3 mRNA	20404318
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of TIMP3 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP3 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of TIMP3 mRNA	16474171\|1916744
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of TIMP3 mRNA	20226447
C006780	bisphenol A	bisphenol A results in decreased expression of TIMP3 mRNA	16474171\|2660402
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of TIMP3 mRNA	25594700
C006780	bisphenol A	bisphenol A results in decreased expression of TIMP3 mRNA	15866537
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of TIMP3 mRNA	15336504
D002087	Butyrates	Butyrates results in increased expression of TIMP3 mRNA	14674679
C584509	C646 compound	C646 compound results in increased expression of TIMP3 mRNA	23698071
D002104	Cadmium	Cadmium results in increased expression of TIMP3 mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TIMP3 mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TIMP3 mRNA	25993096
C081643	candesartan	candesartan results in decreased expression of TIMP3 mRNA	19047581
C459604	candoxin	candoxin results in decreased expression of TIMP3 mRNA	16309724
D002211	Capsaicin	Capsaicin results in increased expression of TIMP3 mRNA	21310942
D002211	Capsaicin	Capsaicin results in increased expression of TIMP3 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TIMP3 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP3 mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP3 mRNA	19784758
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of TIMP3 mRNA	20350560
D002784	Cholesterol	Cholesterol results in increased expression of TIMP3 mRNA	26296894
D002784	Cholesterol	CLEC4E protein inhibits the reaction [Cholesterol results in increased expression of TIMP3 mRNA]	26296894
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA	17605605
C038142	chondroitin sulfate glycosaminoglycan	[N6L peptide binds to chondroitin sulfate glycosaminoglycan] which results in increased secretion of TIMP3 protein	23109338
D002857	Chromium	Chromium results in increased expression of TIMP3 mRNA	21437242
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of TIMP3 mRNA	16197558
D002922	Ciguatoxins	Ciguatoxins affects the expression of TIMP3 mRNA	18353800
D002994	Clofibrate	Clofibrate affects the expression of TIMP3 mRNA	16081524
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TIMP3 mRNA	15467011
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TIMP3 mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TIMP3 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of TIMP3 mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of TIMP3 mRNA	26577399
D003474	Curcumin	Curcumin results in decreased expression of TIMP3	18462866
D016572	Cyclosporine	Cyclosporine results in decreased expression of TIMP3 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of TIMP3 mRNA	27989131
D003561	Cytarabine	TIMP3 gene modified form results in decreased susceptibility to Cytarabine	18202788
D003561	Cytarabine	TIMP3 protein affects the susceptibility to Cytarabine	18202788
C017180	decamethrin	decamethrin results in increased expression of TIMP3 mRNA	19017407
C014347	decitabine	decitabine affects the methylation of TIMP3 promoter	17671114
C014347	decitabine	decitabine results in increased expression of TIMP3 mRNA	16367923\|1921582
C014347	decitabine	[[decitabine co-treated with trichostatin A] affects the methylation of TIMP3 promoter] which affects the expression of TIMP3 mRNA	18836996\|1883699
C014347	decitabine	decitabine results in increased expression of TIMP3 mRNA	27915011
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP3 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of TIMP3 mRNA	22733784
D003907	Dexamethasone	Dexamethasone inhibits the reaction [sephadex results in decreased expression of TIMP3 mRNA]	25878373
D016264	Dextran Sulfate	ADAM17 protein affects the reaction [Dextran Sulfate results in decreased expression of TIMP3 mRNA]	24548422
D016264	Dextran Sulfate	Dextran Sulfate results in decreased expression of TIMP3 mRNA	24548422
D016264	Dextran Sulfate	resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of TIMP3 mRNA]	24548422
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TIMP3 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TIMP3 mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of TIMP3 mRNA	21151649
D004026	Dieldrin	Dieldrin affects the expression of TIMP3 mRNA	22546817
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of TIMP3 mRNA	17490981
D004041	Dietary Fats	Dietary Fats results in increased expression of TIMP3 mRNA	21852083
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of TIMP3 mRNA]	21852083
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of TIMP3 protein	21163286
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of TIMP3 gene	21163286
D002117	Calcitriol	Calcitriol results in decreased expression of TIMP3 mRNA	16002434
D002117	Calcitriol	Calcitriol results in increased expression of TIMP3 mRNA	26485663
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TIMP3 mRNA	23197195
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of TIMP3 mRNA	16314067
D004237	Diuron	Diuron results in decreased expression of TIMP3 mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in increased expression of TIMP3 mRNA	22016648
D004317	Doxorubicin	Doxorubicin results in increased expression of TIMP3 protein	17609194
C118739	entinostat	entinostat results in increased expression of TIMP3 mRNA	27188386
C045651	epigallocatechin gallate	[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA	12628509
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TIMP3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TIMP3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMP3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TIMP3 mRNA	15866537\|1735126
C540355	fenamidone	fenamidone results in increased expression of TIMP3 mRNA	27029645
D005467	Floxuridine	TIMP3 gene modified form results in decreased susceptibility to Floxuridine	18202788
D005467	Floxuridine	TIMP3 protein affects the susceptibility to Floxuridine	18202788
D005557	Formaldehyde	Formaldehyde results in decreased expression of TIMP3 mRNA	17285311
D005707	Gallic Acid	Gallic Acid inhibits the reaction [ALB modified form results in decreased expression of TIMP3 mRNA]	24309158
D019833	Genistein	Genistein results in decreased expression of TIMP3 mRNA	15754008\|1647417
D005897	Glafenine	Glafenine results in increased expression of TIMP3 mRNA	24136188
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA	17605605
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in decreased expression of TIMP3 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of TIMP3 mRNA	17109745
D005944	Glucosamine	IL1B affects the reaction [Glucosamine results in increased expression of TIMP3 mRNA]	17109745
C065632	glucosamine 3-O-sulfate	glucosamine 3-O-sulfate results in decreased expression of TIMP3 mRNA	16300972
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of TIMP3 mRNA	22634610
C424943	glutamyl-Se-methylselenocysteine	glutamyl-Se-methylselenocysteine results in decreased expression of TIMP3 mRNA	11306469
C071834	glycidamide	glycidamide results in decreased expression of TIMP3 mRNA	17822822
C010974	glyphosate	glyphosate results in increased expression of TIMP3 mRNA	17984146
C121944	HB-19 peptide	HB-19 peptide results in increased secretion of TIMP3 protein	23109338
D006497	Heparitin Sulfate	[N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein	23109338
D007166	Immunosuppressive Agents	Immunosuppressive Agents affects the expression of TIMP3 protein	19652986
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIMP3 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TIMP3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP3 mRNA	16054899
D007545	Isoproterenol	Isoproterenol results in increased expression of TIMP3 protein	24286936
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TIMP3 mRNA	25961927
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TIMP3 mRNA	26644586
C410337	K 7174	K 7174 results in decreased expression of TIMP3 mRNA	24086573
C045463	leflunomide	leflunomide results in increased expression of TIMP3 mRNA	28988120
D008044	Linuron	Linuron affects the expression of TIMP3 mRNA	12730624
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 affects the expression of TIMP3 mRNA"	18986645
C433788	lipopolysaccharide, E. coli O26-B6	"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA"	18986645
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TIMP3 mRNA"	11578593
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TIMP3 mRNA	26378955
D008294	Malathion	Malathion results in decreased expression of TIMP3 mRNA	19784758
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in decreased expression of TIMP3 mRNA	20843944
D008713	Methimazole	Methimazole results in decreased expression of TIMP3 mRNA	17403546
D008727	Methotrexate	Methotrexate results in increased expression of TIMP3 mRNA	21678067
C005219	methyl cellosolve	methyl cellosolve results in increased expression of TIMP3 mRNA	21061450
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of TIMP3 protein	21163286
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of TIMP3 gene	21163286
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TIMP3 mRNA	28001369
D008743	Methyl Parathion	Methyl Parathion affects the expression of TIMP3 mRNA	19784758
D008743	Methyl Parathion	Methyl Parathion results in increased expression of TIMP3 mRNA	19784758
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]"	20230807
C000873	methylprednisolone acetate	methylprednisolone acetate results in increased expression of TIMP3 mRNA	15693093
C451426	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of TIMP3 mRNA"	25461557
C580583	N6L peptide	[N6L peptide binds to chondroitin sulfate glycosaminoglycan] which results in increased secretion of TIMP3 protein	23109338
C580583	N6L peptide	[N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein	23109338
C580583	N6L peptide	N6L peptide results in increased secretion of TIMP3 protein	23109338
C580583	N6L peptide	[N6L peptide results in increased secretion of TIMP3 protein] which results in decreased activity of ADAM17 protein	23109338
C580583	N6L peptide	[N6L peptide results in increased secretion of TIMP3 protein] which results in decreased activity of MMP2 protein	23109338
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of TIMP3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TIMP3 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of TIMP3 mRNA	18978301
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of TIMP3 mRNA	19812364
D009532	Nickel	Nickel results in decreased expression of TIMP3 mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of TIMP3 mRNA	22546817
C029938	nickel sulfate	nickel sulfate results in decreased expression of TIMP3 mRNA	22714537
C029938	nickel sulfate	nickel sulfate results in increased expression of TIMP3 mRNA	16314067
D009538	Nicotine	Nicotine affects the expression of TIMP3 mRNA	18986645
D009538	Nicotine	"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA"	18986645
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]"	20230807
C007350	nitrofen	nitrofen results in decreased expression of TIMP3 mRNA	20638522
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA"	18778698
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA]"	18778698
C025589	ochratoxin A	ochratoxin A results in decreased expression of TIMP3 mRNA	18417182
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP3 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of TIMP3 mRNA	26516004
D010100	Oxygen	Oxygen deficiency results in increased expression of TIMP3 mRNA	16980344
D010269	Paraquat	Paraquat results in increased expression of TIMP3 mRNA	16854511
D052638	Particulate Matter	TIMP3 protein inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]	18474546
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in increased secretion of TIMP3 protein	10968687
C494474	perchlorate	perchlorate results in decreased expression of TIMP3 mRNA	17403546
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TIMP3 mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TIMP3 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in increased expression of TIMP3 mRNA	21061450
C006253	pirinixic acid	pirinixic acid results in increased expression of TIMP3 mRNA	18445702
D010936	Plant Extracts	Plant Extracts results in decreased expression of TIMP3 mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of TIMP3 mRNA	16474171
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of TIMP3 mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TIMP3 mRNA	28903501
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of TIMP3 mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of TIMP3 mRNA	20226447
D011374	Progesterone	Progesterone results in decreased expression of TIMP3 mRNA	26604029
D011374	Progesterone	Progesterone results in increased expression of TIMP3 mRNA	20864642
D011374	Progesterone	Progesterone affects the expression of TIMP3 mRNA	21291521
D011374	Progesterone	Progesterone results in increased expression of TIMP3 mRNA	20726854
D011372	Progestins	Progestins results in decreased expression of TIMP3 mRNA	19609016
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TIMP3 mRNA	17403546
D015237	Dinoprost	Dinoprost results in decreased expression of TIMP3 mRNA	11517196
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TIMP3 mRNA	27029645
C037219	quinoline	quinoline analog results in decreased methylation of TIMP3 promoter	19417133
C037219	quinoline	quinoline analog results in increased expression of TIMP3 mRNA	19417133
C037219	quinoline	quinoline analog results in increased expression of TIMP3 protein	19417133
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of TIMP3 mRNA	19167446
C059514	resveratrol	resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of TIMP3 mRNA]	24548422
C059514	resveratrol	resveratrol results in decreased expression of TIMP3 mRNA	25394648
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of TIMP3 mRNA]	21852083
D015474	Isotretinoin	Isotretinoin results in increased expression of TIMP3 mRNA	20436886
C009166	retinol acetate	retinol acetate results in increased expression of TIMP3 mRNA	16772331
C116926	rofecoxib	rofecoxib results in decreased expression of TIMP3 mRNA	16580899
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP3 mRNA	16054899
D012402	Rotenone	Rotenone results in increased expression of TIMP3 mRNA	22016648
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TIMP3 mRNA	21427059
C010327	salinomycin	salinomycin results in decreased expression of TIMP3 mRNA	19682730
D012643	Selenium	Selenium results in decreased expression of TIMP3 mRNA	17390030
D012643	Selenium	Selenium results in increased expression of TIMP3 mRNA	19244175
C025614	sephadex	Dexamethasone inhibits the reaction [sephadex results in decreased expression of TIMP3 mRNA]	25878373
C025614	sephadex	sephadex results in decreased expression of TIMP3 mRNA	25878373
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of TIMP3 mRNA"	24160326
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of TIMP3 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of TIMP3 mRNA	25351596
D012834	Silver	Silver results in increased expression of TIMP3 mRNA	28959546
D012834	Silver	Silver results in decreased expression of TIMP3 mRNA	27131904
D020123	Sirolimus	Sirolimus results in decreased expression of TIMP3 mRNA	21742783
D020123	Sirolimus	Sirolimus results in decreased expression of TIMP3 protein	21742783
D012906	Smoke	Smoke results in decreased expression of TIMP3 mRNA	21095227\|2174278
D012906	Smoke	Smoke results in decreased expression of TIMP3 protein	21742783
D012906	Smoke	[Smoke co-treated with AGT protein modified form] results in decreased expression of TIMP3 mRNA	20937366
D012906	Smoke	[Smoke results in decreased expression of MTOR] which affects the expression of TIMP3	21742783
C009277	sodium arsenate	sodium arsenate results in increased expression of TIMP3 mRNA	21795629
C017947	sodium arsenite	sodium arsenite affects the methylation of TIMP3 gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of TIMP3 mRNA	22714537
C017947	sodium arsenite	sodium arsenite results in increased expression of TIMP3 mRNA	12634122
D053260	Soot	Soot results in increased expression of TIMP3 mRNA	26551751
C471405	sorafenib	sorafenib results in decreased expression of TIMP3 mRNA	21360571
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TIMP3 mRNA	26378955
D012460	Sulfasalazine	Sulfasalazine results in increased expression of TIMP3 mRNA	22016648
D013467	Sulindac	[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA	12628509
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]	22150557
D013501	Surface-Active Agents	Surface-Active Agents results in increased expression of TIMP3 mRNA	22467014
D013629	Tamoxifen	Tamoxifen affects the expression of TIMP3 mRNA	17555576
C112765	tanespimycin	tanespimycin results in increased expression of TIMP3 mRNA	19514085
D013739	Testosterone	Testosterone results in increased expression of TIMP3 mRNA	15788153
C004648	testosterone enanthate	testosterone enanthate affects the expression of TIMP3 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIMP3 mRNA	12377990\|1669712
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TIMP3 mRNA	19465110\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TIMP3 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIMP3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA	15034205\|1758670
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIMP3 mRNA	18172886\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TIMP3 mRNA	20959002\|2121527
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of TIMP3 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIMP3 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of TIMP3 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of TIMP3 mRNA	27760801
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP3 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TIMP3 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of TIMP3 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of TIMP3 mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of TIMP3 mRNA	24935251
C012589	trichostatin A	[[decitabine co-treated with trichostatin A] affects the methylation of TIMP3 promoter] which affects the expression of TIMP3 mRNA	18836996\|1883699
D014260	Triclosan	Triclosan results in decreased expression of TIMP3 mRNA	26604029
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TIMP3 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of TIMP3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TIMP3 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TIMP3 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of TIMP3 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of TIMP3 mRNA	21427059\|2489608
D014640	Vancomycin	Vancomycin results in increased expression of TIMP3 mRNA	18930951
D001335	Vehicle Emissions	TIMP3 protein inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]	18474546
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of TIMP3 mRNA	15541757
C025643	vinclozolin	vinclozolin affects the expression of TIMP3 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of TIMP3 mRNA	26682919
D014810	Vitamin E	Vitamin E results in increased expression of TIMP3 mRNA	19244175
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TIMP3 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of TIMP3 mRNA	26272509
D015032	Zinc	Zinc results in increased expression of TIMP3 mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of TIMP3 mRNA	17074742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	18344519 18638486
GO:0008191	metalloendopeptidase inhibitor activity	-	IBA	21873635
GO:0008191	metalloendopeptidase inhibitor activity	-	TAS	18638486
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002576	platelet degranulation	-	TAS	-
GO:0007601	visual perception	-	IEA	-
GO:0009725	response to hormone	-	IBA	21873635
GO:0010033	response to organic substance	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0034097	response to cytokine	-	IBA	21873635
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	-	IBA	21873635
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	-	IMP	18383040
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IMP	19962668
GO:0071310	cellular response to organic substance	-	IEA	-
GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	-	IMP	19962668
GO:1904684	negative regulation of metalloendopeptidase activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005604	basement membrane	-	IEA	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005634	nucleus	-	HDA	21630459
GO:0031089	platelet dense granule lumen	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	27068509 27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27601084	A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene. (2016 Sep 7)	Meunier I	Sci Rep
26197083	MMP, VEGF and TIMP as prognostic factors in recurring bladder cancer. (2015 Dec)	Wieczorek E	Clin Biochem
28421310	Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)	Strzelczyk JK	Biochem Genet
26116372	MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)	Melnik BC	J Transl Med
18676844	RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. (2008 Aug 1)	Wolff EM	Cancer Res
15911247	CpG island methylation and expression of tumour-associated genes in lung carcinoma. (2005 May)	Dammann R	Eur J Cancer
22649395	Association of Cigarette Smoking with Aberrant Methylation of the Tumor Suppressor Gene RARbeta2 in Papillary Thyroid Cancer. (2011)	Kiseljak-Vassiliades K	Front Endocrinol (Lausanne)
23838140	Aberrant promoter methylation of cell adhesion-related genes associated with clinicopathologic features in non-small cell lung cancer in China. (2013)	Xu PW	Cancer Biomark
20572039	Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. (2010 Oct 1)	Paun BC	Cancer
22888638	[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. (2012 May-Jun)	Korytina GF	Mol Biol (Mosk)
29487693	Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants. (2018 Jan 30)	Cascella R	Oncotarget