Gene: TIMP4

7079
TIMP-4
TIMP metallopeptidase inhibitor 4
protein-coding
3p25.2
Ensembl:ENSG00000157150 MIM:601915 Vega:OTTHUMG00000129763 UniprotKB:Q99727
NC_000003.12
PubMed
0   ANCO-SNPs
ND
2   
1.518e-2 (AD)  6.185e-1 (ND)   (Frontal_Cortex)
7.561e-1 (AD)  5.898e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSPG40.659
NTN10.635
LHFPL30.629
SMIM100.626
PDLIM30.619
ANTXR10.619
RASL120.614
S100B0.612
VCAN0.606
COPZ20.606

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH5-0.423
FMN1-0.397
HRH2-0.395
PRSS16-0.394
CDCA5-0.391
FBXO40-0.388
OVOL2-0.385
PRSS12-0.385
KCNH1-0.379
MTUS2-0.378

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TIMP4 mRNA16386258
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TIMP4 mRNA"25510870
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of TIMP4 mRNA"25710175
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TIMP4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TIMP4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TIMP4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TIMP4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of TIMP4 mRNA"23829299
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of TIMP4 mRNA28522335
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TIMP4 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of TIMP4 mRNA28959563
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TIMP4 mRNA21871943
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP4 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TIMP4 mRNA19619570
C006780bisphenol Abisphenol A results in increased expression of TIMP4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TIMP4 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of TIMP4 mRNA23125180
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TIMP4 mRNA20971185
D003300CopperCopper deficiency results in increased expression of TIMP4 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of TIMP4 mRNA26577399
C014347decitabinedecitabine affects the expression of TIMP4 mRNA23300844
D003907DexamethasoneDexamethasone results in increased expression of TIMP4 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of TIMP4 mRNA28628672
D002945CisplatinCisplatin affects the expression of TIMP4 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TIMP4 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of TIMP4 mRNA20705681
D002945CisplatinCisplatin results in increased expression of TIMP4 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of TIMP4 mRNA26033743
C118739entinostatentinostat results in increased expression of TIMP4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP4 mRNA"27188386
D004397FonofosFonofos results in increased methylation of TIMP4 promoter22847954
D017313FenretinideFenretinide results in decreased expression of TIMP4 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of TIMP4 protein16514196
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of TIMP4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of TIMP4 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of TIMP4 protein24286936
D007545IsoproterenolIsoproterenol results in increased expression of TIMP4 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TIMP4 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TIMP4 mRNA27392435
D007854LeadLead affects the expression of TIMP4 mRNA28903495
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 affects the expression of TIMP4 mRNA"18986645
C433788lipopolysaccharide, E. coli O26-B6"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP4 mRNA"18986645
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of TIMP4 mRNA16507785
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TIMP4 mRNA"26251327
C523799MRK 003MRK 003 results in decreased expression of TIMP4 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TIMP4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TIMP4 mRNA"25554681
D009532NickelNickel results in decreased expression of TIMP4 mRNA24768652|2558310
D009538NicotineNicotine affects the expression of TIMP4 mRNA18986645
D009538Nicotine"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP4 mRNA"18986645
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TIMP4 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP4 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TIMP4 mRNA16980344
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of TIMP4 mRNA20705681
D010278ParathionParathion results in increased methylation of TIMP4 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of TIMP4 mRNA21708214
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TIMP4 mRNA"25510870
C410127PCB 180PCB 180 results in increased expression of TIMP4 mRNA23829299
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of TIMP4 mRNA16386258
D011374ProgesteroneProgesterone results in increased expression of TIMP4 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of TIMP4 mRNA24780913
D017257RamiprilRamipril results in increased expression of TIMP4 mRNA11851355
C059514resveratrolresveratrol results in increased expression of TIMP4 mRNA25888808
C059514resveratrolresveratrol results in decreased expression of TIMP4 mRNA25394648
C410733scriptaidscriptaid affects the expression of TIMP4 mRNA18813790
D012643SeleniumSelenium results in decreased expression of TIMP4 mRNA17390030
C012568terbufosterbufos results in increased methylation of TIMP4 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TIMP4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TIMP4 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of TIMP4 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of TIMP4 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TIMP4 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TIMP4 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TIMP4 mRNA25729387
C032910triadimefontriadimefon results in decreased expression of TIMP4 mRNA26705709
C009954trilostanetrilostane inhibits the reaction [GNRH1 protein results in increased expression of TIMP4 mRNA]17332517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TIMP4 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of TIMP4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TIMP4 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IBA21873635  
GO:0008191metalloendopeptidase inhibitor activity-IBA21873635  
GO:0008191metalloendopeptidase inhibitor activity-NAS8939999  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007219Notch signaling pathway-IEA-  
GO:0007417central nervous system development-IEA-  
GO:0008150biological_process-ND-  
GO:0009725response to hormone-IBA21873635  
GO:0010033response to organic substance-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0034097response to cytokine-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0042698ovulation cycle-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0051045negative regulation of membrane protein ectodomain proteolysis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0030017sarcomere-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15911247CpG island methylation and expression of tumour-associated genes in lung carcinoma. (2005 May)Dammann REur J Cancer
22978719Tissue inhibitor of matrix metalloproteinases 4 (TIMP4) in a population of young adults: relations to cardiovascular risk markers and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study. (2012 Nov)Oikonen MScand J Clin Lab Invest