Gene: TJP1

7082
ZO-1
tight junction protein 1
protein-coding
15q13.1
Ensembl:ENSG00000104067 MIM:601009 Vega:OTTHUMG00000137397 UniprotKB:Q07157
NC_000015.10
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.211e-1 (AD)  7.026e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2229515chr15:29726423 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs17683205chr15:29709124 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EFCAB140.902
SOS20.88
KIF13A0.877
RDX0.876
TCF120.872
DOCK10.859
STAG20.854
BAZ2B0.852
QKI0.852
KANK10.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.524
OR4F5-0.494
BHLHA9-0.413
KLK5-0.407
RTP1-0.402
ADRA1D-0.4
MCHR1-0.394
FBLN7-0.394
HAS1-0.387
ABCC12-0.387

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]"16716901
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TJP1 mRNA"19162173
C4172072,2',4,6,6'-pentachlorobiphenyl"2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C4172072,2',4,6,6'-pentachlorobiphenyl"acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C4172072,2',4,6,6'-pentachlorobiphenyl"2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]24200059
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TJP1 mRNA"19114083
C0700552,3',4,4',5-pentachlorobiphenyl"2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C0700552,3',4,4',5-pentachlorobiphenyl"acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C0700552,3',4,4',5-pentachlorobiphenyl"2,3',4,4',5-pentachlorobiphenyl affects the reaction [TJP1 protein binds to OCLN protein]"20064788
C0700552,3',4,4',5-pentachlorobiphenyl"2,3',4,4',5-pentachlorobiphenyl results in increased expression of TJP1 protein"20064788
C0700552,3',4,4',5-pentachlorobiphenyl"2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C0140242,4,5,2',4',5'-hexachlorobiphenyl"acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [TJP1 protein binds to OCLN protein]"20064788
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TJP1 protein"20064788
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]24200059
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]19252288
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]19252288
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]19252288
C0228302-methoxyestradiol2-methoxyestradiol inhibits the reaction [Glucose results in decreased expression of TJP1 protein]21617913
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein"20299304
C0230353,4,5,3',4'-pentachlorobiphenyl"acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [TJP1 protein binds to OCLN protein]"20064788
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [Carrageenan results in decreased expression of and affects the localization of TJP1 protein]22561171
C0909373-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Glucose results in decreased expression of TJP1 protein]21617913
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TJP1 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TJP1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TJP1 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TJP1 mRNA"27188386
C4732178-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in decreased localization of TJP1 protein]21745194
C4732178-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphateRAPGEF3 mutant form inhibits the reaction [8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in decreased localization of TJP1 protein]]21745194
D000079AcetaldehydeAcetaldehyde affects the localization of TJP1 protein17991733|2256337
D000079Acetaldehydechelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]17991733
D000079AcetaldehydeEGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]17991733
D000079AcetaldehydePLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]17991733
D000079AcetaldehydeRo 32-0432 inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]17991733
D000082AcetaminophenAcetaminophen affects the expression of TJP1 mRNA17562736
C056165acetovanillone"acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C056165acetovanillone"acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C056165acetovanillone"acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C056165acetovanillone"acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]"20299304
C056165acetovanilloneacetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]21647593
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Glucose results in decreased expression of TJP1 protein]27783111
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tributyltin results in decreased expression of TJP1 protein]26079211
D020106AcrylamideAcrylamide results in decreased expression of TJP1 mRNA22801078
D020106AcrylamideAcrylamide results in decreased expression of TJP1 protein22801078
D006710Homocysteineacetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]21647593
D006710HomocysteineCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]21647593
D006710HomocysteineCYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]21647593
D006710Homocysteine[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA21647593
D006710HomocysteineHomocysteine results in decreased expression of TJP1 mRNA21647593
D006710HomocysteineHomocysteine results in decreased expression of TJP1 protein21647593
D000872AnthocyaninsAnthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein]25451569
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TJP1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of TJP1 protein"22573546
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Ethanol results in decreased expression of TJP1 mRNA]24239723
D001374AzacitidineAzacitidine results in increased expression of TJP1 mRNA18661270
D001548Benzalkonium CompoundsBenzalkonium Compounds affects the localization of TJP1 protein22815857
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TJP1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TJP1 protein26657896
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TJP1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TJP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TJP1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TJP1 mRNA"26238291
D004958Estradiol[Estradiol co-treated with bisphenol A] results in decreased expression of TJP1 mRNA27174447
D004958EstradiolEstradiol results in decreased expression of TJP1 mRNA27174447
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Cadmium Chloride affects the localization of TJP1 protein]25851441
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of TJP1 mRNA]28780155
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of TJP1 protein]28780155
C006780bisphenol Abisphenol A results in decreased expression of and affects the localization of TJP1 protein24532171
C006780bisphenol Abisphenol A results in decreased expression of TJP1 mRNA26363213
C006780bisphenol Abisphenol A results in decreased expression of TJP1 protein26363213|2692290
C006780bisphenol Abisphenol A results in increased expression of TJP1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TJP1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of TJP1 mRNA12075121
C006780bisphenol Abisphenol A results in decreased expression of TJP1 protein19497385
C006780bisphenol Abisphenol A results in increased expression of TJP1 protein19782717
C006780bisphenol A[Estradiol co-treated with bisphenol A] results in decreased expression of TJP1 mRNA27174447
C013418bromfenacoumbromfenacoum results in decreased expression of TJP1 protein28903499
D020122tert-Butylhydroperoxide"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]"16716901
D020122tert-Butylhydroperoxide1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D020122tert-ButylhydroperoxideBucladesine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D020122tert-ButylhydroperoxideGo 6976 inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D020122tert-ButylhydroperoxideStaurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the localization of TJP1 protein16716901
C584509C646 compoundC646 compound results in decreased expression of TJP1 mRNA26191083
C400541CA 074 methyl esterCA 074 methyl ester inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]27689324
D019256Cadmium Chloridebisindolylmaleimide I inhibits the reaction [Cadmium Chloride affects the localization of TJP1 protein]25851441
D019256Cadmium ChlorideCadmium Chloride affects the localization of and results in decreased expression of TJP1 protein25851441
D019256Cadmium ChlorideCadmium Chloride affects the localization of TJP1 protein24532171
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TJP1 mRNA25851441|2588268
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TJP1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TJP1 protein15618353
D019256Cadmium Chloride"N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of TJP1 protein]"15618353
D002118CalciumCalcium deficiency inhibits the reaction [TJP1 protein binds to OCLN protein]11054866
D002220CarbamazepineCarbamazepine affects the expression of TJP1 mRNA24752500
D002331CarnitineCarnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein]28973641
D002351Carrageenan3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [Carrageenan results in decreased expression of and affects the localization of TJP1 protein]22561171
D002351CarrageenanCarrageenan results in decreased expression of and affects the localization of TJP1 protein22561171
D002351CarrageenanEGR1 protein inhibits the reaction [Carrageenan results in decreased expression of and affects the localization of TJP1 protein]22561171
C016299chelerythrinechelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]17991733
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TJP1 mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TJP1 protein23650126
D004390ChlorpyrifosChlorpyrifos affects the expression of TJP1 mRNA22611033
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TJP1 mRNA25019507
C011730clay[clay analog co-treated with deoxynivalenol] results in increased expression of TJP1 mRNA23922676
C055162clopidogrelclopidogrel results in decreased expression of TJP1 protein23220562
C055162clopidogrelSB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]23220562
C018021cobaltous chloridecobaltous chloride results in decreased expression of TJP1 protein21617913
D003300CopperCopper results in decreased expression of TJP1 mRNA25461751
D003300CopperCopper results in increased expression of TJP1 mRNA16629173
D019327Copper SulfateCopper Sulfate results in increased expression of TJP1 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]26191140
D003474CurcuminCurcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein]26191140
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of TJP1 protein25986756
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of TJP1 protein27758031
D003513CycloheximideCycloheximide inhibits the reaction [IFNG protein results in increased expression of TJP1 protein]16087364
D003513CycloheximideCycloheximide results in decreased expression of TJP1 protein16087364
D003520CyclophosphamideAnthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein]25451569
D003520CyclophosphamideCyclophosphamide results in decreased expression of TJP1 protein25451569
D003520CyclophosphamidePlant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein]25451569
D016572CyclosporineCyclosporine results in increased expression of TJP1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of TJP1 mRNA22416070
D016572CyclosporineCyclosporine results in decreased expression of TJP1 protein22155090
D016572CyclosporineN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein]22155090
D016572Cyclosporinesalubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein]22155090
D016572CyclosporineCyclosporine inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TJP1 protein]15744817
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of TJP1 mRNA17524140
C014347decitabinedecitabine results in increased expression of TJP1 mRNA17524140
C007262deoxynivalenol[clay analog co-treated with deoxynivalenol] results in increased expression of TJP1 mRNA23922676
C007262deoxynivalenoldeoxynivalenol affects the localization of TJP1 protein24568843
C007262deoxynivalenoldeoxynivalenol results in increased expression of TJP1 mRNA24568843
C007262deoxynivalenoldeoxynivalenol results in increased expression of TJP1 mRNA24568843
C007262deoxynivalenoldeoxynivalenol results in decreased expression of TJP1 protein20937367
C007262deoxynivalenoldeoxynivalenol results in increased expression of TJP1 mRNA26417708
D064791Desoxycorticosterone AcetateCD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]]21992601
D064791Desoxycorticosterone Acetate[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]21992601
D003994BucladesineBucladesine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TJP1 mRNA27392435
D002945Cisplatin8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in decreased localization of TJP1 protein]21745194
D002945CisplatinCisplatin results in decreased localization of TJP1 protein21745194
D002945CisplatinRAPGEF3 mutant form inhibits the reaction [8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate inhibits the reaction [Cisplatin results in decreased localization of TJP1 protein]]21745194
D004008DiclofenacDiclofenac affects the expression of TJP1 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of TJP1 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of TJP1 protein15082077
D004041Dietary FatsDietary Fats results in decreased expression of TJP1 protein26293846
D004041Dietary FatsDietary Fats results in increased expression of TJP1 mRNA18042831|1903023
D004041Dietary FatsNLRP3 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of TJP1 protein]26293846
D004041Dietary FatsNLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein]27783111
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein27783111
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of TJP1 mRNA18661270
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein]16670640
C007488dinitrobenzenesulfonic aciddinitrobenzenesulfonic acid affects the localization of TJP1 protein16670640
C007488dinitrobenzenesulfonic aciddinitrobenzenesulfonic acid results in decreased expression of TJP1 protein16680017
C007488dinitrobenzenesulfonic acidThalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein]16680017
C007488dinitrobenzenesulfonic acidzileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein]16670640
D004178DiquatDiquat results in decreased expression of TJP1 protein26338884
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TJP1 protein23301498
C025483estradiol-17 beta-glucuronideestradiol-17 beta-glucuronide affects the localization of TJP1 protein17463180
D000431EthanolAscorbic Acid inhibits the reaction [Ethanol results in decreased expression of TJP1 mRNA]24239723
D000431EthanolEthanol results in decreased expression of TJP1 mRNA24239723
D000431EthanolSilymarin inhibits the reaction [Ethanol results in decreased expression of TJP1 mRNA]24239723
D000431EthanolEthanol affects the localization of TJP1 protein10198341|2256337
D000431EthanolEthanol results in decreased expression of TJP1 mRNA25226407
D000431EthanolEthanol results in decreased expression of TJP1 protein25226407
D000431EthanolFlavonoids inhibits the reaction [Ethanol affects the localization of TJP1 protein]28412402
D000431EthanolPlant Extracts inhibits the reaction [Ethanol affects the localization of TJP1 protein]28412402
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TJP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TJP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TJP1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TJP1 mRNA12075121|1557682
D005419FlavonoidsFlavonoids inhibits the reaction [Ethanol affects the localization of TJP1 protein]28412402
D005492Folic AcidCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]21647593
D005492Folic Acid[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA21647593
D017965gamma-Linolenic Acid[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein16514648
D019833GenisteinGenistein results in decreased expression of TJP1 mRNA12075121
C102521GGTI 298GGTI 298 inhibits the reaction [Hydrocortisone results in increased localization of TJP1 protein]25763180
C049864ginsenoside Reginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein]22849695
D005947Glucose2-methoxyestradiol inhibits the reaction [Glucose results in decreased expression of TJP1 protein]21617913
D005947Glucose3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Glucose results in decreased expression of TJP1 protein]21617913
D005947GlucoseGlucose results in decreased expression of TJP1 protein21617913
D005947GlucoseAcetylcysteine inhibits the reaction [Glucose results in decreased expression of TJP1 protein]27783111
D005947GlucoseGlucose results in decreased expression of TJP1 protein21617913|2778311
D005947GlucoseGlycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP1 protein]27783111
D005947GlucoseNLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP1 protein]27783111
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP1 protein]27783111
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]27689324
C081021Go 6976Go 6976 inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D006854HydrocortisoneGGTI 298 inhibits the reaction [Hydrocortisone results in increased localization of TJP1 protein]25763180
D006854HydrocortisoneHydrocortisone results in increased localization of TJP1 protein25763180
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TJP1 mRNA18661270
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TJP1 mRNA12419474
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TJP1 protein20445016
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]20445016
C031927hydroquinonehydroquinone results in decreased degradation of and results in increased expression of TJP1 protein27587462
C082359imidaclopridimidacloprid results in decreased expression of TJP1 mRNA27792329
D007213IndomethacinIndomethacin affects the localization of TJP1 protein23668856
D007213IndomethacinIndomethacin results in decreased expression of TJP1 mRNA23668856
D007213IndomethacinQuercetin inhibits the reaction [Indomethacin affects the localization of TJP1 protein]23668856
D007213IndomethacinQuercetin inhibits the reaction [Indomethacin results in decreased expression of TJP1 mRNA]23668856
D007455Iodine[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein16514648
D007455IodineIodine results in increased expression of and results in increased localization of TJP1 protein16514648
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TJP1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TJP1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TJP1 mRNA27392435
C410337K 7174K 7174 results in increased expression of TJP1 mRNA24086573
C096429L 709049L 709049 analog inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]27689324
C554430LDN 193189LDN 193189 results in increased expression of TJP1 protein23243027
D007854LeadLead results in decreased expression of TJP1 protein20970449|2443121
D007854Lead[malaoxon co-treated with Lead] results in decreased expression of TJP1 protein20970449
D007854Lead[Malathion co-treated with Lead] results in decreased expression of TJP1 protein20970449
C008261lead acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]24200059
C008261lead acetate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]24200059
C008261lead acetatelead acetate results in decreased expression of TJP1 protein24200059
D001556LindaneLindane affects the localization of TJP1 protein11532877
D001556LindaneLindane results in decreased expression of TJP1 protein11532877
D001556LindaneLindane affects the localization of TJP1 protein15194225
D001556LindaneLindane promotes the reaction [GJA1 protein binds to TJP1 protein]15194225
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the localization of TJP1 protein"19503810
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TJP1 protein22344225
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TJP1 protein15763998
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TJP1 protein26357463
D008094LithiumLithium results in decreased expression of TJP1 protein17533168
D019808LosartanLosartan results in decreased expression of TJP1 protein18400868
C100082malaoxon[malaoxon co-treated with Lead] results in decreased expression of TJP1 protein20970449
C100082malaoxonmalaoxon results in decreased expression of TJP1 protein20970449
D008294Malathion[Malathion co-treated with Lead] results in decreased expression of TJP1 protein20970449
D008294MalathionMalathion results in decreased expression of TJP1 protein20970449
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [HMGB1 protein results in decreased expression of TJP1 protein]25979658
D008727MethotrexateMethotrexate results in increased expression of TJP1 mRNA21678067
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein"25064079
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein]"25064079
D015735MifepristoneMifepristone results in increased expression of TJP1 mRNA17584828
C070571ML 7ML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein]20164382
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of TJP1 protein18214902
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of TJP1 protein26922907
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of TJP1 protein18214902
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein]22155090
C496401N-((3-(aminomethyl)phenyl)methyl)ethanimidamideN-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Phosgene results in decreased expression of TJP1 mRNA]25870319
C001020N(6),N(6)-dimethyladenine"N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of TJP1 protein]"15618353
D009538NicotineNicotine results in decreased expression of TJP1 protein18844224
D009538NicotineNicotine results in decreased expression of TJP1 protein20722969
D009538Nicotine[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein20722969
D009538Nicotine[Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein20722969
D009538NicotineVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
D009538NicotineVitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
D009569Nitric Oxide[NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased expression of TJP1 mRNA25870319
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of TJP1 protein15763998
C025589ochratoxin Aochratoxin A affects the localization of TJP1 protein14994279
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of TJP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TJP1 mRNA25729387
D010100OxygenML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein]20164382
D010100OxygenOxygen deficiency affects the localization of TJP1 protein20164382
D019308Palmitic AcidCA 074 methyl ester inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]27689324
D019308Palmitic AcidGlycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]27689324
D019308Palmitic AcidL 709049 analog inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]27689324
D019308Palmitic AcidPalmitic Acid results in decreased expression of TJP1 protein27689324
D000073878Palm OilPalm Oil results in increased expression of TJP1 mRNA18042831
D010269ParaquatHIF1A protein affects the reaction [Paraquat results in decreased expression of TJP1 protein]26781174
D010269ParaquatParaquat results in decreased expression of TJP1 protein26781174
D010269ParaquatHIF1A protein affects the reaction [Paraquat results in decreased expression of TJP1 protein]26781174
D010269ParaquatParaquat results in decreased expression of TJP1 protein25873302|2678117
D052638Particulate MatterParticulate Matter results in decreased expression of TJP1 protein20576493
D052638Particulate MatterParticulate Matter affects the reaction [TJP1 protein binds to OCLN protein]21122029
D010365PatulinPatulin results in decreased expression of TJP1 protein19013514
D010416PentachlorophenolPentachlorophenol results in increased expression of TJP1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TJP1 protein23761298
C076994perfluorooctane sulfonic acidSB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein]23761298
C076994perfluorooctane sulfonic acidCarnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein]28973641
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TJP1 mRNA19162173|2897364
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TJP1 protein28973641
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TJP1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of TJP1 mRNA19162173
D019800PhenolPhenol affects the localization of TJP1 protein19679145
D010705PhosgeneN-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Phosgene results in decreased expression of TJP1 mRNA]25870319
D010705PhosgenePhosgene results in decreased expression of TJP1 mRNA25870319
D010862PilocarpinePilocarpine results in decreased expression of TJP1 protein17533168
C006253pirinixic acidpirinixic acid results in decreased expression of TJP1 mRNA18445702
D010936Plant ExtractsPlant Extracts inhibits the reaction [Ethanol affects the localization of TJP1 protein]28412402
D010936Plant ExtractsPlant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein]25451569
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TJP1 mRNA23608068
D011339Probenecid"[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein"25064079
D011339Probenecid"Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein]"25064079
D011441PropylthiouracilPropylthiouracil results in decreased expression of TJP1 mRNA24780913
C034912puag-haadbisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of TJP1 mRNA]28780155
C034912puag-haadbisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of TJP1 protein]28780155
C034912puag-haadpuag-haad results in increased expression of TJP1 mRNA28780155
C034912puag-haadpuag-haad results in increased expression of TJP1 protein28780155
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the localization of TJP1 protein15798086
D011692Puromycin AminonucleosideCyclosporine inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TJP1 protein]15744817
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of TJP1 protein15744817
D011794QuercetinQuercetin affects the localization of TJP1 protein19297429
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]20445016
D011794QuercetinQuercetin inhibits the reaction [Indomethacin affects the localization of TJP1 protein]23668856
D011794QuercetinQuercetin inhibits the reaction [Indomethacin results in decreased expression of TJP1 mRNA]23668856
D011794QuercetinQuercetin inhibits the reaction [Rotenone affects the localization of TJP1 protein]23668856
D011794QuercetinQuercetin results in decreased expression of TJP1 mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [HMGB1 protein results in decreased expression of TJP1 protein]25979658
D012293RifampinRifampin affects the localization of TJP1 protein19577586
D012293RifampinRifampin results in decreased expression of TJP1 mRNA19577586
D019438RitonavirRitonavir results in decreased expression of TJP1 protein20722969
D019438Ritonavir[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein20722969
D019438RitonavirVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
C085989Ro 32-0432Ro 32-0432 inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]17991733
D012402RotenoneQuercetin inhibits the reaction [Rotenone affects the localization of TJP1 protein]23668856
D012402RotenoneRotenone affects the localization of TJP1 protein23668856
C085746rottlerinrottlerin affects the localization of TJP1 protein19297429
C496827salubrinalsalubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein]22155090
D019258Saquinavir[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein20722969
D019258Saquinavir[Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein20722969
D019258SaquinavirSaquinavir results in decreased expression of TJP1 protein20722969
D019258SaquinavirVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
D019258SaquinavirVitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
C093642SB 203580SB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]23220562
C093642SB 203580SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein]23761298
D012643Selenium[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein16514648
D012643SeleniumSelenium results in increased expression of and results in increased localization of TJP1 protein16514648
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TJP1 mRNA"21148743
D012838SilymarinSilymarin inhibits the reaction [Ethanol results in decreased expression of TJP1 mRNA]24239723
D012965Sodium ChlorideCD38 gene mutant form promotes the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]]21992601
D012965Sodium Chloride[Desoxycorticosterone Acetate co-treated with Sodium Chloride] affects the localization of [NPHS2 protein co-treated with TJP1 protein]21992601
D012969Sodium FluorideSodium Fluoride affects the localization of TJP1 protein27548804
D012969Sodium FluorideSodium Fluoride results in decreased expression of TJP1 mRNA27237588
C471405sorafenibsorafenib inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]21360571
D019311StaurosporineStaurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]16716901
D013311StreptozocinNLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein]27783111
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in decreased expression of TJP1 protein27783111
D013629TamoxifenTamoxifen affects the expression of TJP1 mRNA17555576
C084178telmisartan2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]19252288
C084178telmisartan2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]19252288
C084178telmisartan2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]19252288
C084178telmisartantelmisartan affects the localization of TJP1 protein19252288
C084178telmisartantelmisartan results in decreased expression of TJP1 mRNA19252288
C084178telmisartantelmisartan results in decreased expression of TJP1 protein19252288
C084178telmisartanwortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]19252288
C084178telmisartanwortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]19252288
C084178telmisartanwortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]19252288
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TJP1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TJP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TJP1 mRNA17942748
D013749TetrachlorodibenzodioxinGDNF protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TJP1 protein]26582458
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TJP1 protein26582458
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TJP1 mRNA25613284
D013792ThalidomideThalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein]16680017
D019284ThapsigarginThapsigargin results in increased expression of TJP1 protein24648495
D013853ThioacetamideThioacetamide results in increased expression of TJP1 mRNA23411599
D013853ThioacetamideThioacetamide results in increased expression of TJP1 protein15350541
C009495titanium dioxidetitanium dioxide results in decreased expression of TJP1 mRNA23557971
D014028Tobacco Smoke PollutionCurcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]26191140
D014028Tobacco Smoke PollutionCurcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein]26191140
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TJP1 mRNA26191140
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TJP1 protein26191140
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of TJP1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of TJP1 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of TJP1 mRNA"16650747
D014199Trehalose"Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein]"25064079
D014212TretinoinCYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]17035595
D014212TretinoinTretinoin results in increased expression of TJP1 mRNA17035595
D014212TretinoinTretinoin results in increased expression of TJP1 protein17035595
D014212TretinoinTretinoin results in increased expression of TJP1 mRNA16236135
C011559tributyltinAcetylcysteine inhibits the reaction [tributyltin results in decreased expression of TJP1 protein]26079211
C011559tributyltintributyltin results in decreased expression of TJP1 protein26079211
C012589trichostatin Atrichostatin A results in increased expression of TJP1 mRNA18661270
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of TJP1 mRNA17524140
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TJP1 mRNA19042947
D014302Trinitrobenzenesulfonic Acidginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein]22849695
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA22147983
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein22849695
C057693troglitazonetroglitazone results in decreased expression of TJP1 mRNA28973697
D017974Uranium CompoundsUranium Compounds results in decreased expression of TJP1 mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of TJP1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of TJP1 protein20576493
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TJP1 gene25560391
D001335Vehicle EmissionsCAT protein inhibits the reaction [Vehicle Emissions affects the reaction [TJP1 protein binds to OCLN protein]]21122029
D001335Vehicle EmissionsSOD2 protein inhibits the reaction [Vehicle Emissions affects the reaction [TJP1 protein binds to OCLN protein]]21122029
D001335Vehicle EmissionsVehicle Emissions affects the reaction [TJP1 protein binds to OCLN protein]21122029
D002762CholecalciferolCholecalciferol results in increased expression of TJP1 mRNA16508948
D014810Vitamin EVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
D014810Vitamin EVitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]20722969
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TJP1 mRNA"27188386
C009687wortmanninwortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]19252288
C009687wortmanninwortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]19252288
C009687wortmanninwortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]19252288
C066436zardaverinezardaverine results in decreased localization of TJP1 protein15082077
C063449zileutonzileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein]16670640

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9707407  11042084  11557048  11734628  12154091  16944923  
17724469  18823282  19332538  20164257  20850437  21402783  
22262837  23885123  
GO:0005516calmodulin binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0007043cell-cell junction assembly-TAS8486731  
GO:0035329hippo signaling-TAS-  
GO:0090557establishment of endothelial intestinal barrier-IMP23885123  
GO:1901350cell-cell signaling involved in cell-cell junction organization-NAS8395056  
GO:2000810regulation of bicellular tight junction assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002102podosome-IEA-  
GO:0005737cytoplasm-IDA11734628  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-TAS8486731  
GO:0005921gap junction-IEA-  
GO:0005923bicellular tight junction-IDA11734628  14757759  18823282  22006950  
GO:0016323basolateral plasma membrane-IDA16427635  
GO:0030054cell junction-IDA28169360  
GO:0030054cell junction-TAS-  
GO:0042995cell projection-IEA-  
GO:0043296apical junction complex-IDA16427635  
GO:0045177apical part of cell-IDA22006950  
KEGG ID KEGG Term
hsa04520Adherens junction
hsa04530Tight junction
hsa04540Gap junction
hsa05110Vibrio cholerae infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-157858Gap junction trafficking and regulationIEA
R-HSA-162582Signal TransductionTAS
R-HSA-191647c-src mediated regulation of Cx43 function and closure of gap junctionsTAS
R-HSA-191647c-src mediated regulation of Cx43 function and closure of gap junctionsIEA
R-HSA-191650Regulation of gap junction activityTAS
R-HSA-191650Regulation of gap junction activityIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-2028269Signaling by HippoTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-351906Apoptotic cleavage of cell adhesion proteinsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75153Apoptotic execution phaseTAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8935964RUNX1 regulates expression of components of tight junctionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal