Gene: TLE4

7091
BCE-1|BCE1|E(spI)|ESG|ESG4|GRG4|Grg-4
transducin like enhancer of split 4
protein-coding
9q21.31
Ensembl:ENSG00000106829 MIM:605132 Vega:OTTHUMG00000020072 UniprotKB:Q04727
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.425e-1 (AD)  5.100e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC8D0.856
NXPE30.856
UNC5C0.851
CPOX0.849
STARD130.843
SPTLC20.841
MSH60.839
CEP850.834
PXK0.826
SLCO3A10.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.437
OR4F29-0.43
DIO2-0.353
OR4F16-0.33
TNNT1-0.316
FOXL1-0.302
WNT7B-0.297
KCNJ16-0.296
PLA2G5-0.291
RNF43-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TLE4 mRNA"12376462
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of TLE4 mRNA19643169
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TLE4 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of TLE4 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TLE4 protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TLE4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TLE4 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TLE4 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of TLE4 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of TLE4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TLE4 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TLE4 mRNA"19150397
D004958EstradiolEstradiol affects the expression of TLE4 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of TLE4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TLE4 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TLE4 mRNA15336504
D019327Copper SulfateCopper Sulfate affects the expression of TLE4 mRNA19549813
C014347decitabinedecitabine results in increased expression of TLE4 mRNA27915011
D003907DexamethasoneDexamethasone results in decreased expression of TLE4 mRNA12782123
D002945CisplatinCisplatin results in decreased expression of TLE4 mRNA27594783
D002945CisplatinCisplatin results in increased expression of TLE4 mRNA27392435
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TLE4 mRNA"12376462
C118739entinostatentinostat results in decreased expression of TLE4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLE4 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TLE4 mRNA23649840
D004397FonofosFonofos results in increased methylation of TLE4 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of TLE4 mRNA20655997|2364984
C001277geldanamycingeldanamycin results in increased expression of TLE4 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of TLE4 mRNA22061828
D017313FenretinideFenretinide results in increased expression of TLE4 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of TLE4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TLE4 mRNA27432991
C005219methyl cellosolvemethyl cellosolve results in increased expression of TLE4 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TLE4 mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TLE4 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of TLE4 mRNA29191790
C029938nickel sulfatenickel sulfate results in increased expression of TLE4 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TLE4 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of TLE4 mRNA26272509
D010278ParathionParathion results in increased methylation of TLE4 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of TLE4 mRNA22178795
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TLE4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of TLE4 mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of TLE4 mRNA]20059764
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLE4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TLE4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TLE4 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of TLE4 mRNA24780913
D012402RotenoneRotenone affects the expression of TLE4 mRNA27900601
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TLE4 mRNA21427059
D012715Sesame OilSesame Oil results in decreased expression of TLE4 mRNA29191790
D012834SilverSilver results in decreased expression of TLE4 mRNA27131904
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of TLE4 mRNA16214533
C012568terbufosterbufos results in increased methylation of TLE4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TLE4 mRNA19465110
D013849ThimerosalThimerosal results in decreased expression of TLE4 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TLE4 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TLE4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TLE4 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of TLE4 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of TLE4 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TLE4 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of TLE4 mRNA28973697
D014520UrethaneUrethane results in increased expression of TLE4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TLE4 mRNA23179753|2627250
D014635Valproic AcidValproic Acid analog results in decreased expression of TLE4 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of TLE4 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TLE4 gene25560391
C111237vorinostatvorinostat results in decreased expression of TLE4 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of TLE4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0003682chromatin binding-IEA-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IEA-  
GO:0005515protein binding-IPI24676634  
GO:0070491repressing transcription factor binding-IBA21873635  
GO:0070491repressing transcription factor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0008150biological_process-ND-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS1303260  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:1990907beta-catenin-TCF complex-IDA28296634  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195253Degradation of beta-catenin by the destruction complexIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-4641265Repression of WNT target genesTAS
R-HSA-4641265Repression of WNT target genesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26642056In Utero Cigarette Smoke Affects Allergic Airway Disease But Does Not Alter the Lung Methylome. (2015)Eyring KRPLoS One