Gene info: ID 7080

Gene: NKX2-1

GENE ID: 7080

Synonyms: BCH|BHC|NK-2|NKX2.1|NKX2A|NMTC1|T/EBP|TEBP|TITF1|TTF-1|TTF1

Description: NK2 homeobox 1

Gene type: protein-coding

Location: 14q13.3

dbXrefs: Ensembl:ENSG00000136352 MIM:600635 Vega:OTTHUMG00000140225 UniprotKB:P43699

RefSeq: NG_013365.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.819e-1 (AD) 3.479e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SFTA3	0.835
SLITRK6	0.805
ISL1	0.78
SLC5A7	0.773
CRNDE	0.771
IRX2	0.764
TH	0.756
FEZF1	0.751
IRX1	0.746
FAM183A	0.734

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNNT2	-0.37
SOHLH1	-0.344
SLC17A7	-0.317
COL5A3	-0.316
NXPH3	-0.311
LHX2	-0.307
OTX1	-0.303
TNFRSF14	-0.298
SLC6A12	-0.295
TNFRSF4	-0.294

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C496492	abrine	abrine results in decreased expression of NKX2-1 mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of NKX2-1 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of NKX2-1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NKX2-1 gene	28458013
D000447	Aldehydes	Aldehydes results in increased expression of NKX2-1 mRNA	25014914
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NKX2-1 mRNA	16483693
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	15083329
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	15083329
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	16863852
D001241	Aspirin	Aspirin affects the expression of NKX2-1 mRNA	12800193
D001280	Atrazine	Atrazine results in decreased expression of NKX2-1 mRNA	25929836
C006780	bisphenol A	bisphenol A affects the methylation of NKX2-1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of NKX2-1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of NKX2-1 mRNA	23238275
C006780	bisphenol A	bisphenol A results in increased expression of NKX2-1 protein	23238275
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of NKX2-1 mRNA	16997883
C018475	butyraldehyde	butyraldehyde results in increased expression of NKX2-1 mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in decreased expression of NKX2-1 mRNA	12800193
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of NKX2-1 mRNA	21337468
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NKX2-1 gene	20938992
D005576	Colforsin	Colforsin results in increased expression of NKX2-1 mRNA	16837620
C000541	cyclopamine	cyclopamine results in decreased expression of NKX2-1 mRNA	20865013
C014347	decitabine	decitabine affects the expression of NKX2-1 mRNA	18852534
C014347	decitabine	[decitabine co-treated with Tretinoin] results in increased expression of NKX2-1 mRNA	19524134
C014347	decitabine	decitabine results in increased expression of NKX2-1 mRNA	19506552
D003907	Dexamethasone	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of NKX2-1 mRNA	16997883
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]	10830305
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	10830305
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	10830305
D003994	Bucladesine	Bucladesine results in increased expression of NKX2-1 mRNA	16837620
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of NKX2-1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of NKX2-1 mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of NKX2-1 mRNA	26924002
C042080	diisodecyl phthalate	diisodecyl phthalate results in increased expression of NKX2-1 mRNA	25270620
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NKX2-1 mRNA	23550701
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NKX2-1 gene	20938992
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of NKX2-1 mRNA	16997883
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of NKX2-1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of NKX2-1 mRNA	27392435
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NKX2-1 gene	20938992
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of NKX2-1 mRNA	26924002
C007350	nitrofen	Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	15083329
C007350	nitrofen	Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	15083329
C007350	nitrofen	nitrofen results in decreased expression of NKX2-1 mRNA	10370019\|1508332
C007350	nitrofen	nitrofen results in decreased expression of NKX2-1 protein	15083329\|1649093
C007350	nitrofen	Vitamin A inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	16490937
C007350	nitrofen	Vitamin E inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	16490937
C007350	nitrofen	nitrofen affects the expression of NKX2-1 protein	9575882
C007350	nitrofen	nitrofen results in decreased expression of NKX2-1 mRNA	12194114
C007350	nitrofen	Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	16863852
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]	10830305
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	10830305
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	10830305
C007350	nitrofen	[nitrofen co-treated with Tretinoin] results in decreased expression of NKX2-1 mRNA	18280292
C007350	nitrofen	nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]	10830305
C007350	nitrofen	nitrofen results in decreased expression of NKX2-1 mRNA	10370019\|1083030
C007350	nitrofen	nitrofen results in decreased expression of NKX2-1 protein	10830305\|1686385
C007350	nitrofen	nitrofen results in increased expression of NKX2-1 protein	15764645\|1724559
C007350	nitrofen	NKX2-1 protein affects the reaction [nitrofen results in decreased expression of SFTPB protein]	10830305
C007350	nitrofen	Tretinoin inhibits the reaction [nitrofen results in increased expression of NKX2-1 protein]	18280292
C007350	nitrofen	Vitamin A inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	16863852
C007350	nitrofen	Vitamin E inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	16863852
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of NKX2-1 mRNA	12102619
C046012	pentanal	pentanal results in increased expression of NKX2-1 mRNA	26079696
D010936	Plant Extracts	Plant Extracts results in decreased expression of NKX2-1 mRNA	23557933
D059808	Polyphenols	Polyphenols results in decreased expression of NKX2-1 mRNA	16293270
C005556	propionaldehyde	propionaldehyde results in increased expression of NKX2-1 mRNA	26079696
C059514	resveratrol	NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of NKX2-1 mRNA]	23594881
C059514	resveratrol	resveratrol results in increased expression of NKX2-1 mRNA	23594881
C059514	resveratrol	resveratrol results in increased expression of NKX2-1 protein	23594881
C059514	resveratrol	resveratrol results in decreased expression of NKX2-1 mRNA	28668442
C022088	silicon carbide	silicon carbide results in decreased expression of NKX2-1 mRNA	14646272
C017947	sodium arsenite	sodium arsenite affects the methylation of NKX2-1 gene	28589171
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NKX2-1 mRNA	24058054
D014212	Tretinoin	[decitabine co-treated with Tretinoin] results in increased expression of NKX2-1 mRNA	19524134
D014212	Tretinoin	Tretinoin results in decreased expression of NKX2-1 mRNA	21924320
D014212	Tretinoin	[nitrofen co-treated with Tretinoin] results in decreased expression of NKX2-1 mRNA	18280292
D014212	Tretinoin	Tretinoin inhibits the reaction [nitrofen results in increased expression of NKX2-1 protein]	18280292
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of NKX2-1 mRNA	25646720
D014635	Valproic Acid	Valproic Acid affects the expression of NKX2-1 mRNA	17292431
C025643	vinclozolin	vinclozolin affects the expression of NKX2-1 mRNA	19015723
D014801	Vitamin A	Vitamin A inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	16490937
D014801	Vitamin A	Vitamin A inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	16863852
D014810	Vitamin E	Vitamin E inhibits the reaction [nitrofen results in decreased expression of NKX2-1 mRNA]	16490937
D014810	Vitamin E	Vitamin E inhibits the reaction [nitrofen results in decreased expression of NKX2-1 protein]	16863852

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	23143308
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	ISS	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001012	RNA polymerase II regulatory region DNA binding	-	IDA	23143308
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	-	ISS	-
GO:0003677	DNA binding	-	IMP	7635972
GO:0003700	DNA-binding transcription factor activity	-	IDA	7559607 7713914 16960125
GO:0003700	DNA-binding transcription factor activity	-	IMP	19176457
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	IEA	-
GO:0005515	protein binding	-	IPI	11152647 17474147 19010321
GO:0019899	enzyme binding	-	IPI	23382074
GO:0044212	transcription regulatory region DNA binding	-	IDA	1735431 7559607 14960358
GO:0044212	transcription regulatory region DNA binding	-	IMP	19176457
GO:0044213	intronic transcription regulatory region DNA binding	-	IDA	23143308

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	23143308
GO:0001764	neuron migration	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006644	phospholipid metabolic process	-	IEA	-
GO:0007411	axon guidance	-	IEA	-
GO:0007420	brain development	-	IMP	11971878
GO:0007492	endoderm development	-	IEA	-
GO:0007626	locomotory behavior	-	IEA	-
GO:0009725	response to hormone	-	IEP	16960125
GO:0010628	positive regulation of gene expression	-	IDA	16960125
GO:0010719	negative regulation of epithelial to mesenchymal transition	-	IDA	19293183
GO:0021759	globus pallidus development	-	IMP	11854319
GO:0021766	hippocampus development	-	IEA	-
GO:0021795	cerebral cortex cell migration	-	IEA	-
GO:0021798	forebrain dorsal/ventral pattern formation	-	IEA	-
GO:0021877	forebrain neuron fate commitment	-	IEA	-
GO:0021892	cerebral cortex GABAergic interneuron differentiation	-	IEA	-
GO:0021983	pituitary gland development	-	IEA	-
GO:0030324	lung development	-	IEP	15494458 16960125
GO:0030336	negative regulation of cell migration	-	IDA	19293183
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IDA	19293183
GO:0030878	thyroid gland development	-	IEP	15494458
GO:0030878	thyroid gland development	-	IMP	11854319
GO:0030900	forebrain development	-	IEP	15494458
GO:0031128	developmental induction	-	IEA	-
GO:0033327	Leydig cell differentiation	-	IEA	-
GO:0042753	positive regulation of circadian rhythm	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	14960358
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	19176457
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	7559607 7713914 16960125
GO:0048511	rhythmic process	-	IEA	-
GO:0048646	anatomical structure formation involved in morphogenesis	-	IEA	-
GO:0048709	oligodendrocyte differentiation	-	IEA	-
GO:0060430	lung saccule development	-	IEA	-
GO:0060441	epithelial tube branching involved in lung morphogenesis	-	IEP	8675988
GO:0060486	Clara cell differentiation	-	IEA	-
GO:0060510	type II pneumocyte differentiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	7713914 8675988
GO:0005654	nucleoplasm	-	ISS	-
GO:0005667	transcription factor complex	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29302581	Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure. (2017 Dec)	Choi JR	J Cancer Prev
23365103	SGCE mutations cause psychiatric disorders: clinical and genetic characterization. (2013 Jan)	Peall KJ	Brain
28652369	Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. (2017 Jul 11)	Gocheva V	Proc Natl Acad Sci U S A
27496897	CCSP G38A polymorphism environment interactions regulate CCSP levels differentially in COPD. (2016 Oct 1)	Knabe L	Am J Physiol Lung Cell Mol Physiol