Gene info: ID 7096

Gene: TLR1

GENE ID: 7096

Synonyms: CD281|TIL|TIL. LPRS5|rsc786

Description: toll like receptor 1

Gene type: protein-coding

Location: 4p14

dbXrefs: Ensembl:ENSG00000174125 MIM:601194 Vega:OTTHUMG00000160413 UniprotKB:Q15399

RefSeq: NG_016228.1

Retrived from: PubMed|SNP Mapped

SNPs: 5 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.034e-1 (AD) 7.246e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs5743604	chr4:38799664 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs4833095	chr4:38798089 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4543123	chr4:38790903 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs6531663	chr4:38790719 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4833093	chr4:38788119 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PTPRC	0.945
TFEC	0.936
DAPP1	0.935
PIK3AP1	0.93
GPR65	0.925
RUNX1	0.925
SAMSN1	0.922
SNX20	0.922
BTK	0.921
ALOX5	0.92

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASPDH	-0.491
KCNIP3	-0.49
WNT7A	-0.455
MAGIX	-0.452
HAGHL	-0.449
KCNK4	-0.448
TMEM179	-0.447
ATP2C2	-0.441
CHRNA4	-0.437
ARSF	-0.428

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"[FSL-1 lipoprotein, synthetic co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR1 mRNA"	23405061
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR1 mRNA	23405061
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA]	23405061
C003898	2-anisidine	2-anisidine results in increased expression of TLR1 mRNA	28089782
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]"	23452621
D000082	Acetaminophen	Acetaminophen results in increased expression of TLR1 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TLR1 protein	20106945
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of TLR1 mRNA	21757418
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of TLR1 mRNA"	23195993
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of TLR1 mRNA	28522335
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA]"	23405061
D015075	2-Aminopurine	"2-Aminopurine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
D015075	2-Aminopurine	2-Aminopurine inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA]	23405061
D000666	Amphotericin B	TLR1 affects the susceptibility to Amphotericin B	18466103
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TLR1 mRNA	24449571
D001151	Arsenic	Arsenic results in increased expression of TLR1 mRNA	27838757
C015001	arsenite	arsenite results in decreased expression of TLR1 mRNA	18191166
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of TLR1 mRNA	26377693
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of TLR1 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TLR1 mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TLR1 mRNA	20713471
C018475	butyraldehyde	butyraldehyde results in decreased expression of TLR1 mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in increased expression of TLR1 mRNA	15196572
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TLR1 mRNA	23741332
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TLR1 mRNA	27339419
D002737	Chloroprene	Chloroprene results in decreased expression of TLR1 mRNA	23125180
D002738	Chloroquine	[Chloroquine co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
D002738	Chloroquine	"[FSL-1 lipoprotein, synthetic co-treated with Chloroquine] results in increased expression of TLR1 mRNA"	23405061
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR1 mRNA	20938992
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of TLR1 mRNA	23405061
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of TLR1 mRNA	23405061
D003471	Cuprizone	Cuprizone results in increased expression of TLR1 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D016572	Cyclosporine	Cyclosporine results in decreased expression of TLR1 mRNA	20106945
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of TLR1 mRNA	26763390
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TLR1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of TLR1 mRNA	27594783
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of TLR1 mRNA	26924002
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TLR1 mRNA	24535843
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of TLR1 mRNA	26924002
D004317	Doxorubicin	Doxorubicin results in increased expression of TLR1 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of TLR1 mRNA]	27181935
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR1 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of TLR1 mRNA	23649840
C460864	FSL-1 lipoprotein, synthetic	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
C460864	FSL-1 lipoprotein, synthetic	"2-Aminopurine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
C460864	FSL-1 lipoprotein, synthetic	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic co-treated with Chloroquine] results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic co-treated with SB 203580] results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic co-treated with tripterine] results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic co-treated with U 0126] results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic co-treated with wortmannin] results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA"	23405061
C460864	FSL-1 lipoprotein, synthetic	"pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of TLR1 mRNA]	27181935
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D019833	Genistein	Genistein results in increased expression of TLR1 mRNA	22553218
D005944	Glucosamine	Glucosamine results in increased expression of TLR1 mRNA	17178593
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR1 mRNA	25613284
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of TLR1 mRNA"	23090859
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR1 mRNA	23405061
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR1 mRNA	23405061
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR1 mRNA	23405061
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TLR1 mRNA	23405061
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR1 mRNA	23405061
D008070	Lipopolysaccharides	pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR1 mRNA]	23405061
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR1 mRNA	27339419
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR1 mRNA	20938992
D008727	Methotrexate	Methotrexate results in increased expression of TLR1 mRNA	21678067
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TLR1 mRNA	23103053
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of TLR1 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in increased expression of TLR1 mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TLR1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TLR1 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of TLR1 mRNA	23195993
D009532	Nickel	Nickel results in increased expression of TLR1 mRNA	24768652\|2558310
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TLR1 mRNA	25729387
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of TLR1 mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
C508075	Pam(3)CSK(4) peptide	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
C508075	Pam(3)CSK(4) peptide	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA]	23405061
C508075	Pam(3)CSK(4) peptide	2-Aminopurine inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA]	23405061
C508075	Pam(3)CSK(4) peptide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA]"	23405061
C508075	Pam(3)CSK(4) peptide	[Chloroquine co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide results in decreased expression of TLR1 mRNA	23405061
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide results in increased expression of TLR1 mRNA	23405061
C508075	Pam(3)CSK(4) peptide	[U 0126 co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
C508075	Pam(3)CSK(4) peptide	[wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide binds to and results in increased activity of TLR1 protein	23266719
C006253	pirinixic acid	pirinixic acid results in increased expression of TLR1 mRNA	23811191
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D011070	Poly I-C	Poly I-C results in increased expression of TLR1 mRNA	23405061
C432165	pyrazolanthrone	"pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR1 mRNA]"	23405061
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR1 mRNA]	23405061
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]	23452621
D012293	Rifampin	Rifampin results in increased expression of TLR1 mRNA	24552687
C093642	SB 203580	"[FSL-1 lipoprotein, synthetic co-treated with SB 203580] results in increased expression of TLR1 mRNA"	23405061
C093642	SB 203580	[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR1 mRNA	23405061
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of TLR1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TLR1 mRNA	25351596
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TLR1 mRNA	25461914
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TLR1 mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TLR1 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TLR1 mRNA	26290441
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of TLR1 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TLR1 mRNA	25729387
C050414	tripterine	"[FSL-1 lipoprotein, synthetic co-treated with tripterine] results in increased expression of TLR1 mRNA"	23405061
C113580	U 0126	"[FSL-1 lipoprotein, synthetic co-treated with U 0126] results in increased expression of TLR1 mRNA"	23405061
C113580	U 0126	[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR1 mRNA	23405061
C113580	U 0126	[U 0126 co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
D014520	Urethane	Urethane results in increased expression of TLR1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of TLR1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TLR1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of TLR1 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of TLR1 mRNA	18629315
C009687	wortmannin	"[FSL-1 lipoprotein, synthetic co-treated with wortmannin] results in increased expression of TLR1 mRNA"	23405061
C009687	wortmannin	[wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR1 mRNA	23405061
D015034	Zinc Oxide	Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR1 mRNA]	25127755

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	NAS	11081518
GO:0005515	protein binding	-	IPI	16880211 23155421
GO:0035663	Toll-like receptor 2 binding	-	IBA	21873635
GO:0035663	Toll-like receptor 2 binding	-	IPI	16880211
GO:0038023	signaling receptor activity	-	TAS	10426995
GO:0042802	identical protein binding	-	IPI	23155421
GO:0046982	protein heterodimerization activity	-	IDA	17889651
GO:0071723	lipopeptide binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001775	cell activation	-	IDA	15294986
GO:0002224	toll-like receptor signaling pathway	-	IBA	21873635
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	TAS	10426995
GO:0007165	signal transduction	-	TAS	9435236 10426995
GO:0034130	toll-like receptor 1 signaling pathway	-	IEA	-
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	-	IGI	22198949
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	-	TAS	-
GO:0042116	macrophage activation	-	NAS	11607792
GO:0042495	detection of triacyl bacterial lipopeptide	-	IDA	19931471
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	-	ISS	12077222
GO:0045087	innate immune response	-	IEA	-
GO:0045410	positive regulation of interleukin-6 biosynthetic process	-	ISS	12077222
GO:0071221	cellular response to bacterial lipopeptide	-	IBA	21873635
GO:0071727	cellular response to triacyl bacterial lipopeptide	-	IBA	21873635
GO:0071727	cellular response to triacyl bacterial lipopeptide	-	IDA	16880211 19931471
GO:2000484	positive regulation of interleukin-8 secretion	-	IGI	22198949

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005794	Golgi apparatus	-	IDA	16880211
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	9435236
GO:0016020	membrane	-	NAS	11081518
GO:0030670	phagocytic vesicle membrane	-	IEA	-
GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	-	IBA	21873635
GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	-	IDA	17889651
GO:0045121	membrane raft	-	IDA	16880211

KEGG ID	KEGG Term
hsa04620	Toll-like receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1236974	ER-Phagosome pathway	TAS
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1461957	Beta defensins	TAS
R-HSA-1461973	Defensins	TAS
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-5260271	Diseases of Immune System	TAS
R-HSA-5602358	Diseases associated with the TLR signaling cascade	TAS
R-HSA-5602498	MyD88 deficiency (TLR2/4)	TAS
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-6803157	Antimicrobial peptides	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25332681	Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study. (2014 Dec)	Slattery ML	Mutat Res
26061394	Expression of Toll-like receptors in nasal epithelium in allergic rhinitis. (2015 Aug)	Renkonen J	APMIS
26208141	TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. (2015 Sep)	Bailey KL	Alcohol Clin Exp Res
23823019	A TLR6 polymorphism is associated with increased risk of Legionnaires' disease. (2013 Oct)	Misch EA	Genes Immun