Gene: TK1

7083
TK2
thymidine kinase 1
protein-coding
17q25.3
Ensembl:ENSG00000167900 MIM:188300 Vega:OTTHUMG00000150674 UniprotKB:P04183
NG_051962.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.866e-1 (AD)  7.093e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNGR20.66
SPP10.636
EFNA10.634
H2AFJ0.631
SGK10.601
ANKRD13A0.59
HEBP10.588
BEST10.588
SPATA130.585
RHOG0.585

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRP-0.352
SLC6A2-0.347
VIP-0.347
ADAMTS5-0.338
IGF1-0.335
CHRNA2-0.332
DIO2-0.326
HPSE2-0.314
PRLHR-0.294
CPLX3-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TK1 mRNA"26377693
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of TK1 mRNA"22101062
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TK1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TK1 mRNA"25614096
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of TK1 mRNA"18343893
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TK1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TK1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TK1 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased mutagenesis of TK1 gene"6694660
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of TK1 mRNA"20713471
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased mutagenesis of TK1 gene"6694660
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TK1 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of TK1 gene"26091049
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[Benzo(a)pyrene co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of TK1 gene"26091049
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TK1 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in increased expression of TK1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TK1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased activity of TK1 protein17431590
D020106AcrylamideAcrylamide results in increased expression of TK1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TK1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TK1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TK1 mRNA19770486
C008088alfacalcidolalfacalcidol inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA]17893519
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TK1 mRNA16483693
C006632arsenic trioxidearsenic trioxide affects the expression of TK1 protein25335113
C006632arsenic trioxidearsenic trioxide results in decreased expression of TK1 protein25174355
C015001arsenitearsenite results in increased methylation of TK1 promoter23974009
C015001arsenitearsenite results in decreased expression of TK1 mRNA18929588
D001379AzathioprineAzathioprine results in decreased expression of TK1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of TK1 mRNA22323515
D001397Azoxymethanealfacalcidol inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA]17893519
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA17893519
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TK1 mRNA26377693
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of TK1 gene"26091049
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TK1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TK1 gene26091049
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of TK1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TK1 mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased mutagenesis of TK1 gene"28077981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"POLK protein inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased mutagenesis of TK1 gene]"28077981
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TK1 mRNA20061341
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TK1 mRNA25566086
D004958EstradiolEstradiol results in increased expression of TK1 mRNA16474171|1831028
C044887beta-methylcholinebeta-methylcholine affects the expression of TK1 mRNA21179406
C053541bicalutamidebicalutamide results in decreased expression of TK1 mRNA15638997
C006780bisphenol Abisphenol A affects the expression of TK1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TK1 mRNA25047013|2768578
C006780bisphenol Abisphenol A results in increased expression of TK1 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of TK1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TK1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TK1 mRNA12414654
D002104CadmiumCadmium results in decreased expression of TK1 mRNA21120746|2129735
C028031cadmium acetatecadmium acetate results in decreased expression of TK1 mRNA20839231
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TK1 mRNA25993096
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TK1 mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of TK1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TK1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TK1 mRNA27339419
D002392CatechinCatechin results in decreased expression of TK1 mRNA15465739
D002713ChlorineChlorine results in decreased expression of TK1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of TK1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TK1 mRNA23650126
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of TK1 mRNA21356183
C018021cobaltous chloridecobaltous chloride results in decreased expression of TK1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of TK1 mRNA24386269
D003042CocaineCocaine results in decreased expression of TK1 mRNA17898221
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of TK1 mRNA21356183
D003300CopperCopper results in decreased expression of TK1 mRNA21356183
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TK1 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of TK1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of TK1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of TK1 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TK1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TK1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TK1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of TK1 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of TK1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TK1 mRNA20106945|2163298
D003561CytarabineCytarabine results in decreased activity of TK1 protein12893260
D003561CytarabineCytarabine results in decreased expression of TK1 mRNA12893260
D000069439DasatinibDasatinib results in decreased expression of TK1 mRNA20579391
D016047ZalcitabineZalcitabine results in decreased expression of TK1 mRNA14659972
D016047ZalcitabineZalcitabine results in decreased expression of TK1 protein14659972
C014347decitabine[decitabine results in decreased methylation of TK1 gene modified form] which affects the susceptibility to Zidovudine8464912
D016264Dextran Sulfatealfacalcidol inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA]17893519
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA17893519
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TK1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TK1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of TK1 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of TK1 mRNA24752500
D004026DieldrinDieldrin results in decreased expression of TK1 mRNA20438755
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TK1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of TK1 mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TK1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TK1 mRNA]17854601
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TK1 mRNA20360939
D002117CalcitriolCalcitriol results in decreased expression of TK1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TK1 mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TK1 protein23301498
D000431EthanolEthanol inhibits the reaction [Zidovudine results in increased activity of TK1 protein]11923581
D000431EthanolEthanol results in decreased activity of TK1 protein11923581
D000431EthanolZidovudine inhibits the reaction [Ethanol results in decreased activity of TK1 protein]11923581
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TK1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TK1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TK1 mRNA16174780
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TK1 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of TK1 mRNA15465739
D005467FloxuridineFloxuridine results in increased expression of TK1 protein16951200
D005472FluorouracilFluorouracil affects the expression of TK1 mRNA16557594
D005472FluorouracilFluorouracil promotes the reaction [geraniol results in decreased expression of TK1 mRNA]15374632
D005472FluorouracilTK1 protein affects the susceptibility to Fluorouracil15548681
D005485FlutamideFlutamide results in increased expression of TK1 mRNA21126777
D005485FlutamideFlutamide results in increased expression of TK1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of TK1 mRNA18045764
C039281furanfuran results in increased expression of TK1 mRNA25539665
D019833GenisteinGenistein results in increased expression of TK1 mRNA16474171
C007836geraniolFluorouracil promotes the reaction [geraniol results in decreased expression of TK1 mRNA]15374632
C007836geraniolgeraniol results in decreased expression of TK1 mRNA15374632
D005944GlucosamineGlucosamine results in decreased expression of TK1 mRNA17109745
D017313FenretinideFenretinide results in increased expression of TK1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TK1 mRNA12414654
C492448ICG 001ICG 001 results in decreased expression of TK1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TK1 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of TK1 mRNA21335049
C544151jinfukangjinfukang results in increased expression of TK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of TK124394663
C410337K 7174K 7174 results in decreased expression of TK1 mRNA24086573
C006552kaempferolkaempferol results in increased mutagenesis of TK1 gene6828043
D007840LatexLatex analog results in increased expression of TK1 mRNA24768652
C008261lead acetatelead acetate results in increased expression of TK1 mRNA22609695
C045463leflunomideleflunomide results in decreased expression of TK1 mRNA24136188
D008727MethotrexateMethotrexate results in decreased expression of TK1 mRNA24136188
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TK1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TK1 mRNA23649840
D016685MitomycinMitomycin results in increased mutagenesis of TK1 gene28077981
D016685MitomycinPOLK protein inhibits the reaction [Mitomycin results in increased mutagenesis of TK1 gene]28077981
D016685MitomycinMitomycin results in increased mutagenesis of TK1 gene19237551
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TK1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TK1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TK1 mRNA"25620056
C031721naphthalenenaphthalene results in increased expression of TK1 mRNA18978301
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TK1 mRNA19812364
D009532NickelNickel results in increased expression of TK1 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of TK1 mRNA22110744
D009569Nitric OxideNitric Oxide results in increased mutagenesis of TK1 gene22303861|2845427
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased mutagenesis of TK1 gene28454271
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TK1 mRNA20971185
C464660obeticholic acidobeticholic acid results in decreased expression of TK1 mRNA27939613
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TK1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TK1 mRNA25729387
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TK1 mRNA]19555225
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of TK1 mRNA18636392
D017239PaclitaxelPaclitaxel results in increased mutagenesis of TK1 gene19237551
C500026palbociclibpalbociclib analog results in decreased expression of TK1 mRNA15542782
C500026palbociclibpalbociclib results in decreased expression of TK1 mRNA22869556
C500026palbociclibpalbociclib results in decreased expression of TK1 protein22170262
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TK1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of TK1 mRNA24642059
D010634PhenobarbitalPhenobarbital affects the expression of TK1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of TK1 mRNA19270015|2309116
D048789PhytoestrogensPhytoestrogens results in increased expression of TK1 mRNA18310284
C006253pirinixic acidpirinixic acid results in decreased expression of TK1 mRNA17426115
D010894PiroxicamPiroxicam results in decreased expression of TK1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in decreased expression of TK1 mRNA15465739
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of TK1 mRNA16474171
D059808PolyphenolsPolyphenols results in decreased expression of TK1 mRNA15465739
C019536potassium bromatepotassium bromate results in increased mutagenesis of TK1 gene19853637
D011192Potassium DichromatePotassium Dichromate results in increased expression of TK1 protein23718831
D011344ProcarbazineProcarbazine results in increased mutagenesis of TK1 gene3288842
D011374ProgesteroneProgesterone results in decreased expression of TK1 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of TK1 mRNA18070364
D011374ProgesteroneProgesterone results in decreased expression of TK1 mRNA16966611
D011374ProgesteroneProgesterone results in decreased expression of TK1 mRNA20726854
D011374ProgesteroneProgesterone results in increased expression of TK117510236
D011441PropylthiouracilPropylthiouracil results in increased expression of TK1 mRNA24780913
C031280pyrazolepyrazole results in decreased expression of TK1 mRNA17945193
D011794QuercetinQuercetin results in increased mutagenesis of TK1 gene6828043
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TK1 mRNA19167446
C089730rosiglitazonerosiglitazone results in increased expression of TK1 mRNA21515302
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of TK1 mRNA"16678137
C009250sevofluranesevoflurane results in increased expression of TK1 mRNA26206149
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TK1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of TK1 mRNA25351596
D012834SilverSilver results in increased mutagenesis of TK1 gene22576574
C017947sodium arseniteAPEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of TK1 gene]17938202
C017947sodium arsenite[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of TK1 gene17938202
C017947sodium arsenitesodium arsenite results in decreased expression of TK1 mRNA20371982|2129735
D012999SomanSoman results in increased expression of TK1 mRNA19281266
D053260SootSoot results in increased expression of TK1 mRNA22461453|2655175
C025462sulindac sulfidesulindac sulfide results in decreased expression of TK1 mRNA16184548
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TK1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of TK1 mRNA17555576
C021751tanshinonetanshinone results in increased expression of TK1 mRNA15849732
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TK1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TK1 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of TK1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TK1 mRNA21496263
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TK1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TK1 mRNA18343893|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of TK1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TK1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TK1 mRNA15034205|1661135
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TK1 mRNA15667827|2149626
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TK1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of TK1 mRNA22378314
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of TK1 mRNA23825117
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TK1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in decreased expression of TK1 mRNA26489853
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TK1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TK1 mRNA25729387
C099150trabectedintrabectedin results in decreased expression of TK1 mRNA15961672
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of TK1 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of TK1 mRNA16249480
D014212TretinoinTretinoin results in increased expression of TK1 mRNA16054129
D014212TretinoinTretinoin results in increased expression of TK1 mRNA16604517
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TK1 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of TK1 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TK1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TK1 mRNA19140230
C057693troglitazonetroglitazone results in increased expression of TK1 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of TK1 mRNA22378314
D014425TurpentineTurpentine results in decreased expression of TK1 mRNA16044259
D014520UrethaneUrethane results in decreased expression of TK1 mRNA28818685
D014640VancomycinVancomycin results in decreased expression of TK1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TK1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TK1 mRNA21126777
C025643vinclozolinvinclozolin results in decreased expression of TK1 mRNA20566332
C029297vinylidene chloridevinylidene chloride results in increased expression of TK1 mRNA26682919
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of TK1 mRNA23825117
D014800VitalliumVitallium analog results in decreased expression of TK1 mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of TK1 mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in decreased expression of TK1 mRNA12414654
D015215Zidovudine[decitabine results in decreased methylation of TK1 gene modified form] which affects the susceptibility to Zidovudine8464912
D015215ZidovudineTK1 gene modified form results in decreased metabolism of Zidovudine8464912
D015215ZidovudineTK1 gene modified form results in decreased susceptibility to Zidovudine8464912
D015215ZidovudineZidovudine results in increased methylation of TK1 gene8464912
D015215ZidovudineEthanol inhibits the reaction [Zidovudine results in increased activity of TK1 protein]11923581
D015215ZidovudineTK1 gene modified form results in decreased susceptibility to Zidovudine8915012
D015215ZidovudineTK1 protein affects the transport of Zidovudine17067265
D015215ZidovudineTK1 protein results in increased susceptibility to Zidovudine17067265|8941356
D015215ZidovudineZidovudine inhibits the reaction [Ethanol results in decreased activity of TK1 protein]11923581
D015215ZidovudineZidovudine results in decreased activity of TK1 protein8941356
D015215ZidovudineZidovudine results in decreased expression of TK1 mRNA24292225|8941356
D015215ZidovudineZidovudine results in decreased expression of TK1 protein20106944|2429222
D015215ZidovudineZidovudine results in increased activity of TK1 protein11923581
D015215ZidovudineZidovudine results in increased expression of TK1 mRNA24292225
D015215ZidovudineZidovudine results in increased expression of TK1 protein24292225
D015215ZidovudineZidovudine results in increased methylation of TK1 exon8915012
D015215ZidovudineTK1 protein results in increased metabolism of Zidovudine15708581
D015215ZidovudineTK1 protein results in increased susceptibility to Zidovudine15708581
D015215ZidovudineZidovudine results in increased mutagenesis of TK1 gene15013700|1923755
D015032ZincZinc deficiency results in increased expression of TK1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004797thymidine kinase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-IDA17407781  
GO:0019206nucleoside kinase activity-EXP15733844  
GO:0042802identical protein binding-IPI21900206  22385435  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS3335503  
GO:0006259DNA metabolic process-IBA21873635  
GO:0009157deoxyribonucleoside monophosphate biosynthetic process-IEA-  
GO:0009165nucleotide biosynthetic process-IEA-  
GO:0016310phosphorylation-IEA-  
GO:0043097pyrimidine nucleoside salvage-TAS-  
GO:0046104thymidine metabolic process-IBA21873635  
GO:0051289protein homotetramerization-IPI17407781  
GO:0071897DNA biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-1640170Cell CycleIEA
R-HSA-453279Mitotic G1-G1/S phasesIEA
R-HSA-539107Activation of E2F1 target genes at G1/SIEA
R-HSA-69205G1/S-Specific TranscriptionIEA
R-HSA-69206G1/S TransitionIEA
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-73614Pyrimidine salvageTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20666582Smoking increases transcription of human endogenous retroviruses in a newly established in vitro cell model and in normal urothelium. (2010 Aug)Gabriel UAIDS Res Hum Retroviruses