Gene: ICAM5

7087
TLCN|TLN
intercellular adhesion molecule 5
protein-coding
19p13.2
Ensembl:ENSG00000105376 MIM:601852 Vega:OTTHUMG00000180406 UniprotKB:Q9UMF0
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.400e-1 (AD)  6.160e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D50.952
PRKCG0.942
PTPN50.941
IQSEC20.941
CAMKK10.935
NGEF0.935
KIAA05130.934
SYT70.933
CAMKV0.932
CACNG80.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.542
MYL3-0.533
HEY2-0.528
REST-0.523
COPZ2-0.521
WWTR1-0.518
RAI14-0.516
ZNF114-0.514
CNN2-0.509
CLEC2B-0.499

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ICAM5 mRNA"23146750
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ICAM5 gene28458013
D001151ArsenicArsenic affects the expression of ICAM5 mRNA28793237
D001151ArsenicArsenic affects the expression of ICAM5 protein24675094
D001151Arsenic[Arsenic results in increased abundance of Arsenicals] which affects the expression of ICAM5 mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of ICAM5 mRNA28793237
D001152Arsenicals[Arsenic results in increased abundance of Arsenicals] which affects the expression of ICAM5 mRNA28793237
C015001arsenitearsenite results in increased methylation of ICAM5 promoter23974009
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in decreased expression of ICAM5 mRNA]26789235
D004958EstradiolEstradiol results in decreased expression of ICAM5 mRNA26789235
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of ICAM5 mRNA]26789235
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in decreased expression of ICAM5 mRNA]26789235
C006780bisphenol Abisphenol A results in decreased expression of ICAM5 mRNA26789235
C006780bisphenol Abisphenol A results in increased expression of ICAM5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ICAM5 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of ICAM5 mRNA26079696
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of ICAM5 mRNA28793237
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ICAM5 mRNA24982889
D002330CarmustineCarmustine results in decreased expression of ICAM5 mRNA15980968
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ICAM5 gene20938992
D003471CuprizoneCuprizone results in decreased expression of ICAM5 mRNA26577399
D003976DiazinonDiazinon results in decreased methylation of ICAM5 gene22964155
D005473FluoxetineFluoxetine results in decreased expression of ICAM5 mRNA17033635
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ICAM5 gene20938992
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of ICAM5 mRNA]26789235
C412815GW 4064GW 4064 results in increased expression of ICAM5 mRNA26655953
C410337K 7174K 7174 results in decreased expression of ICAM5 mRNA24086573
D007649KetamineKetamine results in increased expression of ICAM5 mRNA20080153
D007854LeadLead affects the expression of ICAM5 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM5 mRNA"24972896
C013592mangiferinmangiferin results in decreased expression of ICAM5 mRNA15135318
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ICAM5 gene20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ICAM5 mRNA24810058
C005556propionaldehydepropionaldehyde results in increased expression of ICAM5 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of ICAM5 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of ICAM5 mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ICAM5 mRNA23806026
D012969Sodium FluorideSodium Fluoride results in increased expression of ICAM5 mRNA27862939
D012999SomanSoman results in decreased expression of ICAM5 mRNA19281266
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ICAM5 mRNA28065790
C025643vinclozolinvinclozolin affects the expression of ICAM5 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IBA21873635  
GO:0005515protein binding-IPI16820411  
GO ID GO Term Qualifier Evidence PubMed
GO:0006909phagocytosis-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0050776regulation of immune response-TAS-  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8995416  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-216083Integrin cell surface interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27616475Gene variants as risk factors for gastroschisis. (2016 Nov)Padula AMAm J Med Genet A